Putative nuclear cap binding complex subunit CBP30

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding complex subunit CBP30, putative

Species:

Leishmania major

UniProt:

Q4QDH4_LEIMA

TriTrypDb:

LmjF.19.0470 , LMJLV39_190010000 , LMJSD75_190009900

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

Q4QDH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.251
CLV_NRD_NRD_1	105	107	PF00675	0.415
CLV_NRD_NRD_1	277	279	PF00675	0.318
CLV_NRD_NRD_1	305	307	PF00675	0.471
CLV_NRD_NRD_1	319	321	PF00675	0.402
CLV_PCSK_KEX2_1	104	106	PF00082	0.306
CLV_PCSK_KEX2_1	305	307	PF00082	0.400
CLV_PCSK_KEX2_1	319	321	PF00082	0.277
CLV_PCSK_SKI1_1	279	283	PF00082	0.401
CLV_PCSK_SKI1_1	62	66	PF00082	0.285
DEG_SPOP_SBC_1	149	153	PF00917	0.313
DEG_SPOP_SBC_1	159	163	PF00917	0.228
DOC_CKS1_1	23	28	PF01111	0.285
DOC_CYCLIN_RxL_1	32	40	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.304
DOC_MAPK_DCC_7	239	248	PF00069	0.370
DOC_MAPK_FxFP_2	208	211	PF00069	0.285
DOC_MAPK_gen_1	319	326	PF00069	0.318
DOC_PP2B_PxIxI_1	222	228	PF00149	0.370
DOC_PP4_FxxP_1	208	211	PF00568	0.285
DOC_USP7_MATH_1	149	153	PF00917	0.390
DOC_USP7_MATH_1	157	161	PF00917	0.393
DOC_USP7_MATH_1	179	183	PF00917	0.326
DOC_USP7_MATH_1	195	199	PF00917	0.463
DOC_USP7_MATH_1	287	291	PF00917	0.370
DOC_WW_Pin1_4	120	125	PF00397	0.464
DOC_WW_Pin1_4	22	27	PF00397	0.285
DOC_WW_Pin1_4	241	246	PF00397	0.304
LIG_14-3-3_CanoR_1	140	150	PF00244	0.425
LIG_14-3-3_CanoR_1	266	273	PF00244	0.415
LIG_Actin_WH2_2	343	360	PF00022	0.415
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	268	272	PF00533	0.415
LIG_CtBP_PxDLS_1	55	59	PF00389	0.415
LIG_DLG_GKlike_1	268	276	PF00625	0.415
LIG_FHA_1	34	40	PF00498	0.415
LIG_FHA_2	134	140	PF00498	0.448
LIG_FHA_2	171	177	PF00498	0.417
LIG_FHA_2	226	232	PF00498	0.374
LIG_FHA_2	245	251	PF00498	0.188
LIG_FHA_2	332	338	PF00498	0.369
LIG_LIR_Gen_1	18	27	PF02991	0.329
LIG_LIR_Gen_1	71	81	PF02991	0.416
LIG_LIR_Nem_3	18	23	PF02991	0.329
LIG_LIR_Nem_3	212	216	PF02991	0.318
LIG_LIR_Nem_3	63	68	PF02991	0.341
LIG_LIR_Nem_3	71	77	PF02991	0.311
LIG_MYND_1	90	94	PF01753	0.304
LIG_Pex14_1	61	65	PF04695	0.285
LIG_SH2_CRK	213	217	PF00017	0.318
LIG_SH2_NCK_1	329	333	PF00017	0.370
LIG_SH2_PTP2	242	245	PF00017	0.329
LIG_SH2_SRC	329	332	PF00017	0.370
LIG_SH2_STAP1	74	78	PF00017	0.384
LIG_SH2_STAT5	242	245	PF00017	0.317
LIG_SH2_STAT5	31	34	PF00017	0.415
LIG_SH3_2	94	99	PF14604	0.370
