Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDG1_LEIMA

TriTrypDb:

LmjF.19.0600 , LMJLV39_190011600 , LMJSD75_190011200

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.517
CLV_C14_Caspase3-7	714	718	PF00656	0.614
CLV_NRD_NRD_1	282	284	PF00675	0.813
CLV_NRD_NRD_1	399	401	PF00675	0.784
CLV_NRD_NRD_1	442	444	PF00675	0.560
CLV_NRD_NRD_1	474	476	PF00675	0.631
CLV_NRD_NRD_1	483	485	PF00675	0.523
CLV_NRD_NRD_1	628	630	PF00675	0.573
CLV_NRD_NRD_1	69	71	PF00675	0.761
CLV_PCSK_FUR_1	388	392	PF00082	0.626
CLV_PCSK_KEX2_1	282	284	PF00082	0.739
CLV_PCSK_KEX2_1	390	392	PF00082	0.622
CLV_PCSK_KEX2_1	460	462	PF00082	0.664
CLV_PCSK_KEX2_1	474	476	PF00082	0.427
CLV_PCSK_KEX2_1	628	630	PF00082	0.573
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.622
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.664
CLV_PCSK_SKI1_1	467	471	PF00082	0.581
CLV_PCSK_SKI1_1	485	489	PF00082	0.441
CLV_PCSK_SKI1_1	521	525	PF00082	0.694
DEG_SCF_FBW7_1	756	763	PF00400	0.603
DEG_SPOP_SBC_1	212	216	PF00917	0.751
DEG_SPOP_SBC_1	37	41	PF00917	0.771
DOC_ANK_TNKS_1	335	342	PF00023	0.749
DOC_CKS1_1	204	209	PF01111	0.753
DOC_CKS1_1	298	303	PF01111	0.611
DOC_CKS1_1	729	734	PF01111	0.756
DOC_PP2B_LxvP_1	573	576	PF13499	0.621
DOC_PP2B_PxIxI_1	206	212	PF00149	0.712
DOC_SPAK_OSR1_1	699	703	PF12202	0.563
DOC_USP7_MATH_1	100	104	PF00917	0.745
DOC_USP7_MATH_1	129	133	PF00917	0.742
DOC_USP7_MATH_1	162	166	PF00917	0.813
DOC_USP7_MATH_1	168	172	PF00917	0.734
DOC_USP7_MATH_1	212	216	PF00917	0.675
DOC_USP7_MATH_1	221	225	PF00917	0.651
DOC_USP7_MATH_1	250	254	PF00917	0.823
DOC_USP7_MATH_1	292	296	PF00917	0.772
DOC_USP7_MATH_1	37	41	PF00917	0.815
DOC_USP7_MATH_1	386	390	PF00917	0.865
DOC_USP7_MATH_1	50	54	PF00917	0.630
DOC_USP7_MATH_1	511	515	PF00917	0.690
DOC_USP7_MATH_1	523	527	PF00917	0.639
DOC_USP7_MATH_1	534	538	PF00917	0.606
DOC_USP7_MATH_1	732	736	PF00917	0.684
DOC_WW_Pin1_4	101	106	PF00397	0.846
DOC_WW_Pin1_4	146	151	PF00397	0.749
DOC_WW_Pin1_4	164	169	PF00397	0.602
DOC_WW_Pin1_4	191	196	PF00397	0.657
DOC_WW_Pin1_4	203	208	PF00397	0.601
DOC_WW_Pin1_4	281	286	PF00397	0.643
DOC_WW_Pin1_4	297	302	PF00397	0.567
DOC_WW_Pin1_4	360	365	PF00397	0.817
DOC_WW_Pin1_4	415	420	PF00397	0.718
DOC_WW_Pin1_4	582	587	PF00397	0.704
DOC_WW_Pin1_4	728	733	PF00397	0.832
DOC_WW_Pin1_4	745	750	PF00397	0.558
DOC_WW_Pin1_4	756	761	PF00397	0.560
DOC_WW_Pin1_4	78	83	PF00397	0.830
LIG_14-3-3_CanoR_1	131	138	PF00244	0.827
LIG_14-3-3_CanoR_1	198	207	PF00244	0.722
LIG_14-3-3_CanoR_1	265	271	PF00244	0.815
LIG_14-3-3_CanoR_1	286	292	PF00244	0.798
LIG_14-3-3_CanoR_1	484	488	PF00244	0.440
LIG_14-3-3_CanoR_1	628	634	PF00244	0.691
LIG_14-3-3_CanoR_1	70	74	PF00244	0.819
LIG_Actin_WH2_2	332	348	PF00022	0.707
LIG_Actin_WH2_2	485	502	PF00022	0.422
LIG_Actin_WH2_2	583	599	PF00022	0.603
LIG_BIR_III_2	20	24	PF00653	0.743
LIG_EVH1_2	109	113	PF00568	0.767
LIG_FHA_1	186	192	PF00498	0.757
LIG_FHA_1	204	210	PF00498	0.521
LIG_FHA_1	351	357	PF00498	0.774
LIG_FHA_1	40	46	PF00498	0.660
LIG_FHA_1	757	763	PF00498	0.606
LIG_FHA_2	659	665	PF00498	0.687
LIG_LIR_Apic_2	230	236	PF02991	0.810
LIG_LIR_Apic_2	748	753	PF02991	0.643
LIG_LIR_Nem_3	432	438	PF02991	0.668
LIG_LIR_Nem_3	440	445	PF02991	0.501
LIG_LIR_Nem_3	617	623	PF02991	0.586
LIG_LIR_Nem_3	692	698	PF02991	0.790
LIG_LYPXL_yS_3	620	623	PF13949	0.591
LIG_MYND_1	749	753	PF01753	0.639
LIG_Pex14_2	667	671	PF04695	0.547
LIG_PTAP_UEV_1	104	109	PF05743	0.611
LIG_SH2_CRK	233	237	PF00017	0.817
LIG_SH2_CRK	435	439	PF00017	0.658
LIG_SH2_CRK	695	699	PF00017	0.795
LIG_SH2_STAT3	138	141	PF00017	0.863
LIG_SH2_STAT5	437	440	PF00017	0.644
LIG_SH2_STAT5	491	494	PF00017	0.417
LIG_SH2_STAT5	649	652	PF00017	0.595
LIG_SH2_STAT5	750	753	PF00017	0.649
LIG_SH3_1	750	756	PF00018	0.647
LIG_SH3_3	102	108	PF00018	0.840
LIG_SH3_3	201	207	PF00018	0.835
LIG_SH3_3	304	310	PF00018	0.695
LIG_SH3_3	358	364	PF00018	0.802
LIG_SH3_3	420	426	PF00018	0.798
LIG_SH3_3	559	565	PF00018	0.803
LIG_SH3_3	569	575	PF00018	0.644
LIG_SH3_3	606	612	PF00018	0.778
LIG_SH3_3	699	705	PF00018	0.793
LIG_SH3_3	743	749	PF00018	0.722
LIG_SH3_3	750	756	PF00018	0.636
LIG_SH3_3	80	86	PF00018	0.660
LIG_SUMO_SIM_par_1	585	592	PF11976	0.618
MOD_CDK_SPK_2	281	286	PF00069	0.589
MOD_CDK_SPxxK_3	191	198	PF00069	0.766
MOD_CK1_1	103	109	PF00069	0.836
MOD_CK1_1	132	138	PF00069	0.779
MOD_CK1_1	166	172	PF00069	0.833
MOD_CK1_1	194	200	PF00069	0.821
MOD_CK1_1	258	264	PF00069	0.824
MOD_CK1_1	39	45	PF00069	0.823
MOD_CK1_1	53	59	PF00069	0.644
MOD_CK1_1	552	558	PF00069	0.667
MOD_CK1_1	64	70	PF00069	0.694
MOD_CK1_1	672	678	PF00069	0.709
MOD_CK1_1	713	719	PF00069	0.823
MOD_CK1_1	735	741	PF00069	0.692
MOD_CK2_1	586	592	PF00069	0.628
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.602
MOD_GlcNHglycan	127	130	PF01048	0.824
MOD_GlcNHglycan	170	173	PF01048	0.768
MOD_GlcNHglycan	185	188	PF01048	0.584
MOD_GlcNHglycan	201	204	PF01048	0.560
MOD_GlcNHglycan	223	226	PF01048	0.773
MOD_GlcNHglycan	229	232	PF01048	0.691
MOD_GlcNHglycan	270	273	PF01048	0.719
MOD_GlcNHglycan	358	361	PF01048	0.777
MOD_GlcNHglycan	384	387	PF01048	0.868
MOD_GlcNHglycan	478	481	PF01048	0.580
MOD_GlcNHglycan	514	517	PF01048	0.637
MOD_GlcNHglycan	536	539	PF01048	0.578
MOD_GlcNHglycan	566	569	PF01048	0.591
MOD_GlcNHglycan	582	585	PF01048	0.705
MOD_GlcNHglycan	63	66	PF01048	0.782
MOD_GlcNHglycan	656	659	PF01048	0.482
MOD_GlcNHglycan	734	737	PF01048	0.735
MOD_GlcNHglycan	89	92	PF01048	0.800
MOD_GSK3_1	121	128	PF00069	0.835
MOD_GSK3_1	129	136	PF00069	0.700
MOD_GSK3_1	162	169	PF00069	0.840
MOD_GSK3_1	181	188	PF00069	0.530
MOD_GSK3_1	194	201	PF00069	0.639
MOD_GSK3_1	250	257	PF00069	0.820
MOD_GSK3_1	259	266	PF00069	0.685
MOD_GSK3_1	270	277	PF00069	0.505
MOD_GSK3_1	341	348	PF00069	0.788
MOD_GSK3_1	356	363	PF00069	0.588
MOD_GSK3_1	36	43	PF00069	0.820
MOD_GSK3_1	382	389	PF00069	0.852
MOD_GSK3_1	50	57	PF00069	0.618
MOD_GSK3_1	534	541	PF00069	0.505
MOD_GSK3_1	560	567	PF00069	0.766
MOD_GSK3_1	582	589	PF00069	0.662
MOD_GSK3_1	654	661	PF00069	0.663
MOD_GSK3_1	69	76	PF00069	0.581
MOD_GSK3_1	728	735	PF00069	0.788
MOD_GSK3_1	756	763	PF00069	0.603
MOD_LATS_1	196	202	PF00433	0.843
MOD_N-GLC_1	199	204	PF02516	0.646
MOD_N-GLC_1	263	268	PF02516	0.723
MOD_N-GLC_1	278	283	PF02516	0.679
MOD_N-GLC_1	552	557	PF02516	0.594
MOD_N-GLC_2	456	458	PF02516	0.423
MOD_NEK2_1	125	130	PF00069	0.855
MOD_NEK2_1	244	249	PF00069	0.705
MOD_NEK2_1	263	268	PF00069	0.577
MOD_NEK2_1	270	275	PF00069	0.750
MOD_NEK2_1	287	292	PF00069	0.563
MOD_NEK2_1	324	329	PF00069	0.751
MOD_NEK2_1	345	350	PF00069	0.727
MOD_NEK2_1	54	59	PF00069	0.687
MOD_NEK2_2	341	346	PF00069	0.738
MOD_PIKK_1	375	381	PF00454	0.747
MOD_PIKK_1	669	675	PF00454	0.758
MOD_PIKK_1	73	79	PF00454	0.856
MOD_PIKK_1	735	741	PF00454	0.770
MOD_PIKK_1	8	14	PF00454	0.787
MOD_PKA_1	443	449	PF00069	0.567
MOD_PKA_1	628	634	PF00069	0.551
MOD_PKA_2	130	136	PF00069	0.827
MOD_PKA_2	483	489	PF00069	0.436
MOD_PKA_2	627	633	PF00069	0.711
MOD_PKA_2	69	75	PF00069	0.856
MOD_Plk_1	199	205	PF00069	0.763
MOD_Plk_1	266	272	PF00069	0.687
MOD_Plk_1	461	467	PF00069	0.504
MOD_Plk_1	552	558	PF00069	0.601
MOD_Plk_1	616	622	PF00069	0.700
MOD_Plk_2-3	408	414	PF00069	0.744
MOD_Plk_2-3	616	622	PF00069	0.739
MOD_Plk_4	270	276	PF00069	0.827
MOD_Plk_4	351	357	PF00069	0.770
MOD_Plk_4	483	489	PF00069	0.436
MOD_ProDKin_1	101	107	PF00069	0.843
MOD_ProDKin_1	146	152	PF00069	0.750
MOD_ProDKin_1	164	170	PF00069	0.601
MOD_ProDKin_1	191	197	PF00069	0.656
MOD_ProDKin_1	203	209	PF00069	0.603
MOD_ProDKin_1	281	287	PF00069	0.646
MOD_ProDKin_1	297	303	PF00069	0.568
MOD_ProDKin_1	360	366	PF00069	0.817
MOD_ProDKin_1	415	421	PF00069	0.716
MOD_ProDKin_1	582	588	PF00069	0.695
MOD_ProDKin_1	728	734	PF00069	0.835
MOD_ProDKin_1	745	751	PF00069	0.560
MOD_ProDKin_1	756	762	PF00069	0.563
MOD_ProDKin_1	78	84	PF00069	0.829
MOD_SUMO_for_1	459	462	PF00179	0.627
MOD_SUMO_rev_2	479	487	PF00179	0.427
TRG_DiLeu_BaEn_1	483	488	PF01217	0.670
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.708
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.667
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.613
TRG_ENDOCYTIC_2	239	242	PF00928	0.816
TRG_ENDOCYTIC_2	435	438	PF00928	0.663
TRG_ENDOCYTIC_2	620	623	PF00928	0.591
TRG_ENDOCYTIC_2	695	698	PF00928	0.791
TRG_ER_diArg_1	3	6	PF00400	0.831
TRG_ER_diArg_1	473	475	PF00400	0.658
TRG_NES_CRM1_1	490	504	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEG9	Leishmania donovani	83%	98%
A4HA18	Leishmania braziliensis	53%	100%
A4HY81	Leishmania infantum	84%	98%
E9AS12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%