Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDH6_LEIMA

TriTrypDb:

LmjF.19.0450 , LMJLV39_190009700 , LMJSD75_190009600

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.748
CLV_C14_Caspase3-7	158	162	PF00656	0.582
CLV_C14_Caspase3-7	231	235	PF00656	0.670
CLV_C14_Caspase3-7	477	481	PF00656	0.581
CLV_C14_Caspase3-7	64	68	PF00656	0.660
CLV_C14_Caspase3-7	810	814	PF00656	0.544
CLV_C14_Caspase3-7	830	834	PF00656	0.475
CLV_C14_Caspase3-7	938	942	PF00656	0.629
CLV_NRD_NRD_1	146	148	PF00675	0.734
CLV_NRD_NRD_1	171	173	PF00675	0.793
CLV_NRD_NRD_1	176	178	PF00675	0.699
CLV_NRD_NRD_1	223	225	PF00675	0.819
CLV_NRD_NRD_1	248	250	PF00675	0.772
CLV_NRD_NRD_1	275	277	PF00675	0.776
CLV_NRD_NRD_1	412	414	PF00675	0.731
CLV_NRD_NRD_1	48	50	PF00675	0.583
CLV_NRD_NRD_1	97	99	PF00675	0.784
CLV_PCSK_KEX2_1	146	148	PF00082	0.703
CLV_PCSK_KEX2_1	169	171	PF00082	0.782
CLV_PCSK_KEX2_1	176	178	PF00082	0.696
CLV_PCSK_KEX2_1	223	225	PF00082	0.819
CLV_PCSK_KEX2_1	248	250	PF00082	0.700
CLV_PCSK_KEX2_1	275	277	PF00082	0.776
CLV_PCSK_KEX2_1	97	99	PF00082	0.784
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.718
CLV_PCSK_PC7_1	165	171	PF00082	0.702
CLV_PCSK_PC7_1	172	178	PF00082	0.635
CLV_PCSK_SKI1_1	497	501	PF00082	0.711
CLV_PCSK_SKI1_1	50	54	PF00082	0.605
CLV_PCSK_SKI1_1	638	642	PF00082	0.663
DEG_APCC_DBOX_1	19	27	PF00400	0.522
DEG_APCC_DBOX_1	544	552	PF00400	0.663
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.749
DOC_MAPK_gen_1	611	620	PF00069	0.832
DOC_MAPK_MEF2A_6	414	423	PF00069	0.681
DOC_MIT_MIM_1	14	24	PF04212	0.628
DOC_PP1_RVXF_1	495	501	PF00149	0.592
DOC_PP2B_LxvP_1	469	472	PF13499	0.740
DOC_PP4_FxxP_1	115	118	PF00568	0.680
DOC_PP4_FxxP_1	355	358	PF00568	0.722
DOC_USP7_MATH_1	141	145	PF00917	0.789
DOC_USP7_MATH_1	309	313	PF00917	0.792
DOC_USP7_MATH_1	337	341	PF00917	0.601
DOC_USP7_MATH_1	510	514	PF00917	0.764
DOC_USP7_MATH_1	577	581	PF00917	0.740
DOC_USP7_MATH_1	600	604	PF00917	0.757
DOC_USP7_MATH_1	652	656	PF00917	0.718
DOC_USP7_MATH_1	7	11	PF00917	0.585
DOC_USP7_MATH_1	721	725	PF00917	0.780
DOC_USP7_MATH_1	829	833	PF00917	0.712
DOC_USP7_MATH_1	92	96	PF00917	0.736
DOC_USP7_UBL2_3	534	538	PF12436	0.716
DOC_WW_Pin1_4	299	304	PF00397	0.717
DOC_WW_Pin1_4	330	335	PF00397	0.718
DOC_WW_Pin1_4	353	358	PF00397	0.700
DOC_WW_Pin1_4	367	372	PF00397	0.537
DOC_WW_Pin1_4	392	397	PF00397	0.784
DOC_WW_Pin1_4	412	417	PF00397	0.469
