HTH cro/C1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

multiprotein-bridging factor 1, putative

Species:

Leishmania major

UniProt:

Q4QDK2_LEIMA

TriTrypDb:

LmjF.19.0190 , LMJLV39_190006800 , LMJSD75_190006700

Length:

163

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.509
CLV_MEL_PAP_1	110	116	PF00089	0.351
CLV_NRD_NRD_1	30	32	PF00675	0.365
CLV_NRD_NRD_1	51	53	PF00675	0.337
CLV_PCSK_SKI1_1	144	148	PF00082	0.537
CLV_PCSK_SKI1_1	31	35	PF00082	0.343
CLV_PCSK_SKI1_1	91	95	PF00082	0.363
CLV_PCSK_SKI1_1	96	100	PF00082	0.348
DOC_MAPK_gen_1	134	143	PF00069	0.291
DOC_MAPK_gen_1	80	90	PF00069	0.567
DOC_MAPK_HePTP_8	131	143	PF00069	0.407
DOC_MAPK_MEF2A_6	134	143	PF00069	0.407
DOC_MAPK_MEF2A_6	82	90	PF00069	0.560
DOC_USP7_MATH_1	41	45	PF00917	0.537
LIG_14-3-3_CanoR_1	109	117	PF00244	0.467
LIG_Actin_WH2_2	128	146	PF00022	0.291
LIG_deltaCOP1_diTrp_1	11	19	PF00928	0.481
LIG_FHA_1	76	82	PF00498	0.476
LIG_FHA_2	32	38	PF00498	0.554
LIG_FHA_2	6	12	PF00498	0.556
LIG_SUMO_SIM_anti_2	111	119	PF11976	0.367
LIG_TRAF2_1	125	128	PF00917	0.451
MOD_CK1_1	24	30	PF00069	0.595
MOD_GlcNHglycan	121	124	PF01048	0.319
MOD_GlcNHglycan	23	26	PF01048	0.265
MOD_GlcNHglycan	43	46	PF01048	0.352
MOD_GlcNHglycan	63	66	PF01048	0.337
MOD_GSK3_1	108	115	PF00069	0.432
MOD_N-GLC_1	75	80	PF02516	0.322
MOD_N-GLC_1	99	104	PF02516	0.407
MOD_NEK2_1	152	157	PF00069	0.590
MOD_NEK2_1	99	104	PF00069	0.407
MOD_PIKK_1	99	105	PF00454	0.331
MOD_PKA_1	31	37	PF00069	0.565
MOD_PKA_2	108	114	PF00069	0.432
MOD_PKA_2	21	27	PF00069	0.407
MOD_Plk_1	75	81	PF00069	0.522
MOD_Plk_4	112	118	PF00069	0.407
MOD_SUMO_for_1	133	136	PF00179	0.291
TRG_ER_diArg_1	88	91	PF00400	0.526
TRG_NES_CRM1_1	104	119	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K7	Leptomonas seymouri	82%	100%
A0A1X0P7A2	Trypanosomatidae	64%	100%
A0A3S7WV69	Leishmania donovani	97%	100%
A0A422NCU0	Trypanosoma rangeli	59%	98%
A4H9X6	Leishmania braziliensis	91%	100%
D0A0D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AGS1	Leishmania infantum	97%	100%
E9ARX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O14467	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
O60869	Homo sapiens	36%	100%
O94700	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P69736	Rattus norvegicus	36%	100%
Q3T0V7	Bos taurus	36%	100%
Q53IP3	Gibberella fujikuroi	28%	100%
Q5A940	Candida albicans (strain SC5314 / ATCC MYA-2876)	32%	100%
Q5ZMC0	Gallus gallus	35%	100%
Q6BXQ8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	35%	100%
Q6CIP4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	100%
Q6FJN0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	35%	100%
Q6GPQ6	Xenopus laevis	36%	100%
Q6PBY3	Danio rerio	31%	100%
Q752P7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	34%	100%
Q871W6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q8TG23	Yarrowia lipolytica (strain CLIB 122 / E 150)	34%	100%
Q9JMG1	Mus musculus	36%	100%
Q9LV58	Arabidopsis thaliana	39%	100%
Q9LXT3	Arabidopsis thaliana	37%	100%
Q9SJI8	Arabidopsis thaliana	36%	100%