Putative extracellular receptor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

extracellular receptor, putative

Species:

Leishmania major

UniProt:

Q4QDF7_LEIMA

TriTrypDb:

LmjF.19.0640 , LMJLV39_190012000 , LMJSD75_190011600

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QDF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDF7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	5
GO:0004930	G protein-coupled receptor activity	4	5
GO:0004965	G protein-coupled GABA receptor activity	5	3
GO:0016917	GABA receptor activity	4	3
GO:0038023	signaling receptor activity	2	5
GO:0060089	molecular transducer activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	790	794	PF00656	0.488
CLV_NRD_NRD_1	106	108	PF00675	0.538
CLV_NRD_NRD_1	205	207	PF00675	0.652
CLV_NRD_NRD_1	215	217	PF00675	0.662
CLV_NRD_NRD_1	661	663	PF00675	0.619
CLV_PCSK_FUR_1	213	217	PF00082	0.646
CLV_PCSK_KEX2_1	106	108	PF00082	0.661
CLV_PCSK_KEX2_1	205	207	PF00082	0.637
CLV_PCSK_KEX2_1	215	217	PF00082	0.613
CLV_PCSK_SKI1_1	120	124	PF00082	0.543
CLV_PCSK_SKI1_1	377	381	PF00082	0.558
CLV_PCSK_SKI1_1	856	860	PF00082	0.541
DEG_APCC_DBOX_1	119	127	PF00400	0.356
DEG_APCC_DBOX_1	226	234	PF00400	0.405
DEG_SPOP_SBC_1	174	178	PF00917	0.514
DOC_CDC14_PxL_1	230	238	PF14671	0.480
DOC_CYCLIN_yCln2_LP_2	27	33	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.363
DOC_MAPK_gen_1	213	223	PF00069	0.381
DOC_MAPK_gen_1	624	633	PF00069	0.346
DOC_MAPK_HePTP_8	566	578	PF00069	0.368
DOC_MAPK_MEF2A_6	569	578	PF00069	0.336
DOC_MAPK_MEF2A_6	765	772	PF00069	0.469
DOC_PP1_RVXF_1	305	312	PF00149	0.345
DOC_PP4_FxxP_1	467	470	PF00568	0.366
DOC_USP7_MATH_1	151	155	PF00917	0.520
DOC_USP7_MATH_1	217	221	PF00917	0.424
DOC_USP7_MATH_1	384	388	PF00917	0.371
DOC_USP7_MATH_1	614	618	PF00917	0.394
DOC_USP7_MATH_1	68	72	PF00917	0.411
DOC_USP7_MATH_1	92	96	PF00917	0.402
DOC_USP7_MATH_2	258	264	PF00917	0.480
DOC_USP7_UBL2_3	565	569	PF12436	0.419
DOC_WW_Pin1_4	253	258	PF00397	0.404
DOC_WW_Pin1_4	371	376	PF00397	0.383
DOC_WW_Pin1_4	382	387	PF00397	0.345
DOC_WW_Pin1_4	458	463	PF00397	0.316
DOC_WW_Pin1_4	680	685	PF00397	0.395
DOC_WW_Pin1_4	764	769	PF00397	0.404
DOC_WW_Pin1_4	802	807	PF00397	0.475
LIG_14-3-3_CanoR_1	106	110	PF00244	0.323
LIG_14-3-3_CanoR_1	216	222	PF00244	0.414
LIG_14-3-3_CanoR_1	443	448	PF00244	0.316
LIG_14-3-3_CanoR_1	530	535	PF00244	0.368
LIG_14-3-3_CanoR_1	591	599	PF00244	0.419
LIG_14-3-3_CanoR_1	662	671	PF00244	0.370
LIG_14-3-3_CanoR_1	721	728	PF00244	0.329
LIG_Actin_WH2_2	363	379	PF00022	0.478
LIG_BRCT_BRCA1_1	262	266	PF00533	0.494
LIG_BRCT_BRCA1_1	396	400	PF00533	0.429
LIG_BRCT_BRCA1_1	59	63	PF00533	0.435
LIG_BRCT_BRCA1_1	754	758	PF00533	0.445
LIG_BRCT_BRCA1_1	798	802	PF00533	0.501
LIG_Clathr_ClatBox_1	290	294	PF01394	0.420
LIG_deltaCOP1_diTrp_1	774	779	PF00928	0.385
LIG_DLG_GKlike_1	792	800	PF00625	0.496
LIG_EH_1	578	582	PF12763	0.419
LIG_EH1_1	829	837	PF00400	0.643
LIG_eIF4E_1	830	836	PF01652	0.587
LIG_FHA_1	151	157	PF00498	0.505
LIG_FHA_1	160	166	PF00498	0.432
LIG_FHA_1	202	208	PF00498	0.444
LIG_FHA_1	313	319	PF00498	0.356
LIG_FHA_1	345	351	PF00498	0.405
LIG_FHA_1	365	371	PF00498	0.248
LIG_FHA_1	376	382	PF00498	0.350
LIG_FHA_1	459	465	PF00498	0.313
LIG_FHA_1	47	53	PF00498	0.426
LIG_FHA_1	480	486	PF00498	0.409
LIG_FHA_1	546	552	PF00498	0.375
LIG_FHA_1	65	71	PF00498	0.390
LIG_FHA_1	817	823	PF00498	0.423
LIG_FHA_1	82	88	PF00498	0.352
LIG_FHA_1	9	15	PF00498	0.454
LIG_FHA_2	175	181	PF00498	0.420
LIG_FHA_2	271	277	PF00498	0.491
LIG_FHA_2	347	353	PF00498	0.338
LIG_FHA_2	497	503	PF00498	0.372
LIG_FHA_2	519	525	PF00498	0.419
LIG_FHA_2	556	562	PF00498	0.419
LIG_FHA_2	582	588	PF00498	0.369
LIG_FHA_2	648	654	PF00498	0.372
LIG_FHA_2	655	661	PF00498	0.328
LIG_FHA_2	721	727	PF00498	0.346
LIG_FHA_2	788	794	PF00498	0.466
LIG_FHA_2	81	87	PF00498	0.475
LIG_FHA_2	846	852	PF00498	0.663
LIG_LIR_Apic_2	253	258	PF02991	0.422
LIG_LIR_Apic_2	466	470	PF02991	0.354
LIG_LIR_Gen_1	329	337	PF02991	0.371
LIG_LIR_Gen_1	499	508	PF02991	0.337
LIG_LIR_Gen_1	564	575	PF02991	0.395
LIG_LIR_Gen_1	691	700	PF02991	0.334
LIG_LIR_Gen_1	773	780	PF02991	0.463
LIG_LIR_Nem_3	276	281	PF02991	0.410
LIG_LIR_Nem_3	329	335	PF02991	0.350
LIG_LIR_Nem_3	415	421	PF02991	0.391
LIG_LIR_Nem_3	487	491	PF02991	0.351
LIG_LIR_Nem_3	499	503	PF02991	0.326
LIG_LIR_Nem_3	564	570	PF02991	0.391
LIG_LIR_Nem_3	57	61	PF02991	0.450
LIG_LIR_Nem_3	587	592	PF02991	0.368
LIG_LIR_Nem_3	593	598	PF02991	0.344
LIG_LIR_Nem_3	683	688	PF02991	0.348
LIG_LIR_Nem_3	691	697	PF02991	0.310
LIG_LIR_Nem_3	773	778	PF02991	0.425
LIG_LYPXL_S_1	633	637	PF13949	0.619
LIG_LYPXL_yS_3	634	637	PF13949	0.419
LIG_NRBOX	282	288	PF00104	0.409
LIG_OCRL_FandH_1	824	836	PF00620	0.481
LIG_PDZ_Class_3	857	862	PF00595	0.749
LIG_Pex14_1	247	251	PF04695	0.362
LIG_Pex14_2	758	762	PF04695	0.440
LIG_PTB_Apo_2	138	145	PF02174	0.407
LIG_PTB_Apo_2	475	482	PF02174	0.386
LIG_PTB_Apo_2	648	655	PF02174	0.252
LIG_PTB_Phospho_1	138	144	PF10480	0.408
LIG_PTB_Phospho_1	648	654	PF10480	0.252
LIG_REV1ctd_RIR_1	587	595	PF16727	0.428
LIG_SH2_CRK	255	259	PF00017	0.427
LIG_SH2_CRK	567	571	PF00017	0.391
LIG_SH2_GRB2like	649	652	PF00017	0.252
LIG_SH2_NCK_1	255	259	PF00017	0.404
LIG_SH2_PTP2	694	697	PF00017	0.395
LIG_SH2_SRC	544	547	PF00017	0.391
LIG_SH2_STAP1	133	137	PF00017	0.387
LIG_SH2_STAP1	353	357	PF00017	0.480
LIG_SH2_STAP1	567	571	PF00017	0.365
LIG_SH2_STAP1	745	749	PF00017	0.395
LIG_SH2_STAT3	598	601	PF00017	0.419
LIG_SH2_STAT3	830	833	PF00017	0.599
LIG_SH2_STAT5	23	26	PF00017	0.441
LIG_SH2_STAT5	255	258	PF00017	0.373
LIG_SH2_STAT5	314	317	PF00017	0.431
LIG_SH2_STAT5	480	483	PF00017	0.367
LIG_SH2_STAT5	490	493	PF00017	0.301
LIG_SH2_STAT5	544	547	PF00017	0.419
LIG_SH2_STAT5	550	553	PF00017	0.348
LIG_SH2_STAT5	595	598	PF00017	0.349
LIG_SH2_STAT5	602	605	PF00017	0.286
LIG_SH2_STAT5	649	652	PF00017	0.375
LIG_SH2_STAT5	694	697	PF00017	0.344
LIG_SH2_STAT5	719	722	PF00017	0.395
LIG_SH2_STAT5	824	827	PF00017	0.580
LIG_SH3_5	470	474	PF00018	0.368
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.466
LIG_SUMO_SIM_anti_2	515	522	PF11976	0.316
LIG_SUMO_SIM_anti_2	572	578	PF11976	0.346
LIG_SUMO_SIM_anti_2	82	91	PF11976	0.402
LIG_SUMO_SIM_par_1	121	127	PF11976	0.419
LIG_SUMO_SIM_par_1	288	294	PF11976	0.417
LIG_SUMO_SIM_par_1	31	37	PF11976	0.429
LIG_SUMO_SIM_par_1	421	427	PF11976	0.378
LIG_SUMO_SIM_par_1	48	53	PF11976	0.420
LIG_SUMO_SIM_par_1	515	522	PF11976	0.368
LIG_SUMO_SIM_par_1	82	91	PF11976	0.463
LIG_SxIP_EBH_1	432	443	PF03271	0.366
LIG_TRAF2_1	657	660	PF00917	0.420
LIG_TRAF2_1	848	851	PF00917	0.678
LIG_TYR_ITIM	323	328	PF00017	0.405
LIG_UBA3_1	290	297	PF00899	0.401
LIG_WRC_WIRS_1	788	793	PF05994	0.467
MOD_CDC14_SPxK_1	374	377	PF00782	0.370
MOD_CDK_SPxK_1	371	377	PF00069	0.382
MOD_CK1_1	131	137	PF00069	0.315
MOD_CK1_1	226	232	PF00069	0.425
MOD_CK1_1	253	259	PF00069	0.402
MOD_CK1_1	333	339	PF00069	0.373
MOD_CK1_1	533	539	PF00069	0.431
MOD_CK1_1	673	679	PF00069	0.374
MOD_CK1_1	680	686	PF00069	0.329
MOD_CK1_1	764	770	PF00069	0.396
MOD_CK1_1	91	97	PF00069	0.395
MOD_CK2_1	2	8	PF00069	0.421
MOD_CK2_1	581	587	PF00069	0.280
MOD_CK2_1	654	660	PF00069	0.372
MOD_CK2_1	669	675	PF00069	0.242
MOD_CK2_1	80	86	PF00069	0.344
MOD_CK2_1	845	851	PF00069	0.669
MOD_GlcNHglycan	17	20	PF01048	0.684
MOD_GlcNHglycan	252	255	PF01048	0.605
MOD_GlcNHglycan	303	306	PF01048	0.582
MOD_GlcNHglycan	367	370	PF01048	0.668
MOD_GlcNHglycan	429	432	PF01048	0.499
MOD_GlcNHglycan	607	610	PF01048	0.619
MOD_GlcNHglycan	616	619	PF01048	0.513
MOD_GlcNHglycan	69	73	PF01048	0.609
MOD_GlcNHglycan	754	757	PF01048	0.625
MOD_GlcNHglycan	802	805	PF01048	0.689
MOD_GlcNHglycan	90	93	PF01048	0.583
MOD_GSK3_1	101	108	PF00069	0.392
MOD_GSK3_1	124	131	PF00069	0.424
MOD_GSK3_1	133	140	PF00069	0.366
MOD_GSK3_1	151	158	PF00069	0.342
MOD_GSK3_1	266	273	PF00069	0.496
MOD_GSK3_1	333	340	PF00069	0.356
MOD_GSK3_1	371	378	PF00069	0.419
MOD_GSK3_1	4	11	PF00069	0.425
MOD_GSK3_1	446	453	PF00069	0.374
MOD_GSK3_1	46	53	PF00069	0.430
MOD_GSK3_1	526	533	PF00069	0.326
MOD_GSK3_1	545	552	PF00069	0.238
MOD_GSK3_1	581	588	PF00069	0.430
MOD_GSK3_1	590	597	PF00069	0.388
MOD_GSK3_1	64	71	PF00069	0.399
MOD_GSK3_1	649	656	PF00069	0.412
MOD_GSK3_1	669	676	PF00069	0.320
MOD_GSK3_1	726	733	PF00069	0.349
MOD_GSK3_1	792	799	PF00069	0.470
MOD_GSK3_1	88	95	PF00069	0.390
MOD_N-GLC_1	15	20	PF02516	0.698
MOD_N-GLC_1	240	245	PF02516	0.721
MOD_N-GLC_1	301	306	PF02516	0.611
MOD_N-GLC_1	364	369	PF02516	0.650
MOD_N-GLC_1	411	416	PF02516	0.686
MOD_N-GLC_1	555	560	PF02516	0.571
MOD_N-GLC_1	635	640	PF02516	0.597
MOD_N-GLC_1	706	711	PF02516	0.537
MOD_N-GLC_1	752	757	PF02516	0.583
MOD_N-GLC_1	781	786	PF02516	0.664
MOD_N-GLC_1	80	85	PF02516	0.675
MOD_NEK2_1	14	19	PF00069	0.492
MOD_NEK2_1	240	245	PF00069	0.377
MOD_NEK2_1	281	286	PF00069	0.356
MOD_NEK2_1	370	375	PF00069	0.426
MOD_NEK2_1	394	399	PF00069	0.424
MOD_NEK2_1	400	405	PF00069	0.453
MOD_NEK2_1	433	438	PF00069	0.252
MOD_NEK2_1	491	496	PF00069	0.328
MOD_NEK2_1	526	531	PF00069	0.389
MOD_NEK2_1	581	586	PF00069	0.392
MOD_NEK2_1	605	610	PF00069	0.424
MOD_NEK2_1	696	701	PF00069	0.379
MOD_NEK2_1	752	757	PF00069	0.457
MOD_NEK2_1	758	763	PF00069	0.365
MOD_NEK2_1	780	785	PF00069	0.454
MOD_NEK2_1	796	801	PF00069	0.389
MOD_NEK2_1	816	821	PF00069	0.311
MOD_NEK2_1	88	93	PF00069	0.421
MOD_NEK2_2	217	222	PF00069	0.441
MOD_NEK2_2	23	28	PF00069	0.433
MOD_NEK2_2	337	342	PF00069	0.326
MOD_NEK2_2	644	649	PF00069	0.363
MOD_NEK2_2	787	792	PF00069	0.381
MOD_PIKK_1	260	266	PF00454	0.402
MOD_PIKK_1	389	395	PF00454	0.441
MOD_PIKK_1	43	49	PF00454	0.447
MOD_PIKK_1	503	509	PF00454	0.363
MOD_PIKK_1	581	587	PF00454	0.428
MOD_PIKK_1	635	641	PF00454	0.407
MOD_PK_1	721	727	PF00069	0.342
MOD_PKA_2	105	111	PF00069	0.433
MOD_PKA_2	226	232	PF00069	0.429
MOD_PKA_2	590	596	PF00069	0.419
MOD_PKA_2	720	726	PF00069	0.316
MOD_PKB_1	310	318	PF00069	0.435
MOD_Plk_1	2	8	PF00069	0.432
MOD_Plk_1	301	307	PF00069	0.407
MOD_Plk_1	545	551	PF00069	0.337
MOD_Plk_1	555	561	PF00069	0.332
MOD_Plk_1	677	683	PF00069	0.319
MOD_Plk_1	706	712	PF00069	0.352
MOD_Plk_1	730	736	PF00069	0.411
MOD_Plk_1	773	779	PF00069	0.460
MOD_Plk_1	781	787	PF00069	0.476
MOD_Plk_1	792	798	PF00069	0.316
MOD_Plk_4	128	134	PF00069	0.461
MOD_Plk_4	161	167	PF00069	0.434
MOD_Plk_4	183	189	PF00069	0.412
MOD_Plk_4	217	223	PF00069	0.446
MOD_Plk_4	327	333	PF00069	0.328
MOD_Plk_4	394	400	PF00069	0.359
MOD_Plk_4	413	419	PF00069	0.357
MOD_Plk_4	434	440	PF00069	0.379
MOD_Plk_4	443	449	PF00069	0.306
MOD_Plk_4	545	551	PF00069	0.383
MOD_Plk_4	57	63	PF00069	0.415
MOD_Plk_4	585	591	PF00069	0.379
MOD_Plk_4	594	600	PF00069	0.350
MOD_Plk_4	644	650	PF00069	0.407
MOD_Plk_4	70	76	PF00069	0.422
MOD_Plk_4	792	798	PF00069	0.508
MOD_ProDKin_1	253	259	PF00069	0.412
MOD_ProDKin_1	371	377	PF00069	0.380
MOD_ProDKin_1	382	388	PF00069	0.347
MOD_ProDKin_1	458	464	PF00069	0.316
MOD_ProDKin_1	680	686	PF00069	0.395
MOD_ProDKin_1	764	770	PF00069	0.398
MOD_ProDKin_1	802	808	PF00069	0.471
MOD_SUMO_rev_2	95	104	PF00179	0.458
TRG_DiLeu_BaEn_1	660	665	PF01217	0.363
TRG_DiLeu_BaEn_2	276	282	PF01217	0.425
TRG_DiLeu_BaEn_4	850	856	PF01217	0.680
TRG_ENDOCYTIC_2	278	281	PF00928	0.386
TRG_ENDOCYTIC_2	325	328	PF00928	0.386
TRG_ENDOCYTIC_2	488	491	PF00928	0.316
TRG_ENDOCYTIC_2	567	570	PF00928	0.395
TRG_ENDOCYTIC_2	602	605	PF00928	0.316
TRG_ENDOCYTIC_2	634	637	PF00928	0.419
TRG_ENDOCYTIC_2	685	688	PF00928	0.343
TRG_ENDOCYTIC_2	694	697	PF00928	0.298
TRG_ER_diArg_1	190	193	PF00400	0.402
TRG_ER_diArg_1	205	207	PF00400	0.316
TRG_ER_diArg_1	213	216	PF00400	0.406
TRG_NES_CRM1_1	115	129	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	662	667	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	856	860	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK8	Leptomonas seymouri	66%	87%
A0A0S4ITA9	Bodo saltans	37%	100%
A0A1X0P7Q8	Trypanosomatidae	43%	97%
A0A3S7WVK2	Leishmania donovani	97%	100%
A0A422NN34	Trypanosoma rangeli	41%	97%
A4HA22	Leishmania braziliensis	83%	92%
A4HY85	Leishmania infantum	96%	94%
E9AS16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	94%
V5C1V3	Trypanosoma cruzi	43%	97%