Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDH1_LEIMA

TriTrypDb:

LmjF.19.0500 , LMJLV39_190010300 , LMJSD75_190010200

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.677
CLV_NRD_NRD_1	42	44	PF00675	0.505
CLV_NRD_NRD_1	93	95	PF00675	0.520
CLV_PCSK_KEX2_1	215	217	PF00082	0.723
CLV_PCSK_KEX2_1	41	43	PF00082	0.561
CLV_PCSK_KEX2_1	75	77	PF00082	0.481
CLV_PCSK_KEX2_1	93	95	PF00082	0.543
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.512
CLV_PCSK_PC7_1	211	217	PF00082	0.670
CLV_PCSK_SKI1_1	144	148	PF00082	0.522
CLV_PCSK_SKI1_1	244	248	PF00082	0.633
DEG_APCC_DBOX_1	83	91	PF00400	0.510
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DOC_ANK_TNKS_1	184	191	PF00023	0.531
DOC_MIT_MIM_1	162	171	PF04212	0.489
DOC_PP4_FxxP_1	117	120	PF00568	0.563
DOC_USP7_MATH_1	191	195	PF00917	0.640
DOC_USP7_MATH_1	231	235	PF00917	0.785
DOC_USP7_UBL2_3	57	61	PF12436	0.496
DOC_WW_Pin1_4	225	230	PF00397	0.727
DOC_WW_Pin1_4	234	239	PF00397	0.716
DOC_WW_Pin1_4	9	14	PF00397	0.550
LIG_14-3-3_CanoR_1	171	177	PF00244	0.511
LIG_14-3-3_CanoR_1	185	189	PF00244	0.439
LIG_14-3-3_CterR_2	294	299	PF00244	0.500
LIG_BRCT_BRCA1_1	113	117	PF00533	0.620
LIG_FHA_1	2	8	PF00498	0.666
LIG_FHA_2	121	127	PF00498	0.490
LIG_FHA_2	171	177	PF00498	0.562
LIG_FHA_2	76	82	PF00498	0.557
LIG_IRF3_LxIS_1	292	298	PF10401	0.467
LIG_LIR_Apic_2	114	120	PF02991	0.586
LIG_LIR_Gen_1	164	174	PF02991	0.421
LIG_LIR_Nem_3	145	149	PF02991	0.399
LIG_LIR_Nem_3	16	22	PF02991	0.524
LIG_LIR_Nem_3	164	170	PF02991	0.425
LIG_MAD2	200	208	PF02301	0.537
LIG_NRBOX	34	40	PF00104	0.558
LIG_SH2_PTP2	22	25	PF00017	0.542
LIG_SH2_STAT5	22	25	PF00017	0.542
LIG_SH3_1	22	28	PF00018	0.543
LIG_SH3_3	106	112	PF00018	0.506
LIG_SH3_3	202	208	PF00018	0.596
LIG_SH3_3	22	28	PF00018	0.543
LIG_SH3_3	63	69	PF00018	0.567
LIG_SH3_4	57	64	PF00018	0.554
LIG_TRAF2_1	101	104	PF00917	0.529
LIG_TRAF2_1	173	176	PF00917	0.610
LIG_TRAF2_1	77	80	PF00917	0.516
MOD_CK1_1	194	200	PF00069	0.732
MOD_CK1_1	234	240	PF00069	0.783
MOD_CK1_1	26	32	PF00069	0.528
MOD_CK1_1	260	266	PF00069	0.494
MOD_CK2_1	120	126	PF00069	0.527
MOD_CK2_1	170	176	PF00069	0.489
MOD_CK2_1	260	266	PF00069	0.633
MOD_CK2_1	75	81	PF00069	0.511
MOD_Cter_Amidation	73	76	PF01082	0.506
MOD_GlcNHglycan	186	189	PF01048	0.600
MOD_GlcNHglycan	196	199	PF01048	0.672
MOD_GlcNHglycan	233	236	PF01048	0.718
MOD_GSK3_1	210	217	PF00069	0.749
MOD_GSK3_1	23	30	PF00069	0.529
MOD_GSK3_1	245	252	PF00069	0.630
MOD_GSK3_1	257	264	PF00069	0.469
MOD_GSK3_1	273	280	PF00069	0.541
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	170	175	PF00069	0.508
MOD_NEK2_1	184	189	PF00069	0.575
MOD_PIKK_1	210	216	PF00454	0.704
MOD_PKA_1	75	81	PF00069	0.511
MOD_PKA_2	165	171	PF00069	0.494
MOD_PKA_2	184	190	PF00069	0.635
MOD_PKA_2	210	216	PF00069	0.717
MOD_PKA_2	75	81	PF00069	0.495
MOD_PKA_2	92	98	PF00069	0.535
MOD_Plk_1	1	7	PF00069	0.670
MOD_Plk_4	277	283	PF00069	0.527
MOD_ProDKin_1	225	231	PF00069	0.727
MOD_ProDKin_1	234	240	PF00069	0.715
MOD_ProDKin_1	9	15	PF00069	0.537
TRG_ER_diArg_1	151	154	PF00400	0.491
TRG_ER_diArg_1	41	43	PF00400	0.526
TRG_ER_diArg_1	68	71	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK6	Leptomonas seymouri	63%	98%
A0A0S4IWH4	Bodo saltans	36%	100%
A0A1X0P771	Trypanosomatidae	40%	100%
A0A3S5H756	Leishmania donovani	92%	100%
A4HA08	Leishmania braziliensis	80%	100%
A4HY72	Leishmania infantum	92%	100%
E9AS02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DTM1	Trypanosoma cruzi	40%	100%