LeishMANIAdb
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TOG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TOG domain-containing protein
Gene product:
centrosomal protein of 104 kDa
Species:
Leishmania major
UniProt:
Q4QDJ6_LEIMA
TriTrypDb:
LmjF.19.0250 , LMJLV39_190007400 * , LMJSD75_190007300 *
Length:
875

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0097542 ciliary tip 2 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

Q4QDJ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDJ6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 358 362 PF00656 0.624
CLV_MEL_PAP_1 213 219 PF00089 0.253
CLV_NRD_NRD_1 43 45 PF00675 0.376
CLV_NRD_NRD_1 437 439 PF00675 0.436
CLV_NRD_NRD_1 553 555 PF00675 0.449
CLV_NRD_NRD_1 743 745 PF00675 0.439
CLV_NRD_NRD_1 800 802 PF00675 0.431
CLV_PCSK_KEX2_1 105 107 PF00082 0.413
CLV_PCSK_KEX2_1 400 402 PF00082 0.508
CLV_PCSK_KEX2_1 553 555 PF00082 0.447
CLV_PCSK_KEX2_1 743 745 PF00082 0.433
CLV_PCSK_KEX2_1 799 801 PF00082 0.429
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.497
CLV_PCSK_PC1ET2_1 400 402 PF00082 0.394
CLV_PCSK_PC1ET2_1 799 801 PF00082 0.464
CLV_PCSK_SKI1_1 101 105 PF00082 0.422
CLV_PCSK_SKI1_1 123 127 PF00082 0.323
CLV_PCSK_SKI1_1 138 142 PF00082 0.286
CLV_PCSK_SKI1_1 212 216 PF00082 0.445
CLV_PCSK_SKI1_1 270 274 PF00082 0.414
CLV_PCSK_SKI1_1 400 404 PF00082 0.485
CLV_PCSK_SKI1_1 631 635 PF00082 0.319
DEG_Nend_Nbox_1 1 3 PF02207 0.503
DEG_SCF_FBW7_2 193 200 PF00400 0.533
DEG_SPOP_SBC_1 637 641 PF00917 0.501
DOC_ANK_TNKS_1 593 600 PF00023 0.380
DOC_CDC14_PxL_1 608 616 PF14671 0.396
DOC_CDC14_PxL_1 730 738 PF14671 0.519
DOC_CKS1_1 174 179 PF01111 0.511
DOC_CKS1_1 194 199 PF01111 0.397
DOC_CKS1_1 203 208 PF01111 0.466
DOC_CYCLIN_RxL_1 270 281 PF00134 0.397
DOC_CYCLIN_RxL_1 628 639 PF00134 0.330
DOC_CYCLIN_yCln2_LP_2 403 409 PF00134 0.355
DOC_MAPK_gen_1 105 112 PF00069 0.404
DOC_MAPK_gen_1 270 279 PF00069 0.518
DOC_MAPK_gen_1 553 561 PF00069 0.490
DOC_MAPK_MEF2A_6 132 141 PF00069 0.306
DOC_MAPK_MEF2A_6 270 279 PF00069 0.441
DOC_MAPK_MEF2A_6 553 560 PF00069 0.440
DOC_MAPK_MEF2A_6 7 14 PF00069 0.350
DOC_MAPK_MEF2A_6 74 83 PF00069 0.326
DOC_PP1_RVXF_1 629 635 PF00149 0.326
DOC_PP2B_LxvP_1 403 406 PF13499 0.333
DOC_PP2B_LxvP_1 722 725 PF13499 0.491
DOC_PP4_FxxP_1 307 310 PF00568 0.601
DOC_PP4_FxxP_1 634 637 PF00568 0.356
