ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDG9_LEIMA

TriTrypDb:

LmjF.19.0520 , LMJLV39_190010500 , LMJSD75_190010400

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.606
CLV_C14_Caspase3-7	470	474	PF00656	0.552
CLV_NRD_NRD_1	142	144	PF00675	0.627
CLV_NRD_NRD_1	176	178	PF00675	0.420
CLV_NRD_NRD_1	214	216	PF00675	0.526
CLV_NRD_NRD_1	287	289	PF00675	0.572
CLV_NRD_NRD_1	290	292	PF00675	0.573
CLV_NRD_NRD_1	433	435	PF00675	0.496
CLV_PCSK_FUR_1	136	140	PF00082	0.709
CLV_PCSK_FUR_1	288	292	PF00082	0.682
CLV_PCSK_KEX2_1	138	140	PF00082	0.703
CLV_PCSK_KEX2_1	142	144	PF00082	0.669
CLV_PCSK_KEX2_1	175	177	PF00082	0.425
CLV_PCSK_KEX2_1	289	291	PF00082	0.612
CLV_PCSK_KEX2_1	433	435	PF00082	0.506
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.706
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.661
CLV_PCSK_SKI1_1	121	125	PF00082	0.546
CLV_PCSK_SKI1_1	170	174	PF00082	0.429
CLV_PCSK_SKI1_1	220	224	PF00082	0.547
CLV_PCSK_SKI1_1	291	295	PF00082	0.620
CLV_PCSK_SKI1_1	326	330	PF00082	0.676
CLV_PCSK_SKI1_1	408	412	PF00082	0.466
DEG_APCC_DBOX_1	204	212	PF00400	0.417
DEG_SCF_TRCP1_1	79	84	PF00400	0.622
DOC_ANK_TNKS_1	438	445	PF00023	0.371
DOC_MAPK_gen_1	424	432	PF00069	0.462
DOC_MAPK_gen_1	521	530	PF00069	0.605
DOC_MAPK_gen_1	538	545	PF00069	0.534
DOC_MAPK_MEF2A_6	424	432	PF00069	0.528
DOC_MAPK_RevD_3	419	434	PF00069	0.395
DOC_PP1_RVXF_1	233	240	PF00149	0.501
DOC_PP1_RVXF_1	252	259	PF00149	0.510
DOC_PP2B_LxvP_1	123	126	PF13499	0.617
DOC_PP2B_LxvP_1	364	367	PF13499	0.480
DOC_PP4_FxxP_1	124	127	PF00568	0.673
DOC_USP7_UBL2_3	216	220	PF12436	0.541
DOC_WW_Pin1_4	11	16	PF00397	0.721
DOC_WW_Pin1_4	561	566	PF00397	0.470
LIG_14-3-3_CanoR_1	179	185	PF00244	0.491
LIG_14-3-3_CanoR_1	524	529	PF00244	0.564
LIG_14-3-3_CanoR_1	68	78	PF00244	0.543
LIG_Actin_WH2_2	165	181	PF00022	0.520
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_2	62	66	PF00653	0.606
LIG_BRCT_BRCA1_1	1	5	PF00533	0.703
LIG_BRCT_BRCA1_1	12	16	PF00533	0.724
LIG_CaM_IQ_9	192	207	PF13499	0.515
LIG_CaM_IQ_9	249	265	PF13499	0.428
LIG_CaM_IQ_9	425	441	PF13499	0.599
LIG_eIF4E_1	118	124	PF01652	0.577
LIG_EVH1_2	105	109	PF00568	0.577
LIG_FHA_1	232	238	PF00498	0.554
LIG_FHA_1	375	381	PF00498	0.623
LIG_FHA_1	416	422	PF00498	0.496
LIG_FHA_2	181	187	PF00498	0.561
LIG_FHA_2	316	322	PF00498	0.662
LIG_FHA_2	340	346	PF00498	0.521
LIG_FHA_2	363	369	PF00498	0.483
LIG_FHA_2	515	521	PF00498	0.576
LIG_FHA_2	70	76	PF00498	0.545
LIG_GBD_Chelix_1	422	430	PF00786	0.359
LIG_LIR_Apic_2	122	127	PF02991	0.553
LIG_LIR_Gen_1	497	505	PF02991	0.537
LIG_LIR_Gen_1	522	531	PF02991	0.472
LIG_LIR_Nem_3	108	112	PF02991	0.577
LIG_LIR_Nem_3	166	172	PF02991	0.508
LIG_LIR_Nem_3	497	501	PF02991	0.477
LIG_PCNA_yPIPBox_3	157	169	PF02747	0.476
LIG_PDZ_Class_1	564	569	PF00595	0.549
LIG_REV1ctd_RIR_1	291	298	PF16727	0.462
LIG_SH2_CRK	498	502	PF00017	0.478
LIG_SH2_CRK	510	514	PF00017	0.516
LIG_SH2_GRB2like	147	150	PF00017	0.592
LIG_SH2_NCK_1	245	249	PF00017	0.484
LIG_SH2_NCK_1	498	502	PF00017	0.552
LIG_SH2_SRC	113	116	PF00017	0.640
LIG_SH2_SRC	245	248	PF00017	0.487
LIG_SH2_SRC	547	550	PF00017	0.671
LIG_SH2_STAP1	147	151	PF00017	0.592
LIG_SH2_STAP1	218	222	PF00017	0.374
LIG_SH2_STAP1	245	249	PF00017	0.516
LIG_SH2_STAT5	226	229	PF00017	0.555
LIG_SH2_STAT5	259	262	PF00017	0.398
LIG_SH2_STAT5	414	417	PF00017	0.444
LIG_SH2_STAT5	544	547	PF00017	0.577
LIG_SH3_1	12	18	PF00018	0.619
LIG_SH3_3	12	18	PF00018	0.619
LIG_SH3_3	123	129	PF00018	0.573
LIG_SH3_3	331	337	PF00018	0.581
LIG_SH3_3	35	41	PF00018	0.713
LIG_SH3_3	502	508	PF00018	0.490
LIG_WW_3	133	137	PF00397	0.623
MOD_CK1_1	119	125	PF00069	0.578
MOD_CK1_1	26	32	PF00069	0.669
MOD_CK2_1	180	186	PF00069	0.529
MOD_CK2_1	339	345	PF00069	0.516
MOD_CK2_1	362	368	PF00069	0.503
MOD_CK2_1	514	520	PF00069	0.516
MOD_GlcNHglycan	473	477	PF01048	0.539
MOD_GlcNHglycan	59	62	PF01048	0.773
MOD_GlcNHglycan	79	82	PF01048	0.732
MOD_GSK3_1	21	28	PF00069	0.758
MOD_GSK3_1	77	84	PF00069	0.644
MOD_N-GLC_1	26	31	PF02516	0.638
MOD_N-GLC_2	95	97	PF02516	0.604
MOD_NEK2_1	362	367	PF00069	0.553
MOD_NEK2_1	395	400	PF00069	0.529
MOD_NEK2_1	415	420	PF00069	0.468
MOD_NEK2_1	472	477	PF00069	0.546
MOD_NEK2_1	77	82	PF00069	0.664
MOD_NEK2_1	91	96	PF00069	0.634
MOD_NEK2_2	198	203	PF00069	0.312
MOD_PIKK_1	339	345	PF00454	0.628
MOD_PIKK_1	514	520	PF00454	0.425
MOD_PK_1	34	40	PF00069	0.606
MOD_PKA_2	283	289	PF00069	0.436
MOD_PKB_1	406	414	PF00069	0.518
MOD_Plk_1	163	169	PF00069	0.529
MOD_Plk_1	26	32	PF00069	0.623
MOD_Plk_2-3	313	319	PF00069	0.527
MOD_Plk_4	549	555	PF00069	0.565
MOD_ProDKin_1	11	17	PF00069	0.723
MOD_ProDKin_1	561	567	PF00069	0.470
MOD_SUMO_for_1	461	464	PF00179	0.547
MOD_SUMO_rev_2	114	119	PF00179	0.469
MOD_SUMO_rev_2	368	377	PF00179	0.605
MOD_SUMO_rev_2	443	448	PF00179	0.500
TRG_ENDOCYTIC_2	113	116	PF00928	0.636
TRG_ENDOCYTIC_2	498	501	PF00928	0.538
TRG_ENDOCYTIC_2	510	513	PF00928	0.518
TRG_ER_diArg_1	141	143	PF00400	0.697
TRG_ER_diArg_1	175	177	PF00400	0.425
TRG_ER_diArg_1	202	205	PF00400	0.429
TRG_ER_diArg_1	206	209	PF00400	0.446
TRG_ER_diArg_1	288	291	PF00400	0.569
TRG_ER_diArg_1	432	434	PF00400	0.533
TRG_ER_diArg_1	439	442	PF00400	0.492
TRG_NLS_MonoCore_2	287	292	PF00514	0.650
TRG_NLS_MonoExtC_3	287	292	PF00514	0.650
TRG_NLS_MonoExtN_4	285	292	PF00514	0.581
TRG_NLS_MonoExtN_4	433	440	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	408	413	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9S0	Leptomonas seymouri	45%	95%
A0A1X0P7R9	Trypanosomatidae	33%	100%
A0A3S7WVD7	Leishmania donovani	91%	100%
A0A422P367	Trypanosoma rangeli	34%	100%
A4HA10	Leishmania braziliensis	65%	95%
A4HY74	Leishmania infantum	90%	100%
D0A0J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AS04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BSD1	Trypanosoma cruzi	35%	100%