LeishMANIAdb
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Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative kinesin
Gene product:
Flagellum attachment zone protein 7
Species:
Leishmania major
UniProt:
Q4QDF3_LEIMA
TriTrypDb:
LmjF.19.0680 * , LMJLV39_190012400 * , LMJSD75_190012000 * , LMJSD75_190012100 *
Length:
1061

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
TermNameLevelCount
GO:0005856 cytoskeleton 5 3
GO:0005871 kinesin complex 3 3
GO:0005874 microtubule 6 4
GO:0005875 microtubule associated complex 2 3
GO:0032991 protein-containing complex 1 3
GO:0043226 organelle 2 3
GO:0043228 non-membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043232 intracellular non-membrane-bounded organelle 4 3
GO:0099080 supramolecular complex 2 4
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Expansion

Sequence features

Q4QDF3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDF3

Function

Biological processes
TermNameLevelCount
GO:0007017 microtubule-based process 2 14
GO:0007018 microtubule-based movement 3 14
GO:0009987 cellular process 1 14
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 14
GO:0003774 cytoskeletal motor activity 1 14
GO:0003777 microtubule motor activity 2 14
GO:0003824 catalytic activity 1 10
GO:0005488 binding 1 14
GO:0005515 protein binding 2 14
GO:0005524 ATP binding 5 14
GO:0008017 microtubule binding 5 14
GO:0008092 cytoskeletal protein binding 3 14
GO:0015631 tubulin binding 4 14
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 121 125 PF00656 0.615
CLV_C14_Caspase3-7 368 372 PF00656 0.413
CLV_NRD_NRD_1 1009 1011 PF00675 0.757
CLV_NRD_NRD_1 116 118 PF00675 0.799
CLV_NRD_NRD_1 206 208 PF00675 0.487
CLV_NRD_NRD_1 333 335 PF00675 0.371
CLV_NRD_NRD_1 489 491 PF00675 0.506
CLV_NRD_NRD_1 599 601 PF00675 0.704
CLV_NRD_NRD_1 782 784 PF00675 0.623
CLV_NRD_NRD_1 852 854 PF00675 0.568
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0P696 Trypanosomatidae 40% 91%
A0A3Q8IBD8 Leishmania donovani 56% 100%
A0A3R7L3H0 Trypanosoma rangeli 36% 91%
A0A3S5H759 Leishmania donovani 96% 100%
A4HA26 Leishmania braziliensis 57% 97%
A4HA40 Leishmania braziliensis 86% 100%
A4HY89 Leishmania infantum 56% 97%
A4HYA2 Leishmania infantum 96% 94%
E9AS20 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 94%
E9AS21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS