LeishMANIAdb
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Protein tweety homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein tweety homolog
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QDG5_LEIMA
TriTrypDb:
LmjF.19.0570 , LMJLV39_000012300 , LMJSD75_190010800 *
Length:
548

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 19, no: 1
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

Q4QDG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDG5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 38 42 PF00082 0.452
CLV_PCSK_SKI1_1 405 409 PF00082 0.641
DEG_APCC_DBOX_1 143 151 PF00400 0.563
DEG_SPOP_SBC_1 507 511 PF00917 0.331
DOC_MAPK_gen_1 133 142 PF00069 0.711
DOC_MAPK_gen_1 38 46 PF00069 0.479
DOC_MAPK_gen_1 534 542 PF00069 0.509
DOC_MAPK_MEF2A_6 144 153 PF00069 0.569
DOC_MAPK_MEF2A_6 534 542 PF00069 0.546
DOC_PP2B_LxvP_1 10 13 PF13499 0.576
DOC_PP2B_LxvP_1 20 23 PF13499 0.580
DOC_PP4_FxxP_1 5 8 PF00568 0.577
DOC_USP7_MATH_1 11 15 PF00917 0.580
DOC_USP7_MATH_1 459 463 PF00917 0.458
DOC_USP7_MATH_1 63 67 PF00917 0.404
DOC_USP7_MATH_1 78 82 PF00917 0.335
DOC_WW_Pin1_4 31 36 PF00397 0.584
DOC_WW_Pin1_4 74 79 PF00397 0.479
LIG_14-3-3_CanoR_1 195 201 PF00244 0.469
LIG_14-3-3_CanoR_1 27 35 PF00244 0.695
LIG_14-3-3_CanoR_1 428 437 PF00244 0.454
LIG_14-3-3_CanoR_1 508 513 PF00244 0.418
LIG_14-3-3_CanoR_1 537 541 PF00244 0.597
LIG_14-3-3_CanoR_1 91 100 PF00244 0.451
LIG_EH1_1 257 265 PF00400 0.522
LIG_EH1_1 517 525 PF00400 0.398
LIG_FHA_1 175 181 PF00498 0.431
LIG_FHA_1 197 203 PF00498 0.456
LIG_FHA_1 226 232 PF00498 0.443
LIG_FHA_1 296 302 PF00498 0.494
LIG_FHA_1 40 46 PF00498 0.581
LIG_FHA_1 407 413 PF00498 0.415
LIG_FHA_1 424 430 PF00498 0.332
LIG_FHA_1 444 450 PF00498 0.402
LIG_FHA_1 507 513 PF00498 0.367
LIG_FHA_1 537 543 PF00498 0.692
LIG_FHA_1 87 93 PF00498 0.427
LIG_FHA_2 415 421 PF00498 0.521
LIG_FHA_2 494 500 PF00498 0.513
LIG_GBD_Chelix_1 288 296 PF00786 0.450
LIG_LIR_Apic_2 129 134 PF02991 0.647
LIG_LIR_Apic_2 401 406 PF02991 0.446
LIG_LIR_Apic_2 466 470 PF02991 0.401
LIG_LIR_Gen_1 219 227 PF02991 0.372
LIG_LIR_Gen_1 228 238 PF02991 0.394
LIG_LIR_Nem_3 182 188 PF02991 0.417
LIG_LIR_Nem_3 219 223 PF02991 0.367
LIG_LIR_Nem_3 228 233 PF02991 0.367
LIG_LIR_Nem_3 280 286 PF02991 0.363
LIG_LIR_Nem_3 466 472 PF02991 0.476
LIG_LIR_Nem_3 94 99 PF02991 0.393
LIG_LYPXL_S_1 100 104 PF13949 0.565
