Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDH8_LEIMA

TriTrypDb:

LmjF.19.0430 , LMJLV39_190009500 , LMJSD75_190009400

Length:

1129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH8

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	2
GO:0006914	autophagy	3	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0034058	endosomal vesicle fusion	7	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0061919	process utilizing autophagic mechanism	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0006810	transport	3	6
GO:0016192	vesicle-mediated transport	4	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1053	1057	PF00656	0.536
CLV_C14_Caspase3-7	959	963	PF00656	0.553
CLV_MEL_PAP_1	160	166	PF00089	0.623
CLV_NRD_NRD_1	232	234	PF00675	0.607
CLV_NRD_NRD_1	269	271	PF00675	0.526
CLV_NRD_NRD_1	49	51	PF00675	0.655
CLV_NRD_NRD_1	492	494	PF00675	0.519
CLV_NRD_NRD_1	743	745	PF00675	0.533
CLV_NRD_NRD_1	851	853	PF00675	0.631
CLV_NRD_NRD_1	991	993	PF00675	0.627
CLV_PCSK_KEX2_1	232	234	PF00082	0.607
CLV_PCSK_KEX2_1	269	271	PF00082	0.526
CLV_PCSK_KEX2_1	48	50	PF00082	0.663
CLV_PCSK_KEX2_1	491	493	PF00082	0.513
CLV_PCSK_KEX2_1	743	745	PF00082	0.533
CLV_PCSK_KEX2_1	851	853	PF00082	0.631
CLV_PCSK_KEX2_1	991	993	PF00082	0.627
CLV_PCSK_PC7_1	45	51	PF00082	0.559
CLV_PCSK_SKI1_1	1018	1022	PF00082	0.535
CLV_PCSK_SKI1_1	206	210	PF00082	0.563
CLV_PCSK_SKI1_1	546	550	PF00082	0.461
CLV_PCSK_SKI1_1	647	651	PF00082	0.593
CLV_PCSK_SKI1_1	865	869	PF00082	0.525
CLV_PCSK_SKI1_1	899	903	PF00082	0.505
CLV_PCSK_SKI1_1	916	920	PF00082	0.478
DEG_APCC_DBOX_1	291	299	PF00400	0.636
DEG_APCC_DBOX_1	432	440	PF00400	0.620
DEG_APCC_DBOX_1	467	475	PF00400	0.454
DEG_APCC_DBOX_1	545	553	PF00400	0.465
DEG_APCC_DBOX_1	805	813	PF00400	0.401
DEG_COP1_1	314	323	PF00400	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.499
DEG_SCF_FBW7_1	92	99	PF00400	0.568
DEG_SPOP_SBC_1	652	656	PF00917	0.646
DOC_CDC14_PxL_1	12	20	PF14671	0.626
DOC_CDC14_PxL_1	867	875	PF14671	0.542
DOC_CKS1_1	72	77	PF01111	0.739
DOC_CKS1_1	829	834	PF01111	0.573
DOC_CKS1_1	93	98	PF01111	0.664
DOC_CYCLIN_RxL_1	862	872	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	732	735	PF00134	0.571
DOC_MAPK_DCC_7	200	209	PF00069	0.654
DOC_MAPK_gen_1	151	160	PF00069	0.592
DOC_MAPK_gen_1	232	239	PF00069	0.611
DOC_MAPK_gen_1	269	277	PF00069	0.510
DOC_MAPK_gen_1	48	56	PF00069	0.709
DOC_MAPK_gen_1	784	794	PF00069	0.494
DOC_MAPK_HePTP_8	148	160	PF00069	0.570
DOC_MAPK_MEF2A_6	151	160	PF00069	0.568
DOC_MAPK_MEF2A_6	200	209	PF00069	0.521
DOC_MAPK_MEF2A_6	575	583	PF00069	0.682
DOC_MAPK_RevD_3	731	744	PF00069	0.446
DOC_PP2B_LxvP_1	550	553	PF13499	0.488
DOC_PP2B_LxvP_1	731	734	PF13499	0.593
DOC_PP2B_LxvP_1	868	871	PF13499	0.622
DOC_PP4_FxxP_1	1083	1086	PF00568	0.525
DOC_PP4_FxxP_1	239	242	PF00568	0.549
DOC_SPAK_OSR1_1	936	940	PF12202	0.569
DOC_USP7_MATH_1	100	104	PF00917	0.763
DOC_USP7_MATH_1	1057	1061	PF00917	0.636
DOC_USP7_MATH_1	1065	1069	PF00917	0.518
DOC_USP7_MATH_1	171	175	PF00917	0.701
DOC_USP7_MATH_1	245	249	PF00917	0.615
DOC_USP7_MATH_1	361	365	PF00917	0.711
DOC_USP7_MATH_1	375	379	PF00917	0.528
DOC_USP7_MATH_1	41	45	PF00917	0.686
DOC_USP7_MATH_1	513	517	PF00917	0.468
DOC_USP7_MATH_1	652	656	PF00917	0.646
DOC_USP7_MATH_1	768	772	PF00917	0.557
DOC_USP7_MATH_1	832	836	PF00917	0.610
DOC_USP7_MATH_1	918	922	PF00917	0.612
DOC_USP7_MATH_1	974	978	PF00917	0.667
DOC_USP7_MATH_1	997	1001	PF00917	0.523
DOC_WW_Pin1_4	1059	1064	PF00397	0.668
DOC_WW_Pin1_4	199	204	PF00397	0.731
DOC_WW_Pin1_4	223	228	PF00397	0.630
DOC_WW_Pin1_4	559	564	PF00397	0.670
DOC_WW_Pin1_4	648	653	PF00397	0.475
DOC_WW_Pin1_4	699	704	PF00397	0.642
DOC_WW_Pin1_4	71	76	PF00397	0.740
DOC_WW_Pin1_4	828	833	PF00397	0.702
DOC_WW_Pin1_4	92	97	PF00397	0.698
LIG_14-3-3_CanoR_1	1092	1100	PF00244	0.469
LIG_14-3-3_CanoR_1	163	172	PF00244	0.609
LIG_14-3-3_CanoR_1	48	56	PF00244	0.653
LIG_14-3-3_CanoR_1	67	75	PF00244	0.663
LIG_14-3-3_CanoR_1	806	810	PF00244	0.526
LIG_14-3-3_CanoR_1	86	96	PF00244	0.506
LIG_14-3-3_CanoR_1	878	884	PF00244	0.555
LIG_14-3-3_CanoR_1	904	910	PF00244	0.496
LIG_14-3-3_CanoR_1	936	940	PF00244	0.593
LIG_14-3-3_CanoR_1	991	995	PF00244	0.649
LIG_Actin_WH2_2	808	824	PF00022	0.557
LIG_BIR_III_2	1056	1060	PF00653	0.576
LIG_Clathr_ClatBox_1	883	887	PF01394	0.535
LIG_deltaCOP1_diTrp_1	644	650	PF00928	0.592
LIG_DLG_GKlike_1	270	277	PF00625	0.565
LIG_FHA_1	1114	1120	PF00498	0.522
LIG_FHA_1	24	30	PF00498	0.697
LIG_FHA_1	280	286	PF00498	0.752
LIG_FHA_1	302	308	PF00498	0.593
LIG_FHA_1	49	55	PF00498	0.664
LIG_FHA_1	658	664	PF00498	0.664
LIG_FHA_1	67	73	PF00498	0.653
LIG_FHA_1	727	733	PF00498	0.661
LIG_FHA_1	735	741	PF00498	0.527
LIG_FHA_1	828	834	PF00498	0.575
LIG_FHA_1	951	957	PF00498	0.594
LIG_FHA_2	1108	1114	PF00498	0.530
LIG_FHA_2	312	318	PF00498	0.735
LIG_FHA_2	391	397	PF00498	0.565
LIG_FHA_2	503	509	PF00498	0.488
LIG_FHA_2	660	666	PF00498	0.527
LIG_FHA_2	707	713	PF00498	0.632
LIG_FHA_2	72	78	PF00498	0.675
LIG_FHA_2	880	886	PF00498	0.477
LIG_FHA_2	957	963	PF00498	0.597
LIG_HP1_1	205	209	PF01393	0.616
LIG_LIR_Apic_2	627	632	PF02991	0.613
LIG_LIR_Gen_1	1109	1120	PF02991	0.454
LIG_LIR_Gen_1	281	288	PF02991	0.684
LIG_LIR_Gen_1	481	489	PF02991	0.474
LIG_LIR_Gen_1	593	604	PF02991	0.628
LIG_LIR_Gen_1	668	678	PF02991	0.501
LIG_LIR_Gen_1	747	754	PF02991	0.476
LIG_LIR_Gen_1	929	939	PF02991	0.597
LIG_LIR_Nem_3	1003	1009	PF02991	0.500
LIG_LIR_Nem_3	1109	1115	PF02991	0.450
LIG_LIR_Nem_3	281	286	PF02991	0.683
LIG_LIR_Nem_3	481	487	PF02991	0.411
LIG_LIR_Nem_3	593	599	PF02991	0.623
LIG_LIR_Nem_3	668	674	PF02991	0.581
LIG_LIR_Nem_3	747	751	PF02991	0.472
LIG_LIR_Nem_3	788	792	PF02991	0.427
LIG_LIR_Nem_3	929	935	PF02991	0.598
LIG_NRBOX	1068	1074	PF00104	0.520
LIG_NRBOX	1075	1081	PF00104	0.482
LIG_Pex14_1	646	650	PF04695	0.518
LIG_Pex14_2	402	406	PF04695	0.463
LIG_RPA_C_Fungi	487	499	PF08784	0.474
LIG_RPA_C_Fungi	524	536	PF08784	0.479
LIG_SH2_CRK	441	445	PF00017	0.611
LIG_SH2_CRK	596	600	PF00017	0.480
LIG_SH2_CRK	748	752	PF00017	0.415
LIG_SH2_CRK	789	793	PF00017	0.382
LIG_SH2_PTP2	213	216	PF00017	0.578
LIG_SH2_STAP1	596	600	PF00017	0.625
LIG_SH2_STAP1	748	752	PF00017	0.429
LIG_SH2_STAT5	1007	1010	PF00017	0.438
LIG_SH2_STAT5	159	162	PF00017	0.580
LIG_SH2_STAT5	213	216	PF00017	0.578
LIG_SH2_STAT5	582	585	PF00017	0.636
LIG_SH2_STAT5	932	935	PF00017	0.615
LIG_SH3_3	11	17	PF00018	0.655
LIG_SH3_3	315	321	PF00018	0.628
LIG_SH3_3	431	437	PF00018	0.586
LIG_SH3_3	853	859	PF00018	0.716
LIG_SH3_3	90	96	PF00018	0.630
LIG_SH3_3	965	971	PF00018	0.611
LIG_SUMO_SIM_anti_2	1044	1050	PF11976	0.578
LIG_SUMO_SIM_anti_2	271	276	PF11976	0.585
LIG_SUMO_SIM_anti_2	414	420	PF11976	0.487
LIG_SUMO_SIM_par_1	294	301	PF11976	0.635
LIG_SUMO_SIM_par_1	414	420	PF11976	0.487
LIG_SUMO_SIM_par_1	547	554	PF11976	0.485
LIG_SUMO_SIM_par_1	585	594	PF11976	0.578
LIG_SUMO_SIM_par_1	811	816	PF11976	0.505
LIG_SUMO_SIM_par_1	866	872	PF11976	0.621
LIG_TYR_ITIM	439	444	PF00017	0.614
LIG_WRC_WIRS_1	635	640	PF05994	0.614
LIG_WRC_WIRS_1	9	14	PF05994	0.576
LIG_WW_3	203	207	PF00397	0.614
MOD_CDK_SPxxK_3	199	206	PF00069	0.587
MOD_CK1_1	10	16	PF00069	0.707
MOD_CK1_1	1000	1006	PF00069	0.576
MOD_CK1_1	103	109	PF00069	0.704
MOD_CK1_1	134	140	PF00069	0.656
MOD_CK1_1	195	201	PF00069	0.678
MOD_CK1_1	23	29	PF00069	0.607
MOD_CK1_1	273	279	PF00069	0.591
MOD_CK1_1	297	303	PF00069	0.588
MOD_CK1_1	364	370	PF00069	0.752
MOD_CK1_1	44	50	PF00069	0.812
MOD_CK1_1	455	461	PF00069	0.555
MOD_CK1_1	52	58	PF00069	0.651
MOD_CK1_1	603	609	PF00069	0.643
MOD_CK1_1	654	660	PF00069	0.663
MOD_CK1_1	66	72	PF00069	0.770
MOD_CK1_1	691	697	PF00069	0.577
MOD_CK1_1	698	704	PF00069	0.553
MOD_CK1_1	719	725	PF00069	0.659
MOD_CK1_1	76	82	PF00069	0.600
MOD_CK1_1	835	841	PF00069	0.603
MOD_CK1_1	84	90	PF00069	0.581
MOD_CK1_1	894	900	PF00069	0.481
MOD_CK2_1	175	181	PF00069	0.683
MOD_CK2_1	311	317	PF00069	0.616
MOD_CK2_1	390	396	PF00069	0.567
MOD_CK2_1	414	420	PF00069	0.542
MOD_CK2_1	71	77	PF00069	0.677
MOD_CK2_1	894	900	PF00069	0.616
MOD_CK2_1	905	911	PF00069	0.429
MOD_CK2_1	928	934	PF00069	0.546
MOD_CK2_1	974	980	PF00069	0.650
MOD_CMANNOS	626	629	PF00535	0.552
MOD_GlcNHglycan	138	141	PF01048	0.673
MOD_GlcNHglycan	166	169	PF01048	0.796
MOD_GlcNHglycan	177	180	PF01048	0.698
MOD_GlcNHglycan	190	193	PF01048	0.777
MOD_GlcNHglycan	22	25	PF01048	0.653
MOD_GlcNHglycan	321	324	PF01048	0.530
MOD_GlcNHglycan	367	370	PF01048	0.737
MOD_GlcNHglycan	569	572	PF01048	0.647
MOD_GlcNHglycan	602	605	PF01048	0.654
MOD_GlcNHglycan	697	700	PF01048	0.648
MOD_GlcNHglycan	717	721	PF01048	0.629
MOD_GlcNHglycan	815	818	PF01048	0.589
MOD_GlcNHglycan	83	86	PF01048	0.663
MOD_GlcNHglycan	895	899	PF01048	0.417
MOD_GlcNHglycan	920	923	PF01048	0.662
MOD_GlcNHglycan	944	947	PF01048	0.485
MOD_GlcNHglycan	999	1002	PF01048	0.602
MOD_GSK3_1	131	138	PF00069	0.654
MOD_GSK3_1	16	23	PF00069	0.595
MOD_GSK3_1	162	169	PF00069	0.754
MOD_GSK3_1	171	178	PF00069	0.678
MOD_GSK3_1	188	195	PF00069	0.682
MOD_GSK3_1	297	304	PF00069	0.608
MOD_GSK3_1	361	368	PF00069	0.664
MOD_GSK3_1	4	11	PF00069	0.606
MOD_GSK3_1	44	51	PF00069	0.671
MOD_GSK3_1	617	624	PF00069	0.694
MOD_GSK3_1	63	70	PF00069	0.818
MOD_GSK3_1	648	655	PF00069	0.629
MOD_GSK3_1	691	698	PF00069	0.685
MOD_GSK3_1	712	719	PF00069	0.636
MOD_GSK3_1	76	83	PF00069	0.642
MOD_GSK3_1	828	835	PF00069	0.617
MOD_GSK3_1	84	91	PF00069	0.802
MOD_GSK3_1	905	912	PF00069	0.530
MOD_GSK3_1	92	99	PF00069	0.717
MOD_GSK3_1	935	942	PF00069	0.658
MOD_GSK3_1	946	953	PF00069	0.567
MOD_GSK3_1	976	983	PF00069	0.619
MOD_LATS_1	46	52	PF00433	0.680
MOD_LATS_1	65	71	PF00433	0.715
MOD_LATS_1	914	920	PF00433	0.501
MOD_N-GLC_1	1107	1112	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	101	106	PF00069	0.581
MOD_NEK2_1	1072	1077	PF00069	0.465
MOD_NEK2_1	131	136	PF00069	0.642
MOD_NEK2_1	188	193	PF00069	0.667
MOD_NEK2_1	288	293	PF00069	0.615
MOD_NEK2_1	306	311	PF00069	0.472
MOD_NEK2_1	406	411	PF00069	0.532
MOD_NEK2_1	600	605	PF00069	0.629
MOD_NEK2_1	666	671	PF00069	0.588
MOD_NEK2_1	716	721	PF00069	0.755
MOD_NEK2_1	88	93	PF00069	0.650
MOD_NEK2_1	935	940	PF00069	0.617
MOD_NEK2_1	956	961	PF00069	0.663
MOD_NEK2_2	171	176	PF00069	0.556
MOD_NEK2_2	805	810	PF00069	0.513
MOD_PIKK_1	1041	1047	PF00454	0.553
MOD_PIKK_1	306	312	PF00454	0.613
MOD_PIKK_1	832	838	PF00454	0.605
MOD_PIKK_1	974	980	PF00454	0.549
MOD_PKA_1	48	54	PF00069	0.585
MOD_PKA_2	1057	1063	PF00069	0.522
MOD_PKA_2	162	168	PF00069	0.630
MOD_PKA_2	175	181	PF00069	0.689
MOD_PKA_2	44	50	PF00069	0.630
MOD_PKA_2	52	58	PF00069	0.631
MOD_PKA_2	600	606	PF00069	0.673
MOD_PKA_2	66	72	PF00069	0.606
MOD_PKA_2	707	713	PF00069	0.642
MOD_PKA_2	805	811	PF00069	0.462
MOD_PKA_2	935	941	PF00069	0.604
MOD_PKA_2	990	996	PF00069	0.615
MOD_Plk_1	101	107	PF00069	0.653
MOD_Plk_1	1107	1113	PF00069	0.539
MOD_Plk_1	270	276	PF00069	0.530
MOD_Plk_1	31	37	PF00069	0.685
MOD_Plk_1	455	461	PF00069	0.553
MOD_Plk_1	58	64	PF00069	0.566
MOD_Plk_1	691	697	PF00069	0.529
MOD_Plk_1	7	13	PF00069	0.692
MOD_Plk_1	76	82	PF00069	0.609
MOD_Plk_1	928	934	PF00069	0.569
MOD_Plk_2-3	414	420	PF00069	0.525
MOD_Plk_2-3	712	718	PF00069	0.613
MOD_Plk_4	1065	1071	PF00069	0.412
MOD_Plk_4	16	22	PF00069	0.621
MOD_Plk_4	270	276	PF00069	0.577
MOD_Plk_4	301	307	PF00069	0.552
MOD_Plk_4	31	37	PF00069	0.590
MOD_Plk_4	311	317	PF00069	0.545
MOD_Plk_4	414	420	PF00069	0.502
MOD_Plk_4	447	453	PF00069	0.417
MOD_Plk_4	621	627	PF00069	0.632
MOD_Plk_4	691	697	PF00069	0.504
MOD_Plk_4	727	733	PF00069	0.574
MOD_Plk_4	747	753	PF00069	0.479
MOD_Plk_4	879	885	PF00069	0.576
MOD_Plk_4	88	94	PF00069	0.566
MOD_Plk_4	905	911	PF00069	0.478
MOD_Plk_4	956	962	PF00069	0.618
MOD_ProDKin_1	1059	1065	PF00069	0.660
MOD_ProDKin_1	199	205	PF00069	0.726
MOD_ProDKin_1	223	229	PF00069	0.631
MOD_ProDKin_1	559	565	PF00069	0.672
MOD_ProDKin_1	648	654	PF00069	0.480
MOD_ProDKin_1	699	705	PF00069	0.642
MOD_ProDKin_1	71	77	PF00069	0.740
MOD_ProDKin_1	828	834	PF00069	0.697
MOD_ProDKin_1	92	98	PF00069	0.697
MOD_SUMO_for_1	674	677	PF00179	0.429
TRG_AP2beta_CARGO_1	481	491	PF09066	0.473
TRG_DiLeu_BaEn_1	747	752	PF01217	0.472
TRG_DiLeu_BaEn_2	533	539	PF01217	0.350
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.605
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.616
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.412
TRG_DiLeu_BaLyEn_6	952	957	PF01217	0.644
TRG_ENDOCYTIC_2	441	444	PF00928	0.605
TRG_ENDOCYTIC_2	596	599	PF00928	0.627
TRG_ENDOCYTIC_2	635	638	PF00928	0.699
TRG_ENDOCYTIC_2	748	751	PF00928	0.416
TRG_ENDOCYTIC_2	789	792	PF00928	0.383
TRG_ENDOCYTIC_2	932	935	PF00928	0.615
TRG_ER_diArg_1	231	233	PF00400	0.651
TRG_ER_diArg_1	268	270	PF00400	0.539
TRG_ER_diArg_1	48	50	PF00400	0.583
TRG_ER_diArg_1	491	493	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF85	Leptomonas seymouri	40%	86%
A0A1X0P7T2	Trypanosomatidae	25%	100%
A0A3S7WVA5	Leishmania donovani	91%	89%
A4HA01	Leishmania braziliensis	73%	88%
A4HY65	Leishmania infantum	91%	89%
E9ARZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	89%