TOG domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centrosomal protein of 104 kDa

Species:

Leishmania major

UniProt:

Q4QDJ6_LEIMA

TriTrypDb:

LmjF.19.0250 , LMJLV39_190007400 , LMJSD75_190007300

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QDJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.624
CLV_MEL_PAP_1	213	219	PF00089	0.253
CLV_NRD_NRD_1	43	45	PF00675	0.376
CLV_NRD_NRD_1	437	439	PF00675	0.436
CLV_NRD_NRD_1	553	555	PF00675	0.449
CLV_NRD_NRD_1	743	745	PF00675	0.439
CLV_NRD_NRD_1	800	802	PF00675	0.431
CLV_PCSK_KEX2_1	105	107	PF00082	0.413
CLV_PCSK_KEX2_1	400	402	PF00082	0.508
CLV_PCSK_KEX2_1	553	555	PF00082	0.447
CLV_PCSK_KEX2_1	743	745	PF00082	0.433
CLV_PCSK_KEX2_1	799	801	PF00082	0.429
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.497
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.394
CLV_PCSK_PC1ET2_1	799	801	PF00082	0.464
CLV_PCSK_SKI1_1	101	105	PF00082	0.422
CLV_PCSK_SKI1_1	123	127	PF00082	0.323
CLV_PCSK_SKI1_1	138	142	PF00082	0.286
CLV_PCSK_SKI1_1	212	216	PF00082	0.445
CLV_PCSK_SKI1_1	270	274	PF00082	0.414
CLV_PCSK_SKI1_1	400	404	PF00082	0.485
CLV_PCSK_SKI1_1	631	635	PF00082	0.319
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DEG_SCF_FBW7_2	193	200	PF00400	0.533
DEG_SPOP_SBC_1	637	641	PF00917	0.501
DOC_ANK_TNKS_1	593	600	PF00023	0.380
DOC_CDC14_PxL_1	608	616	PF14671	0.396
DOC_CDC14_PxL_1	730	738	PF14671	0.519
DOC_CKS1_1	174	179	PF01111	0.511
DOC_CKS1_1	194	199	PF01111	0.397
DOC_CKS1_1	203	208	PF01111	0.466
DOC_CYCLIN_RxL_1	270	281	PF00134	0.397
DOC_CYCLIN_RxL_1	628	639	PF00134	0.330
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.355
DOC_MAPK_gen_1	105	112	PF00069	0.404
DOC_MAPK_gen_1	270	279	PF00069	0.518
DOC_MAPK_gen_1	553	561	PF00069	0.490
DOC_MAPK_MEF2A_6	132	141	PF00069	0.306
DOC_MAPK_MEF2A_6	270	279	PF00069	0.441
DOC_MAPK_MEF2A_6	553	560	PF00069	0.440
DOC_MAPK_MEF2A_6	7	14	PF00069	0.350
DOC_MAPK_MEF2A_6	74	83	PF00069	0.326
DOC_PP1_RVXF_1	629	635	PF00149	0.326
DOC_PP2B_LxvP_1	403	406	PF13499	0.333
DOC_PP2B_LxvP_1	722	725	PF13499	0.491
DOC_PP4_FxxP_1	307	310	PF00568	0.601
DOC_PP4_FxxP_1	634	637	PF00568	0.356
DOC_USP7_MATH_1	320	324	PF00917	0.684
DOC_USP7_MATH_1	450	454	PF00917	0.494
DOC_USP7_MATH_1	458	462	PF00917	0.375
DOC_USP7_MATH_1	505	509	PF00917	0.401
DOC_USP7_MATH_1	575	579	PF00917	0.443
DOC_USP7_MATH_1	701	705	PF00917	0.725
DOC_USP7_UBL2_3	101	105	PF12436	0.489
DOC_USP7_UBL2_3	369	373	PF12436	0.516
DOC_USP7_UBL2_3	421	425	PF12436	0.486
DOC_USP7_UBL2_3	565	569	PF12436	0.536
DOC_WW_Pin1_4	173	178	PF00397	0.504
DOC_WW_Pin1_4	193	198	PF00397	0.559
DOC_WW_Pin1_4	202	207	PF00397	0.694
DOC_WW_Pin1_4	306	311	PF00397	0.660
DOC_WW_Pin1_4	312	317	PF00397	0.779
DOC_WW_Pin1_4	407	412	PF00397	0.439
DOC_WW_Pin1_4	545	550	PF00397	0.472
DOC_WW_Pin1_4	690	695	PF00397	0.692
DOC_WW_Pin1_4	855	860	PF00397	0.392
LIG_14-3-3_CanoR_1	132	137	PF00244	0.376
LIG_14-3-3_CanoR_1	185	189	PF00244	0.568
LIG_14-3-3_CanoR_1	216	223	PF00244	0.517
LIG_14-3-3_CanoR_1	401	406	PF00244	0.457
LIG_14-3-3_CanoR_1	44	50	PF00244	0.477
