Putative nucleosome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein, putative

Species:

Leishmania major

UniProt:

Q4QDH7_LEIMA

TriTrypDb:

LmjF.19.0440 , LMJLV39_190009600 , LMJSD75_190009500

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	14
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	14
GO:0043227	membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043231	intracellular membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q4QDH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	14
GO:0006334	nucleosome assembly	7	14
GO:0006338	chromatin remodeling	5	14
GO:0009987	cellular process	1	14
GO:0016043	cellular component organization	3	14
GO:0022607	cellular component assembly	4	14
GO:0034728	nucleosome organization	6	14
GO:0043933	protein-containing complex organization	4	14
GO:0065003	protein-containing complex assembly	5	14
GO:0065004	protein-DNA complex assembly	6	14
GO:0071824	protein-DNA complex subunit organization	5	14
GO:0071840	cellular component organization or biogenesis	2	14

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.251
CLV_NRD_NRD_1	93	95	PF00675	0.280
CLV_PCSK_FUR_1	236	240	PF00082	0.300
CLV_PCSK_KEX2_1	238	240	PF00082	0.205
CLV_PCSK_KEX2_1	81	83	PF00082	0.213
CLV_PCSK_KEX2_1	93	95	PF00082	0.211
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.205
DEG_SPOP_SBC_1	243	247	PF00917	0.484
DOC_MAPK_gen_1	207	215	PF00069	0.431
DOC_MAPK_gen_1	4	13	PF00069	0.529
DOC_MAPK_gen_1	70	79	PF00069	0.542
DOC_MAPK_MEF2A_6	248	255	PF00069	0.409
DOC_USP7_MATH_1	101	105	PF00917	0.431
DOC_USP7_MATH_1	202	206	PF00917	0.431
DOC_USP7_UBL2_3	234	238	PF12436	0.416
DOC_WW_Pin1_4	187	192	PF00397	0.515
DOC_WW_Pin1_4	213	218	PF00397	0.417
LIG_14-3-3_CanoR_1	172	176	PF00244	0.413
LIG_14-3-3_CanoR_1	244	251	PF00244	0.543
LIG_14-3-3_CanoR_1	283	287	PF00244	0.500
LIG_APCC_ABBA_1	157	162	PF00400	0.431
LIG_BIR_III_4	135	139	PF00653	0.431
LIG_BRCT_BRCA1_1	39	43	PF00533	0.379
LIG_FHA_1	199	205	PF00498	0.469
LIG_FHA_1	238	244	PF00498	0.426
LIG_FHA_1	245	251	PF00498	0.415
LIG_FHA_1	261	267	PF00498	0.418
LIG_FHA_1	290	296	PF00498	0.458
LIG_FHA_2	244	250	PF00498	0.527
LIG_LIR_Gen_1	140	151	PF02991	0.484
LIG_LIR_Gen_1	182	191	PF02991	0.433
LIG_LIR_Nem_3	140	146	PF02991	0.484
LIG_LIR_Nem_3	177	183	PF02991	0.404
LIG_LIR_Nem_3	254	259	PF02991	0.440
LIG_LIR_Nem_3	30	34	PF02991	0.402
LIG_LIR_Nem_3	84	90	PF02991	0.405
LIG_Pex14_2	183	187	PF04695	0.417
LIG_Pex14_2	255	259	PF04695	0.457
LIG_Pex14_2	39	43	PF04695	0.404
LIG_SH2_CRK	83	87	PF00017	0.442
LIG_SH2_SRC	34	37	PF00017	0.516
LIG_SH2_STAP1	61	65	PF00017	0.431
LIG_SH2_STAP1	83	87	PF00017	0.405
LIG_SH2_STAT5	302	305	PF00017	0.441
LIG_SH2_STAT5	34	37	PF00017	0.384
LIG_SH3_3	8	14	PF00018	0.641
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.500
LIG_SUMO_SIM_par_1	118	123	PF11976	0.409
LIG_SUMO_SIM_par_1	167	174	PF11976	0.458
LIG_SUMO_SIM_par_1	201	209	PF11976	0.431
LIG_SUMO_SIM_par_1	8	19	PF11976	0.530
LIG_TRAF2_1	104	107	PF00917	0.441
LIG_UBA3_1	86	95	PF00899	0.409
LIG_WRC_WIRS_1	180	185	PF05994	0.415
LIG_WRC_WIRS_1	186	191	PF05994	0.420
MOD_CK1_1	211	217	PF00069	0.443
MOD_CK2_1	101	107	PF00069	0.441
MOD_CK2_1	152	158	PF00069	0.443
MOD_CK2_1	171	177	PF00069	0.548
MOD_CK2_1	282	288	PF00069	0.500
MOD_CK2_1	43	49	PF00069	0.450
MOD_GlcNHglycan	58	61	PF01048	0.295
MOD_GlcNHglycan	64	68	PF01048	0.300
MOD_GSK3_1	196	203	PF00069	0.440
MOD_NEK2_1	227	232	PF00069	0.571
MOD_NEK2_1	43	48	PF00069	0.390
MOD_NEK2_2	202	207	PF00069	0.431
MOD_NEK2_2	251	256	PF00069	0.497
MOD_PKA_1	260	266	PF00069	0.409
MOD_PKA_2	171	177	PF00069	0.398
MOD_PKA_2	243	249	PF00069	0.461
MOD_PKA_2	282	288	PF00069	0.500
MOD_Plk_1	153	159	PF00069	0.431
MOD_Plk_1	196	202	PF00069	0.441
MOD_Plk_1	211	217	PF00069	0.464
MOD_Plk_4	251	257	PF00069	0.441
MOD_ProDKin_1	187	193	PF00069	0.515
MOD_ProDKin_1	213	219	PF00069	0.417
MOD_SUMO_rev_2	205	211	PF00179	0.574
TRG_DiLeu_BaEn_3	325	331	PF01217	0.684
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.458
TRG_ENDOCYTIC_2	180	183	PF00928	0.399
TRG_ENDOCYTIC_2	83	86	PF00928	0.485
TRG_ER_diArg_1	332	335	PF00400	0.692
TRG_ER_diArg_1	51	54	PF00400	0.471
TRG_ER_diArg_1	80	82	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	70%	100%
A0A0N1IJI7	Leptomonas seymouri	30%	86%
A0A1X0P6J1	Trypanosomatidae	49%	84%
A0A3Q8IA70	Leishmania donovani	96%	100%
A0A3R7KRI5	Trypanosoma rangeli	48%	100%
A0A3S7X4M4	Leishmania donovani	30%	87%
A2ZX50	Oryza sativa subsp. japonica	26%	100%
A4HA02	Leishmania braziliensis	82%	99%
A4HJF7	Leishmania braziliensis	33%	86%
A4HY66	Leishmania infantum	96%	100%
A4I6V2	Leishmania infantum	30%	87%
A6H767	Bos taurus	28%	90%
B8AW64	Oryza sativa subsp. indica	27%	96%
B8B4K9	Oryza sativa subsp. indica	26%	100%
B9FU45	Oryza sativa subsp. japonica	26%	100%
C9ZXT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	83%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	86%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	89%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	84%
P28656	Mus musculus	29%	90%
P51860	Mus musculus	26%	76%
P55209	Homo sapiens	28%	90%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	92%
Q28EB4	Xenopus tropicalis	29%	89%
Q2TA40	Bos taurus	29%	91%
Q4Q687	Leishmania major	31%	100%
Q4U0Y4	Xenopus laevis	28%	89%
Q53WK4	Oryza sativa subsp. japonica	27%	96%
Q55ED1	Dictyostelium discoideum	32%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	80%
Q5MGA9	Oryza sativa subsp. indica	25%	100%
Q5R4D4	Pongo abelii	28%	90%
Q5U2Z3	Rattus norvegicus	31%	91%
Q70Z16	Nicotiana tabacum	24%	98%
Q70Z17	Nicotiana tabacum	25%	93%
Q70Z18	Nicotiana tabacum	24%	93%
Q70Z19	Nicotiana tabacum	26%	94%
Q78ZA7	Mus musculus	30%	93%
Q7ZY81	Xenopus laevis	28%	89%
Q94K07	Arabidopsis thaliana	28%	94%
Q99733	Homo sapiens	31%	93%
Q9SZI2	Arabidopsis thaliana	28%	94%
Q9ULW6	Homo sapiens	26%	76%
Q9Z2G8	Rattus norvegicus	29%	90%
Q9ZUP3	Arabidopsis thaliana	24%	92%
V5BX23	Trypanosoma cruzi	49%	98%