Proteasome maturation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome maturation factor UMP1, putative

Species:

Leishmania major

UniProt:

Q4QDI0_LEIMA

TriTrypDb:

LmjF.19.0410 , LMJLV39_190009300 , LMJSD75_190009200

Length:

124

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0000502	proteasome complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

Q4QDI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDI0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043248	proteasome assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.600
CLV_PCSK_KEX2_1	63	65	PF00082	0.600
DOC_CKS1_1	101	106	PF01111	0.647
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.641
DOC_MAPK_gen_1	13	23	PF00069	0.663
DOC_WW_Pin1_4	100	105	PF00397	0.705
LIG_14-3-3_CanoR_1	79	87	PF00244	0.541
LIG_FHA_1	41	47	PF00498	0.627
LIG_LIR_Apic_2	89	94	PF02991	0.559
LIG_LIR_Nem_3	73	78	PF02991	0.507
LIG_PDZ_Class_2	119	124	PF00595	0.717
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.665
LIG_TRAF2_1	12	15	PF00917	0.708
LIG_TRAF2_1	29	32	PF00917	0.622
MOD_CDK_SPK_2	100	105	PF00069	0.654
MOD_GlcNHglycan	26	29	PF01048	0.565
MOD_GSK3_1	55	62	PF00069	0.527
MOD_N-GLC_1	80	85	PF02516	0.600
MOD_NEK2_1	59	64	PF00069	0.568
MOD_PKA_2	40	46	PF00069	0.557
MOD_Plk_1	115	121	PF00069	0.536
MOD_Plk_1	55	61	PF00069	0.521
MOD_Plk_4	55	61	PF00069	0.532
MOD_Plk_4	70	76	PF00069	0.615
MOD_ProDKin_1	100	106	PF00069	0.698
TRG_ER_diArg_1	63	65	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC2	Leptomonas seymouri	89%	100%
A0A0S4ISS2	Bodo saltans	39%	100%
A0A3S5H754	Leishmania donovani	98%	100%
A0A422P399	Trypanosoma rangeli	58%	100%
A4H9Z9	Leishmania braziliensis	90%	100%
A4HY63	Leishmania infantum	98%	100%
D0A0I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9ARZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BBY6	Trypanosoma cruzi	58%	100%