Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDG8_LEIMA

TriTrypDb:

LmjF.19.0530 , LMJLV39_190010600 , LMJSD75_190010500

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

Q4QDG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.624
CLV_C14_Caspase3-7	445	449	PF00656	0.419
CLV_C14_Caspase3-7	566	570	PF00656	0.625
CLV_C14_Caspase3-7	597	601	PF00656	0.664
CLV_NRD_NRD_1	220	222	PF00675	0.558
CLV_NRD_NRD_1	474	476	PF00675	0.703
CLV_NRD_NRD_1	589	591	PF00675	0.596
CLV_NRD_NRD_1	618	620	PF00675	0.543
CLV_PCSK_FUR_1	56	60	PF00082	0.669
CLV_PCSK_KEX2_1	132	134	PF00082	0.679
CLV_PCSK_KEX2_1	220	222	PF00082	0.650
CLV_PCSK_KEX2_1	474	476	PF00082	0.649
CLV_PCSK_KEX2_1	58	60	PF00082	0.701
CLV_PCSK_KEX2_1	588	590	PF00082	0.595
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.688
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.712
CLV_PCSK_SKI1_1	233	237	PF00082	0.462
CLV_PCSK_SKI1_1	334	338	PF00082	0.450
CLV_PCSK_SKI1_1	395	399	PF00082	0.473
CLV_PCSK_SKI1_1	547	551	PF00082	0.706
CLV_PCSK_SKI1_1	590	594	PF00082	0.647
CLV_PCSK_SKI1_1	739	743	PF00082	0.596
DEG_APCC_DBOX_1	729	737	PF00400	0.520
DEG_SCF_FBW7_1	591	597	PF00400	0.532
DEG_SPOP_SBC_1	642	646	PF00917	0.502
DOC_ANK_TNKS_1	290	297	PF00023	0.277
DOC_CKS1_1	169	174	PF01111	0.625
DOC_CKS1_1	591	596	PF01111	0.568
DOC_CKS1_1	692	697	PF01111	0.519
DOC_CYCLIN_RxL_1	298	307	PF00134	0.435
DOC_MAPK_gen_1	286	295	PF00069	0.367
DOC_MAPK_gen_1	474	480	PF00069	0.660
DOC_MAPK_gen_1	552	560	PF00069	0.585
DOC_MAPK_MEF2A_6	289	297	PF00069	0.280
DOC_PIKK_1	488	495	PF02985	0.587
DOC_PP1_RVXF_1	97	104	PF00149	0.594
DOC_PP2B_LxvP_1	326	329	PF13499	0.423
DOC_PP2B_LxvP_1	438	441	PF13499	0.435
DOC_PP2B_LxvP_1	476	479	PF13499	0.632
DOC_PP2B_LxvP_1	77	80	PF13499	0.615
DOC_USP7_MATH_1	110	114	PF00917	0.590
DOC_USP7_MATH_1	25	29	PF00917	0.604
DOC_USP7_MATH_1	41	45	PF00917	0.515
DOC_USP7_MATH_1	463	467	PF00917	0.588
DOC_USP7_MATH_1	526	530	PF00917	0.594
DOC_USP7_MATH_1	548	552	PF00917	0.612
DOC_USP7_MATH_1	583	587	PF00917	0.664
DOC_USP7_MATH_1	592	596	PF00917	0.708
DOC_USP7_MATH_1	608	612	PF00917	0.707
DOC_USP7_MATH_1	624	628	PF00917	0.695
DOC_USP7_MATH_1	659	663	PF00917	0.647
DOC_USP7_MATH_1	698	702	PF00917	0.721
DOC_USP7_MATH_1	715	719	PF00917	0.557
DOC_USP7_MATH_1	741	745	PF00917	0.637
DOC_WW_Pin1_4	168	173	PF00397	0.691
DOC_WW_Pin1_4	199	204	PF00397	0.575
DOC_WW_Pin1_4	334	339	PF00397	0.366
DOC_WW_Pin1_4	414	419	PF00397	0.671
DOC_WW_Pin1_4	590	595	PF00397	0.674
DOC_WW_Pin1_4	691	696	PF00397	0.629
LIG_14-3-3_CanoR_1	142	149	PF00244	0.654
LIG_14-3-3_CanoR_1	220	229	PF00244	0.709
LIG_14-3-3_CanoR_1	233	240	PF00244	0.502
LIG_14-3-3_CanoR_1	373	378	PF00244	0.409
LIG_14-3-3_CanoR_1	525	535	PF00244	0.564
LIG_14-3-3_CanoR_1	619	629	PF00244	0.553
LIG_14-3-3_CanoR_1	635	641	PF00244	0.550
LIG_14-3-3_CanoR_1	676	686	PF00244	0.713
LIG_14-3-3_CanoR_1	81	91	PF00244	0.783
LIG_BIR_III_4	126	130	PF00653	0.600
LIG_BRCT_BRCA1_1	222	226	PF00533	0.430
LIG_BRCT_BRCA1_1	594	598	PF00533	0.586
LIG_deltaCOP1_diTrp_1	242	246	PF00928	0.440
LIG_deltaCOP1_diTrp_1	663	670	PF00928	0.658
LIG_FHA_1	195	201	PF00498	0.594
LIG_FHA_1	234	240	PF00498	0.406
LIG_FHA_1	252	258	PF00498	0.426
LIG_FHA_1	343	349	PF00498	0.403
LIG_FHA_1	43	49	PF00498	0.598
LIG_FHA_1	573	579	PF00498	0.564
LIG_FHA_1	582	588	PF00498	0.530
LIG_FHA_1	643	649	PF00498	0.660
LIG_FHA_1	74	80	PF00498	0.545
LIG_FHA_2	22	28	PF00498	0.601
LIG_FHA_2	226	232	PF00498	0.582
LIG_FHA_2	242	248	PF00498	0.377
LIG_FHA_2	443	449	PF00498	0.454
LIG_FHA_2	480	486	PF00498	0.598
LIG_FHA_2	706	712	PF00498	0.615
LIG_LIR_Gen_1	223	234	PF02991	0.400
LIG_LIR_Gen_1	244	253	PF02991	0.402
LIG_LIR_Gen_1	506	515	PF02991	0.561
LIG_LIR_Gen_1	664	675	PF02991	0.587
LIG_LIR_Gen_1	701	707	PF02991	0.686
LIG_LIR_Nem_3	223	229	PF02991	0.421
LIG_LIR_Nem_3	244	249	PF02991	0.457
LIG_LIR_Nem_3	325	330	PF02991	0.350
LIG_LIR_Nem_3	392	397	PF02991	0.460
LIG_LIR_Nem_3	506	511	PF02991	0.527
LIG_LIR_Nem_3	664	670	PF02991	0.517
LIG_LIR_Nem_3	701	705	PF02991	0.698
LIG_MYND_1	418	422	PF01753	0.501
LIG_MYND_1	535	539	PF01753	0.665
LIG_MYND_3	440	444	PF01753	0.399
LIG_Pex14_2	549	553	PF04695	0.624
LIG_SH2_CRK	15	19	PF00017	0.608
LIG_SH2_CRK	523	527	PF00017	0.551
LIG_SH2_CRK	702	706	PF00017	0.616
LIG_SH2_NCK_1	523	527	PF00017	0.534
LIG_SH2_STAP1	230	234	PF00017	0.471
LIG_SH2_STAT5	118	121	PF00017	0.650
LIG_SH2_STAT5	302	305	PF00017	0.405
LIG_SH2_STAT5	327	330	PF00017	0.467
LIG_SH2_STAT5	523	526	PF00017	0.555
LIG_SH2_STAT5	636	639	PF00017	0.746
LIG_SH2_STAT5	707	710	PF00017	0.576
LIG_SH3_3	197	203	PF00018	0.613
LIG_SH3_3	415	421	PF00018	0.597
LIG_SH3_3	457	463	PF00018	0.473
LIG_SH3_3	542	548	PF00018	0.568
LIG_SUMO_SIM_anti_2	247	254	PF11976	0.479
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.339
LIG_SUMO_SIM_par_1	343	350	PF11976	0.366
LIG_TRAF2_1	468	471	PF00917	0.621
LIG_TRAF2_1	662	665	PF00917	0.586
LIG_TYR_ITIM	300	305	PF00017	0.435
LIG_UBA3_1	50	58	PF00899	0.664
MOD_CDK_SPK_2	168	173	PF00069	0.541
MOD_CK1_1	138	144	PF00069	0.588
MOD_CK1_1	152	158	PF00069	0.588
MOD_CK1_1	17	23	PF00069	0.611
MOD_CK1_1	194	200	PF00069	0.601
MOD_CK1_1	275	281	PF00069	0.462
MOD_CK1_1	28	34	PF00069	0.734
MOD_CK1_1	285	291	PF00069	0.456
MOD_CK1_1	454	460	PF00069	0.615
MOD_CK1_1	466	472	PF00069	0.556
MOD_CK1_1	551	557	PF00069	0.568
MOD_CK1_1	571	577	PF00069	0.562
MOD_CK1_1	65	71	PF00069	0.652
MOD_CK1_1	677	683	PF00069	0.699
MOD_CK2_1	225	231	PF00069	0.590
MOD_CK2_1	241	247	PF00069	0.362
MOD_CK2_1	319	325	PF00069	0.396
MOD_CK2_1	464	470	PF00069	0.664
MOD_CK2_1	659	665	PF00069	0.645
MOD_CMANNOS	243	246	PF00535	0.432
MOD_Cter_Amidation	617	620	PF01082	0.524
MOD_GlcNHglycan	113	116	PF01048	0.482
MOD_GlcNHglycan	135	138	PF01048	0.655
MOD_GlcNHglycan	151	154	PF01048	0.602
MOD_GlcNHglycan	180	184	PF01048	0.628
MOD_GlcNHglycan	30	33	PF01048	0.696
MOD_GlcNHglycan	342	345	PF01048	0.452
MOD_GlcNHglycan	39	42	PF01048	0.735
MOD_GlcNHglycan	403	406	PF01048	0.668
MOD_GlcNHglycan	604	609	PF01048	0.698
MOD_GlcNHglycan	611	614	PF01048	0.677
MOD_GlcNHglycan	622	625	PF01048	0.494
MOD_GlcNHglycan	626	629	PF01048	0.616
MOD_GlcNHglycan	64	67	PF01048	0.637
MOD_GlcNHglycan	680	683	PF01048	0.691
MOD_GlcNHglycan	85	88	PF01048	0.726
MOD_GlcNHglycan	94	97	PF01048	0.691
MOD_GSK3_1	133	140	PF00069	0.636
MOD_GSK3_1	147	154	PF00069	0.572
MOD_GSK3_1	17	24	PF00069	0.749
MOD_GSK3_1	220	227	PF00069	0.675
MOD_GSK3_1	229	236	PF00069	0.627
MOD_GSK3_1	272	279	PF00069	0.555
MOD_GSK3_1	304	311	PF00069	0.340
MOD_GSK3_1	33	40	PF00069	0.699
MOD_GSK3_1	451	458	PF00069	0.568
MOD_GSK3_1	466	473	PF00069	0.584
MOD_GSK3_1	50	57	PF00069	0.576
MOD_GSK3_1	521	528	PF00069	0.524
MOD_GSK3_1	547	554	PF00069	0.654
MOD_GSK3_1	559	566	PF00069	0.642
MOD_GSK3_1	568	575	PF00069	0.449
MOD_GSK3_1	590	597	PF00069	0.592
MOD_GSK3_1	604	611	PF00069	0.652
MOD_GSK3_1	61	68	PF00069	0.566
MOD_GSK3_1	620	627	PF00069	0.619
MOD_GSK3_1	636	643	PF00069	0.686
MOD_GSK3_1	670	677	PF00069	0.645
MOD_GSK3_1	83	90	PF00069	0.782
MOD_N-GLC_1	138	143	PF02516	0.673
MOD_N-GLC_1	282	287	PF02516	0.338
MOD_N-GLC_1	455	460	PF02516	0.500
MOD_N-GLC_1	581	586	PF02516	0.629
MOD_N-GLC_1	609	614	PF02516	0.666
MOD_N-GLC_2	306	308	PF02516	0.449
MOD_NEK2_1	103	108	PF00069	0.669
MOD_NEK2_1	179	184	PF00069	0.654
MOD_NEK2_1	229	234	PF00069	0.477
MOD_NEK2_1	251	256	PF00069	0.407
MOD_NEK2_1	282	287	PF00069	0.345
MOD_NEK2_1	340	345	PF00069	0.482
MOD_NEK2_1	464	469	PF00069	0.723
MOD_NEK2_1	50	55	PF00069	0.625
MOD_NEK2_1	670	675	PF00069	0.607
MOD_NEK2_1	705	710	PF00069	0.743
MOD_NEK2_1	72	77	PF00069	0.713
MOD_NEK2_2	304	309	PF00069	0.432
MOD_NEK2_2	583	588	PF00069	0.661
MOD_PIKK_1	65	71	PF00454	0.706
MOD_PIKK_1	674	680	PF00454	0.607
MOD_PIKK_1	705	711	PF00454	0.716
MOD_PKA_1	220	226	PF00069	0.542
MOD_PKA_1	619	625	PF00069	0.520
MOD_PKA_2	141	147	PF00069	0.642
MOD_PKA_2	220	226	PF00069	0.534
MOD_PKA_2	285	291	PF00069	0.318
MOD_PKA_2	524	530	PF00069	0.621
MOD_PKA_2	551	557	PF00069	0.645
MOD_PKA_2	83	89	PF00069	0.810
MOD_PKB_1	59	67	PF00069	0.672
MOD_Plk_1	103	109	PF00069	0.541
MOD_Plk_1	191	197	PF00069	0.643
MOD_Plk_1	224	230	PF00069	0.589
MOD_Plk_1	25	31	PF00069	0.580
MOD_Plk_1	451	457	PF00069	0.621
MOD_Plk_1	568	574	PF00069	0.662
MOD_Plk_1	731	737	PF00069	0.548
MOD_Plk_2-3	225	231	PF00069	0.618
MOD_Plk_4	225	231	PF00069	0.585
MOD_Plk_4	319	325	PF00069	0.415
MOD_Plk_4	373	379	PF00069	0.479
MOD_Plk_4	568	574	PF00069	0.646
MOD_Plk_4	670	676	PF00069	0.576
MOD_ProDKin_1	168	174	PF00069	0.690
MOD_ProDKin_1	199	205	PF00069	0.573
MOD_ProDKin_1	334	340	PF00069	0.369
MOD_ProDKin_1	414	420	PF00069	0.668
MOD_ProDKin_1	590	596	PF00069	0.676
MOD_ProDKin_1	691	697	PF00069	0.630
MOD_SUMO_for_1	209	212	PF00179	0.694
TRG_AP2beta_CARGO_1	224	233	PF09066	0.407
TRG_DiLeu_BaEn_1	247	252	PF01217	0.417
TRG_DiLeu_BaEn_1	493	498	PF01217	0.583
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.382
TRG_ENDOCYTIC_2	15	18	PF00928	0.609
TRG_ENDOCYTIC_2	302	305	PF00928	0.386
TRG_ENDOCYTIC_2	327	330	PF00928	0.353
TRG_ENDOCYTIC_2	394	397	PF00928	0.501
TRG_ENDOCYTIC_2	702	705	PF00928	0.756
TRG_ER_diArg_1	156	159	PF00400	0.504
TRG_ER_diArg_1	474	476	PF00400	0.643
TRG_ER_diArg_1	587	590	PF00400	0.577
TRG_ER_diArg_1	59	62	PF00400	0.758
TRG_ER_diArg_1	735	738	PF00400	0.529
TRG_NES_CRM1_1	247	262	PF08389	0.423
TRG_NES_CRM1_1	485	500	PF08389	0.586
TRG_NLS_MonoExtN_4	56	62	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	395	400	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	437	442	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I334	Leptomonas seymouri	45%	84%
A0A1X0P7D2	Trypanosomatidae	33%	86%
A0A3Q8IBC8	Leishmania donovani	91%	100%
A0A422P3D4	Trypanosoma rangeli	30%	94%
A4HA11	Leishmania braziliensis	71%	100%
A4HY75	Leishmania infantum	91%	100%
E9AS05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	82%
V5BBW9	Trypanosoma cruzi	31%	95%