Putative histone H3 variant

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone H3 variant V

Species:

Leishmania major

UniProt:

Q4QDF8_LEIMA

TriTrypDb:

LmjF.19.0630 , LMJLV39_190011900 , LMJSD75_190011500

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000781	chromosome, telomeric region	3	2
GO:0000786	nucleosome	3	7
GO:0005634	nucleus	5	2
GO:0032991	protein-containing complex	1	7
GO:0032993	protein-DNA complex	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0044815	DNA packaging complex	2	7
GO:0098687	chromosomal region	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDF8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006353	DNA-templated transcription termination	6	2
GO:0006369	termination of RNA polymerase II transcription	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0005198	structural molecule activity	1	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0030527	structural constituent of chromatin	2	7
GO:0046982	protein heterodimerization activity	4	7
GO:0046983	protein dimerization activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.328
CLV_NRD_NRD_1	48	50	PF00675	0.326
CLV_NRD_NRD_1	60	62	PF00675	0.362
CLV_NRD_NRD_1	77	79	PF00675	0.341
CLV_PCSK_KEX2_1	124	126	PF00082	0.341
CLV_PCSK_KEX2_1	48	50	PF00082	0.323
CLV_PCSK_KEX2_1	77	79	PF00082	0.341
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.341
CLV_PCSK_PC7_1	73	79	PF00082	0.341
CLV_PCSK_SKI1_1	124	128	PF00082	0.341
CLV_PCSK_SKI1_1	33	37	PF00082	0.304
CLV_PCSK_SKI1_1	78	82	PF00082	0.414
DOC_MAPK_gen_1	48	57	PF00069	0.538
DOC_MAPK_gen_1	61	71	PF00069	0.538
DOC_MAPK_MEF2A_6	131	139	PF00069	0.611
DOC_USP7_MATH_1	104	108	PF00917	0.525
DOC_USP7_UBL2_3	22	26	PF12436	0.558
DOC_USP7_UBL2_3	32	36	PF12436	0.541
DOC_WW_Pin1_4	71	76	PF00397	0.614
LIG_14-3-3_CanoR_1	125	129	PF00244	0.541
LIG_14-3-3_CanoR_1	65	71	PF00244	0.475
LIG_14-3-3_CanoR_1	94	101	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_FHA_1	52	58	PF00498	0.541
LIG_FHA_1	65	71	PF00498	0.541
LIG_FHA_2	84	90	PF00498	0.541
LIG_LIR_Nem_3	74	79	PF02991	0.567
LIG_NRBOX	108	114	PF00104	0.530
LIG_SH2_STAT5	108	111	PF00017	0.541
LIG_SUMO_SIM_par_1	53	59	PF11976	0.541
LIG_WRC_WIRS_1	84	89	PF05994	0.525
MOD_CDK_SPxK_1	71	77	PF00069	0.614
MOD_CDK_SPxxK_3	71	78	PF00069	0.614
MOD_CK2_1	93	99	PF00069	0.588
MOD_GlcNHglycan	41	44	PF01048	0.251
MOD_GlcNHglycan	95	98	PF01048	0.414
MOD_GSK3_1	104	111	PF00069	0.558
MOD_GSK3_1	83	90	PF00069	0.541
MOD_LATS_1	122	128	PF00433	0.541
MOD_N-GLC_2	117	119	PF02516	0.341
MOD_NEK2_1	87	92	PF00069	0.527
MOD_NEK2_1	93	98	PF00069	0.546
MOD_PK_1	26	32	PF00069	0.447
MOD_PKA_1	124	130	PF00069	0.541
MOD_PKA_2	124	130	PF00069	0.541
MOD_PKA_2	64	70	PF00069	0.475
MOD_PKA_2	93	99	PF00069	0.547
MOD_PKB_1	49	57	PF00069	0.515
MOD_Plk_4	104	110	PF00069	0.525
MOD_Plk_4	124	130	PF00069	0.433
MOD_ProDKin_1	71	77	PF00069	0.614
MOD_SUMO_for_1	31	34	PF00179	0.525
MOD_SUMO_rev_2	29	38	PF00179	0.558
TRG_ER_diArg_1	137	140	PF00400	0.541
TRG_ER_diArg_1	48	50	PF00400	0.528
TRG_ER_diArg_1	76	78	PF00400	0.541
TRG_NLS_Bipartite_1	15	29	PF00514	0.430
TRG_NLS_MonoExtN_4	22	29	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE44	Leptomonas seymouri	74%	99%
A0A0S4IWA8	Bodo saltans	58%	100%
A0A0S4J721	Bodo saltans	62%	100%
A0A1X0P6L2	Trypanosomatidae	55%	93%
A0A3Q8IC67	Leishmania donovani	56%	100%
A0A3R7KFK4	Trypanosoma rangeli	53%	95%
A0A3S7WVC7	Leishmania donovani	91%	99%
A0A422MY47	Trypanosoma rangeli	59%	100%
A1CP80	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	54%	100%
A1D240	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	54%	100%
A2QRR5	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	54%	100%
A2XHJ3	Oryza sativa subsp. indica	56%	100%
A2Y533	Oryza sativa subsp. indica	63%	100%
A3GHN6	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	55%	100%
A3LXD5	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	53%	100%
A4H675	Leishmania braziliensis	56%	100%
A4HA21	Leishmania braziliensis	73%	99%
A4HUJ9	Leishmania infantum	56%	100%
A4HWV9	Leishmania infantum	62%	100%
A4HY84	Leishmania infantum	91%	99%
A4RCX7	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	55%	100%
A5DFC5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	53%	100%
A5DG57	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	61%	100%
A5DWE2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	53%	100%
A5E094	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	54%	100%
A5PK61	Bos taurus	58%	100%
C0HL66	Drosophila melanogaster	55%	100%
C0HL67	Drosophila melanogaster	55%	100%
C9ZIG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AN97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9AQL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9AS15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
G9CU80	Leishmania donovani	62%	100%
O15819	Dictyostelium discoideum	49%	100%
O35216	Mus musculus	40%	100%
P02299	Drosophila melanogaster	62%	100%
P02301	Mus musculus	59%	100%
P02302	Xenopus laevis	56%	100%
P06352	Strongylocentrotus purpuratus	62%	100%
P06902	Cairina moschata	49%	100%
P07041	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	55%	100%
P08437	Volvox carteri	56%	100%
P08898	Caenorhabditis elegans	57%	100%
P08903	Encephalartos altensteinii	62%	100%
P09988	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	100%
P0CO04	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	53%	100%
P0CO05	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	53%	100%
P0DPK2	Homo sapiens	50%	100%
P0DPK5	Homo sapiens	53%	98%
P10651	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	100%
P15512	Tetrahymena pyriformis	50%	100%
P22843	Acropora formosa	58%	100%
P23753	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	54%	100%
P40285	Leishmania infantum	54%	100%
P41353	Tetrahymena thermophila (strain SB210)	50%	100%
P49450	Homo sapiens	49%	100%
P50564	Chlamydomonas reinhardtii	55%	100%
P59169	Arabidopsis thaliana	56%	100%
P59226	Arabidopsis thaliana	63%	100%
P61830	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	52%	100%
P61831	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	52%	100%
P61832	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	54%	100%
P61833	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	52%	100%
P61834	Talaromyces funiculosus	54%	100%
P61835	Hypocrea jecorina	55%	100%
P61836	Zygosaccharomyces bailii	52%	100%
P68427	Pisum sativum	63%	100%
P68428	Triticum aestivum	63%	100%
P68429	Medicago sativa	63%	100%
P68430	Onobrychis viciifolia	63%	100%
P68431	Homo sapiens	56%	100%
P68432	Bos taurus	56%	100%
P68433	Mus musculus	56%	100%
P69071	Dermasterias imbricata	62%	100%
P69072	Lytechinus pictus	62%	100%
P69073	Paracentrotus lividus	62%	100%
P69074	Pisaster brevispinus	62%	100%
P69075	Pisaster ochraceus	62%	100%
P69076	Psammechinus miliaris	62%	100%
P69077	Pycnopodia helianthoides	62%	100%
P69078	Solaster stimpsoni	62%	100%
P69079	Strongylocentrotus droebachiensis	62%	100%
P69149	Tetrahymena pyriformis	59%	100%
P69150	Tetrahymena thermophila	59%	100%
P69244	Medicago sativa	56%	100%
P69245	Lolium temulentum	56%	100%
P69246	Zea mays	63%	100%
P69248	Petroselinum crispum	63%	100%
P80553	Narcissus pseudonarcissus	56%	100%
P81198	Stylonychia lemnae	54%	100%
P81199	Stylonychia lemnae	46%	100%
P81202	Stylonychia lemnae	48%	100%
P84227	Bos taurus	62%	100%
P84228	Mus musculus	62%	100%
P84229	Gallus gallus	62%	100%
P84230	Cairina moschata	62%	100%
P84231	Ictiobus bubalus	62%	100%
P84232	Poroderma africanum	62%	100%
P84233	Xenopus laevis	62%	100%
P84234	Oncorhynchus mykiss	62%	100%
P84235	Platynereis dumerilii	62%	100%
P84236	Drosophila hydei	62%	100%
P84237	Tigriopus californicus	62%	100%
P84238	Chironomus thummi thummi	62%	100%
P84239	Urechis caupo	62%	100%
P84243	Homo sapiens	55%	100%
P84244	Mus musculus	55%	100%
P84245	Rattus norvegicus	55%	100%
P84246	Oryctolagus cuniculus	55%	100%
P84247	Gallus gallus	55%	100%
P84248	Spisula solidissima	55%	100%
P84250	Drosophila hydei	55%	100%
P90543	Euplotes crassus	54%	100%
Q06196	Entamoeba histolytica	49%	100%
Q0D0E8	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	54%	100%
Q0JCT1	Oryza sativa subsp. japonica	56%	100%
Q0MTC0	Kluyveromyces marxianus	49%	75%
Q0MXD1	Millerozyma farinosa	55%	91%
Q0UY45	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	55%	100%
Q10453	Caenorhabditis elegans	55%	100%
Q16695	Homo sapiens	53%	100%
Q1E225	Coccidioides immitis (strain RS)	61%	100%
Q22RG7	Tetrahymena thermophila (strain SB210)	50%	100%
Q27489	Caenorhabditis elegans	57%	100%
Q27490	Caenorhabditis elegans	51%	100%
Q27532	Caenorhabditis elegans	60%	100%
Q28D37	Xenopus tropicalis	62%	100%
Q28I31	Xenopus tropicalis	44%	96%
Q2N2K6	Tetrahymena thermophila (strain SB210)	44%	77%
Q2RAD9	Oryza sativa subsp. japonica	63%	100%
Q2UCQ0	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	54%	100%
Q2Z2F4	Lilium longiflorum	59%	100%
Q3C2E5	Lolium multiflorum	56%	100%
Q402E1	Lilium longiflorum	64%	100%
Q402E2	Lilium longiflorum	54%	100%
Q42681	Chlamydomonas reinhardtii	55%	100%
Q4IER8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	55%	100%
Q4P7J7	Ustilago maydis (strain 521 / FGSC 9021)	59%	100%
Q4PB04	Ustilago maydis (strain 521 / FGSC 9021)	61%	100%
Q4QEV9	Leishmania major	56%	100%
Q4QHB5	Leishmania major	56%	100%
Q4QRF4	Danio rerio	62%	100%
Q55BN9	Dictyostelium discoideum	59%	100%
Q55BP0	Dictyostelium discoideum	60%	100%
Q569M3	Xenopus laevis	50%	96%
Q59LN9	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	68%
Q59VN2	Candida albicans (strain SC5314 / ATCC MYA-2876)	53%	100%
Q5ADQ0	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	100%
Q5DWI3	Marchantia polymorpha	55%	100%
Q5E9F8	Bos taurus	55%	100%
Q5MYA4	Cichorium intybus	63%	100%
Q5RCC9	Pongo abelii	54%	100%
Q5TEC6	Homo sapiens	55%	100%
Q64400	Cricetulus longicaudatus	55%	100%
Q6BMU4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	55%	100%
Q6BRZ5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	53%	100%
Q6C0C4	Yarrowia lipolytica (strain CLIB 122 / E 150)	50%	100%
Q6CER9	Yarrowia lipolytica (strain CLIB 122 / E 150)	51%	96%
Q6CTI2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	41%	78%
Q6DL03	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	55%	100%
Q6LBE3	Asparagus officinalis	63%	100%
Q6LBE8	Mus pahari	62%	100%
Q6LBF0	Mus pahari	56%	100%
Q6LCK1	Brassica napus	63%	100%
Q6LCW8	Chlamydomonas reinhardtii	56%	100%
Q6LED0	Rattus norvegicus	56%	100%
Q6NXT2	Homo sapiens	55%	100%
Q6P823	Xenopus tropicalis	55%	100%
Q6PI20	Danio rerio	55%	100%
Q6PI79	Xenopus laevis	55%	100%
Q6RUR1	Capsicum annuum	56%	100%
Q6T367	Oryza sativa subsp. japonica	55%	88%
Q711T2	Pinus pinaster	56%	100%
Q71DI3	Homo sapiens	62%	100%
Q71H73	Vitis vinifera	56%	100%
Q71LE2	Sus scrofa	55%	100%
Q71T45	Euphorbia esula	63%	100%
Q71U98	Oryza coarctata	56%	100%
Q71V89	Gossypium hirsutum	56%	100%
Q757N1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	52%	100%
Q75DE4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	53%	71%
Q76MV0	Nicotiana tabacum	63%	100%
Q76N23	Nicotiana tabacum	56%	100%
Q7RXR3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	93%
Q7XYZ0	Griffithsia japonica	54%	100%
Q803H4	Danio rerio	52%	99%
Q8R565	Cricetulus griseus	45%	100%
Q8RVQ9	Arabidopsis thaliana	47%	81%
Q8SQP3	Encephalitozoon cuniculi (strain GB-M1)	39%	100%
Q8SS77	Encephalitozoon cuniculi (strain GB-M1)	50%	100%
Q8WSF1	Trichinella pseudospiralis	55%	100%
Q98RY4	Guillardia theta	54%	100%
Q9FKQ3	Arabidopsis thaliana	54%	100%
Q9FX60	Arabidopsis thaliana	53%	100%
Q9FXI7	Arabidopsis thaliana	54%	100%
Q9HDN1	Mortierella alpina	63%	100%
Q9LR02	Arabidopsis thaliana	56%	100%
Q9LXU8	Arabidopsis thaliana	53%	100%
Q9P427	Ajellomyces capsulatus	53%	100%
Q9U281	Caenorhabditis elegans	55%	100%
Q9U7D1	Mastigamoeba balamuthi	54%	100%
Q9Y812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
V5BEW0	Trypanosoma cruzi	59%	100%
V5BSE9	Trypanosoma cruzi	54%	95%