Putative transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania major

UniProt:

Q4QDE5_LEIMA

TriTrypDb:

LmjF.19.0760 , LMJLV39_190013200 , LMJSD75_190012900

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	16
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QDE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0009914	hormone transport	4	16
GO:0009987	cellular process	1	16
GO:0010817	regulation of hormone levels	3	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0060918	auxin transport	5	16
GO:0065007	biological regulation	1	16
GO:0065008	regulation of biological quality	2	16
GO:0080162	endoplasmic reticulum to cytosol auxin transport	3	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	363	367	PF00656	0.539
CLV_NRD_NRD_1	184	186	PF00675	0.295
CLV_NRD_NRD_1	98	100	PF00675	0.281
CLV_PCSK_FUR_1	265	269	PF00082	0.376
CLV_PCSK_KEX2_1	183	185	PF00082	0.315
CLV_PCSK_KEX2_1	267	269	PF00082	0.338
CLV_PCSK_KEX2_1	346	348	PF00082	0.219
CLV_PCSK_KEX2_1	98	100	PF00082	0.297
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.376
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.219
CLV_PCSK_PC7_1	94	100	PF00082	0.219
CLV_PCSK_SKI1_1	18	22	PF00082	0.297
CLV_PCSK_SKI1_1	271	275	PF00082	0.313
CLV_PCSK_SKI1_1	299	303	PF00082	0.481
CLV_PCSK_SKI1_1	431	435	PF00082	0.475
CLV_PCSK_SKI1_1	49	53	PF00082	0.330
CLV_PCSK_SKI1_1	94	98	PF00082	0.254
DEG_APCC_DBOX_1	270	278	PF00400	0.513
DEG_APCC_DBOX_1	48	56	PF00400	0.275
DEG_SPOP_SBC_1	341	345	PF00917	0.403
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.427
DOC_MAPK_DCC_7	49	57	PF00069	0.309
DOC_MAPK_gen_1	265	274	PF00069	0.516
DOC_MAPK_gen_1	346	352	PF00069	0.419
DOC_MAPK_gen_1	98	106	PF00069	0.544
DOC_MAPK_HePTP_8	315	327	PF00069	0.319
DOC_MAPK_JIP1_4	431	437	PF00069	0.275
DOC_MAPK_MEF2A_6	318	327	PF00069	0.319
DOC_MAPK_MEF2A_6	49	57	PF00069	0.313
DOC_MAPK_NFAT4_5	318	326	PF00069	0.319
DOC_PP1_RVXF_1	124	131	PF00149	0.254
DOC_PP2B_LxvP_1	293	296	PF13499	0.282
DOC_PP4_FxxP_1	305	308	PF00568	0.296
DOC_PP4_FxxP_1	33	36	PF00568	0.468
DOC_PP4_FxxP_1	370	373	PF00568	0.372
DOC_USP7_MATH_1	230	234	PF00917	0.535
DOC_USP7_MATH_1	341	345	PF00917	0.529
DOC_USP7_MATH_1	355	359	PF00917	0.460
DOC_USP7_MATH_1	446	450	PF00917	0.317
DOC_WW_Pin1_4	203	208	PF00397	0.514
DOC_WW_Pin1_4	237	242	PF00397	0.498
DOC_WW_Pin1_4	276	281	PF00397	0.344
DOC_WW_Pin1_4	291	296	PF00397	0.222
DOC_WW_Pin1_4	351	356	PF00397	0.580
DOC_WW_Pin1_4	440	445	PF00397	0.387
LIG_14-3-3_CanoR_1	184	190	PF00244	0.536
LIG_14-3-3_CanoR_1	231	239	PF00244	0.477
LIG_14-3-3_CanoR_1	271	280	PF00244	0.475
LIG_14-3-3_CanoR_1	349	355	PF00244	0.356
LIG_BIR_III_4	364	368	PF00653	0.372
LIG_BRCT_BRCA1_1	140	144	PF00533	0.211
LIG_BRCT_BRCA1_1	29	33	PF00533	0.408
LIG_CORNRBOX	283	291	PF00104	0.275
LIG_EH1_1	116	124	PF00400	0.414
LIG_eIF4E_1	5	11	PF01652	0.343
LIG_FHA_1	114	120	PF00498	0.328
LIG_FHA_1	207	213	PF00498	0.479
LIG_FHA_1	292	298	PF00498	0.408
LIG_FHA_1	387	393	PF00498	0.483
LIG_FHA_1	403	409	PF00498	0.197
LIG_FHA_1	475	481	PF00498	0.289
LIG_FHA_2	217	223	PF00498	0.458
LIG_FHA_2	361	367	PF00498	0.568
LIG_IRF3_LxIS_1	286	292	PF10401	0.275
LIG_LIR_Apic_2	30	36	PF02991	0.475
LIG_LIR_Apic_2	302	308	PF02991	0.360
LIG_LIR_Apic_2	368	373	PF02991	0.485
LIG_LIR_Apic_2	70	76	PF02991	0.266
LIG_LIR_Gen_1	100	111	PF02991	0.482
LIG_LIR_Gen_1	141	149	PF02991	0.282
LIG_LIR_Gen_1	462	471	PF02991	0.461
LIG_LIR_Gen_1	65	73	PF02991	0.246
LIG_LIR_Nem_3	100	106	PF02991	0.433
LIG_LIR_Nem_3	141	145	PF02991	0.282
LIG_LIR_Nem_3	3	8	PF02991	0.276
LIG_LIR_Nem_3	65	69	PF02991	0.240
LIG_MLH1_MIPbox_1	29	33	PF16413	0.435
LIG_Pex14_1	74	78	PF04695	0.368
LIG_Pex14_2	305	309	PF04695	0.234
LIG_SH2_CRK	101	105	PF00017	0.478
LIG_SH2_CRK	146	150	PF00017	0.284
LIG_SH2_PTP2	142	145	PF00017	0.272
LIG_SH2_STAP1	463	467	PF00017	0.441
LIG_SH2_STAT5	142	145	PF00017	0.272
LIG_SH2_STAT5	32	35	PF00017	0.455
LIG_SH2_STAT5	45	48	PF00017	0.299
LIG_SH2_STAT5	471	474	PF00017	0.267
LIG_SH2_STAT5	488	491	PF00017	0.244
LIG_SH2_STAT5	5	8	PF00017	0.405
LIG_SH3_3	238	244	PF00018	0.550
LIG_SH3_3	331	337	PF00018	0.517
LIG_SH3_3	405	411	PF00018	0.356
LIG_SH3_3	438	444	PF00018	0.187
LIG_SH3_3	47	53	PF00018	0.387
LIG_SUMO_SIM_anti_2	284	292	PF11976	0.404
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.319
LIG_SUMO_SIM_par_1	103	110	PF11976	0.367
LIG_SUMO_SIM_par_1	233	240	PF11976	0.548
LIG_SUMO_SIM_par_1	289	294	PF11976	0.369
LIG_SUMO_SIM_par_1	324	331	PF11976	0.416
LIG_SUMO_SIM_par_1	436	443	PF11976	0.291
LIG_TRFH_1	78	82	PF08558	0.253
LIG_UBA3_1	122	126	PF00899	0.324
MOD_CK1_1	206	212	PF00069	0.486
MOD_CK1_1	240	246	PF00069	0.485
MOD_CK1_1	276	282	PF00069	0.414
MOD_CK1_1	330	336	PF00069	0.477
MOD_CK1_1	353	359	PF00069	0.529
MOD_CK1_1	474	480	PF00069	0.319
MOD_CK2_1	216	222	PF00069	0.447
MOD_GlcNHglycan	357	360	PF01048	0.326
MOD_GlcNHglycan	46	49	PF01048	0.408
MOD_GSK3_1	113	120	PF00069	0.381
MOD_GSK3_1	202	209	PF00069	0.535
MOD_GSK3_1	254	261	PF00069	0.432
MOD_GSK3_1	27	34	PF00069	0.423
MOD_GSK3_1	272	279	PF00069	0.417
MOD_GSK3_1	328	335	PF00069	0.361
