LeishMANIAdb
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CYTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CYTH domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QDF9_LEIMA
TriTrypDb:
LmjF.19.0620 , LMJLV39_190011800 * , LMJSD75_190011400 *
Length:
745

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDF9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0016462 pyrophosphatase activity 5 4
GO:0016787 hydrolase activity 2 4
GO:0016817 hydrolase activity, acting on acid anhydrides 3 4
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 195 199 PF00656 0.629
CLV_C14_Caspase3-7 255 259 PF00656 0.697
CLV_NRD_NRD_1 318 320 PF00675 0.365
CLV_NRD_NRD_1 438 440 PF00675 0.532
CLV_NRD_NRD_1 459 461 PF00675 0.774
CLV_NRD_NRD_1 507 509 PF00675 0.594
CLV_NRD_NRD_1 515 517 PF00675 0.496
CLV_PCSK_KEX2_1 438 440 PF00082 0.532
CLV_PCSK_KEX2_1 459 461 PF00082 0.732
CLV_PCSK_KEX2_1 507 509 PF00082 0.553
CLV_PCSK_KEX2_1 517 519 PF00082 0.478
CLV_PCSK_PC1ET2_1 517 519 PF00082 0.509
CLV_PCSK_SKI1_1 145 149 PF00082 0.503
CLV_PCSK_SKI1_1 319 323 PF00082 0.479
CLV_PCSK_SKI1_1 510 514 PF00082 0.569
CLV_PCSK_SKI1_1 523 527 PF00082 0.436
CLV_PCSK_SKI1_1 588 592 PF00082 0.428
DEG_APCC_DBOX_1 437 445 PF00400 0.543
DEG_Nend_UBRbox_3 1 3 PF02207 0.516
DEG_SPOP_SBC_1 106 110 PF00917 0.651
DOC_CDC14_PxL_1 655 663 PF14671 0.536
DOC_CYCLIN_yClb5_NLxxxL_5 438 445 PF00134 0.527
DOC_CYCLIN_yCln2_LP_2 133 139 PF00134 0.576
DOC_CYCLIN_yCln2_LP_2 597 603 PF00134 0.517
DOC_MAPK_DCC_7 654 663 PF00069 0.589
DOC_MAPK_DCC_7 95 104 PF00069 0.511
DOC_MAPK_FxFP_2 37 40 PF00069 0.426
DOC_MAPK_gen_1 345 355 PF00069 0.519
DOC_MAPK_gen_1 438 446 PF00069 0.536
DOC_MAPK_gen_1 507 515 PF00069 0.480
DOC_MAPK_MEF2A_6 128 137 PF00069 0.573
DOC_MAPK_MEF2A_6 348 355 PF00069 0.491
DOC_MAPK_MEF2A_6 419 428 PF00069 0.510
DOC_MAPK_MEF2A_6 47 55 PF00069 0.444
DOC_MAPK_MEF2A_6 654 663 PF00069 0.628
DOC_MAPK_MEF2A_6 95 104 PF00069 0.659
DOC_PP2B_LxvP_1 133 136 PF13499 0.647
DOC_PP2B_LxvP_1 369 372 PF13499 0.416
DOC_PP2B_LxvP_1 444 447 PF13499 0.541
DOC_PP2B_LxvP_1 53 56 PF13499 0.406
DOC_PP2B_LxvP_1 597 600 PF13499 0.490
DOC_PP2B_PxIxI_1 99 105 PF00149 0.524
DOC_PP4_FxxP_1 37 40 PF00568 0.426
DOC_PP4_FxxP_1 499 502 PF00568 0.539
DOC_USP7_MATH_1 105 109 PF00917 0.770
DOC_USP7_MATH_1 247 251 PF00917 0.753
DOC_USP7_MATH_1 254 258 PF00917 0.613
DOC_USP7_MATH_1 268 272 PF00917 0.615