LIG_14-3-3_CanoR_1	703	707	PF00244	0.697
LIG_14-3-3_CanoR_1	814	822	PF00244	0.416
LIG_14-3-3_CanoR_1	843	849	PF00244	0.285
LIG_Actin_WH2_2	268	285	PF00022	0.301
LIG_AP2alpha_1	586	590	PF02296	0.456
LIG_BIR_III_4	361	365	PF00653	0.655
LIG_Clathr_ClatBox_1	558	562	PF01394	0.478
LIG_Clathr_ClatBox_1	632	636	PF01394	0.449
LIG_eIF4E_1	430	436	PF01652	0.288
LIG_eIF4E_1	662	668	PF01652	0.398
LIG_FHA_1	125	131	PF00498	0.365
LIG_FHA_1	185	191	PF00498	0.489
LIG_FHA_1	208	214	PF00498	0.607
LIG_FHA_1	279	285	PF00498	0.458
LIG_FHA_1	361	367	PF00498	0.667
LIG_FHA_1	402	408	PF00498	0.463
LIG_FHA_1	422	428	PF00498	0.443
LIG_FHA_1	466	472	PF00498	0.348
LIG_FHA_1	495	501	PF00498	0.422
LIG_FHA_1	515	521	PF00498	0.458
LIG_FHA_1	522	528	PF00498	0.507
LIG_FHA_1	600	606	PF00498	0.497
LIG_FHA_1	63	69	PF00498	0.355
LIG_FHA_1	681	687	PF00498	0.741
LIG_FHA_1	724	730	PF00498	0.562
LIG_FHA_1	831	837	PF00498	0.341
LIG_FHA_2	583	589	PF00498	0.428
LIG_FHA_2	793	799	PF00498	0.428
LIG_FHA_2	85	91	PF00498	0.377
LIG_LIR_Apic_2	304	310	PF02991	0.604
LIG_LIR_Gen_1	135	144	PF02991	0.369
LIG_LIR_Gen_1	464	474	PF02991	0.317
LIG_LIR_Nem_3	135	139	PF02991	0.349
LIG_LIR_Nem_3	464	470	PF02991	0.353
LIG_LIR_Nem_3	739	745	PF02991	0.516
LIG_MAD2	401	409	PF02301	0.313
LIG_MYND_1	772	776	PF01753	0.305
LIG_NRBOX	628	634	PF00104	0.383
LIG_Pex14_2	586	590	PF04695	0.456
LIG_PTAP_UEV_1	724	729	PF05743	0.478
LIG_SH2_CRK	473	477	PF00017	0.369
LIG_SH2_CRK	742	746	PF00017	0.511
LIG_SH2_NCK_1	99	103	PF00017	0.378
LIG_SH2_SRC	201	204	PF00017	0.629
LIG_SH2_STAP1	423	427	PF00017	0.437
LIG_SH2_STAP1	99	103	PF00017	0.426
LIG_SH2_STAT5	136	139	PF00017	0.291
LIG_SH2_STAT5	15	18	PF00017	0.393
LIG_SH2_STAT5	423	426	PF00017	0.354
LIG_SH2_STAT5	430	433	PF00017	0.259
LIG_SH2_STAT5	643	646	PF00017	0.466
LIG_SH2_STAT5	767	770	PF00017	0.448
LIG_SH2_STAT5	82	85	PF00017	0.435
LIG_SH3_1	691	697	PF00018	0.607
LIG_SH3_2	203	208	PF14604	0.547
LIG_SH3_3	200	206	PF00018	0.705
LIG_SH3_3	403	409	PF00018	0.522
LIG_SH3_3	606	612	PF00018	0.448
LIG_SH3_3	691	697	PF00018	0.743
LIG_SH3_3	722	728	PF00018	0.645
LIG_SH3_3	80	86	PF00018	0.384
LIG_SH3_3	856	862	PF00018	0.400
LIG_SH3_3	92	98	PF00018	0.433
LIG_SH3_4	421	428	PF00018	0.368
LIG_SH3_4	648	655	PF00018	0.414
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.459
LIG_SUMO_SIM_par_1	242	247	PF11976	0.498
LIG_SUMO_SIM_par_1	557	562	PF11976	0.435
LIG_SUMO_SIM_par_1	607	613	PF11976	0.401
LIG_TRAF2_1	227	230	PF00917	0.467
LIG_TRAF2_1	716	719	PF00917	0.630
LIG_TRAF2_1	87	90	PF00917	0.396
LIG_TYR_ITIM	471	476	PF00017	0.351
LIG_TYR_ITIM	740	745	PF00017	0.509
LIG_WRC_WIRS_1	583	588	PF05994	0.442
MOD_CDK_SPxK_1	202	208	PF00069	0.524
MOD_CK1_1	332	338	PF00069	0.601
MOD_CK1_1	360	366	PF00069	0.744
MOD_CK1_1	410	416	PF00069	0.523
MOD_CK1_1	461	467	PF00069	0.383
MOD_CK1_1	604	610	PF00069	0.419
MOD_CK1_1	638	644	PF00069	0.481
MOD_CK1_1	693	699	PF00069	0.720
MOD_CK2_1	18	24	PF00069	0.436
MOD_CK2_1	735	741	PF00069	0.432
MOD_CK2_1	754	760	PF00069	0.428
MOD_CK2_1	792	798	PF00069	0.386
MOD_CK2_1	84	90	PF00069	0.387
MOD_CK2_1	844	850	PF00069	0.484
MOD_GlcNHglycan	298	301	PF01048	0.671
MOD_GlcNHglycan	320	323	PF01048	0.712
MOD_GlcNHglycan	384	387	PF01048	0.575
MOD_GlcNHglycan	507	510	PF01048	0.423
MOD_GlcNHglycan	640	643	PF01048	0.452
MOD_GlcNHglycan	704	707	PF01048	0.740
MOD_GlcNHglycan	768	771	PF01048	0.469
MOD_GlcNHglycan	869	873	PF01048	0.452
MOD_GSK3_1	301	308	PF00069	0.684
MOD_GSK3_1	314	321	PF00069	0.634
MOD_GSK3_1	329	336	PF00069	0.621
MOD_GSK3_1	360	367	PF00069	0.609
MOD_GSK3_1	461	468	PF00069	0.415
MOD_GSK3_1	534	541	PF00069	0.390
MOD_N-GLC_1	330	335	PF02516	0.746
MOD_N-GLC_1	674	679	PF02516	0.428
MOD_N-GLC_1	754	759	PF02516	0.458
MOD_NEK2_1	472	477	PF00069	0.391
MOD_NEK2_1	527	532	PF00069	0.425
MOD_NEK2_1	62	67	PF00069	0.453
MOD_NEK2_1	832	837	PF00069	0.457
MOD_PIKK_1	465	471	PF00454	0.403
MOD_PIKK_1	662	668	PF00454	0.446
MOD_PK_1	569	575	PF00069	0.466
MOD_PKA_2	184	190	PF00069	0.465
MOD_PKA_2	207	213	PF00069	0.622
MOD_PKA_2	215	221	PF00069	0.344
MOD_PKA_2	702	708	PF00069	0.757
MOD_PKA_2	813	819	PF00069	0.410
MOD_Plk_1	538	544	PF00069	0.370
MOD_Plk_1	668	674	PF00069	0.395
MOD_Plk_1	754	760	PF00069	0.470
MOD_Plk_4	132	138	PF00069	0.432
MOD_Plk_4	538	544	PF00069	0.350
MOD_Plk_4	582	588	PF00069	0.329
MOD_Plk_4	604	610	PF00069	0.390
MOD_ProDKin_1	173	179	PF00069	0.503
MOD_ProDKin_1	193	199	PF00069	0.570
MOD_ProDKin_1	202	208	PF00069	0.693
MOD_ProDKin_1	306	312	PF00069	0.660
MOD_ProDKin_1	407	413	PF00069	0.446
MOD_ProDKin_1	545	551	PF00069	0.470
MOD_ProDKin_1	690	696	PF00069	0.693
MOD_ProDKin_1	855	861	PF00069	0.384
MOD_SUMO_rev_2	118	128	PF00179	0.411
MOD_SUMO_rev_2	641	650	PF00179	0.476
TRG_DiLeu_BaEn_1	798	803	PF01217	0.385
TRG_DiLeu_BaLyEn_6	725	730	PF01217	0.525
TRG_ENDOCYTIC_2	136	139	PF00928	0.291
TRG_ENDOCYTIC_2	149	152	PF00928	0.383
TRG_ENDOCYTIC_2	356	359	PF00928	0.548
TRG_ENDOCYTIC_2	473	476	PF00928	0.328
TRG_ENDOCYTIC_2	742	745	PF00928	0.523
TRG_ER_diArg_1	553	555	PF00400	0.493
TRG_ER_diArg_1	688	691	PF00400	0.573
TRG_ER_diArg_1	707	710	PF00400	0.592
TRG_ER_diArg_1	742	744	PF00400	0.507
TRG_ER_diArg_1	800	802	PF00400	0.431
TRG_NES_CRM1_1	274	287	PF08389	0.396
TRG_Pf-PMV_PEXEL_1	518	522	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	553	557	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	800	805	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K1	Leptomonas seymouri	63%	99%
A0A0S4ILQ6	Bodo saltans	27%	88%
A0A1X0P6E5	Trypanosomatidae	39%	100%
A0A3R7MW28	Trypanosoma rangeli	38%	100%
A0A3S7WVF9	Leishmania donovani	94%	100%
A0A3S7X6A2	Leishmania donovani	24%	100%
A0A422NYA4	Trypanosoma rangeli	25%	100%
A4H9Y2	Leishmania braziliensis	76%	100%
A4HL43	Leishmania braziliensis	24%	100%
A4HY47	Leishmania infantum	94%	100%
A4I8M3	Leishmania infantum	24%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
D3Z8X7	Rattus norvegicus	26%	95%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O60308	Homo sapiens	25%	95%
Q4Q4L6	Leishmania major	24%	100%
Q80V31	Mus musculus	26%	94%
V5DTJ3	Trypanosoma cruzi	38%	100%