DOC_USP7_MATH_1 320 324 PF00917 0.684
DOC_USP7_MATH_1 450 454 PF00917 0.494
DOC_USP7_MATH_1 458 462 PF00917 0.375
DOC_USP7_MATH_1 505 509 PF00917 0.401
DOC_USP7_MATH_1 575 579 PF00917 0.443
DOC_USP7_MATH_1 701 705 PF00917 0.725
DOC_USP7_UBL2_3 101 105 PF12436 0.489
DOC_USP7_UBL2_3 369 373 PF12436 0.516
DOC_USP7_UBL2_3 421 425 PF12436 0.486
DOC_USP7_UBL2_3 565 569 PF12436 0.536
DOC_WW_Pin1_4 173 178 PF00397 0.504
DOC_WW_Pin1_4 193 198 PF00397 0.559
DOC_WW_Pin1_4 202 207 PF00397 0.694
DOC_WW_Pin1_4 306 311 PF00397 0.660
DOC_WW_Pin1_4 312 317 PF00397 0.779
DOC_WW_Pin1_4 407 412 PF00397 0.439
DOC_WW_Pin1_4 545 550 PF00397 0.472
DOC_WW_Pin1_4 690 695 PF00397 0.692
DOC_WW_Pin1_4 855 860 PF00397 0.392
LIG_14-3-3_CanoR_1 132 137 PF00244 0.376
LIG_14-3-3_CanoR_1 185 189 PF00244 0.568
LIG_14-3-3_CanoR_1 216 223 PF00244 0.517
LIG_14-3-3_CanoR_1 401 406 PF00244 0.457
LIG_14-3-3_CanoR_1 44 50 PF00244 0.477
LIG_14-3-3_CanoR_1 703 707 PF00244 0.697
LIG_14-3-3_CanoR_1 814 822 PF00244 0.416
LIG_14-3-3_CanoR_1 843 849 PF00244 0.285
LIG_Actin_WH2_2 268 285 PF00022 0.301
LIG_AP2alpha_1 586 590 PF02296 0.456
LIG_BIR_III_4 361 365 PF00653 0.655
LIG_Clathr_ClatBox_1 558 562 PF01394 0.478
LIG_Clathr_ClatBox_1 632 636 PF01394 0.449
LIG_eIF4E_1 430 436 PF01652 0.288
LIG_eIF4E_1 662 668 PF01652 0.398
LIG_FHA_1 125 131 PF00498 0.365
LIG_FHA_1 185 191 PF00498 0.489
LIG_FHA_1 208 214 PF00498 0.607
LIG_FHA_1 279 285 PF00498 0.458
LIG_FHA_1 361 367 PF00498 0.667
LIG_FHA_1 402 408 PF00498 0.463
LIG_FHA_1 422 428 PF00498 0.443
LIG_FHA_1 466 472 PF00498 0.348
LIG_FHA_1 495 501 PF00498 0.422
LIG_FHA_1 515 521 PF00498 0.458
LIG_FHA_1 522 528 PF00498 0.507
LIG_FHA_1 600 606 PF00498 0.497
LIG_FHA_1 63 69 PF00498 0.355
LIG_FHA_1 681 687 PF00498 0.741
LIG_FHA_1 724 730 PF00498 0.562
LIG_FHA_1 831 837 PF00498 0.341
LIG_FHA_2 583 589 PF00498 0.428
LIG_FHA_2 793 799 PF00498 0.428
LIG_FHA_2 85 91 PF00498 0.377
LIG_LIR_Apic_2 304 310 PF02991 0.604
LIG_LIR_Gen_1 135 144 PF02991 0.369
LIG_LIR_Gen_1 464 474 PF02991 0.317
LIG_LIR_Nem_3 135 139 PF02991 0.349
LIG_LIR_Nem_3 464 470 PF02991 0.353
LIG_LIR_Nem_3 739 745 PF02991 0.516
LIG_MAD2 401 409 PF02301 0.313
LIG_MYND_1 772 776 PF01753 0.305
LIG_NRBOX 628 634 PF00104 0.383
LIG_Pex14_2 586 590 PF04695 0.456
LIG_PTAP_UEV_1 724 729 PF05743 0.478
LIG_SH2_CRK 473 477 PF00017 0.369