DOC_WW_Pin1_4	428	433	PF00397	0.661
DOC_WW_Pin1_4	502	507	PF00397	0.653
DOC_WW_Pin1_4	521	526	PF00397	0.699
DOC_WW_Pin1_4	564	569	PF00397	0.707
DOC_WW_Pin1_4	595	600	PF00397	0.665
DOC_WW_Pin1_4	609	614	PF00397	0.719
DOC_WW_Pin1_4	638	643	PF00397	0.735
DOC_WW_Pin1_4	648	653	PF00397	0.644
DOC_WW_Pin1_4	841	846	PF00397	0.725
DOC_WW_Pin1_4	847	852	PF00397	0.600
DOC_WW_Pin1_4	854	859	PF00397	0.619
DOC_WW_Pin1_4	90	95	PF00397	0.778
DOC_WW_Pin1_4	98	103	PF00397	0.663
LIG_14-3-3_CanoR_1	106	111	PF00244	0.600
LIG_14-3-3_CanoR_1	146	150	PF00244	0.744
LIG_14-3-3_CanoR_1	165	173	PF00244	0.639
LIG_14-3-3_CanoR_1	176	182	PF00244	0.605
LIG_14-3-3_CanoR_1	184	193	PF00244	0.671
LIG_14-3-3_CanoR_1	381	387	PF00244	0.747
LIG_14-3-3_CanoR_1	490	500	PF00244	0.658
LIG_14-3-3_CanoR_1	614	619	PF00244	0.712
LIG_14-3-3_CanoR_1	725	733	PF00244	0.628
LIG_14-3-3_CanoR_1	900	910	PF00244	0.565
LIG_14-3-3_CanoR_1	915	921	PF00244	0.504
LIG_14-3-3_CanoR_1	97	102	PF00244	0.719
LIG_Actin_WH2_2	684	702	PF00022	0.646
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BRCT_BRCA1_1	379	383	PF00533	0.688
LIG_BRCT_BRCA1_1	560	564	PF00533	0.738
LIG_BRCT_BRCA1_1	658	662	PF00533	0.569
LIG_BRCT_BRCA1_1	742	746	PF00533	0.675
LIG_EVH1_2	358	362	PF00568	0.624
LIG_FHA_1	176	182	PF00498	0.660
LIG_FHA_1	333	339	PF00498	0.818
LIG_FHA_1	39	45	PF00498	0.536
LIG_FHA_1	445	451	PF00498	0.796
LIG_FHA_1	516	522	PF00498	0.815
LIG_FHA_1	615	621	PF00498	0.730
LIG_FHA_1	663	669	PF00498	0.552
LIG_FHA_1	779	785	PF00498	0.704
LIG_FHA_1	848	854	PF00498	0.611
LIG_FHA_1	858	864	PF00498	0.672
LIG_FHA_1	902	908	PF00498	0.625
LIG_FHA_1	915	921	PF00498	0.446
LIG_FHA_1	94	100	PF00498	0.739
LIG_FHA_2	344	350	PF00498	0.746
LIG_FHA_2	395	401	PF00498	0.637
LIG_FHA_2	405	411	PF00498	0.585
LIG_FHA_2	432	438	PF00498	0.748
LIG_FHA_2	463	469	PF00498	0.731
LIG_FHA_2	707	713	PF00498	0.512
LIG_FHA_2	808	814	PF00498	0.646
LIG_Integrin_RGD_1	224	226	PF01839	0.815
LIG_LIR_Apic_2	352	358	PF02991	0.689
LIG_LIR_Apic_2	633	637	PF02991	0.797
LIG_LIR_Gen_1	11	21	PF02991	0.640
LIG_LIR_Gen_1	190	199	PF02991	0.632
LIG_LIR_Gen_1	380	391	PF02991	0.710
LIG_LIR_Gen_1	480	487	PF02991	0.710
LIG_LIR_Gen_1	680	688	PF02991	0.612
LIG_LIR_Gen_1	922	932	PF02991	0.457
LIG_LIR_Nem_3	11	17	PF02991	0.648
LIG_LIR_Nem_3	190	196	PF02991	0.618
LIG_LIR_Nem_3	380	386	PF02991	0.708
LIG_LIR_Nem_3	480	485	PF02991	0.751
LIG_LIR_Nem_3	680	684	PF02991	0.619
LIG_LIR_Nem_3	922	928	PF02991	0.512
LIG_MAD2	73	81	PF02301	0.713
LIG_MYND_1	851	855	PF01753	0.723
LIG_PCNA_yPIPBox_3	696	704	PF02747	0.552
LIG_PTAP_UEV_1	415	420	PF05743	0.712
LIG_PTB_Apo_2	888	895	PF02174	0.606
LIG_PTB_Phospho_1	888	894	PF10480	0.609
LIG_Rb_LxCxE_1	208	228	PF01857	0.723
LIG_REV1ctd_RIR_1	190	198	PF16727	0.627
LIG_SH2_CRK	294	298	PF00017	0.760
LIG_SH2_CRK	634	638	PF00017	0.786
LIG_SH2_CRK	802	806	PF00017	0.558
LIG_SH2_NCK_1	138	142	PF00017	0.549
LIG_SH2_SRC	282	285	PF00017	0.676
LIG_SH2_SRC	939	942	PF00017	0.525
LIG_SH2_STAP1	138	142	PF00017	0.549
LIG_SH2_STAP1	327	331	PF00017	0.757
LIG_SH2_STAP1	581	585	PF00017	0.587
LIG_SH2_STAP1	789	793	PF00017	0.546
LIG_SH2_STAT5	149	152	PF00017	0.582
LIG_SH2_STAT5	173	176	PF00017	0.668
LIG_SH2_STAT5	802	805	PF00017	0.562
LIG_SH2_STAT5	894	897	PF00017	0.611
LIG_SH2_STAT5	939	942	PF00017	0.525
LIG_SH3_1	293	299	PF00018	0.718
LIG_SH3_1	413	419	PF00018	0.720
LIG_SH3_2	866	871	PF14604	0.560
LIG_SH3_3	293	299	PF00018	0.741
LIG_SH3_3	331	337	PF00018	0.615
LIG_SH3_3	413	419	PF00018	0.720
LIG_SH3_3	426	432	PF00018	0.553
LIG_SH3_3	445	451	PF00018	0.647
LIG_SH3_3	607	613	PF00018	0.746
LIG_SH3_3	852	858	PF00018	0.689
LIG_SH3_3	860	866	PF00018	0.744
LIG_SH3_3	96	102	PF00018	0.689
LIG_SH3_CIN85_PxpxPR_1	299	304	PF14604	0.606
LIG_TRAF2_1	156	159	PF00917	0.581
LIG_TRAF2_1	680	683	PF00917	0.578
LIG_TYR_ITIM	800	805	PF00017	0.562
LIG_WRC_WIRS_1	438	443	PF05994	0.687
LIG_WW_3	868	872	PF00397	0.541
MOD_CDC14_SPxK_1	374	377	PF00782	0.588
MOD_CDK_SPK_2	299	304	PF00069	0.565
MOD_CDK_SPK_2	502	507	PF00069	0.812
MOD_CDK_SPK_2	521	526	PF00069	0.699
MOD_CDK_SPK_2	609	614	PF00069	0.719
MOD_CDK_SPxK_1	371	377	PF00069	0.592
MOD_CDK_SPxxK_3	841	848	PF00069	0.729
MOD_CDK_SPxxK_3	90	97	PF00069	0.635
MOD_CK1_1	101	107	PF00069	0.659
MOD_CK1_1	148	154	PF00069	0.724
MOD_CK1_1	431	437	PF00069	0.735
MOD_CK1_1	474	480	PF00069	0.656
MOD_CK1_1	491	497	PF00069	0.687
MOD_CK1_1	513	519	PF00069	0.738
MOD_CK1_1	674	680	PF00069	0.660
MOD_CK1_1	724	730	PF00069	0.755
MOD_CK1_1	740	746	PF00069	0.651
MOD_CK1_1	766	772	PF00069	0.564
MOD_CK1_1	856	862	PF00069	0.714
MOD_CK1_1	905	911	PF00069	0.549
MOD_CK1_1	93	99	PF00069	0.823
MOD_CK2_1	130	136	PF00069	0.763
MOD_CK2_1	182	188	PF00069	0.668
MOD_CK2_1	367	373	PF00069	0.715
MOD_CK2_1	394	400	PF00069	0.744
MOD_CK2_1	404	410	PF00069	0.611
MOD_CK2_1	462	468	PF00069	0.729
MOD_CK2_1	56	62	PF00069	0.694
MOD_CK2_1	677	683	PF00069	0.660
MOD_CK2_1	7	13	PF00069	0.528
MOD_CK2_1	706	712	PF00069	0.500
MOD_CK2_1	741	747	PF00069	0.696
MOD_Cter_Amidation	221	224	PF01082	0.624
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.679
MOD_GlcNHglycan	103	106	PF01048	0.687
MOD_GlcNHglycan	119	122	PF01048	0.720
MOD_GlcNHglycan	132	135	PF01048	0.472
MOD_GlcNHglycan	139	142	PF01048	0.612
MOD_GlcNHglycan	266	269	PF01048	0.816
MOD_GlcNHglycan	299	302	PF01048	0.717
MOD_GlcNHglycan	455	458	PF01048	0.764
MOD_GlcNHglycan	476	479	PF01048	0.662
MOD_GlcNHglycan	494	497	PF01048	0.822
MOD_GlcNHglycan	512	515	PF01048	0.682
MOD_GlcNHglycan	554	557	PF01048	0.640
MOD_GlcNHglycan	558	561	PF01048	0.644
MOD_GlcNHglycan	575	578	PF01048	0.678
MOD_GlcNHglycan	58	61	PF01048	0.692
MOD_GlcNHglycan	593	596	PF01048	0.720
MOD_GlcNHglycan	602	605	PF01048	0.752
MOD_GlcNHglycan	658	661	PF01048	0.750
MOD_GlcNHglycan	673	676	PF01048	0.567
MOD_GlcNHglycan	685	688	PF01048	0.619
MOD_GlcNHglycan	791	794	PF01048	0.620
MOD_GSK3_1	137	144	PF00069	0.758
MOD_GSK3_1	145	152	PF00069	0.632
MOD_GSK3_1	184	191	PF00069	0.632
MOD_GSK3_1	361	368	PF00069	0.753
MOD_GSK3_1	437	444	PF00069	0.716
MOD_GSK3_1	488	495	PF00069	0.736
MOD_GSK3_1	510	517	PF00069	0.774
MOD_GSK3_1	552	559	PF00069	0.649
MOD_GSK3_1	560	567	PF00069	0.680
MOD_GSK3_1	569	576	PF00069	0.653
MOD_GSK3_1	591	598	PF00069	0.714
MOD_GSK3_1	641	648	PF00069	0.721
MOD_GSK3_1	652	659	PF00069	0.608
MOD_GSK3_1	662	669	PF00069	0.798
MOD_GSK3_1	703	710	PF00069	0.642
MOD_GSK3_1	729	736	PF00069	0.712
MOD_GSK3_1	737	744	PF00069	0.592
MOD_GSK3_1	763	770	PF00069	0.720
MOD_GSK3_1	774	781	PF00069	0.740
MOD_GSK3_1	829	836	PF00069	0.703
MOD_GSK3_1	853	860	PF00069	0.731
MOD_GSK3_1	901	908	PF00069	0.567
MOD_GSK3_1	93	100	PF00069	0.806
MOD_N-GLC_1	238	243	PF02516	0.737
MOD_N-GLC_1	342	347	PF02516	0.760
MOD_N-GLC_1	902	907	PF02516	0.574
MOD_NEK2_1	182	187	PF00069	0.702
MOD_NEK2_1	362	367	PF00069	0.598
MOD_NEK2_1	38	43	PF00069	0.584
MOD_NEK2_1	441	446	PF00069	0.732
MOD_NEK2_1	558	563	PF00069	0.783
MOD_NEK2_1	664	669	PF00069	0.595
MOD_NEK2_1	800	805	PF00069	0.562
MOD_NEK2_1	85	90	PF00069	0.728
MOD_NEK2_1	901	906	PF00069	0.575
MOD_NEK2_2	141	146	PF00069	0.791
MOD_NEK2_2	560	565	PF00069	0.570
MOD_PIKK_1	337	343	PF00454	0.739
MOD_PIKK_1	516	522	PF00454	0.799
MOD_PIKK_1	724	730	PF00454	0.628
MOD_PIKK_1	800	806	PF00454	0.559
MOD_PIKK_1	807	813	PF00454	0.545
MOD_PIKK_1	905	911	PF00454	0.549
MOD_PKA_1	275	281	PF00069	0.722
MOD_PKA_1	97	103	PF00069	0.744
MOD_PKA_2	145	151	PF00069	0.729
MOD_PKA_2	164	170	PF00069	0.613
MOD_PKA_2	175	181	PF00069	0.605
MOD_PKA_2	188	194	PF00069	0.688
MOD_PKA_2	275	281	PF00069	0.676
MOD_PKA_2	362	368	PF00069	0.598
MOD_PKA_2	474	480	PF00069	0.573
MOD_PKA_2	489	495	PF00069	0.613
MOD_PKA_2	724	730	PF00069	0.716
MOD_PKA_2	914	920	PF00069	0.505
MOD_PKA_2	97	103	PF00069	0.768
MOD_Plk_1	327	333	PF00069	0.749
MOD_Plk_1	66	72	PF00069	0.791
MOD_Plk_1	767	773	PF00069	0.798
MOD_Plk_1	902	908	PF00069	0.591
MOD_Plk_2-3	228	234	PF00069	0.613
MOD_Plk_2-3	462	468	PF00069	0.763
MOD_Plk_2-3	931	937	PF00069	0.612
MOD_Plk_4	188	194	PF00069	0.630
MOD_Plk_4	462	468	PF00069	0.589
MOD_Plk_4	641	647	PF00069	0.742
MOD_Plk_4	931	937	PF00069	0.612
MOD_ProDKin_1	299	305	PF00069	0.721
MOD_ProDKin_1	330	336	PF00069	0.721
MOD_ProDKin_1	353	359	PF00069	0.697
MOD_ProDKin_1	367	373	PF00069	0.538
MOD_ProDKin_1	392	398	PF00069	0.787
MOD_ProDKin_1	412	418	PF00069	0.467
MOD_ProDKin_1	428	434	PF00069	0.662
MOD_ProDKin_1	502	508	PF00069	0.653
MOD_ProDKin_1	521	527	PF00069	0.698
MOD_ProDKin_1	564	570	PF00069	0.709
MOD_ProDKin_1	595	601	PF00069	0.667
MOD_ProDKin_1	609	615	PF00069	0.718
MOD_ProDKin_1	638	644	PF00069	0.737
MOD_ProDKin_1	648	654	PF00069	0.644
MOD_ProDKin_1	841	847	PF00069	0.726
MOD_ProDKin_1	854	860	PF00069	0.633
MOD_ProDKin_1	90	96	PF00069	0.780
MOD_ProDKin_1	98	104	PF00069	0.662
MOD_SUMO_rev_2	65	75	PF00179	0.716
TRG_DiLeu_BaEn_1	13	18	PF01217	0.532
TRG_DiLeu_BaEn_1	796	801	PF01217	0.560
TRG_DiLeu_BaLyEn_6	848	853	PF01217	0.572
TRG_ENDOCYTIC_2	294	297	PF00928	0.797
TRG_ENDOCYTIC_2	802	805	PF00928	0.562
TRG_ER_diArg_1	145	147	PF00400	0.705
TRG_ER_diArg_1	170	172	PF00400	0.798
TRG_ER_diArg_1	175	177	PF00400	0.698
TRG_ER_diArg_1	199	202	PF00400	0.754
TRG_ER_diArg_1	248	251	PF00400	0.730
TRG_ER_diArg_1	275	277	PF00400	0.681
TRG_ER_diArg_1	378	381	PF00400	0.595
TRG_ER_diArg_1	870	873	PF00400	0.570
TRG_ER_diArg_1	97	99	PF00400	0.792
TRG_NES_CRM1_1	682	694	PF08389	0.643
TRG_NES_CRM1_1	811	822	PF08389	0.665
TRG_NLS_MonoCore_2	168	173	PF00514	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K8	Leptomonas seymouri	35%	95%
A0A3S7WVC5	Leishmania donovani	87%	100%
A4HA03	Leishmania braziliensis	57%	100%
A4HY67	Leishmania infantum	87%	100%
E9ARZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%