LIG_PCNA_yPIPBox_3 218 231 PF02747 0.351
LIG_Pex14_1 279 283 PF04695 0.605
LIG_Pex14_2 286 290 PF04695 0.416
LIG_SH2_CRK 167 171 PF00017 0.435
LIG_SH2_CRK 185 189 PF00017 0.465
LIG_SH2_GRB2like 190 193 PF00017 0.405
LIG_SH2_PTP2 131 134 PF00017 0.640
LIG_SH2_PTP2 230 233 PF00017 0.480
LIG_SH2_PTP2 403 406 PF00017 0.447
LIG_SH2_PTP2 467 470 PF00017 0.449
LIG_SH2_SRC 530 533 PF00017 0.319
LIG_SH2_SRC 99 102 PF00017 0.436
LIG_SH2_STAP1 447 451 PF00017 0.448
LIG_SH2_STAT3 447 450 PF00017 0.393
LIG_SH2_STAT5 131 134 PF00017 0.640
LIG_SH2_STAT5 190 193 PF00017 0.378
LIG_SH2_STAT5 230 233 PF00017 0.403
LIG_SH2_STAT5 238 241 PF00017 0.383
LIG_SH2_STAT5 283 286 PF00017 0.378
LIG_SH2_STAT5 302 305 PF00017 0.308
LIG_SH2_STAT5 325 328 PF00017 0.342
LIG_SH2_STAT5 403 406 PF00017 0.442
LIG_SH2_STAT5 421 424 PF00017 0.409
LIG_SH2_STAT5 467 470 PF00017 0.440
LIG_SH2_STAT5 500 503 PF00017 0.503
LIG_SH2_STAT5 530 533 PF00017 0.342
LIG_SH2_STAT5 99 102 PF00017 0.374
LIG_SH3_3 206 212 PF00018 0.486
LIG_SH3_3 5 11 PF00018 0.576
LIG_SUMO_SIM_anti_2 393 402 PF11976 0.453
LIG_SUMO_SIM_par_1 148 154 PF11976 0.268
LIG_TRFH_1 98 102 PF08558 0.566
LIG_TYR_ITIM 165 170 PF00017 0.506
LIG_TYR_ITIM 435 440 PF00017 0.372
LIG_WRC_WIRS_1 217 222 PF05994 0.553
LIG_WW_2 8 11 PF00397 0.454
MOD_CDK_SPxxK_3 31 38 PF00069 0.456
MOD_CK1_1 14 20 PF00069 0.482
MOD_CK1_1 369 375 PF00069 0.509
MOD_CK1_1 489 495 PF00069 0.684
MOD_CK1_1 536 542 PF00069 0.520
MOD_CK2_1 123 129 PF00069 0.677
MOD_CK2_1 414 420 PF00069 0.623
MOD_CK2_1 493 499 PF00069 0.490
MOD_CK2_1 78 84 PF00069 0.600
MOD_DYRK1A_RPxSP_1 31 35 PF00069 0.475
MOD_GlcNHglycan 205 208 PF01048 0.566
MOD_GlcNHglycan 304 307 PF01048 0.520
MOD_GlcNHglycan 352 355 PF01048 0.511
MOD_GlcNHglycan 504 507 PF01048 0.566
MOD_GlcNHglycan 61 64 PF01048 0.533
MOD_GSK3_1 11 18 PF00069 0.767
MOD_GSK3_1 180 187 PF00069 0.568
MOD_GSK3_1 196 203 PF00069 0.364
MOD_GSK3_1 384 391 PF00069 0.498
MOD_GSK3_1 459 466 PF00069 0.485
MOD_GSK3_1 486 493 PF00069 0.593
MOD_GSK3_1 502 509 PF00069 0.547
MOD_GSK3_1 59 66 PF00069 0.511
MOD_GSK3_1 74 81 PF00069 0.405
MOD_N-GLC_1 15 20 PF02516 0.484
MOD_N-GLC_1 196 201 PF02516 0.462
MOD_N-GLC_1 203 208 PF02516 0.475
MOD_N-GLC_1 414 419 PF02516 0.654
MOD_N-GLC_1 459 464 PF02516 0.464
MOD_N-GLC_1 490 495 PF02516 0.619
MOD_N-GLC_1 78 83 PF02516 0.585
MOD_N-GLC_2 360 362 PF02516 0.536
MOD_NEK2_1 109 114 PF00069 0.450
MOD_NEK2_1 15 20 PF00069 0.736
MOD_NEK2_1 200 205 PF00069 0.532
MOD_NEK2_1 39 44 PF00069 0.619
MOD_NEK2_1 408 413 PF00069 0.534
MOD_NEK2_1 429 434 PF00069 0.457
MOD_NEK2_1 513 518 PF00069 0.393
MOD_NEK2_1 56 61 PF00069 0.360
MOD_OFUCOSY 121 127 PF10250 0.593
MOD_OFUCOSY 275 281 PF10250 0.536
MOD_PIKK_1 174 180 PF00454 0.543
MOD_PIKK_1 342 348 PF00454 0.571
MOD_PIKK_1 384 390 PF00454 0.551
MOD_PIKK_1 484 490 PF00454 0.502
MOD_PIKK_1 493 499 PF00454 0.593
MOD_PIKK_1 91 97 PF00454 0.560
MOD_PK_1 508 514 PF00069 0.502
MOD_PKA_2 26 32 PF00069 0.608
MOD_PKA_2 507 513 PF00069 0.516
MOD_PKA_2 533 539 PF00069 0.347
MOD_Plk_1 15 21 PF00069 0.484
MOD_Plk_1 196 202 PF00069 0.522
MOD_Plk_1 225 231 PF00069 0.501
MOD_Plk_1 490 496 PF00069 0.675
MOD_Plk_1 78 84 PF00069 0.583
MOD_Plk_2-3 216 222 PF00069 0.511
MOD_Plk_4 166 172 PF00069 0.455
MOD_Plk_4 399 405 PF00069 0.454
MOD_Plk_4 40 46 PF00069 0.414
MOD_Plk_4 463 469 PF00069 0.530
MOD_Plk_4 508 514 PF00069 0.386
MOD_Plk_4 78 84 PF00069 0.603
MOD_ProDKin_1 31 37 PF00069 0.461
MOD_ProDKin_1 74 80 PF00069 0.594
MOD_SUMO_for_1 134 137 PF00179 0.559
TRG_DiLeu_BaLyEn_6 467 472 PF01217 0.472
TRG_ENDOCYTIC_2 101 104 PF00928 0.385
TRG_ENDOCYTIC_2 167 170 PF00928 0.507
TRG_ENDOCYTIC_2 185 188 PF00928 0.528
TRG_ENDOCYTIC_2 230 233 PF00928 0.562
TRG_ENDOCYTIC_2 283 286 PF00928 0.346
TRG_ENDOCYTIC_2 437 440 PF00928 0.441
TRG_ER_diLys_1 544 548 PF00400 0.593
TRG_NLS_MonoExtN_4 23 28 PF00514 0.716

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y8 Leptomonas seymouri 53% 100%
A0A0S4ITY9 Bodo saltans 25% 100%
A0A0S4IXB1 Bodo saltans 28% 100%
A0A0S4IXU4 Bodo saltans 28% 100%
A0A1X0NVP9 Trypanosomatidae 38% 100%
A0A1X0NWC8 Trypanosomatidae 35% 100%
A0A1X0P6A6 Trypanosomatidae 28% 100%
A0A3Q8IB78 Leishmania donovani 89% 100%
A0A3S7WVB2 Leishmania donovani 89% 100%
A0A422N059 Trypanosoma rangeli 37% 100%
A4HA16 Leishmania braziliensis 71% 100%
A4HY78 Leishmania infantum 89% 100%
A4HY79 Leishmania infantum 88% 100%
C9ZWF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
D0A5X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 96%
E9AS08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9AS09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
Q4QDG4 Leishmania major 94% 100%
V5C1U9 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS