Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDH2_LEIMA

TriTrypDb:

LmjF.19.0490 , LMJLV39_190010200 , LMJSD75_190010100

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0020016	ciliary pocket	2	2
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QDH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.237
CLV_NRD_NRD_1	20	22	PF00675	0.456
CLV_NRD_NRD_1	203	205	PF00675	0.414
CLV_NRD_NRD_1	39	41	PF00675	0.453
CLV_NRD_NRD_1	80	82	PF00675	0.426
CLV_PCSK_KEX2_1	181	183	PF00082	0.237
CLV_PCSK_KEX2_1	20	22	PF00082	0.440
CLV_PCSK_KEX2_1	203	205	PF00082	0.323
CLV_PCSK_KEX2_1	39	41	PF00082	0.493
CLV_PCSK_PC7_1	199	205	PF00082	0.413
CLV_PCSK_PC7_1	35	41	PF00082	0.521
CLV_PCSK_SKI1_1	195	199	PF00082	0.243
CLV_PCSK_SKI1_1	203	207	PF00082	0.307
CLV_PCSK_SKI1_1	40	44	PF00082	0.500
DEG_APCC_DBOX_1	3	11	PF00400	0.700
DEG_Nend_Nbox_1	1	3	PF02207	0.648
DEG_SCF_FBW7_1	10	16	PF00400	0.571
DOC_CKS1_1	10	15	PF01111	0.622
DOC_CYCLIN_RxL_1	203	210	PF00134	0.469
DOC_MAPK_gen_1	20	28	PF00069	0.629
DOC_MAPK_gen_1	203	211	PF00069	0.526
DOC_MAPK_gen_1	85	93	PF00069	0.591
DOC_MAPK_MEF2A_6	20	28	PF00069	0.613
DOC_PP1_RVXF_1	179	186	PF00149	0.274
DOC_PP4_FxxP_1	103	106	PF00568	0.553
DOC_USP7_MATH_1	13	17	PF00917	0.713
DOC_USP7_MATH_1	22	26	PF00917	0.699
DOC_USP7_MATH_1	47	51	PF00917	0.665
DOC_USP7_MATH_1	98	102	PF00917	0.650
DOC_USP7_UBL2_3	44	48	PF12436	0.784
DOC_WW_Pin1_4	9	14	PF00397	0.621
LIG_14-3-3_CanoR_1	182	188	PF00244	0.437
LIG_14-3-3_CanoR_1	23	29	PF00244	0.743
LIG_14-3-3_CanoR_1	4	8	PF00244	0.668
LIG_deltaCOP1_diTrp_1	145	154	PF00928	0.248
LIG_FHA_2	41	47	PF00498	0.733
LIG_FHA_2	49	55	PF00498	0.739
LIG_FHA_2	84	90	PF00498	0.601
LIG_GBD_Chelix_1	107	115	PF00786	0.257
LIG_LIR_Apic_2	101	106	PF02991	0.555
LIG_LIR_Gen_1	167	175	PF02991	0.334
LIG_LIR_Nem_3	167	171	PF02991	0.341
LIG_NRBOX	204	210	PF00104	0.619
LIG_Pex14_1	154	158	PF04695	0.196
LIG_SH2_CRK	160	164	PF00017	0.293
LIG_SH2_CRK	168	172	PF00017	0.308
LIG_SH2_STAP1	168	172	PF00017	0.274
LIG_SH2_STAT5	126	129	PF00017	0.318
LIG_SH2_STAT5	134	137	PF00017	0.252
LIG_SH2_STAT5	160	163	PF00017	0.274
LIG_SH2_STAT5	92	95	PF00017	0.576
MOD_CK2_1	40	46	PF00069	0.697
MOD_CK2_1	48	54	PF00069	0.727
MOD_CK2_1	83	89	PF00069	0.626
MOD_Cter_Amidation	179	182	PF01082	0.274
MOD_GlcNHglycan	121	124	PF01048	0.310
MOD_GlcNHglycan	13	16	PF01048	0.474
MOD_GlcNHglycan	28	31	PF01048	0.423
MOD_GlcNHglycan	58	61	PF01048	0.543
MOD_GSK3_1	115	122	PF00069	0.289
MOD_GSK3_1	191	198	PF00069	0.462
MOD_GSK3_1	22	29	PF00069	0.752
MOD_GSK3_1	9	16	PF00069	0.703
MOD_N-GLC_1	199	204	PF02516	0.367
MOD_NEK2_1	115	120	PF00069	0.324
MOD_NEK2_1	26	31	PF00069	0.774
MOD_NEK2_2	15	20	PF00069	0.716
MOD_NEK2_2	98	103	PF00069	0.651
MOD_PIKK_1	68	74	PF00454	0.790
MOD_PKA_2	22	28	PF00069	0.697
MOD_PKA_2	3	9	PF00069	0.625
MOD_Plk_4	166	172	PF00069	0.279
MOD_Plk_4	98	104	PF00069	0.582
MOD_ProDKin_1	9	15	PF00069	0.621
TRG_ENDOCYTIC_2	156	159	PF00928	0.237
TRG_ENDOCYTIC_2	160	163	PF00928	0.274
TRG_ENDOCYTIC_2	168	171	PF00928	0.274
TRG_ER_diArg_1	181	183	PF00400	0.437
TRG_ER_diArg_1	19	21	PF00400	0.639
TRG_ER_diArg_1	203	205	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE20	Leptomonas seymouri	77%	100%
A0A0S4IUQ3	Bodo saltans	45%	100%
A0A1X0P6B8	Trypanosomatidae	60%	100%
A0A3R7KYF8	Trypanosoma rangeli	60%	100%
A0A3S7WVB3	Leishmania donovani	94%	100%
A4HA07	Leishmania braziliensis	88%	100%
A4HY71	Leishmania infantum	93%	100%
D0A0J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AS01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	75%
V5DTP2	Trypanosoma cruzi	56%	100%