DOC_USP7_MATH_1 452 456 PF00917 0.678
DOC_USP7_MATH_1 624 628 PF00917 0.686
DOC_USP7_MATH_1 71 75 PF00917 0.742
DOC_USP7_UBL2_3 145 149 PF12436 0.472
DOC_USP7_UBL2_3 289 293 PF12436 0.784
DOC_USP7_UBL2_3 575 579 PF12436 0.587
DOC_WW_Pin1_4 498 503 PF00397 0.543
LIG_14-3-3_CanoR_1 17 23 PF00244 0.518
LIG_14-3-3_CanoR_1 319 325 PF00244 0.414
LIG_14-3-3_CanoR_1 427 432 PF00244 0.475
LIG_14-3-3_CanoR_1 47 51 PF00244 0.571
LIG_14-3-3_CanoR_1 507 513 PF00244 0.524
LIG_14-3-3_CanoR_1 588 593 PF00244 0.476
LIG_14-3-3_CanoR_1 596 600 PF00244 0.406
LIG_14-3-3_CanoR_1 65 71 PF00244 0.614
LIG_14-3-3_CanoR_1 680 689 PF00244 0.619
LIG_Actin_WH2_2 305 321 PF00022 0.511
LIG_APCC_ABBA_1 661 666 PF00400 0.419
LIG_BRCT_BRCA1_1 201 205 PF00533 0.611
LIG_DLG_GKlike_1 508 515 PF00625 0.587
LIG_EVH1_1 655 659 PF00568 0.590
LIG_FHA_1 186 192 PF00498 0.614
LIG_FHA_1 406 412 PF00498 0.519
LIG_FHA_1 559 565 PF00498 0.450
LIG_FHA_1 592 598 PF00498 0.424
LIG_FHA_1 694 700 PF00498 0.502
LIG_FHA_1 716 722 PF00498 0.483
LIG_FHA_2 193 199 PF00498 0.624
LIG_FHA_2 334 340 PF00498 0.613
LIG_FHA_2 363 369 PF00498 0.551
LIG_FHA_2 491 497 PF00498 0.536
LIG_FXI_DFP_1 36 40 PF00024 0.420
LIG_GBD_Chelix_1 713 721 PF00786 0.564
LIG_LIR_Apic_2 34 40 PF02991 0.413
LIG_LIR_Apic_2 356 362 PF02991 0.507
LIG_LIR_Apic_2 496 502 PF02991 0.528
LIG_LIR_Apic_2 668 673 PF02991 0.467
LIG_LIR_Gen_1 202 212 PF02991 0.585
LIG_LIR_Gen_1 258 269 PF02991 0.695
LIG_LIR_Gen_1 30 41 PF02991 0.470
LIG_LIR_Gen_1 511 519 PF02991 0.553
LIG_LIR_Gen_1 569 577 PF02991 0.498
LIG_LIR_Gen_1 737 745 PF02991 0.477
LIG_LIR_Gen_1 84 93 PF02991 0.664
LIG_LIR_Nem_3 202 208 PF02991 0.590
LIG_LIR_Nem_3 258 264 PF02991 0.697
LIG_LIR_Nem_3 29 35 PF02991 0.462
LIG_LIR_Nem_3 323 327 PF02991 0.557
LIG_LIR_Nem_3 38 44 PF02991 0.410
LIG_LIR_Nem_3 401 407 PF02991 0.454
LIG_LIR_Nem_3 511 515 PF02991 0.508
LIG_LIR_Nem_3 569 574 PF02991 0.523
LIG_LIR_Nem_3 576 581 PF02991 0.517
LIG_LIR_Nem_3 737 742 PF02991 0.448
LIG_LIR_Nem_3 84 90 PF02991 0.667
LIG_LYPXL_yS_3 41 44 PF13949 0.485
LIG_MYND_3 306 310 PF01753 0.587
LIG_NRBOX 440 446 PF00104 0.541
LIG_PAM2_1 232 244 PF00658 0.592
LIG_PCNA_TLS_4 733 740 PF02747 0.510
LIG_Pex14_2 35 39 PF04695 0.391
LIG_SH2_CRK 324 328 PF00017 0.460
LIG_SH2_CRK 670 674 PF00017 0.518
LIG_SH2_SRC 241 244 PF00017 0.585
LIG_SH2_SRC 434 437 PF00017 0.486
LIG_SH2_SRC 567 570 PF00017 0.497
LIG_SH2_STAP1 33 37 PF00017 0.469
LIG_SH2_STAP1 367 371 PF00017 0.380
LIG_SH2_STAP1 407 411 PF00017 0.548
LIG_SH2_STAP1 567 571 PF00017 0.608
LIG_SH2_STAP1 63 67 PF00017 0.714
LIG_SH2_STAP1 697 701 PF00017 0.471
LIG_SH2_STAP1 87 91 PF00017 0.653
LIG_SH2_STAT3 211 214 PF00017 0.588
LIG_SH2_STAT3 275 278 PF00017 0.690
LIG_SH2_STAT3 637 640 PF00017 0.718
LIG_SH2_STAT5 359 362 PF00017 0.594
LIG_SH2_STAT5 407 410 PF00017 0.543
LIG_SH2_STAT5 489 492 PF00017 0.519
LIG_SH2_STAT5 524 527 PF00017 0.465
LIG_SH2_STAT5 631 634 PF00017 0.707
LIG_SH2_STAT5 637 640 PF00017 0.653
LIG_SH2_STAT5 739 742 PF00017 0.481
LIG_SH3_1 654 660 PF00018 0.626
LIG_SH3_3 237 243 PF00018 0.408
LIG_SH3_3 53 59 PF00018 0.565
LIG_SH3_3 653 659 PF00018 0.652
LIG_SH3_3 676 682 PF00018 0.695
LIG_SH3_3 704 710 PF00018 0.624
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.466
LIG_TRAF2_1 43 46 PF00917 0.527
LIG_UBA3_1 525 529 PF00899 0.459
MOD_CK1_1 108 114 PF00069 0.677
MOD_CK1_1 184 190 PF00069 0.636
MOD_CK1_1 194 200 PF00069 0.732
MOD_CK1_1 222 228 PF00069 0.545
MOD_CK1_1 283 289 PF00069 0.730
MOD_CK1_1 541 547 PF00069 0.589
MOD_CK1_1 66 72 PF00069 0.749
MOD_CK2_1 333 339 PF00069 0.601
MOD_CK2_1 340 346 PF00069 0.633
MOD_CK2_1 362 368 PF00069 0.572
MOD_CK2_1 460 466 PF00069 0.660
MOD_CK2_1 731 737 PF00069 0.448
MOD_GlcNHglycan 208 211 PF01048 0.499
MOD_GlcNHglycan 219 224 PF01048 0.568
MOD_GlcNHglycan 234 237 PF01048 0.483
MOD_GlcNHglycan 249 252 PF01048 0.733
MOD_GlcNHglycan 300 303 PF01048 0.588
MOD_GlcNHglycan 448 451 PF01048 0.561
MOD_GlcNHglycan 534 537 PF01048 0.618
MOD_GlcNHglycan 620 623 PF01048 0.672
MOD_GlcNHglycan 65 68 PF01048 0.676
MOD_GlcNHglycan 71 74 PF01048 0.741
MOD_GSK3_1 105 112 PF00069 0.628
MOD_GSK3_1 11 18 PF00069 0.559
MOD_GSK3_1 181 188 PF00069 0.574
MOD_GSK3_1 215 222 PF00069 0.429
MOD_GSK3_1 279 286 PF00069 0.742
MOD_GSK3_1 477 484 PF00069 0.674
MOD_GSK3_1 498 505 PF00069 0.548
MOD_GSK3_1 586 593 PF00069 0.509
MOD_GSK3_1 607 614 PF00069 0.547
MOD_GSK3_1 632 639 PF00069 0.652
MOD_GSK3_1 681 688 PF00069 0.608
MOD_NEK2_1 185 190 PF00069 0.553
MOD_NEK2_1 280 285 PF00069 0.741
MOD_NEK2_1 392 397 PF00069 0.510
MOD_NEK2_1 426 431 PF00069 0.552
MOD_NEK2_1 586 591 PF00069 0.440
MOD_NEK2_1 611 616 PF00069 0.656
MOD_NEK2_1 665 670 PF00069 0.424
MOD_NEK2_2 314 319 PF00069 0.475
MOD_NEK2_2 362 367 PF00069 0.608
