LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QDG4_LEIMA
TriTrypDb:
LmjF.19.0540 , LMJLV39_000012300 * , LMJSD75_190010900 *
Length:
530

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 18, no: 1
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 18
GO:0110165 cellular anatomical entity 1 18

Expansion

Sequence features

Q4QDG4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDG4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 367 371 PF00082 0.594
CLV_PCSK_SKI1_1 496 500 PF00082 0.418
DEG_APCC_DBOX_1 105 113 PF00400 0.393
DEG_SPOP_SBC_1 469 473 PF00917 0.273
DOC_MAPK_gen_1 95 104 PF00069 0.565
DOC_MAPK_MEF2A_6 106 115 PF00069 0.537
DOC_USP7_MATH_1 25 29 PF00917 0.442
DOC_USP7_MATH_1 40 44 PF00917 0.324
DOC_USP7_MATH_1 421 425 PF00917 0.409
DOC_USP7_MATH_1 522 526 PF00917 0.633
DOC_WW_Pin1_4 36 41 PF00397 0.440
DOC_WW_Pin1_4 514 519 PF00397 0.758
LIG_14-3-3_CanoR_1 157 163 PF00244 0.342
LIG_14-3-3_CanoR_1 470 475 PF00244 0.332
LIG_14-3-3_CanoR_1 53 62 PF00244 0.404
LIG_BIR_II_1 1 5 PF00653 0.533
LIG_EH1_1 219 227 PF00400 0.377
LIG_EH1_1 479 487 PF00400 0.330
LIG_FHA_1 137 143 PF00498 0.292
LIG_FHA_1 159 165 PF00498 0.411
LIG_FHA_1 188 194 PF00498 0.393
LIG_FHA_1 2 8 PF00498 0.610
LIG_FHA_1 258 264 PF00498 0.447
LIG_FHA_1 369 375 PF00498 0.383
LIG_FHA_1 406 412 PF00498 0.360
LIG_FHA_1 469 475 PF00498 0.316
LIG_FHA_1 49 55 PF00498 0.392
LIG_FHA_1 511 517 PF00498 0.731
LIG_FHA_2 377 383 PF00498 0.403
LIG_FHA_2 456 462 PF00498 0.440
LIG_GBD_Chelix_1 250 258 PF00786 0.340
LIG_LIR_Apic_2 363 368 PF02991 0.348
LIG_LIR_Apic_2 428 432 PF02991 0.346
LIG_LIR_Apic_2 91 96 PF02991 0.565
LIG_LIR_Gen_1 151 160 PF02991 0.298
LIG_LIR_Gen_1 181 189 PF02991 0.325
LIG_LIR_Gen_1 190 200 PF02991 0.436
LIG_LIR_Gen_1 295 305 PF02991 0.391
LIG_LIR_Nem_3 144 150 PF02991 0.387
LIG_LIR_Nem_3 151 156 PF02991 0.360
LIG_LIR_Nem_3 181 185 PF02991 0.331
LIG_LIR_Nem_3 190 195 PF02991 0.351
LIG_LIR_Nem_3 242 248 PF02991 0.295
LIG_LIR_Nem_3 295 301 PF02991 0.411
LIG_LIR_Nem_3 428 434 PF02991 0.443
LIG_LIR_Nem_3 56 61 PF02991 0.345
LIG_LYPXL_S_1 62 66 PF13949 0.516
LIG_PCNA_yPIPBox_3 180 193 PF02747 0.291
LIG_Pex14_1 241 245 PF04695 0.564
LIG_Pex14_2 248 252 PF04695 0.350
LIG_SH2_CRK 129 133 PF00017 0.396
LIG_SH2_CRK 399 403 PF00017 0.297
LIG_SH2_GRB2like 152 155 PF00017 0.351
LIG_SH2_PTP2 192 195 PF00017 0.442
LIG_SH2_PTP2 365 368 PF00017 0.350
LIG_SH2_PTP2 429 432 PF00017 0.403
LIG_SH2_PTP2 93 96 PF00017 0.558
LIG_SH2_SRC 192 195 PF00017 0.239
LIG_SH2_SRC 61 64 PF00017 0.387
LIG_SH2_STAP1 409 413 PF00017 0.410
LIG_SH2_STAT3 409 412 PF00017 0.312
LIG_SH2_STAT5 152 155 PF00017 0.331
LIG_SH2_STAT5 192 195 PF00017 0.346
LIG_SH2_STAT5 200 203 PF00017 0.333
LIG_SH2_STAT5 245 248 PF00017 0.320
LIG_SH2_STAT5 264 267 PF00017 0.260
LIG_SH2_STAT5 287 290 PF00017 0.292
LIG_SH2_STAT5 365 368 PF00017 0.403
LIG_SH2_STAT5 383 386 PF00017 0.465
LIG_SH2_STAT5 429 432 PF00017 0.390
LIG_SH2_STAT5 462 465 PF00017 0.497
LIG_SH2_STAT5 61 64 PF00017 0.326
LIG_SH2_STAT5 93 96 PF00017 0.558
LIG_SH3_3 168 174 PF00018 0.438
LIG_SH3_3 513 519 PF00018 0.629
LIG_SH3_3 524 530 PF00018 0.610
LIG_SUMO_SIM_anti_2 355 364 PF11976 0.411
LIG_SUMO_SIM_par_1 110 116 PF11976 0.211
LIG_TRFH_1 60 64 PF08558 0.362
LIG_TYR_ITIM 127 132 PF00017 0.453
LIG_TYR_ITSM 188 195 PF00017 0.236
LIG_WRC_WIRS_1 179 184 PF05994 0.397
MOD_CK1_1 331 337 PF00069 0.387
MOD_CK1_1 391 397 PF00069 0.342
MOD_CK1_1 451 457 PF00069 0.522
MOD_CK2_1 376 382 PF00069 0.392
MOD_CK2_1 40 46 PF00069 0.441
MOD_CK2_1 455 461 PF00069 0.389
MOD_CK2_1 85 91 PF00069 0.691
MOD_Cter_Amidation 503 506 PF01082 0.306
MOD_GlcNHglycan 167 170 PF01048 0.611
MOD_GlcNHglycan 23 26 PF01048 0.591
MOD_GlcNHglycan 266 269 PF01048 0.588
MOD_GlcNHglycan 314 317 PF01048 0.582
MOD_GlcNHglycan 466 469 PF01048 0.624
MOD_GSK3_1 142 149 PF00069 0.413
MOD_GSK3_1 158 165 PF00069 0.288
MOD_GSK3_1 21 28 PF00069 0.443
MOD_GSK3_1 346 353 PF00069 0.359
MOD_GSK3_1 36 43 PF00069 0.290
MOD_GSK3_1 421 428 PF00069 0.336
MOD_GSK3_1 448 455 PF00069 0.435
MOD_GSK3_1 464 471 PF00069 0.435
MOD_GSK3_1 510 517 PF00069 0.726
MOD_GSK3_1 522 529 PF00069 0.629
MOD_N-GLC_1 158 163 PF02516 0.523
MOD_N-GLC_1 165 170 PF02516 0.530
MOD_N-GLC_1 376 381 PF02516 0.630
MOD_N-GLC_1 40 45 PF02516 0.623
MOD_N-GLC_1 421 426 PF02516 0.520
MOD_N-GLC_1 452 457 PF02516 0.625
MOD_N-GLC_2 322 324 PF02516 0.518
MOD_NEK2_1 1 6 PF00069 0.635
MOD_NEK2_1 162 167 PF00069 0.376
MOD_NEK2_1 18 23 PF00069 0.512
MOD_NEK2_1 370 375 PF00069 0.388
MOD_NEK2_1 475 480 PF00069 0.325
MOD_NEK2_1 71 76 PF00069 0.396
MOD_OFUCOSY 237 243 PF10250 0.376
MOD_OFUCOSY 387 392 PF10250 0.533
MOD_OFUCOSY 83 89 PF10250 0.522
MOD_PIKK_1 136 142 PF00454 0.258
MOD_PIKK_1 304 310 PF00454 0.414
MOD_PIKK_1 346 352 PF00454 0.395
MOD_PIKK_1 446 452 PF00454 0.348
MOD_PIKK_1 455 461 PF00454 0.415
MOD_PIKK_1 53 59 PF00454 0.404
MOD_PK_1 470 476 PF00069 0.311
MOD_PKA_2 469 475 PF00069 0.377
MOD_Plk_1 158 164 PF00069 0.369
MOD_Plk_1 187 193 PF00069 0.374
MOD_Plk_1 40 46 PF00069 0.425
MOD_Plk_1 452 458 PF00069 0.454
MOD_Plk_2-3 146 152 PF00069 0.447
MOD_Plk_2-3 178 184 PF00069 0.365
MOD_Plk_4 128 134 PF00069 0.356
MOD_Plk_4 2 8 PF00069 0.530
MOD_Plk_4 361 367 PF00069 0.330
MOD_Plk_4 385 391 PF00069 0.359
MOD_Plk_4 40 46 PF00069 0.355
MOD_Plk_4 425 431 PF00069 0.377
MOD_Plk_4 470 476 PF00069 0.269
MOD_ProDKin_1 36 42 PF00069 0.436
MOD_ProDKin_1 514 520 PF00069 0.761
MOD_SUMO_for_1 96 99 PF00179 0.583
TRG_DiLeu_BaEn_1 385 390 PF01217 0.329
TRG_DiLeu_BaLyEn_6 429 434 PF01217 0.334
TRG_ENDOCYTIC_2 129 132 PF00928 0.366
TRG_ENDOCYTIC_2 147 150 PF00928 0.447
TRG_ENDOCYTIC_2 192 195 PF00928 0.430
TRG_ENDOCYTIC_2 245 248 PF00928 0.285
TRG_ENDOCYTIC_2 63 66 PF00928 0.301

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y8 Leptomonas seymouri 53% 100%
A0A0S4IXB1 Bodo saltans 28% 100%
A0A0S4IXU4 Bodo saltans 29% 100%
A0A1X0NVP9 Trypanosomatidae 38% 100%
A0A1X0NWC8 Trypanosomatidae 36% 100%
A0A1X0P6A6 Trypanosomatidae 29% 100%
A0A3Q8IB78 Leishmania donovani 88% 100%
A0A3S7WVB2 Leishmania donovani 90% 100%
A0A422N059 Trypanosoma rangeli 37% 100%
A4HA16 Leishmania braziliensis 71% 100%
A4HY78 Leishmania infantum 87% 100%
A4HY79 Leishmania infantum 90% 100%
C9ZWF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 97%
D0A5X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 93%
E9AS08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9AS09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QDG5 Leishmania major 94% 97%
V5C1U9 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS