Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QDE8_LEIMA

TriTrypDb:

LmjF.19.0730 , LMJLV39_190012900 , LMJSD75_190012600

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0010257	NADH dehydrogenase complex assembly	6	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0032981	mitochondrial respiratory chain complex I assembly	7	2
GO:0033108	mitochondrial respiratory chain complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.306
CLV_NRD_NRD_1	22	24	PF00675	0.454
CLV_NRD_NRD_1	316	318	PF00675	0.524
CLV_NRD_NRD_1	374	376	PF00675	0.709
CLV_NRD_NRD_1	51	53	PF00675	0.391
CLV_NRD_NRD_1	78	80	PF00675	0.431
CLV_PCSK_KEX2_1	162	164	PF00082	0.372
CLV_PCSK_KEX2_1	257	259	PF00082	0.444
CLV_PCSK_KEX2_1	374	376	PF00082	0.709
CLV_PCSK_KEX2_1	51	53	PF00082	0.391
CLV_PCSK_KEX2_1	56	58	PF00082	0.456
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.425
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.523
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.456
CLV_PCSK_PC7_1	158	164	PF00082	0.425
CLV_PCSK_PC7_1	253	259	PF00082	0.556
CLV_PCSK_PC7_1	52	58	PF00082	0.431
CLV_PCSK_SKI1_1	158	162	PF00082	0.305
CLV_PCSK_SKI1_1	226	230	PF00082	0.379
CLV_PCSK_SKI1_1	23	27	PF00082	0.403
CLV_PCSK_SKI1_1	258	262	PF00082	0.371
DEG_APCC_DBOX_1	316	324	PF00400	0.536
DOC_CKS1_1	231	236	PF01111	0.384
DOC_MAPK_DCC_7	106	115	PF00069	0.321
DOC_MAPK_gen_1	56	63	PF00069	0.399
DOC_MAPK_MEF2A_6	106	115	PF00069	0.321
DOC_MAPK_MEF2A_6	56	65	PF00069	0.388
DOC_PP4_FxxP_1	128	131	PF00568	0.305
DOC_PP4_FxxP_1	217	220	PF00568	0.373
DOC_USP7_MATH_1	131	135	PF00917	0.390
DOC_USP7_MATH_1	301	305	PF00917	0.559
DOC_USP7_MATH_1	308	312	PF00917	0.499
DOC_WW_Pin1_4	123	128	PF00397	0.349
DOC_WW_Pin1_4	193	198	PF00397	0.434
DOC_WW_Pin1_4	230	235	PF00397	0.370
DOC_WW_Pin1_4	288	293	PF00397	0.381
DOC_WW_Pin1_4	32	37	PF00397	0.523
DOC_WW_Pin1_4	56	61	PF00397	0.416
LIG_14-3-3_CanoR_1	181	187	PF00244	0.376
LIG_14-3-3_CanoR_1	30	36	PF00244	0.485
LIG_14-3-3_CanoR_1	51	55	PF00244	0.437
LIG_BRCT_BRCA1_1	361	365	PF00533	0.685
LIG_CSL_BTD_1	289	292	PF09270	0.409
LIG_eIF4E_1	272	278	PF01652	0.399
LIG_FHA_1	150	156	PF00498	0.321
LIG_FHA_1	187	193	PF00498	0.391
LIG_FHA_1	208	214	PF00498	0.350
LIG_FHA_1	219	225	PF00498	0.356
LIG_FHA_1	279	285	PF00498	0.350
LIG_FHA_1	57	63	PF00498	0.387
LIG_FHA_2	174	180	PF00498	0.345
LIG_LIR_Apic_2	126	131	PF02991	0.299
LIG_LIR_Gen_1	112	122	PF02991	0.322
LIG_LIR_Gen_1	232	243	PF02991	0.371
LIG_LIR_Gen_1	281	289	PF02991	0.356
LIG_LIR_Nem_3	112	118	PF02991	0.322
LIG_LIR_Nem_3	281	285	PF02991	0.337
LIG_LIR_Nem_3	341	347	PF02991	0.451
LIG_LIR_Nem_3	81	85	PF02991	0.352
LIG_Pex14_2	278	282	PF04695	0.247
LIG_PTB_Apo_2	166	173	PF02174	0.440
LIG_Rb_LxCxE_1	114	136	PF01857	0.305
LIG_SH2_NCK_1	231	235	PF00017	0.450
LIG_SH2_SRC	102	105	PF00017	0.321
LIG_SH2_STAP1	268	272	PF00017	0.366
LIG_SH2_STAT3	251	254	PF00017	0.586
LIG_SH2_STAT5	72	75	PF00017	0.362
LIG_SH2_STAT5	88	91	PF00017	0.321
LIG_SH3_3	30	36	PF00018	0.427
LIG_SH3_3	377	383	PF00018	0.608
LIG_SUMO_SIM_anti_2	239	247	PF11976	0.485
LIG_SUMO_SIM_par_1	220	225	PF11976	0.459
LIG_SUMO_SIM_par_1	3	8	PF11976	0.597
LIG_SUMO_SIM_par_1	58	64	PF11976	0.362
LIG_TRFH_1	327	331	PF08558	0.626
MOD_CK1_1	140	146	PF00069	0.305
MOD_CK1_1	31	37	PF00069	0.518
MOD_CK1_1	311	317	PF00069	0.481
MOD_CK2_1	173	179	PF00069	0.343
MOD_GlcNHglycan	246	249	PF01048	0.373
MOD_GlcNHglycan	303	306	PF01048	0.499
MOD_GlcNHglycan	349	353	PF01048	0.485
MOD_GSK3_1	182	189	PF00069	0.350
MOD_GSK3_1	193	200	PF00069	0.395
MOD_GSK3_1	28	35	PF00069	0.477
MOD_GSK3_1	284	291	PF00069	0.375
MOD_GSK3_1	307	314	PF00069	0.490
MOD_NEK2_1	137	142	PF00069	0.305
MOD_NEK2_1	150	155	PF00069	0.372
MOD_NEK2_1	244	249	PF00069	0.356
MOD_NEK2_1	28	33	PF00069	0.454
MOD_NEK2_1	5	10	PF00069	0.594
MOD_NEK2_2	173	178	PF00069	0.346
MOD_PIKK_1	292	298	PF00454	0.452
MOD_PKA_2	301	307	PF00069	0.505
MOD_PKA_2	50	56	PF00069	0.448
MOD_Plk_1	131	137	PF00069	0.305
MOD_Plk_1	150	156	PF00069	0.391
MOD_Plk_4	150	156	PF00069	0.413
MOD_Plk_4	173	179	PF00069	0.367
MOD_Plk_4	207	213	PF00069	0.365
MOD_Plk_4	267	273	PF00069	0.512
MOD_Plk_4	319	325	PF00069	0.573
MOD_ProDKin_1	123	129	PF00069	0.349
MOD_ProDKin_1	193	199	PF00069	0.429
MOD_ProDKin_1	230	236	PF00069	0.371
MOD_ProDKin_1	288	294	PF00069	0.395
MOD_ProDKin_1	32	38	PF00069	0.515
MOD_ProDKin_1	56	62	PF00069	0.406
MOD_SUMO_rev_2	103	108	PF00179	0.321
MOD_SUMO_rev_2	371	381	PF00179	0.716
TRG_DiLeu_BaEn_1	350	355	PF01217	0.507
TRG_DiLeu_BaEn_3	103	109	PF01217	0.382
TRG_DiLeu_BaEn_4	371	377	PF01217	0.682
TRG_ENDOCYTIC_2	102	105	PF00928	0.315
TRG_ENDOCYTIC_2	268	271	PF00928	0.371
TRG_ER_diArg_1	374	376	PF00400	0.755
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2I2	Leptomonas seymouri	87%	100%
A0A0S4ISY2	Bodo saltans	61%	99%
A0A1X0P6A4	Trypanosomatidae	77%	98%
A0A3S7WVD3	Leishmania donovani	99%	100%
A0A422NMU6	Trypanosoma rangeli	70%	100%
A1WVM4	Halorhodospira halophila (strain DSM 244 / SL1)	26%	100%
A2APY7	Mus musculus	39%	100%
A3KP37	Danio rerio	36%	100%
A4HA30	Leishmania braziliensis	93%	100%
A4HY93	Leishmania infantum	99%	100%
B2GV71	Rattus norvegicus	40%	100%
B2IAI0	Xylella fastidiosa (strain M23)	27%	100%
C1D5S5	Laribacter hongkongensis (strain HLHK9)	26%	100%
D0A0M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	99%
D9SJ16	Gallionella capsiferriformans (strain ES-2)	26%	100%
E4QJB8	Methylovorus sp. (strain MP688)	27%	100%
E9AS25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O80543	Arabidopsis thaliana	31%	100%
Q2Y9Y6	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)	25%	100%
Q54JW0	Dictyostelium discoideum	30%	88%
Q5RBS1	Pongo abelii	37%	100%
Q5TEU4	Homo sapiens	37%	100%
Q83E64	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	24%	100%
V5AMS7	Trypanosoma cruzi	75%	98%