MOD_NEK2_2 502 507 PF00069 0.570
MOD_PIKK_1 280 286 PF00454 0.715
MOD_PIKK_1 405 411 PF00454 0.578
MOD_PIKK_1 453 459 PF00454 0.664
MOD_PIKK_1 558 564 PF00454 0.492
MOD_PIKK_1 624 630 PF00454 0.705
MOD_PIKK_1 636 642 PF00454 0.637
MOD_PIKK_1 681 687 PF00454 0.731
MOD_PK_1 427 433 PF00069 0.488
MOD_PKA_2 405 411 PF00069 0.579
MOD_PKA_2 426 432 PF00069 0.560
MOD_PKA_2 46 52 PF00069 0.490
MOD_PKA_2 595 601 PF00069 0.514
MOD_PKB_1 516 524 PF00069 0.544
MOD_Plk_1 355 361 PF00069 0.454
MOD_Plk_1 45 51 PF00069 0.552
MOD_Plk_1 477 483 PF00069 0.669
MOD_Plk_1 502 508 PF00069 0.578
MOD_Plk_1 665 671 PF00069 0.389
MOD_Plk_1 715 721 PF00069 0.576
MOD_Plk_1 726 732 PF00069 0.549
MOD_Plk_4 158 164 PF00069 0.484
MOD_Plk_4 181 187 PF00069 0.574
MOD_Plk_4 355 361 PF00069 0.454
MOD_Plk_4 362 368 PF00069 0.510
MOD_Plk_4 46 52 PF00069 0.484
MOD_Plk_4 477 483 PF00069 0.655
MOD_Plk_4 508 514 PF00069 0.525
MOD_Plk_4 573 579 PF00069 0.519
MOD_Plk_4 58 64 PF00069 0.522
MOD_Plk_4 632 638 PF00069 0.685
MOD_Plk_4 716 722 PF00069 0.551
MOD_ProDKin_1 498 504 PF00069 0.544
MOD_SUMO_for_1 27 30 PF00179 0.510
MOD_SUMO_rev_2 395 405 PF00179 0.430
MOD_SUMO_rev_2 418 426 PF00179 0.548
TRG_DiLeu_BaEn_1 86 91 PF01217 0.699
TRG_DiLeu_BaEn_2 383 389 PF01217 0.545
TRG_DiLeu_BaLyEn_6 323 328 PF01217 0.501
TRG_DiLeu_BaLyEn_6 657 662 PF01217 0.552
TRG_ENDOCYTIC_2 32 35 PF00928 0.463
TRG_ENDOCYTIC_2 324 327 PF00928 0.448
TRG_ENDOCYTIC_2 41 44 PF00928 0.522
TRG_ENDOCYTIC_2 434 437 PF00928 0.441
TRG_ENDOCYTIC_2 739 742 PF00928 0.449
TRG_ENDOCYTIC_2 87 90 PF00928 0.658
TRG_ER_diArg_1 351 354 PF00400 0.467
TRG_ER_diArg_1 437 439 PF00400 0.525
TRG_ER_diArg_1 506 508 PF00400 0.512
TRG_ER_diArg_1 51 54 PF00400 0.401
TRG_ER_diArg_1 513 516 PF00400 0.412
TRG_NES_CRM1_1 716 727 PF08389 0.552
TRG_NLS_MonoExtN_4 514 520 PF00514 0.463
TRG_Pf-PMV_PEXEL_1 229 233 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 285 290 PF00026 0.694
TRG_Pf-PMV_PEXEL_1 439 443 PF00026 0.562
TRG_Pf-PMV_PEXEL_1 554 558 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMD6 Leptomonas seymouri 55% 93%
A0A1X0P6B2 Trypanosomatidae 28% 100%
A0A3S7WVE7 Leishmania donovani 93% 100%
A0A422NMW0 Trypanosoma rangeli 26% 100%
A4HA20 Leishmania braziliensis 79% 100%
A4HY83 Leishmania infantum 93% 100%
E9AS14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BX15 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS