Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDE6_LEIMA

TriTrypDb:

LmjF.19.0750 , LMJLV39_190013100 , LMJSD75_190012800

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	499	503	PF00656	0.675
CLV_C14_Caspase3-7	50	54	PF00656	0.741
CLV_C14_Caspase3-7	81	85	PF00656	0.485
CLV_NRD_NRD_1	110	112	PF00675	0.567
CLV_NRD_NRD_1	312	314	PF00675	0.497
CLV_NRD_NRD_1	319	321	PF00675	0.655
CLV_NRD_NRD_1	394	396	PF00675	0.412
CLV_NRD_NRD_1	43	45	PF00675	0.596
CLV_PCSK_KEX2_1	109	111	PF00082	0.526
CLV_PCSK_KEX2_1	143	145	PF00082	0.734
CLV_PCSK_KEX2_1	312	314	PF00082	0.468
CLV_PCSK_KEX2_1	318	320	PF00082	0.591
CLV_PCSK_KEX2_1	394	396	PF00082	0.397
CLV_PCSK_KEX2_1	43	45	PF00082	0.608
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.509
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.734
CLV_PCSK_PC7_1	105	111	PF00082	0.543
CLV_PCSK_SKI1_1	105	109	PF00082	0.419
CLV_PCSK_SKI1_1	270	274	PF00082	0.490
CLV_PCSK_SKI1_1	312	316	PF00082	0.428
DEG_Nend_UBRbox_2	1	3	PF02207	0.703
DEG_SPOP_SBC_1	132	136	PF00917	0.679
DEG_SPOP_SBC_1	63	67	PF00917	0.541
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.484
DOC_PP2B_LxvP_1	272	275	PF13499	0.468
DOC_PP4_FxxP_1	229	232	PF00568	0.399
DOC_USP7_MATH_1	132	136	PF00917	0.694
DOC_USP7_MATH_1	152	156	PF00917	0.572
DOC_USP7_MATH_1	342	346	PF00917	0.569
DOC_USP7_MATH_1	359	363	PF00917	0.355
DOC_USP7_MATH_1	58	62	PF00917	0.774
DOC_USP7_MATH_1	63	67	PF00917	0.767
DOC_WW_Pin1_4	404	409	PF00397	0.449
DOC_WW_Pin1_4	436	441	PF00397	0.597
LIG_14-3-3_CanoR_1	144	149	PF00244	0.564
LIG_14-3-3_CanoR_1	202	211	PF00244	0.547
LIG_14-3-3_CanoR_1	3	8	PF00244	0.675
LIG_14-3-3_CanoR_1	435	440	PF00244	0.490
LIG_14-3-3_CanoR_1	99	104	PF00244	0.370
LIG_BIR_III_2	287	291	PF00653	0.523
LIG_BIR_III_4	433	437	PF00653	0.572
LIG_BRCT_BRCA1_1	352	356	PF00533	0.417
LIG_BRCT_BRCA1_1	399	403	PF00533	0.517
LIG_Clathr_ClatBox_1	294	298	PF01394	0.495
LIG_deltaCOP1_diTrp_1	419	426	PF00928	0.511
LIG_eIF4E_1	225	231	PF01652	0.371
LIG_FHA_1	379	385	PF00498	0.557
LIG_FHA_1	416	422	PF00498	0.526
LIG_FHA_1	451	457	PF00498	0.548
LIG_FHA_1	47	53	PF00498	0.621
LIG_FHA_2	380	386	PF00498	0.494
LIG_FHA_2	414	420	PF00498	0.477
LIG_LIR_Apic_2	227	232	PF02991	0.347
LIG_LIR_Apic_2	446	450	PF02991	0.501
LIG_LIR_Gen_1	300	311	PF02991	0.448
LIG_LIR_Gen_1	458	466	PF02991	0.532
LIG_LIR_LC3C_4	366	371	PF02991	0.507
LIG_LIR_Nem_3	300	306	PF02991	0.455
LIG_LIR_Nem_3	87	93	PF02991	0.548
LIG_PCNA_PIPBox_1	372	381	PF02747	0.531
LIG_Pex14_1	262	266	PF04695	0.455
LIG_Pex14_1	443	447	PF04695	0.511
LIG_REV1ctd_RIR_1	312	322	PF16727	0.544
LIG_SH2_PTP2	447	450	PF00017	0.498
LIG_SH2_SRC	181	184	PF00017	0.429
LIG_SH2_SRC	447	450	PF00017	0.537
LIG_SH2_STAP1	174	178	PF00017	0.518
LIG_SH2_STAT3	38	41	PF00017	0.527
LIG_SH2_STAT5	199	202	PF00017	0.461
LIG_SH2_STAT5	225	228	PF00017	0.376
LIG_SH2_STAT5	378	381	PF00017	0.415
LIG_SH2_STAT5	447	450	PF00017	0.537
LIG_SH2_STAT5	517	520	PF00017	0.398
LIG_SH3_3	114	120	PF00018	0.485
LIG_SH3_3	166	172	PF00018	0.508
LIG_SH3_3	323	329	PF00018	0.470
LIG_SH3_3	402	408	PF00018	0.418
LIG_SH3_3	67	73	PF00018	0.758
LIG_SUMO_SIM_anti_2	365	373	PF11976	0.360
LIG_SUMO_SIM_par_1	245	252	PF11976	0.454
LIG_TRAF2_1	85	88	PF00917	0.651
LIG_WRC_WIRS_1	414	419	PF05994	0.512
MOD_CK1_1	155	161	PF00069	0.646
MOD_CK1_1	362	368	PF00069	0.478
MOD_CK1_1	6	12	PF00069	0.676
MOD_CK1_1	61	67	PF00069	0.774
MOD_CK1_1	71	77	PF00069	0.601
MOD_CK2_1	379	385	PF00069	0.395
MOD_CK2_1	443	449	PF00069	0.447
MOD_GlcNHglycan	135	138	PF01048	0.622
MOD_GlcNHglycan	148	151	PF01048	0.673
MOD_GlcNHglycan	154	157	PF01048	0.585
MOD_GlcNHglycan	163	166	PF01048	0.458
MOD_GlcNHglycan	361	364	PF01048	0.489
MOD_GlcNHglycan	399	402	PF01048	0.531
MOD_GlcNHglycan	73	76	PF01048	0.811
MOD_GlcNHglycan	8	11	PF01048	0.613
MOD_GSK3_1	146	153	PF00069	0.714
MOD_GSK3_1	212	219	PF00069	0.372
MOD_GSK3_1	238	245	PF00069	0.547
MOD_GSK3_1	455	462	PF00069	0.549
MOD_GSK3_1	54	61	PF00069	0.727
MOD_GSK3_1	64	71	PF00069	0.708
MOD_NEK2_1	299	304	PF00069	0.499
MOD_NEK2_1	364	369	PF00069	0.466
MOD_NEK2_1	379	384	PF00069	0.399
MOD_NEK2_1	410	415	PF00069	0.401
MOD_PIKK_1	216	222	PF00454	0.374
MOD_PIKK_1	304	310	PF00454	0.455
MOD_PK_1	246	252	PF00069	0.537
MOD_PK_1	3	9	PF00069	0.458
MOD_PK_1	324	330	PF00069	0.472
MOD_PKB_1	144	152	PF00069	0.758
MOD_Plk_1	299	305	PF00069	0.534
MOD_Plk_1	365	371	PF00069	0.433
MOD_Plk_1	410	416	PF00069	0.428
MOD_Plk_2-3	472	478	PF00069	0.669
MOD_Plk_4	246	252	PF00069	0.449
MOD_Plk_4	299	305	PF00069	0.517
MOD_Plk_4	3	9	PF00069	0.665
MOD_Plk_4	365	371	PF00069	0.470
MOD_Plk_4	443	449	PF00069	0.440
MOD_Plk_4	99	105	PF00069	0.388
MOD_ProDKin_1	404	410	PF00069	0.448
MOD_ProDKin_1	436	442	PF00069	0.595
MOD_SUMO_rev_2	185	195	PF00179	0.550
TRG_ER_diArg_1	110	112	PF00400	0.570
TRG_ER_diArg_1	312	314	PF00400	0.532
TRG_ER_diArg_1	318	320	PF00400	0.658
TRG_ER_diArg_1	393	395	PF00400	0.456
TRG_NLS_MonoExtC_3	108	113	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	464	469	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I161	Leptomonas seymouri	47%	100%
A0A0S4IWK0	Bodo saltans	29%	100%
A0A1X0P685	Trypanosomatidae	32%	99%
A0A3R7KFJ2	Trypanosoma rangeli	31%	100%
A0A3S5H760	Leishmania donovani	92%	100%
A4HA32	Leishmania braziliensis	73%	100%
A4HY95	Leishmania infantum	92%	100%
D0A0M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AS27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B315	Trypanosoma cruzi	30%	100%