Putative sarcoplasmic reticulum glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sarcalumenin, putative

Species:

Leishmania major

UniProt:

Q4QDJ3_LEIMA

TriTrypDb:

LmjF.19.0280 , LMJLV39_190007700 , LMJSD75_190007600

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005886	plasma membrane	3	21
GO:0016020	membrane	2	21
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

Q4QDJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDJ3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006897	endocytosis	5	3
GO:0009987	cellular process	1	3
GO:0016192	vesicle-mediated transport	4	3
GO:0016197	endosomal transport	4	3
GO:0046907	intracellular transport	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0005525	GTP binding	5	21
GO:0017076	purine nucleotide binding	4	21
GO:0019001	guanyl nucleotide binding	5	21
GO:0032553	ribonucleotide binding	3	21
GO:0032555	purine ribonucleotide binding	4	21
GO:0032561	guanyl ribonucleotide binding	5	21
GO:0035639	purine ribonucleoside triphosphate binding	4	21
GO:0036094	small molecule binding	2	21
GO:0043167	ion binding	2	21
GO:0043168	anion binding	3	21
GO:0097159	organic cyclic compound binding	2	21
GO:0097367	carbohydrate derivative binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.429
CLV_NRD_NRD_1	171	173	PF00675	0.345
CLV_NRD_NRD_1	306	308	PF00675	0.345
CLV_NRD_NRD_1	344	346	PF00675	0.311
CLV_PCSK_KEX2_1	306	308	PF00082	0.347
CLV_PCSK_KEX2_1	344	346	PF00082	0.311
CLV_PCSK_SKI1_1	128	132	PF00082	0.343
CLV_PCSK_SKI1_1	139	143	PF00082	0.317
CLV_PCSK_SKI1_1	206	210	PF00082	0.407
CLV_PCSK_SKI1_1	221	225	PF00082	0.347
CLV_PCSK_SKI1_1	306	310	PF00082	0.331
CLV_PCSK_SKI1_1	367	371	PF00082	0.355
CLV_Separin_Metazoa	234	238	PF03568	0.393
CLV_Separin_Metazoa	254	258	PF03568	0.230
DEG_APCC_DBOX_1	185	193	PF00400	0.324
DEG_APCC_DBOX_1	321	329	PF00400	0.360
DEG_SCF_FBW7_1	588	595	PF00400	0.760
DEG_SPOP_SBC_1	506	510	PF00917	0.627
DEG_SPOP_SBC_1	526	530	PF00917	0.624
DOC_CKS1_1	157	162	PF01111	0.322
DOC_CKS1_1	589	594	PF01111	0.684
DOC_CYCLIN_RxL_1	123	135	PF00134	0.439
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.311
DOC_MAPK_gen_1	172	179	PF00069	0.358
DOC_MAPK_gen_1	306	313	PF00069	0.351
DOC_MAPK_MEF2A_6	186	194	PF00069	0.295
DOC_MAPK_MEF2A_6	322	329	PF00069	0.335
DOC_MAPK_NFAT4_5	322	330	PF00069	0.338
DOC_PP2B_LxvP_1	610	613	PF13499	0.548
DOC_PP4_FxxP_1	144	147	PF00568	0.399
DOC_PP4_FxxP_1	193	196	PF00568	0.311
DOC_SPAK_OSR1_1	372	376	PF12202	0.415
DOC_USP7_MATH_1	184	188	PF00917	0.324
DOC_USP7_MATH_1	365	369	PF00917	0.425
DOC_USP7_MATH_1	466	470	PF00917	0.662
DOC_USP7_MATH_1	506	510	PF00917	0.735
DOC_USP7_MATH_1	526	530	PF00917	0.765
DOC_USP7_MATH_1	584	588	PF00917	0.733
DOC_USP7_MATH_1	592	596	PF00917	0.729
DOC_USP7_UBL2_3	331	335	PF12436	0.338
DOC_WW_Pin1_4	156	161	PF00397	0.324
DOC_WW_Pin1_4	266	271	PF00397	0.360
DOC_WW_Pin1_4	491	496	PF00397	0.734
DOC_WW_Pin1_4	513	518	PF00397	0.708
DOC_WW_Pin1_4	527	532	PF00397	0.617
DOC_WW_Pin1_4	588	593	PF00397	0.592
LIG_14-3-3_CanoR_1	153	157	PF00244	0.398
LIG_14-3-3_CanoR_1	557	563	PF00244	0.577
LIG_14-3-3_CanoR_1	65	71	PF00244	0.374
LIG_Actin_WH2_2	390	408	PF00022	0.402
LIG_APCC_ABBA_1	190	195	PF00400	0.311
LIG_APCC_ABBA_1	426	431	PF00400	0.565
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BIR_III_4	200	204	PF00653	0.374
LIG_BRCT_BRCA1_1	273	277	PF00533	0.382
LIG_BRCT_BRCA1_1	493	497	PF00533	0.573
LIG_EH_1	414	418	PF12763	0.678
LIG_eIF4E_1	429	435	PF01652	0.337
LIG_FHA_1	157	163	PF00498	0.322
LIG_FHA_1	230	236	PF00498	0.403
LIG_FHA_1	35	41	PF00498	0.453
LIG_FHA_1	421	427	PF00498	0.576
LIG_FHA_1	445	451	PF00498	0.638
LIG_FHA_1	77	83	PF00498	0.415
LIG_FHA_2	153	159	PF00498	0.315
LIG_FHA_2	589	595	PF00498	0.751
LIG_FHA_2	96	102	PF00498	0.308
LIG_FXI_DFP_1	357	361	PF00024	0.308
LIG_LIR_Apic_2	262	267	PF02991	0.396
LIG_LIR_Apic_2	90	95	PF02991	0.447
LIG_LIR_Gen_1	175	184	PF02991	0.344
LIG_LIR_Gen_1	188	199	PF02991	0.322
LIG_LIR_Gen_1	272	278	PF02991	0.445
LIG_LIR_Gen_1	48	57	PF02991	0.446
LIG_LIR_Gen_1	494	505	PF02991	0.725
LIG_LIR_Gen_1	64	73	PF02991	0.407
LIG_LIR_Gen_1	99	107	PF02991	0.324
LIG_LIR_Nem_3	175	179	PF02991	0.336
LIG_LIR_Nem_3	188	194	PF02991	0.282
LIG_LIR_Nem_3	211	216	PF02991	0.503
LIG_LIR_Nem_3	241	246	PF02991	0.428
LIG_LIR_Nem_3	272	276	PF02991	0.445
LIG_LIR_Nem_3	359	363	PF02991	0.327
LIG_LIR_Nem_3	48	52	PF02991	0.477
LIG_LIR_Nem_3	494	500	PF02991	0.725
LIG_LIR_Nem_3	64	70	PF02991	0.408
LIG_LIR_Nem_3	79	84	PF02991	0.350
LIG_LIR_Nem_3	99	105	PF02991	0.146
LIG_NRBOX	284	290	PF00104	0.471
LIG_PCNA_yPIPBox_3	421	429	PF02747	0.529
LIG_Pex14_1	264	268	PF04695	0.402
LIG_Pex14_2	133	137	PF04695	0.324
LIG_Pex14_2	209	213	PF04695	0.364
LIG_Pex14_2	273	277	PF04695	0.387
LIG_Pex14_2	369	373	PF04695	0.313
LIG_Pex14_2	52	56	PF04695	0.338
LIG_Pex14_2	67	71	PF04695	0.271
LIG_SH2_CRK	174	178	PF00017	0.324
LIG_SH2_CRK	239	243	PF00017	0.383
LIG_SH2_GRB2like	176	179	PF00017	0.253
LIG_SH2_NCK_1	346	350	PF00017	0.367
LIG_SH2_PTP2	176	179	PF00017	0.355
LIG_SH2_SRC	174	177	PF00017	0.384
LIG_SH2_STAP1	36	40	PF00017	0.458
LIG_SH2_STAP1	47	51	PF00017	0.337
LIG_SH2_STAP1	57	61	PF00017	0.373
LIG_SH2_STAT3	547	550	PF00017	0.498
LIG_SH2_STAT3	84	87	PF00017	0.355
LIG_SH2_STAT5	176	179	PF00017	0.343
LIG_SH2_STAT5	259	262	PF00017	0.369
LIG_SH2_STAT5	36	39	PF00017	0.338
LIG_SH2_STAT5	84	87	PF00017	0.332
LIG_SH3_3	264	270	PF00018	0.429
LIG_SH3_3	48	54	PF00018	0.384
LIG_SH3_3	514	520	PF00018	0.760
LIG_SH3_3	586	592	PF00018	0.714
LIG_SH3_3	598	604	PF00018	0.703
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.328
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.444
LIG_TRAF2_1	231	234	PF00917	0.534
LIG_TRAF2_1	416	419	PF00917	0.509
LIG_TRAF2_1	42	45	PF00917	0.439
LIG_TRAF2_1	591	594	PF00917	0.636
LIG_TRAF2_2	293	298	PF00917	0.407
LIG_WRC_WIRS_1	260	265	PF05994	0.379
LIG_WRC_WIRS_1	366	371	PF05994	0.285
LIG_WRC_WIRS_1	46	51	PF05994	0.272
LIG_WW_3	254	258	PF00397	0.399
MOD_CK1_1	269	275	PF00069	0.541
MOD_CK1_1	461	467	PF00069	0.652
MOD_CK1_1	476	482	PF00069	0.688
MOD_CK1_1	568	574	PF00069	0.758
MOD_CK1_1	576	582	PF00069	0.734
MOD_CK1_1	615	621	PF00069	0.659
MOD_CK2_1	228	234	PF00069	0.516
MOD_CK2_1	365	371	PF00069	0.288
MOD_CK2_1	52	58	PF00069	0.324
MOD_CK2_1	572	578	PF00069	0.710
MOD_CK2_1	588	594	PF00069	0.719
MOD_CK2_1	95	101	PF00069	0.308
MOD_GlcNHglycan	16	19	PF01048	0.573
MOD_GlcNHglycan	164	167	PF01048	0.421
MOD_GlcNHglycan	3	6	PF01048	0.605
MOD_GlcNHglycan	460	463	PF01048	0.671
MOD_GlcNHglycan	475	478	PF01048	0.698
MOD_GlcNHglycan	491	494	PF01048	0.696
MOD_GlcNHglycan	523	526	PF01048	0.749
MOD_GlcNHglycan	560	563	PF01048	0.760
MOD_GlcNHglycan	578	582	PF01048	0.744
MOD_GlcNHglycan	620	623	PF01048	0.697
MOD_GlcNHglycan	74	77	PF01048	0.322
MOD_GSK3_1	152	159	PF00069	0.343
MOD_GSK3_1	396	403	PF00069	0.435
MOD_GSK3_1	420	427	PF00069	0.544
MOD_GSK3_1	460	467	PF00069	0.677
MOD_GSK3_1	473	480	PF00069	0.630
MOD_GSK3_1	521	528	PF00069	0.752
MOD_GSK3_1	558	565	PF00069	0.769
MOD_GSK3_1	568	575	PF00069	0.609
MOD_GSK3_1	584	591	PF00069	0.614
MOD_GSK3_1	592	599	PF00069	0.662
MOD_GSK3_1	72	79	PF00069	0.316
MOD_GSK3_1	96	103	PF00069	0.324
MOD_N-GLC_1	244	249	PF02516	0.406
MOD_N-GLC_1	250	255	PF02516	0.433
MOD_N-GLC_2	178	180	PF02516	0.253
MOD_N-GLC_2	614	616	PF02516	0.551
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	119	124	PF00069	0.375
MOD_NEK2_1	133	138	PF00069	0.286
MOD_NEK2_1	208	213	PF00069	0.403
MOD_NEK2_1	329	334	PF00069	0.441
MOD_NEK2_1	396	401	PF00069	0.483
MOD_NEK2_1	505	510	PF00069	0.785
MOD_NEK2_1	572	577	PF00069	0.564
MOD_NEK2_1	583	588	PF00069	0.524
MOD_NEK2_2	424	429	PF00069	0.497
MOD_NEK2_2	66	71	PF00069	0.324
MOD_PIKK_1	229	235	PF00454	0.406
MOD_PIKK_1	34	40	PF00454	0.311
MOD_PIKK_1	615	621	PF00454	0.578
MOD_PKA_2	14	20	PF00069	0.757
MOD_PKA_2	152	158	PF00069	0.367
MOD_PKA_2	52	58	PF00069	0.324
MOD_PKA_2	556	562	PF00069	0.568
MOD_Plk_1	100	106	PF00069	0.308
MOD_Plk_1	57	63	PF00069	0.365
MOD_Plk_1	584	590	PF00069	0.721
MOD_Plk_2-3	152	158	PF00069	0.417
MOD_Plk_2-3	45	51	PF00069	0.425
MOD_Plk_4	133	139	PF00069	0.343
MOD_Plk_4	152	158	PF00069	0.325
MOD_Plk_4	238	244	PF00069	0.422
MOD_Plk_4	259	265	PF00069	0.389
MOD_Plk_4	300	306	PF00069	0.331
MOD_Plk_4	396	402	PF00069	0.391
MOD_Plk_4	424	430	PF00069	0.540
MOD_Plk_4	477	483	PF00069	0.619
MOD_Plk_4	52	58	PF00069	0.322
MOD_Plk_4	602	608	PF00069	0.770
MOD_Plk_4	77	83	PF00069	0.370
MOD_ProDKin_1	156	162	PF00069	0.324
MOD_ProDKin_1	266	272	PF00069	0.354
MOD_ProDKin_1	491	497	PF00069	0.736
MOD_ProDKin_1	513	519	PF00069	0.753
MOD_ProDKin_1	527	533	PF00069	0.611
MOD_ProDKin_1	588	594	PF00069	0.596
MOD_SUMO_rev_2	274	282	PF00179	0.431
MOD_SUMO_rev_2	418	423	PF00179	0.577
MOD_SUMO_rev_2	627	631	PF00179	0.510
TRG_DiLeu_BaEn_1	152	157	PF01217	0.436
TRG_DiLeu_BaEn_1	185	190	PF01217	0.333
TRG_DiLeu_BaEn_1	280	285	PF01217	0.361
TRG_DiLeu_BaEn_1	385	390	PF01217	0.311
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.357
TRG_ENDOCYTIC_2	174	177	PF00928	0.329
TRG_ENDOCYTIC_2	239	242	PF00928	0.377
TRG_ENDOCYTIC_2	346	349	PF00928	0.337
TRG_ENDOCYTIC_2	366	369	PF00928	0.320
TRG_ER_diArg_1	12	15	PF00400	0.517
TRG_ER_diArg_1	219	222	PF00400	0.437
TRG_ER_diArg_1	305	307	PF00400	0.365
TRG_ER_diArg_1	343	345	PF00400	0.462
TRG_ER_diArg_1	39	42	PF00400	0.298
TRG_NES_CRM1_1	280	295	PF08389	0.462
TRG_NLS_MonoExtC_3	334	340	PF00514	0.343
TRG_NLS_MonoExtN_4	333	339	PF00514	0.324
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	78%	100%
A0A0N0P9A4	Leptomonas seymouri	43%	100%
A0A0S4KGM0	Bodo saltans	56%	100%
A0A1X0P6D7	Trypanosomatidae	64%	100%
A0A1X0P9Q8	Trypanosomatidae	46%	100%
A0A3R7LDF3	Trypanosoma rangeli	59%	100%
A0A3S7WV81	Leishmania donovani	92%	100%
A0A3S7X801	Leishmania donovani	45%	100%
A0A422P0G8	Trypanosoma rangeli	43%	100%
A4H9Y5	Leishmania braziliensis	75%	100%
A4HAT9	Leishmania braziliensis	42%	100%
A4HY50	Leishmania infantum	92%	100%
A4IA07	Leishmania infantum	45%	100%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q4Q2X3	Leishmania major	45%	100%
Q7TQ48	Mus musculus	37%	100%
V5BSA9	Trypanosoma cruzi	61%	100%
V5DGT0	Trypanosoma cruzi	45%	100%