Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania major

UniProt:

Q4QDJ5_LEIMA

TriTrypDb:

LmjF.19.0260 , LMJLV39_190007500 , LMJSD75_190007400

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005871	kinesin complex	3	2
GO:0005874	microtubule	6	12
GO:0005875	microtubule associated complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QDJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0005543	phospholipid binding	3	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008289	lipid binding	2	12
GO:0015631	tubulin binding	4	12
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0016887	ATP hydrolysis activity	7	2
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0030554	adenyl nucleotide binding	5	12
GO:0032182	ubiquitin-like protein binding	3	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035091	phosphatidylinositol binding	4	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043130	ubiquitin binding	4	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.793
CLV_C14_Caspase3-7	569	573	PF00656	0.358
CLV_MEL_PAP_1	249	255	PF00089	0.465
CLV_NRD_NRD_1	276	278	PF00675	0.740
CLV_NRD_NRD_1	296	298	PF00675	0.677
CLV_NRD_NRD_1	302	304	PF00675	0.700
CLV_NRD_NRD_1	426	428	PF00675	0.549
CLV_NRD_NRD_1	470	472	PF00675	0.626
CLV_NRD_NRD_1	487	489	PF00675	0.434
CLV_NRD_NRD_1	50	52	PF00675	0.632
CLV_NRD_NRD_1	616	618	PF00675	0.374
CLV_PCSK_FUR_1	299	303	PF00082	0.803
CLV_PCSK_KEX2_1	275	277	PF00082	0.739
CLV_PCSK_KEX2_1	296	298	PF00082	0.676
CLV_PCSK_KEX2_1	301	303	PF00082	0.706
CLV_PCSK_KEX2_1	306	308	PF00082	0.680
CLV_PCSK_KEX2_1	482	484	PF00082	0.601
CLV_PCSK_KEX2_1	50	52	PF00082	0.615
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.732
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.783
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.563
CLV_PCSK_PC7_1	297	303	PF00082	0.776
CLV_PCSK_SKI1_1	103	107	PF00082	0.456
CLV_PCSK_SKI1_1	158	162	PF00082	0.586
CLV_PCSK_SKI1_1	167	171	PF00082	0.786
CLV_PCSK_SKI1_1	173	177	PF00082	0.719
CLV_PCSK_SKI1_1	241	245	PF00082	0.675
CLV_PCSK_SKI1_1	354	358	PF00082	0.569
CLV_PCSK_SKI1_1	420	424	PF00082	0.665
CLV_PCSK_SKI1_1	431	435	PF00082	0.604
CLV_PCSK_SKI1_1	471	475	PF00082	0.553
CLV_PCSK_SKI1_1	483	487	PF00082	0.493
CLV_PCSK_SKI1_1	509	513	PF00082	0.393
CLV_PCSK_SKI1_1	514	518	PF00082	0.393
CLV_PCSK_SKI1_1	588	592	PF00082	0.443
CLV_PCSK_SKI1_1	638	642	PF00082	0.358
CLV_PCSK_SKI1_1	831	835	PF00082	0.699
DEG_APCC_DBOX_1	335	343	PF00400	0.588
DEG_APCC_DBOX_1	419	427	PF00400	0.548
DEG_SPOP_SBC_1	108	112	PF00917	0.557
DOC_CDC14_PxL_1	388	396	PF14671	0.735
DOC_CYCLIN_RxL_1	791	802	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.369
DOC_MAPK_gen_1	327	335	PF00069	0.608
DOC_MAPK_gen_1	746	753	PF00069	0.467
DOC_MAPK_MEF2A_6	702	711	PF00069	0.358
DOC_MAPK_MEF2A_6	794	801	PF00069	0.393
DOC_MAPK_NFAT4_5	702	710	PF00069	0.358
DOC_PP1_RVXF_1	470	477	PF00149	0.542
DOC_PP1_RVXF_1	792	799	PF00149	0.358
DOC_PP1_RVXF_1	820	827	PF00149	0.503
DOC_USP7_MATH_1	401	405	PF00917	0.739
DOC_USP7_MATH_1	671	675	PF00917	0.389
DOC_USP7_MATH_1	768	772	PF00917	0.426
DOC_USP7_UBL2_3	357	361	PF12436	0.602
DOC_USP7_UBL2_3	482	486	PF12436	0.482
DOC_WW_Pin1_4	386	391	PF00397	0.690
DOC_WW_Pin1_4	409	414	PF00397	0.693
DOC_WW_Pin1_4	799	804	PF00397	0.374
LIG_14-3-3_CanoR_1	130	139	PF00244	0.536
LIG_14-3-3_CanoR_1	241	250	PF00244	0.561
LIG_14-3-3_CanoR_1	252	260	PF00244	0.454
LIG_14-3-3_CanoR_1	427	431	PF00244	0.522
LIG_14-3-3_CanoR_1	777	785	PF00244	0.393
LIG_Actin_WH2_2	416	433	PF00022	0.512
LIG_APCC_ABBA_1	630	635	PF00400	0.358
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_4	536	540	PF00653	0.426
LIG_BRCT_BRCA1_1	813	817	PF00533	0.358
LIG_CaM_IQ_9	474	490	PF13499	0.543
LIG_Clathr_ClatBox_1	543	547	PF01394	0.415
LIG_deltaCOP1_diTrp_1	98	105	PF00928	0.493
LIG_eIF4E_1	723	729	PF01652	0.415
LIG_FHA_1	13	19	PF00498	0.684
LIG_FHA_1	190	196	PF00498	0.497
LIG_FHA_1	319	325	PF00498	0.603
LIG_FHA_1	40	46	PF00498	0.590
LIG_FHA_1	475	481	PF00498	0.561
LIG_FHA_1	561	567	PF00498	0.358
LIG_FHA_1	602	608	PF00498	0.383
LIG_FHA_1	622	628	PF00498	0.175
LIG_FHA_1	649	655	PF00498	0.443
LIG_FHA_1	780	786	PF00498	0.358
LIG_FHA_1	99	105	PF00498	0.483
LIG_FHA_2	110	116	PF00498	0.549
LIG_FHA_2	262	268	PF00498	0.514
LIG_FHA_2	285	291	PF00498	0.825
LIG_FHA_2	492	498	PF00498	0.524
LIG_FHA_2	526	532	PF00498	0.509
LIG_FHA_2	593	599	PF00498	0.472
LIG_FHA_2	641	647	PF00498	0.434
LIG_FHA_2	76	82	PF00498	0.485
LIG_LIR_Gen_1	151	160	PF02991	0.496
LIG_LIR_Gen_1	174	181	PF02991	0.711
LIG_LIR_Gen_1	258	268	PF02991	0.505
LIG_LIR_Gen_1	545	554	PF02991	0.358
LIG_LIR_Nem_3	151	156	PF02991	0.501
LIG_LIR_Nem_3	174	178	PF02991	0.715
LIG_LIR_Nem_3	545	549	PF02991	0.358
LIG_LIR_Nem_3	608	614	PF02991	0.374
LIG_NRBOX	780	786	PF00104	0.358
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.580
LIG_Pex14_1	127	131	PF04695	0.460
LIG_Pex14_2	153	157	PF04695	0.588
LIG_PTAP_UEV_1	551	556	PF05743	0.505
LIG_SH2_CRK	122	126	PF00017	0.512
LIG_SH2_CRK	492	496	PF00017	0.482
LIG_SH2_CRK	505	509	PF00017	0.358
LIG_SH2_CRK	67	71	PF00017	0.619
LIG_SH2_CRK	723	727	PF00017	0.415
LIG_SH2_GRB2like	491	494	PF00017	0.494
LIG_SH2_NCK_1	492	496	PF00017	0.482
LIG_SH2_NCK_1	67	71	PF00017	0.619
LIG_SH2_PTP2	708	711	PF00017	0.358
LIG_SH2_SRC	708	711	PF00017	0.415
LIG_SH2_STAP1	370	374	PF00017	0.594
LIG_SH2_STAP1	448	452	PF00017	0.548
LIG_SH2_STAP1	520	524	PF00017	0.428
LIG_SH2_STAT3	448	451	PF00017	0.519
LIG_SH2_STAT3	526	529	PF00017	0.505
LIG_SH2_STAT3	633	636	PF00017	0.443
LIG_SH2_STAT5	122	125	PF00017	0.326
LIG_SH2_STAT5	437	440	PF00017	0.576
LIG_SH2_STAT5	505	508	PF00017	0.407
LIG_SH2_STAT5	633	636	PF00017	0.358
LIG_SH2_STAT5	663	666	PF00017	0.358
LIG_SH2_STAT5	708	711	PF00017	0.358
LIG_SH3_3	546	552	PF00018	0.370
LIG_SUMO_SIM_anti_2	626	631	PF11976	0.370
LIG_SUMO_SIM_par_1	188	196	PF11976	0.594
LIG_SUMO_SIM_par_1	623	631	PF11976	0.368
LIG_SUMO_SIM_par_1	75	81	PF11976	0.482
LIG_TRAF2_1	317	320	PF00917	0.719
LIG_TRAF2_1	494	497	PF00917	0.520
LIG_TYR_ITIM	120	125	PF00017	0.471
LIG_TYR_ITIM	706	711	PF00017	0.358
LIG_UBA3_1	156	161	PF00899	0.649
LIG_UBA3_1	610	618	PF00899	0.383
LIG_WRC_WIRS_1	419	424	PF05994	0.556
MOD_CK1_1	386	392	PF00069	0.749
MOD_CK1_1	525	531	PF00069	0.479
MOD_CK1_1	586	592	PF00069	0.358
MOD_CK1_1	623	629	PF00069	0.373
MOD_CK1_1	648	654	PF00069	0.352
MOD_CK1_1	700	706	PF00069	0.369
MOD_CK1_1	779	785	PF00069	0.370
MOD_CK1_1	802	808	PF00069	0.365
MOD_CK1_1	809	815	PF00069	0.353
MOD_CK2_1	109	115	PF00069	0.598
MOD_CK2_1	13	19	PF00069	0.709
MOD_CK2_1	245	251	PF00069	0.638
MOD_CK2_1	255	261	PF00069	0.556
MOD_CK2_1	426	432	PF00069	0.533
MOD_CK2_1	491	497	PF00069	0.520
MOD_CK2_1	525	531	PF00069	0.391
MOD_CK2_1	592	598	PF00069	0.428
MOD_CK2_1	625	631	PF00069	0.358
MOD_CK2_1	640	646	PF00069	0.358
MOD_CK2_1	737	743	PF00069	0.374
MOD_Cter_Amidation	304	307	PF01082	0.648
MOD_GlcNHglycan	133	136	PF01048	0.527
MOD_GlcNHglycan	15	18	PF01048	0.638
MOD_GlcNHglycan	235	238	PF01048	0.583
MOD_GlcNHglycan	403	406	PF01048	0.726
MOD_GlcNHglycan	448	451	PF01048	0.538
MOD_GlcNHglycan	536	540	PF01048	0.422
MOD_GlcNHglycan	585	588	PF01048	0.358
MOD_GlcNHglycan	646	650	PF01048	0.272
MOD_GlcNHglycan	673	676	PF01048	0.389
MOD_GlcNHglycan	738	742	PF01048	0.374
MOD_GlcNHglycan	757	760	PF01048	0.269
MOD_GlcNHglycan	778	781	PF01048	0.465
MOD_GlcNHglycan	86	89	PF01048	0.587
MOD_GSK3_1	173	180	PF00069	0.687
MOD_GSK3_1	24	31	PF00069	0.496
MOD_GSK3_1	241	248	PF00069	0.626
MOD_GSK3_1	251	258	PF00069	0.491
MOD_GSK3_1	409	416	PF00069	0.651
MOD_GSK3_1	446	453	PF00069	0.537
MOD_GSK3_1	518	525	PF00069	0.406
MOD_GSK3_1	588	595	PF00069	0.472
MOD_GSK3_1	617	624	PF00069	0.335
MOD_GSK3_1	687	694	PF00069	0.370
MOD_GSK3_1	711	718	PF00069	0.364
MOD_GSK3_1	802	809	PF00069	0.374
MOD_GSK3_1	832	839	PF00069	0.666
MOD_GSK3_1	94	101	PF00069	0.479
MOD_LATS_1	239	245	PF00433	0.604
MOD_N-GLC_1	592	597	PF02516	0.428
MOD_N-GLC_1	753	758	PF02516	0.358
MOD_N-GLC_1	806	811	PF02516	0.360
MOD_N-GLC_1	831	836	PF02516	0.710
MOD_N-GLC_2	221	223	PF02516	0.549
MOD_N-GLC_2	575	577	PF02516	0.358
MOD_NEK2_1	143	148	PF00069	0.472
MOD_NEK2_1	233	238	PF00069	0.566
MOD_NEK2_1	376	381	PF00069	0.713
MOD_NEK2_1	394	399	PF00069	0.582
MOD_NEK2_1	560	565	PF00069	0.358
MOD_NEK2_1	566	571	PF00069	0.358
MOD_NEK2_1	640	645	PF00069	0.443
MOD_NEK2_1	776	781	PF00069	0.374
MOD_NEK2_1	785	790	PF00069	0.389
MOD_NEK2_1	816	821	PF00069	0.479
MOD_NEK2_1	84	89	PF00069	0.570
MOD_PIKK_1	439	445	PF00454	0.551
MOD_PIKK_1	474	480	PF00454	0.581
MOD_PIKK_1	525	531	PF00454	0.505
MOD_PIKK_1	69	75	PF00454	0.583
MOD_PKA_1	617	623	PF00069	0.374
MOD_PKA_2	251	257	PF00069	0.483
MOD_PKA_2	426	432	PF00069	0.547
MOD_PKA_2	711	717	PF00069	0.374
MOD_PKA_2	776	782	PF00069	0.358
MOD_Plk_1	173	179	PF00069	0.782
MOD_Plk_1	189	195	PF00069	0.435
MOD_Plk_1	308	314	PF00069	0.786
MOD_Plk_1	39	45	PF00069	0.649
MOD_Plk_1	620	626	PF00069	0.358
MOD_Plk_1	753	759	PF00069	0.358
MOD_Plk_2-3	200	206	PF00069	0.469
MOD_Plk_2-3	245	251	PF00069	0.645
MOD_Plk_2-3	255	261	PF00069	0.453
MOD_Plk_2-3	286	292	PF00069	0.795
MOD_Plk_4	120	126	PF00069	0.441
MOD_Plk_4	189	195	PF00069	0.510
MOD_Plk_4	245	251	PF00069	0.629
MOD_Plk_4	255	261	PF00069	0.556
MOD_Plk_4	566	572	PF00069	0.358
MOD_Plk_4	625	631	PF00069	0.376
MOD_Plk_4	659	665	PF00069	0.383
MOD_Plk_4	724	730	PF00069	0.358
MOD_Plk_4	75	81	PF00069	0.464
MOD_Plk_4	779	785	PF00069	0.372
MOD_Plk_4	811	817	PF00069	0.475
MOD_ProDKin_1	386	392	PF00069	0.690
MOD_ProDKin_1	409	415	PF00069	0.689
MOD_ProDKin_1	799	805	PF00069	0.374
MOD_SUMO_rev_2	222	229	PF00179	0.563
MOD_SUMO_rev_2	429	436	PF00179	0.616
MOD_SUMO_rev_2	464	474	PF00179	0.558
MOD_SUMO_rev_2	479	487	PF00179	0.466
MOD_SUMO_rev_2	596	602	PF00179	0.409
MOD_SUMO_rev_2	615	620	PF00179	0.224
TRG_DiLeu_BaEn_1	190	195	PF01217	0.642
TRG_DiLeu_BaEn_1	21	26	PF01217	0.611
TRG_DiLeu_BaEn_1	245	250	PF01217	0.527
TRG_DiLeu_BaEn_1	320	325	PF01217	0.708
TRG_DiLeu_BaEn_4	190	196	PF01217	0.629
TRG_DiLeu_BaLyEn_6	530	535	PF01217	0.272
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.358
TRG_ENDOCYTIC_2	122	125	PF00928	0.435
TRG_ENDOCYTIC_2	492	495	PF00928	0.491
TRG_ENDOCYTIC_2	505	508	PF00928	0.392
TRG_ENDOCYTIC_2	520	523	PF00928	0.374
TRG_ENDOCYTIC_2	708	711	PF00928	0.358
TRG_ENDOCYTIC_2	723	726	PF00928	0.358
TRG_ER_diArg_1	296	299	PF00400	0.671
TRG_ER_diArg_1	301	303	PF00400	0.680
TRG_ER_diArg_1	49	51	PF00400	0.605
TRG_ER_diArg_1	507	510	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.772
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.730
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X9	Leptomonas seymouri	76%	99%
A0A0S4KHP9	Bodo saltans	51%	92%
A0A1X0P6D6	Trypanosomatidae	61%	100%
A0A3S5H751	Leishmania donovani	96%	100%
A0A422P3A3	Trypanosoma rangeli	60%	100%
A4H9Y3	Leishmania braziliensis	79%	100%
A4HY48	Leishmania infantum	96%	100%
B3H6Z8	Arabidopsis thaliana	37%	78%
D0A0E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ARX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BWY3	Trypanosoma cruzi	62%	100%