LIG_SH2_CRK 742 746 PF00017 0.511
LIG_SH2_NCK_1 99 103 PF00017 0.378
LIG_SH2_SRC 201 204 PF00017 0.629
LIG_SH2_STAP1 423 427 PF00017 0.437
LIG_SH2_STAP1 99 103 PF00017 0.426
LIG_SH2_STAT5 136 139 PF00017 0.291
LIG_SH2_STAT5 15 18 PF00017 0.393
LIG_SH2_STAT5 423 426 PF00017 0.354
LIG_SH2_STAT5 430 433 PF00017 0.259
LIG_SH2_STAT5 643 646 PF00017 0.466
LIG_SH2_STAT5 767 770 PF00017 0.448
LIG_SH2_STAT5 82 85 PF00017 0.435
LIG_SH3_1 691 697 PF00018 0.607
LIG_SH3_2 203 208 PF14604 0.547
LIG_SH3_3 200 206 PF00018 0.705
LIG_SH3_3 403 409 PF00018 0.522
LIG_SH3_3 606 612 PF00018 0.448
LIG_SH3_3 691 697 PF00018 0.743
LIG_SH3_3 722 728 PF00018 0.645
LIG_SH3_3 80 86 PF00018 0.384
LIG_SH3_3 856 862 PF00018 0.400
LIG_SH3_3 92 98 PF00018 0.433
LIG_SH3_4 421 428 PF00018 0.368
LIG_SH3_4 648 655 PF00018 0.414
LIG_SUMO_SIM_anti_2 557 562 PF11976 0.459
LIG_SUMO_SIM_par_1 242 247 PF11976 0.498
LIG_SUMO_SIM_par_1 557 562 PF11976 0.435
LIG_SUMO_SIM_par_1 607 613 PF11976 0.401
LIG_TRAF2_1 227 230 PF00917 0.467
LIG_TRAF2_1 716 719 PF00917 0.630
LIG_TRAF2_1 87 90 PF00917 0.396
LIG_TYR_ITIM 471 476 PF00017 0.351
LIG_TYR_ITIM 740 745 PF00017 0.509
LIG_WRC_WIRS_1 583 588 PF05994 0.442
MOD_CDK_SPxK_1 202 208 PF00069 0.524
MOD_CK1_1 332 338 PF00069 0.601
MOD_CK1_1 360 366 PF00069 0.744
MOD_CK1_1 410 416 PF00069 0.523
MOD_CK1_1 461 467 PF00069 0.383
MOD_CK1_1 604 610 PF00069 0.419
MOD_CK1_1 638 644 PF00069 0.481
MOD_CK1_1 693 699 PF00069 0.720
MOD_CK2_1 18 24 PF00069 0.436
MOD_CK2_1 735 741 PF00069 0.432
MOD_CK2_1 754 760 PF00069 0.428
MOD_CK2_1 792 798 PF00069 0.386
MOD_CK2_1 84 90 PF00069 0.387
MOD_CK2_1 844 850 PF00069 0.484
MOD_GlcNHglycan 298 301 PF01048 0.671
MOD_GlcNHglycan 320 323 PF01048 0.712
MOD_GlcNHglycan 384 387 PF01048 0.575
MOD_GlcNHglycan 507 510 PF01048 0.423
MOD_GlcNHglycan 640 643 PF01048 0.452
MOD_GlcNHglycan 704 707 PF01048 0.740
MOD_GlcNHglycan 768 771 PF01048 0.469
MOD_GlcNHglycan 869 873 PF01048 0.452
MOD_GSK3_1 301 308 PF00069 0.684
MOD_GSK3_1 314 321 PF00069 0.634
MOD_GSK3_1 329 336 PF00069 0.621
MOD_GSK3_1 360 367 PF00069 0.609
MOD_GSK3_1 461 468 PF00069 0.415
MOD_GSK3_1 534 541 PF00069 0.390
MOD_N-GLC_1 330 335 PF02516 0.746
MOD_N-GLC_1 674 679 PF02516 0.428
MOD_N-GLC_1 754 759 PF02516 0.458
MOD_NEK2_1 472 477 PF00069 0.391
MOD_NEK2_1 527 532 PF00069 0.425
MOD_NEK2_1 62 67 PF00069 0.453
MOD_NEK2_1 832 837 PF00069 0.457
MOD_PIKK_1 465 471 PF00454 0.403
MOD_PIKK_1 662 668 PF00454 0.446
MOD_PK_1 569 575 PF00069 0.466
MOD_PKA_2 184 190 PF00069 0.465
MOD_PKA_2 207 213 PF00069 0.622
MOD_PKA_2 215 221 PF00069 0.344
MOD_PKA_2 702 708 PF00069 0.757
MOD_PKA_2 813 819 PF00069 0.410
MOD_Plk_1 538 544 PF00069 0.370
MOD_Plk_1 668 674 PF00069 0.395
MOD_Plk_1 754 760 PF00069 0.470
MOD_Plk_4 132 138 PF00069 0.432
MOD_Plk_4 538 544 PF00069 0.350
MOD_Plk_4 582 588 PF00069 0.329
MOD_Plk_4 604 610 PF00069 0.390
MOD_ProDKin_1 173 179 PF00069 0.503
MOD_ProDKin_1 193 199 PF00069 0.570
MOD_ProDKin_1 202 208 PF00069 0.693
MOD_ProDKin_1 306 312 PF00069 0.660
MOD_ProDKin_1 407 413 PF00069 0.446
MOD_ProDKin_1 545 551 PF00069 0.470
MOD_ProDKin_1 690 696 PF00069 0.693
MOD_ProDKin_1 855 861 PF00069 0.384
MOD_SUMO_rev_2 118 128 PF00179 0.411
MOD_SUMO_rev_2 641 650 PF00179 0.476
TRG_DiLeu_BaEn_1 798 803 PF01217 0.385
TRG_DiLeu_BaLyEn_6 725 730 PF01217 0.525
TRG_ENDOCYTIC_2 136 139 PF00928 0.291
TRG_ENDOCYTIC_2 149 152 PF00928 0.383
TRG_ENDOCYTIC_2 356 359 PF00928 0.548
TRG_ENDOCYTIC_2 473 476 PF00928 0.328
TRG_ENDOCYTIC_2 742 745 PF00928 0.523
TRG_ER_diArg_1 553 555 PF00400 0.493
TRG_ER_diArg_1 688 691 PF00400 0.573
TRG_ER_diArg_1 707 710 PF00400 0.592
TRG_ER_diArg_1 742 744 PF00400 0.507
TRG_ER_diArg_1 800 802 PF00400 0.431
TRG_NES_CRM1_1 274 287 PF08389 0.396
TRG_Pf-PMV_PEXEL_1 518 522 PF00026 0.459
TRG_Pf-PMV_PEXEL_1 553 557 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 67 72 PF00026 0.287
TRG_Pf-PMV_PEXEL_1 800 805 PF00026 0.378

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8K1 Leptomonas seymouri 63% 99%
A0A0S4ILQ6 Bodo saltans 27% 88%
A0A1X0P6E5 Trypanosomatidae 39% 100%
A0A3R7MW28 Trypanosoma rangeli 38% 100%
A0A3S7WVF9 Leishmania donovani 94% 100%
A0A3S7X6A2 Leishmania donovani 24% 100%
A0A422NYA4 Trypanosoma rangeli 25% 100%
A4H9Y2 Leishmania braziliensis 76% 100%
A4HL43 Leishmania braziliensis 24% 100%
A4HY47 Leishmania infantum 94% 100%
A4I8M3 Leishmania infantum 24% 100%
D0A0E4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 97%
D3Z8X7 Rattus norvegicus 26% 95%
E9ARX6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
O60308 Homo sapiens 25% 95%
Q4Q4L6 Leishmania major 24% 100%
Q80V31 Mus musculus 26% 94%
V5DTJ3 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS