Intraflagellar transport protein 80 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 80, putative

Species:

Leishmania major

UniProt:

Q4QDI8_LEIMA

TriTrypDb:

LmjF.19.0330 , LMJLV39_190008500 , LMJSD75_190008400

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	5
GO:0030990	intraciliary transport particle	2	2
GO:0030992	intraciliary transport particle B	2	2
GO:0032991	protein-containing complex	1	2
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5
GO:0031514	motile cilium	5	3

Expansion

Sequence features

Q4QDI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDI8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006996	organelle organization	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0010970	transport along microtubule	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0030705	cytoskeleton-dependent intracellular transport	4	2
GO:0031503	protein-containing complex localization	2	2
GO:0035735	intraciliary transport involved in cilium assembly	4	2
GO:0042073	intraciliary transport	3	2
GO:0044782	cilium organization	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099111	microtubule-based transport	4	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.338
CLV_C14_Caspase3-7	370	374	PF00656	0.461
CLV_NRD_NRD_1	123	125	PF00675	0.360
CLV_NRD_NRD_1	139	141	PF00675	0.330
CLV_NRD_NRD_1	299	301	PF00675	0.327
CLV_NRD_NRD_1	396	398	PF00675	0.352
CLV_NRD_NRD_1	531	533	PF00675	0.406
CLV_NRD_NRD_1	542	544	PF00675	0.372
CLV_PCSK_KEX2_1	139	141	PF00082	0.510
CLV_PCSK_KEX2_1	262	264	PF00082	0.376
CLV_PCSK_KEX2_1	396	398	PF00082	0.352
CLV_PCSK_KEX2_1	542	544	PF00082	0.392
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.376
CLV_PCSK_PC7_1	392	398	PF00082	0.368
CLV_PCSK_SKI1_1	139	143	PF00082	0.497
CLV_PCSK_SKI1_1	159	163	PF00082	0.135
CLV_PCSK_SKI1_1	206	210	PF00082	0.293
CLV_PCSK_SKI1_1	262	266	PF00082	0.309
CLV_PCSK_SKI1_1	3	7	PF00082	0.408
CLV_PCSK_SKI1_1	301	305	PF00082	0.294
CLV_PCSK_SKI1_1	362	366	PF00082	0.351
CLV_PCSK_SKI1_1	433	437	PF00082	0.476
CLV_PCSK_SKI1_1	501	505	PF00082	0.363
CLV_PCSK_SKI1_1	518	522	PF00082	0.373
CLV_PCSK_SKI1_1	553	557	PF00082	0.343
DEG_Nend_UBRbox_1	1	4	PF02207	0.436
DEG_ODPH_VHL_1	556	568	PF01847	0.507
DEG_SPOP_SBC_1	172	176	PF00917	0.357
DOC_ANK_TNKS_1	395	402	PF00023	0.401
DOC_ANK_TNKS_1	58	65	PF00023	0.465
DOC_CKS1_1	479	484	PF01111	0.354
DOC_CYCLIN_RxL_1	260	271	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.463
DOC_MAPK_gen_1	518	528	PF00069	0.451
DOC_MAPK_gen_1	6	15	PF00069	0.348
DOC_MAPK_HePTP_8	393	408	PF00069	0.469
DOC_MAPK_MEF2A_6	195	203	PF00069	0.318
DOC_MAPK_MEF2A_6	225	234	PF00069	0.481
DOC_MAPK_RevD_3	287	301	PF00069	0.390
DOC_PP1_RVXF_1	1	8	PF00149	0.432
DOC_PP1_RVXF_1	122	129	PF00149	0.364
DOC_PP1_RVXF_1	260	267	PF00149	0.294
DOC_PP1_RVXF_1	298	305	PF00149	0.317
DOC_PP1_RVXF_1	565	571	PF00149	0.439
DOC_PP2B_LxvP_1	186	189	PF13499	0.365
DOC_PP2B_LxvP_1	404	407	PF13499	0.471
DOC_PP2B_PxIxI_1	196	202	PF00149	0.443
DOC_USP7_MATH_1	211	215	PF00917	0.458
DOC_USP7_MATH_1	54	58	PF00917	0.359
DOC_USP7_MATH_1	68	72	PF00917	0.237
DOC_USP7_UBL2_3	2	6	PF12436	0.420
DOC_WW_Pin1_4	246	251	PF00397	0.356
DOC_WW_Pin1_4	406	411	PF00397	0.341
DOC_WW_Pin1_4	478	483	PF00397	0.367
LIG_14-3-3_CanoR_1	124	129	PF00244	0.453
LIG_14-3-3_CanoR_1	139	144	PF00244	0.360
LIG_14-3-3_CanoR_1	225	230	PF00244	0.345
LIG_14-3-3_CanoR_1	231	237	PF00244	0.348
LIG_14-3-3_CanoR_1	532	540	PF00244	0.381
LIG_14-3-3_CanoR_1	89	96	PF00244	0.460
LIG_Actin_WH2_2	436	452	PF00022	0.316
LIG_APCC_ABBA_1	556	561	PF00400	0.406
LIG_APCC_ABBAyCdc20_2	262	268	PF00400	0.223
LIG_BRCT_BRCA1_1	355	359	PF00533	0.426
LIG_BRCT_BRCA1_1	56	60	PF00533	0.381
LIG_FHA_1	103	109	PF00498	0.328
LIG_FHA_1	111	117	PF00498	0.355
LIG_FHA_1	130	136	PF00498	0.219
LIG_FHA_1	240	246	PF00498	0.408
LIG_FHA_1	327	333	PF00498	0.343
LIG_FHA_1	366	372	PF00498	0.358
LIG_FHA_1	389	395	PF00498	0.479
LIG_FHA_1	403	409	PF00498	0.336
LIG_FHA_1	410	416	PF00498	0.450
LIG_FHA_2	132	138	PF00498	0.330
LIG_FHA_2	140	146	PF00498	0.339
LIG_FHA_2	148	154	PF00498	0.376
LIG_FHA_2	26	32	PF00498	0.310
LIG_FHA_2	358	364	PF00498	0.495
LIG_FHA_2	368	374	PF00498	0.387
LIG_FHA_2	378	384	PF00498	0.361
LIG_FHA_2	532	538	PF00498	0.396
LIG_LIR_Apic_2	310	315	PF02991	0.423
LIG_LIR_Apic_2	351	355	PF02991	0.284
LIG_LIR_Gen_1	18	27	PF02991	0.334
LIG_LIR_Gen_1	409	419	PF02991	0.372
LIG_LIR_Gen_1	569	577	PF02991	0.392
LIG_LIR_Gen_1	71	77	PF02991	0.327
LIG_LIR_Nem_3	127	131	PF02991	0.470
LIG_LIR_Nem_3	310	316	PF02991	0.314
LIG_LIR_Nem_3	458	464	PF02991	0.330
LIG_LIR_Nem_3	569	573	PF02991	0.391
LIG_LIR_Nem_3	71	75	PF02991	0.314
LIG_Pex14_1	83	87	PF04695	0.388
LIG_SH2_CRK	461	465	PF00017	0.328
LIG_SH2_STAP1	131	135	PF00017	0.426
LIG_SH2_STAP1	411	415	PF00017	0.373
LIG_SH2_STAT5	131	134	PF00017	0.312
LIG_SH2_STAT5	169	172	PF00017	0.297
LIG_SH2_STAT5	312	315	PF00017	0.314
LIG_SH2_STAT5	411	414	PF00017	0.409
LIG_SH2_STAT5	472	475	PF00017	0.333
LIG_SH2_STAT5	546	549	PF00017	0.394
LIG_SH3_3	34	40	PF00018	0.338
LIG_SH3_3	404	410	PF00018	0.426
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.441
LIG_SUMO_SIM_par_1	131	138	PF11976	0.374
LIG_SUMO_SIM_par_1	242	249	PF11976	0.360
LIG_SUMO_SIM_par_1	339	346	PF11976	0.280
LIG_SUMO_SIM_par_1	363	368	PF11976	0.473
LIG_TRAF2_1	150	153	PF00917	0.361
LIG_TYR_ITIM	459	464	PF00017	0.315
LIG_TYR_ITIM	508	513	PF00017	0.311
LIG_UBA3_1	364	369	PF00899	0.428
LIG_UBA3_1	414	422	PF00899	0.430
LIG_WRC_WIRS_1	69	74	PF05994	0.307
MOD_CDK_SPxxK_3	478	485	PF00069	0.362
MOD_CK1_1	20	26	PF00069	0.338
MOD_CK1_1	249	255	PF00069	0.317
MOD_CK1_1	326	332	PF00069	0.345
MOD_CK1_1	337	343	PF00069	0.327
MOD_CK1_1	409	415	PF00069	0.390
MOD_CK2_1	147	153	PF00069	0.432
MOD_CK2_1	25	31	PF00069	0.311
MOD_CK2_1	548	554	PF00069	0.560
MOD_Cter_Amidation	540	543	PF01082	0.469
MOD_GlcNHglycan	22	25	PF01048	0.474
MOD_GlcNHglycan	270	273	PF01048	0.463
MOD_GlcNHglycan	293	296	PF01048	0.482
MOD_GlcNHglycan	561	565	PF01048	0.547
MOD_GlcNHglycan	92	96	PF01048	0.381
MOD_GSK3_1	110	117	PF00069	0.483
MOD_GSK3_1	131	138	PF00069	0.408
MOD_GSK3_1	240	247	PF00069	0.435
MOD_GSK3_1	285	292	PF00069	0.311
MOD_GSK3_1	323	330	PF00069	0.342
MOD_GSK3_1	353	360	PF00069	0.302
MOD_GSK3_1	363	370	PF00069	0.350
MOD_GSK3_1	402	409	PF00069	0.348
MOD_GSK3_1	531	538	PF00069	0.385
MOD_GSK3_1	83	90	PF00069	0.446
MOD_N-GLC_1	110	115	PF02516	0.486
MOD_NEK2_1	135	140	PF00069	0.425
MOD_NEK2_1	232	237	PF00069	0.371
MOD_NEK2_1	25	30	PF00069	0.319
MOD_NEK2_1	267	272	PF00069	0.294
MOD_NEK2_1	291	296	PF00069	0.335
MOD_NEK2_1	328	333	PF00069	0.355
MOD_NEK2_1	365	370	PF00069	0.412
MOD_NEK2_1	388	393	PF00069	0.367
MOD_NEK2_2	41	46	PF00069	0.348
MOD_NEK2_2	54	59	PF00069	0.331
MOD_PIKK_1	102	108	PF00454	0.344
MOD_PIKK_1	173	179	PF00454	0.296
MOD_PIKK_1	211	217	PF00454	0.449
MOD_PIKK_1	289	295	PF00454	0.346
MOD_PIKK_1	315	321	PF00454	0.416
MOD_PIKK_1	417	423	PF00454	0.488
MOD_PIKK_1	548	554	PF00454	0.512
MOD_PK_1	225	231	PF00069	0.464
MOD_PKA_1	124	130	PF00069	0.476
MOD_PKA_1	139	145	PF00069	0.455
MOD_PKA_2	139	145	PF00069	0.471
MOD_PKA_2	20	26	PF00069	0.429
MOD_PKA_2	383	389	PF00069	0.449
MOD_PKA_2	531	537	PF00069	0.386
MOD_PKA_2	88	94	PF00069	0.468
MOD_Plk_1	17	23	PF00069	0.343
MOD_Plk_4	131	137	PF00069	0.328
MOD_Plk_4	337	343	PF00069	0.329
MOD_Plk_4	348	354	PF00069	0.276
MOD_Plk_4	409	415	PF00069	0.358
MOD_Plk_4	41	47	PF00069	0.465
MOD_Plk_4	535	541	PF00069	0.376
MOD_Plk_4	68	74	PF00069	0.333
MOD_ProDKin_1	246	252	PF00069	0.355
MOD_ProDKin_1	406	412	PF00069	0.336
MOD_ProDKin_1	478	484	PF00069	0.363
MOD_SUMO_for_1	161	164	PF00179	0.311
MOD_SUMO_for_1	236	239	PF00179	0.484
MOD_SUMO_for_1	520	523	PF00179	0.462
MOD_SUMO_for_1	577	580	PF00179	0.461
MOD_SUMO_rev_2	117	127	PF00179	0.467
MOD_SUMO_rev_2	294	303	PF00179	0.377
MOD_SUMO_rev_2	527	534	PF00179	0.374
MOD_SUMO_rev_2	569	577	PF00179	0.438
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.403
TRG_ENDOCYTIC_2	169	172	PF00928	0.347
TRG_ENDOCYTIC_2	411	414	PF00928	0.329
TRG_ENDOCYTIC_2	461	464	PF00928	0.318
TRG_ENDOCYTIC_2	510	513	PF00928	0.306
TRG_ER_diArg_1	139	141	PF00400	0.510
TRG_ER_diArg_1	395	397	PF00400	0.347
TRG_NES_CRM1_1	226	239	PF08389	0.485
TRG_NES_CRM1_1	437	453	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK4	Leptomonas seymouri	88%	76%
A0A0S4KKI7	Bodo saltans	57%	89%
A0A1X0P6J7	Trypanosomatidae	68%	76%
A0A3Q8IJX2	Leishmania donovani	98%	100%
A0A3R7N3D3	Trypanosoma rangeli	67%	76%
A4H9Z1	Leishmania braziliensis	94%	76%
A4HY55	Leishmania infantum	98%	100%
D0A0G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	76%
E9ARY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	76%
Q66HB3	Rattus norvegicus	40%	76%
Q8K057	Mus musculus	40%	76%
Q9P2H3	Homo sapiens	40%	76%
V5BWZ3	Trypanosoma cruzi	67%	76%