GtrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDH3_LEIMA

TriTrypDb:

LmjF.19.0480 , LMJLV39_190010100 , LMJSD75_190010000

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QDH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.557
CLV_NRD_NRD_1	160	162	PF00675	0.357
CLV_NRD_NRD_1	168	170	PF00675	0.490
CLV_PCSK_KEX2_1	110	112	PF00082	0.632
CLV_PCSK_KEX2_1	142	144	PF00082	0.557
CLV_PCSK_KEX2_1	160	162	PF00082	0.401
CLV_PCSK_KEX2_1	168	170	PF00082	0.490
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.632
CLV_PCSK_SKI1_1	110	114	PF00082	0.632
CLV_PCSK_SKI1_1	160	164	PF00082	0.557
CLV_PCSK_SKI1_1	82	86	PF00082	0.730
DEG_APCC_DBOX_1	159	167	PF00400	0.758
DEG_SPOP_SBC_1	18	22	PF00917	0.601
DOC_CYCLIN_RxL_1	107	117	PF00134	0.432
DOC_CYCLIN_RxL_1	79	86	PF00134	0.389
DOC_MAPK_RevD_3	145	161	PF00069	0.745
DOC_PP2B_LxvP_1	60	63	PF13499	0.556
DOC_WW_Pin1_4	27	32	PF00397	0.539
LIG_14-3-3_CanoR_1	168	172	PF00244	0.790
LIG_14-3-3_CanoR_1	69	78	PF00244	0.501
LIG_BIR_II_1	1	5	PF00653	0.437
LIG_eIF4E_1	79	85	PF01652	0.389
LIG_FHA_1	116	122	PF00498	0.524
LIG_FHA_1	70	76	PF00498	0.502
LIG_FHA_1	79	85	PF00498	0.369
LIG_GBD_Chelix_1	5	13	PF00786	0.744
LIG_LIR_Apic_2	155	159	PF02991	0.621
LIG_LIR_Nem_3	91	97	PF02991	0.415
LIG_NRBOX	108	114	PF00104	0.289
LIG_PDZ_Class_1	167	172	PF00595	0.784
LIG_Pex14_1	98	102	PF04695	0.481
LIG_Pex14_2	129	133	PF04695	0.524
LIG_SH2_NCK_1	48	52	PF00017	0.568
LIG_SH2_PTP2	156	159	PF00017	0.770
LIG_SH2_STAT5	156	159	PF00017	0.686
LIG_SH2_STAT5	79	82	PF00017	0.422
LIG_SH3_3	12	18	PF00018	0.607
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.545
LIG_TYR_ITIM	92	97	PF00017	0.530
LIG_WRC_WIRS_1	126	131	PF05994	0.524
MOD_CDK_SPK_2	27	32	PF00069	0.539
MOD_CK1_1	19	25	PF00069	0.465
MOD_Cter_Amidation	140	143	PF01082	0.543
MOD_GlcNHglycan	135	138	PF01048	0.524
MOD_NEK2_1	125	130	PF00069	0.444
MOD_NEK2_1	133	138	PF00069	0.394
MOD_NEK2_1	38	43	PF00069	0.540
MOD_NEK2_1	78	83	PF00069	0.463
MOD_Plk_4	104	110	PF00069	0.512
MOD_Plk_4	55	61	PF00069	0.436
MOD_ProDKin_1	27	33	PF00069	0.535
TRG_DiLeu_BaEn_1	56	61	PF01217	0.549
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.535
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.723
TRG_ENDOCYTIC_2	94	97	PF00928	0.507
TRG_ER_diArg_1	159	161	PF00400	0.769
TRG_ER_diArg_1	167	169	PF00400	0.685
TRG_ER_diArg_1	42	45	PF00400	0.566
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJZ2	Leishmania donovani	92%	67%
A4HY70	Leishmania infantum	93%	67%
E9AS00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%