Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDH2_LEIMA

TriTrypDb:

LmjF.19.0490 , LMJLV39_190010200 , LMJSD75_190010100

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0020016	ciliary pocket	2	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

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Expansion

Sequence features

Q4QDH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH2

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.237
CLV_NRD_NRD_1	20	22	PF00675	0.456
CLV_NRD_NRD_1	203	205	PF00675	0.414
CLV_NRD_NRD_1	39	41	PF00675	0.453
CLV_NRD_NRD_1	80	82	PF00675	0.426
CLV_PCSK_KEX2_1	181	183	PF00082	0.237
CLV_PCSK_KEX2_1	20	22	PF00082	0.440
CLV_PCSK_KEX2_1	203	205	PF00082	0.323
CLV_PCSK_KEX2_1	39	41	PF00082	0.493
CLV_PCSK_PC7_1	199	205	PF00082	0.413

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE20	Leptomonas seymouri	77%	100%
A0A0S4IUQ3	Bodo saltans	45%	100%
A0A1X0P6B8	Trypanosomatidae	60%	100%
A0A3R7KYF8	Trypanosoma rangeli	60%	100%
A0A3S7WVB3	Leishmania donovani	94%	100%
A4HA07	Leishmania braziliensis	88%	100%
A4HY71	Leishmania infantum	93%	100%
D0A0J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AS01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	75%
V5DTP2	Trypanosoma cruzi	56%	100%

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