MOD_GSK3_1	350	357	PF00069	0.555
MOD_GSK3_1	372	379	PF00069	0.491
MOD_GSK3_1	442	449	PF00069	0.287
MOD_GSK3_1	471	478	PF00069	0.257
MOD_LATS_1	459	465	PF00433	0.434
MOD_N-GLC_1	255	260	PF02516	0.252
MOD_N-GLC_1	447	452	PF02516	0.272
MOD_N-GLC_1	62	67	PF02516	0.512
MOD_N-GLC_2	59	61	PF02516	0.373
MOD_NEK2_1	107	112	PF00069	0.303
MOD_NEK2_1	252	257	PF00069	0.563
MOD_NEK2_1	27	32	PF00069	0.183
MOD_NEK2_1	289	294	PF00069	0.341
MOD_NEK2_1	328	333	PF00069	0.333
MOD_NEK2_1	421	426	PF00069	0.351
MOD_NEK2_1	433	438	PF00069	0.247
MOD_NEK2_1	451	456	PF00069	0.230
MOD_NEK2_1	87	92	PF00069	0.322
MOD_NEK2_1	9	14	PF00069	0.278
MOD_NEK2_2	365	370	PF00069	0.434
MOD_PIKK_1	372	378	PF00454	0.550
MOD_PIKK_1	402	408	PF00454	0.317
MOD_PKA_2	230	236	PF00069	0.513
MOD_PKA_2	252	258	PF00069	0.421
MOD_PKA_2	348	354	PF00069	0.452
MOD_PKB_1	183	191	PF00069	0.551
MOD_Plk_1	255	261	PF00069	0.410
MOD_Plk_1	447	453	PF00069	0.282
MOD_Plk_1	461	467	PF00069	0.431
MOD_Plk_1	62	68	PF00069	0.251
MOD_Plk_2-3	169	175	PF00069	0.434
MOD_Plk_4	117	123	PF00069	0.330
MOD_Plk_4	138	144	PF00069	0.237
MOD_Plk_4	278	284	PF00069	0.290
MOD_Plk_4	365	371	PF00069	0.466
MOD_Plk_4	433	439	PF00069	0.302
MOD_Plk_4	447	453	PF00069	0.215
MOD_Plk_4	471	477	PF00069	0.332
MOD_Plk_4	484	490	PF00069	0.268
MOD_Plk_4	87	93	PF00069	0.322
MOD_ProDKin_1	203	209	PF00069	0.514
MOD_ProDKin_1	237	243	PF00069	0.498
MOD_ProDKin_1	276	282	PF00069	0.344
MOD_ProDKin_1	291	297	PF00069	0.222
MOD_ProDKin_1	351	357	PF00069	0.580
MOD_ProDKin_1	440	446	PF00069	0.387
TRG_DiLeu_BaEn_1	380	385	PF01217	0.372
TRG_DiLeu_BaEn_1	430	435	PF01217	0.343
TRG_ENDOCYTIC_2	101	104	PF00928	0.478
TRG_ENDOCYTIC_2	142	145	PF00928	0.257
TRG_ENDOCYTIC_2	146	149	PF00928	0.250
TRG_ENDOCYTIC_2	463	466	PF00928	0.441
TRG_ENDOCYTIC_2	5	8	PF00928	0.405
TRG_ER_diArg_1	183	185	PF00400	0.509
TRG_ER_diArg_1	347	350	PF00400	0.468
TRG_ER_diArg_1	97	99	PF00400	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A2	Leptomonas seymouri	51%	95%
A0A0S4J2X2	Bodo saltans	23%	100%
A0A1X0P681	Trypanosomatidae	29%	100%
A0A1X0P6F8	Trypanosomatidae	37%	95%
A0A3Q8IEH9	Leishmania donovani	89%	100%
A0A422ND25	Trypanosoma rangeli	22%	74%
A0A422NMT2	Trypanosoma rangeli	36%	100%
A0A422NN55	Trypanosoma rangeli	31%	100%
A4HA33	Leishmania braziliensis	58%	97%
A4HY96	Leishmania infantum	89%	100%
D0A0N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AS28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5B7J7	Trypanosoma cruzi	30%	100%
V5BC60	Trypanosoma cruzi	35%	100%