LIG_SH3_3	87	93	PF00018	0.285
LIG_SUMO_SIM_par_1	35	40	PF11976	0.415
LIG_TRAF2_1	228	231	PF00917	0.285
LIG_TRAF2_1	249	252	PF00917	0.310
LIG_TRAF2_1	255	258	PF00917	0.298
LIG_TRAF2_1	335	338	PF00917	0.370
LIG_TRAF2_1	69	72	PF00917	0.370
LIG_WRC_WIRS_1	74	79	PF05994	0.318
MOD_CK1_1	130	136	PF00069	0.394
MOD_CK1_1	152	158	PF00069	0.424
MOD_CK1_1	160	166	PF00069	0.435
MOD_CK1_1	174	180	PF00069	0.286
MOD_CK1_1	2	8	PF00069	0.660
MOD_CK1_1	244	250	PF00069	0.370
MOD_CK2_1	225	231	PF00069	0.285
MOD_CK2_1	244	250	PF00069	0.285
MOD_CK2_1	331	337	PF00069	0.402
MOD_CK2_1	44	50	PF00069	0.344
MOD_CK2_1	66	72	PF00069	0.370
MOD_GlcNHglycan	129	132	PF01048	0.488
MOD_GlcNHglycan	157	160	PF01048	0.407
MOD_GlcNHglycan	17	20	PF01048	0.249
MOD_GlcNHglycan	173	176	PF01048	0.265
MOD_GlcNHglycan	217	220	PF01048	0.317
MOD_GlcNHglycan	289	292	PF01048	0.354
MOD_GlcNHglycan	316	319	PF01048	0.480
MOD_GlcNHglycan	39	42	PF01048	0.415
MOD_GlcNHglycan	5	8	PF01048	0.627
MOD_GlcNHglycan	9	12	PF01048	0.585
MOD_GSK3_1	126	133	PF00069	0.472
MOD_GSK3_1	148	155	PF00069	0.357
MOD_GSK3_1	159	166	PF00069	0.438
MOD_GSK3_1	167	174	PF00069	0.378
MOD_GSK3_1	179	186	PF00069	0.343
MOD_GSK3_1	25	32	PF00069	0.360
MOD_GSK3_1	262	269	PF00069	0.313
MOD_GSK3_1	3	10	PF00069	0.588
MOD_GSK3_1	308	315	PF00069	0.347
MOD_GSK3_1	33	40	PF00069	0.370
MOD_NEK2_1	1	6	PF00069	0.752
MOD_NEK2_1	118	123	PF00069	0.494
MOD_NEK2_1	127	132	PF00069	0.469
MOD_NEK2_1	262	267	PF00069	0.285
MOD_NEK2_1	37	42	PF00069	0.415
MOD_PKA_2	15	21	PF00069	0.329
MOD_PKA_2	163	169	PF00069	0.346
MOD_PKA_2	42	48	PF00069	0.417
MOD_PKA_2	66	72	PF00069	0.370
MOD_PKB_1	266	274	PF00069	0.331
MOD_Plk_4	268	274	PF00069	0.392
MOD_Plk_4	56	62	PF00069	0.363
MOD_ProDKin_1	120	126	PF00069	0.464
MOD_ProDKin_1	22	28	PF00069	0.285
MOD_ProDKin_1	241	247	PF00069	0.304
MOD_SUMO_rev_2	333	342	PF00179	0.318
TRG_DiLeu_BaEn_4	257	263	PF01217	0.326
TRG_DiLeu_BaEn_4	337	343	PF01217	0.370
TRG_ENDOCYTIC_2	213	216	PF00928	0.318
TRG_ENDOCYTIC_2	74	77	PF00928	0.420
TRG_ER_diArg_1	103	106	PF00400	0.400
TRG_ER_diArg_1	304	306	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD4	Leptomonas seymouri	56%	100%
A0A1X0P6J9	Trypanosomatidae	42%	100%
A0A3R7N3C2	Trypanosoma rangeli	41%	100%
A0A3S5H755	Leishmania donovani	94%	100%
A4HA05	Leishmania braziliensis	74%	100%
A4HY69	Leishmania infantum	94%	100%
D0A0I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BBW3	Trypanosoma cruzi	37%	100%