RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDJ4_LEIMA

TriTrypDb:

LmjF.19.0270 , LMJLV39_190007600 , LMJSD75_190007500

Length:

961

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.840
CLV_C14_Caspase3-7	806	810	PF00656	0.575
CLV_NRD_NRD_1	15	17	PF00675	0.860
CLV_NRD_NRD_1	158	160	PF00675	0.854
CLV_NRD_NRD_1	424	426	PF00675	0.744
CLV_NRD_NRD_1	54	56	PF00675	0.832
CLV_NRD_NRD_1	730	732	PF00675	0.851
CLV_NRD_NRD_1	781	783	PF00675	0.688
CLV_NRD_NRD_1	896	898	PF00675	0.733
CLV_PCSK_FUR_1	422	426	PF00082	0.743
CLV_PCSK_KEX2_1	15	17	PF00082	0.860
CLV_PCSK_KEX2_1	158	160	PF00082	0.854
CLV_PCSK_KEX2_1	424	426	PF00082	0.744
CLV_PCSK_KEX2_1	54	56	PF00082	0.838
CLV_PCSK_KEX2_1	780	782	PF00082	0.692
CLV_PCSK_KEX2_1	896	898	PF00082	0.733
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.838
CLV_PCSK_SKI1_1	206	210	PF00082	0.867
CLV_PCSK_SKI1_1	291	295	PF00082	0.794
CLV_PCSK_SKI1_1	425	429	PF00082	0.666
CLV_PCSK_SKI1_1	437	441	PF00082	0.675
CLV_PCSK_SKI1_1	817	821	PF00082	0.636
CLV_PCSK_SKI1_1	824	828	PF00082	0.484
CLV_PCSK_SKI1_1	953	957	PF00082	0.737
DEG_APCC_DBOX_1	436	444	PF00400	0.787
DEG_Nend_UBRbox_2	1	3	PF02207	0.867
DEG_SPOP_SBC_1	325	329	PF00917	0.738
DEG_SPOP_SBC_1	542	546	PF00917	0.756
DEG_SPOP_SBC_1	632	636	PF00917	0.807
DEG_SPOP_SBC_1	671	675	PF00917	0.640
DOC_CKS1_1	725	730	PF01111	0.848
DOC_CKS1_1	734	739	PF01111	0.700
DOC_CKS1_1	745	750	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.800
DOC_MAPK_gen_1	677	686	PF00069	0.787
DOC_MAPK_gen_1	821	831	PF00069	0.595
DOC_MAPK_MEF2A_6	552	561	PF00069	0.736
DOC_PP1_RVXF_1	796	803	PF00149	0.420
DOC_PP2B_LxvP_1	630	633	PF13499	0.801
DOC_PP2B_LxvP_1	758	761	PF13499	0.714
DOC_SPAK_OSR1_1	101	105	PF12202	0.758
DOC_USP7_MATH_1	195	199	PF00917	0.855
DOC_USP7_MATH_1	210	214	PF00917	0.611
DOC_USP7_MATH_1	231	235	PF00917	0.864
DOC_USP7_MATH_1	297	301	PF00917	0.813
DOC_USP7_MATH_1	34	38	PF00917	0.866
DOC_USP7_MATH_1	354	358	PF00917	0.775
DOC_USP7_MATH_1	365	369	PF00917	0.554
DOC_USP7_MATH_1	478	482	PF00917	0.734
DOC_USP7_MATH_1	581	585	PF00917	0.754
DOC_USP7_MATH_1	712	716	PF00917	0.821
DOC_USP7_MATH_1	957	961	PF00917	0.804
DOC_USP7_MATH_2	567	573	PF00917	0.841
DOC_WW_Pin1_4	222	227	PF00397	0.850
DOC_WW_Pin1_4	238	243	PF00397	0.841
DOC_WW_Pin1_4	254	259	PF00397	0.576
DOC_WW_Pin1_4	264	269	PF00397	0.663
DOC_WW_Pin1_4	291	296	PF00397	0.734
DOC_WW_Pin1_4	312	317	PF00397	0.578
DOC_WW_Pin1_4	361	366	PF00397	0.824
DOC_WW_Pin1_4	506	511	PF00397	0.729
DOC_WW_Pin1_4	538	543	PF00397	0.817
DOC_WW_Pin1_4	545	550	PF00397	0.740
DOC_WW_Pin1_4	553	558	PF00397	0.600
DOC_WW_Pin1_4	563	568	PF00397	0.542
DOC_WW_Pin1_4	591	596	PF00397	0.685
DOC_WW_Pin1_4	634	639	PF00397	0.812
DOC_WW_Pin1_4	646	651	PF00397	0.649
DOC_WW_Pin1_4	667	672	PF00397	0.870
DOC_WW_Pin1_4	703	708	PF00397	0.697
DOC_WW_Pin1_4	724	729	PF00397	0.850
DOC_WW_Pin1_4	733	738	PF00397	0.698
DOC_WW_Pin1_4	744	749	PF00397	0.522
DOC_WW_Pin1_4	772	777	PF00397	0.709
DOC_WW_Pin1_4	83	88	PF00397	0.772
DOC_WW_Pin1_4	880	885	PF00397	0.752
LIG_14-3-3_CanoR_1	15	19	PF00244	0.693
LIG_14-3-3_CanoR_1	35	43	PF00244	0.535
LIG_14-3-3_CanoR_1	351	361	PF00244	0.631
LIG_14-3-3_CanoR_1	424	432	PF00244	0.801
LIG_14-3-3_CanoR_1	5	13	PF00244	0.853
LIG_14-3-3_CanoR_1	525	533	PF00244	0.808
LIG_14-3-3_CanoR_1	600	610	PF00244	0.869
LIG_14-3-3_CanoR_1	669	678	PF00244	0.794
LIG_14-3-3_CanoR_1	755	761	PF00244	0.751
LIG_14-3-3_CanoR_1	896	904	PF00244	0.700
LIG_BRCT_BRCA1_1	197	201	PF00533	0.856
LIG_BRCT_BRCA1_1	523	527	PF00533	0.817
LIG_BRCT_BRCA1_1	621	625	PF00533	0.712
LIG_BRCT_BRCA1_1	87	91	PF00533	0.796
LIG_BRCT_BRCA1_1	98	102	PF00533	0.698
LIG_CtBP_PxDLS_1	574	578	PF00389	0.825
LIG_eIF4E_1	904	910	PF01652	0.612
LIG_FHA_1	135	141	PF00498	0.793
LIG_FHA_1	325	331	PF00498	0.639
LIG_FHA_1	404	410	PF00498	0.696
LIG_FHA_1	660	666	PF00498	0.751
LIG_FHA_1	725	731	PF00498	0.850
LIG_FHA_1	818	824	PF00498	0.620
LIG_FHA_2	195	201	PF00498	0.855
LIG_FHA_2	468	474	PF00498	0.831
LIG_FHA_2	564	570	PF00498	0.839
LIG_FHA_2	600	606	PF00498	0.755
LIG_FHA_2	930	936	PF00498	0.578
LIG_FHA_2	938	944	PF00498	0.505
LIG_FXI_DFP_1	488	492	PF00024	0.794
LIG_GSK3_LRP6_1	553	558	PF00069	0.770
LIG_Integrin_isoDGR_2	878	880	PF01839	0.682
LIG_LIR_Apic_2	586	591	PF02991	0.650
LIG_LIR_Gen_1	279	289	PF02991	0.801
LIG_LIR_Gen_1	901	910	PF02991	0.632
LIG_LIR_Nem_3	279	284	PF02991	0.795
LIG_LIR_Nem_3	622	628	PF02991	0.787
LIG_LIR_Nem_3	855	861	PF02991	0.601
LIG_LIR_Nem_3	901	907	PF02991	0.652
LIG_NRBOX	283	289	PF00104	0.732
LIG_NRP_CendR_1	959	961	PF00754	0.835
LIG_Pex14_2	491	495	PF04695	0.656
LIG_PTAP_UEV_1	86	91	PF05743	0.761
LIG_Rb_pABgroove_1	837	845	PF01858	0.621
LIG_SH2_CRK	588	592	PF00017	0.851
LIG_SH2_CRK	628	632	PF00017	0.738
LIG_SH2_CRK	927	931	PF00017	0.605
LIG_SH2_NCK_1	275	279	PF00017	0.732
LIG_SH2_NCK_1	588	592	PF00017	0.705
LIG_SH2_NCK_1	628	632	PF00017	0.738
LIG_SH2_SRC	904	907	PF00017	0.632
LIG_SH2_STAT5	275	278	PF00017	0.735
LIG_SH2_STAT5	588	591	PF00017	0.847
LIG_SH2_STAT5	628	631	PF00017	0.748
LIG_SH2_STAT5	746	749	PF00017	0.853
LIG_SH2_STAT5	862	865	PF00017	0.586
LIG_SH3_1	742	748	PF00018	0.854
LIG_SH3_2	595	600	PF14604	0.677
LIG_SH3_2	954	959	PF14604	0.692
LIG_SH3_3	170	176	PF00018	0.850
LIG_SH3_3	223	229	PF00018	0.842
LIG_SH3_3	230	236	PF00018	0.712
LIG_SH3_3	265	271	PF00018	0.836
LIG_SH3_3	346	352	PF00018	0.728
LIG_SH3_3	551	557	PF00018	0.833
LIG_SH3_3	592	598	PF00018	0.826
LIG_SH3_3	647	653	PF00018	0.699
LIG_SH3_3	722	728	PF00018	0.856
LIG_SH3_3	742	748	PF00018	0.523
LIG_SH3_3	750	756	PF00018	0.776
LIG_SH3_3	84	90	PF00018	0.842
LIG_SH3_3	951	957	PF00018	0.624
LIG_SH3_CIN85_PxpxPR_1	595	600	PF14604	0.611
LIG_SUMO_SIM_anti_2	940	949	PF11976	0.618
LIG_TRFH_1	628	632	PF08558	0.815
LIG_UBA3_1	872	876	PF00899	0.673
LIG_UBA3_1	947	956	PF00899	0.657
LIG_WRC_WIRS_1	366	371	PF05994	0.712
LIG_WRC_WIRS_1	828	833	PF05994	0.584
LIG_WW_3	177	181	PF00397	0.854
LIG_WW_3	597	601	PF00397	0.773
MOD_CDK_SPK_2	254	259	PF00069	0.840
MOD_CDK_SPK_2	667	672	PF00069	0.870
MOD_CDK_SPxxK_3	545	552	PF00069	0.860
MOD_CDK_SPxxK_3	553	560	PF00069	0.719
MOD_CDK_SPxxK_3	724	731	PF00069	0.852
MOD_CK1_1	120	126	PF00069	0.821
MOD_CK1_1	14	20	PF00069	0.857
MOD_CK1_1	212	218	PF00069	0.853
MOD_CK1_1	241	247	PF00069	0.827
MOD_CK1_1	353	359	PF00069	0.641
MOD_CK1_1	385	391	PF00069	0.813
MOD_CK1_1	403	409	PF00069	0.748
MOD_CK1_1	502	508	PF00069	0.572
MOD_CK1_1	537	543	PF00069	0.798
MOD_CK1_1	586	592	PF00069	0.732
MOD_CK1_1	601	607	PF00069	0.792
MOD_CK1_1	670	676	PF00069	0.873
MOD_CK1_1	690	696	PF00069	0.861
MOD_CK1_1	703	709	PF00069	0.636
MOD_CK1_1	715	721	PF00069	0.666
MOD_CK2_1	388	394	PF00069	0.815
MOD_CK2_1	417	423	PF00069	0.825
MOD_CK2_1	495	501	PF00069	0.809
MOD_CK2_1	563	569	PF00069	0.840
MOD_CK2_1	599	605	PF00069	0.676
MOD_CK2_1	929	935	PF00069	0.528
MOD_GlcNHglycan	104	107	PF01048	0.583
MOD_GlcNHglycan	189	192	PF01048	0.741
MOD_GlcNHglycan	212	215	PF01048	0.856
MOD_GlcNHglycan	243	246	PF01048	0.680
MOD_GlcNHglycan	259	262	PF01048	0.775
MOD_GlcNHglycan	291	294	PF01048	0.737
MOD_GlcNHglycan	299	302	PF01048	0.660
MOD_GlcNHglycan	352	355	PF01048	0.734
MOD_GlcNHglycan	356	359	PF01048	0.716
MOD_GlcNHglycan	379	382	PF01048	0.812
MOD_GlcNHglycan	401	405	PF01048	0.710
MOD_GlcNHglycan	457	460	PF01048	0.820
MOD_GlcNHglycan	470	473	PF01048	0.605
MOD_GlcNHglycan	480	483	PF01048	0.652
MOD_GlcNHglycan	50	53	PF01048	0.692
MOD_GlcNHglycan	501	504	PF01048	0.582
MOD_GlcNHglycan	583	586	PF01048	0.700
MOD_GlcNHglycan	605	609	PF01048	0.688
MOD_GlcNHglycan	641	644	PF01048	0.743
MOD_GlcNHglycan	71	74	PF01048	0.819
MOD_GlcNHglycan	722	725	PF01048	0.857
MOD_GlcNHglycan	738	741	PF01048	0.588
MOD_GlcNHglycan	758	761	PF01048	0.383
MOD_GlcNHglycan	836	839	PF01048	0.606
MOD_GlcNHglycan	87	90	PF01048	0.569
MOD_GSK3_1	209	216	PF00069	0.857
MOD_GSK3_1	218	225	PF00069	0.711
MOD_GSK3_1	236	243	PF00069	0.538
MOD_GSK3_1	287	294	PF00069	0.632
MOD_GSK3_1	325	332	PF00069	0.796
MOD_GSK3_1	350	357	PF00069	0.629
MOD_GSK3_1	361	368	PF00069	0.701
MOD_GSK3_1	373	380	PF00069	0.611
MOD_GSK3_1	388	395	PF00069	0.645
MOD_GSK3_1	491	498	PF00069	0.684
MOD_GSK3_1	502	509	PF00069	0.624
MOD_GSK3_1	521	528	PF00069	0.812
MOD_GSK3_1	534	541	PF00069	0.600
MOD_GSK3_1	569	576	PF00069	0.801
MOD_GSK3_1	634	641	PF00069	0.773
MOD_GSK3_1	655	662	PF00069	0.766
MOD_GSK3_1	667	674	PF00069	0.697
MOD_GSK3_1	696	703	PF00069	0.861
MOD_GSK3_1	712	719	PF00069	0.597
MOD_GSK3_1	720	727	PF00069	0.729
MOD_GSK3_1	732	739	PF00069	0.517
MOD_GSK3_1	740	747	PF00069	0.523
MOD_LATS_1	207	213	PF00433	0.862
MOD_N-GLC_1	210	215	PF02516	0.858
MOD_N-GLC_1	373	378	PF02516	0.731
MOD_N-GLC_1	455	460	PF02516	0.761
MOD_N-GLC_1	521	526	PF02516	0.815
MOD_N-GLC_1	654	659	PF02516	0.793
MOD_N-GLC_1	817	822	PF02516	0.627
MOD_N-GLC_2	334	336	PF02516	0.663
MOD_NEK2_1	102	107	PF00069	0.835
MOD_NEK2_1	273	278	PF00069	0.803
MOD_NEK2_1	287	292	PF00069	0.600
MOD_NEK2_1	324	329	PF00069	0.742
MOD_NEK2_1	337	342	PF00069	0.585
MOD_NEK2_1	377	382	PF00069	0.680
MOD_NEK2_1	495	500	PF00069	0.806
MOD_NEK2_1	697	702	PF00069	0.860
MOD_NEK2_1	738	743	PF00069	0.852
MOD_NEK2_1	842	847	PF00069	0.622
MOD_NEK2_2	365	370	PF00069	0.736
MOD_NEK2_2	898	903	PF00069	0.696
MOD_PIKK_1	17	23	PF00454	0.855
MOD_PIKK_1	740	746	PF00454	0.751
MOD_PKA_2	14	20	PF00069	0.857
MOD_PKA_2	34	40	PF00069	0.533
MOD_PKA_2	350	356	PF00069	0.698
MOD_PKA_2	423	429	PF00069	0.736
MOD_PKA_2	599	605	PF00069	0.753
MOD_PKA_2	655	661	PF00069	0.792
MOD_PKA_2	671	677	PF00069	0.582
MOD_PKA_2	69	75	PF00069	0.822
MOD_PKA_2	712	718	PF00069	0.861
MOD_PKA_2	754	760	PF00069	0.773
MOD_PKA_2	764	770	PF00069	0.507
MOD_PKB_1	815	823	PF00069	0.636
MOD_Plk_1	307	313	PF00069	0.723
MOD_Plk_1	373	379	PF00069	0.730
MOD_Plk_2-3	423	429	PF00069	0.814
MOD_Plk_4	392	398	PF00069	0.723
MOD_Plk_4	502	508	PF00069	0.728
MOD_Plk_4	583	589	PF00069	0.611
MOD_Plk_4	824	830	PF00069	0.595
MOD_Plk_4	943	949	PF00069	0.613
MOD_ProDKin_1	222	228	PF00069	0.847
MOD_ProDKin_1	238	244	PF00069	0.840
MOD_ProDKin_1	254	260	PF00069	0.577
MOD_ProDKin_1	264	270	PF00069	0.660
MOD_ProDKin_1	291	297	PF00069	0.733
MOD_ProDKin_1	312	318	PF00069	0.571
MOD_ProDKin_1	361	367	PF00069	0.824
MOD_ProDKin_1	506	512	PF00069	0.729
MOD_ProDKin_1	538	544	PF00069	0.821
MOD_ProDKin_1	545	551	PF00069	0.743
MOD_ProDKin_1	553	559	PF00069	0.600
MOD_ProDKin_1	563	569	PF00069	0.543
MOD_ProDKin_1	591	597	PF00069	0.684
MOD_ProDKin_1	634	640	PF00069	0.814
MOD_ProDKin_1	646	652	PF00069	0.648
MOD_ProDKin_1	667	673	PF00069	0.872
MOD_ProDKin_1	703	709	PF00069	0.699
MOD_ProDKin_1	724	730	PF00069	0.851
MOD_ProDKin_1	733	739	PF00069	0.700
MOD_ProDKin_1	744	750	PF00069	0.520
MOD_ProDKin_1	772	778	PF00069	0.701
MOD_ProDKin_1	83	89	PF00069	0.770
MOD_ProDKin_1	880	886	PF00069	0.754
TRG_DiLeu_BaEn_1	392	397	PF01217	0.717
TRG_ENDOCYTIC_2	862	865	PF00928	0.586
TRG_ENDOCYTIC_2	904	907	PF00928	0.632
TRG_ENDOCYTIC_2	927	930	PF00928	0.609
TRG_ER_diArg_1	779	782	PF00400	0.699
TRG_ER_diArg_1	896	898	PF00400	0.733
TRG_NES_CRM1_1	928	943	PF08389	0.610
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.854
TRG_Pf-PMV_PEXEL_1	794	799	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVB1	Leishmania donovani	94%	100%
A4H9Y4	Leishmania braziliensis	80%	100%
A4HY49	Leishmania infantum	94%	100%
E9ARX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%