Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDE3_LEIMA

TriTrypDb:

LmjF.19.0780 , LMJLV39_190013400 , LMJSD75_190013100

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	8
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QDE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.336
CLV_NRD_NRD_1	148	150	PF00675	0.392
CLV_NRD_NRD_1	22	24	PF00675	0.362
CLV_NRD_NRD_1	224	226	PF00675	0.446
CLV_PCSK_FUR_1	146	150	PF00082	0.387
CLV_PCSK_KEX2_1	127	129	PF00082	0.352
CLV_PCSK_KEX2_1	148	150	PF00082	0.392
CLV_PCSK_KEX2_1	22	24	PF00082	0.403
CLV_PCSK_KEX2_1	224	226	PF00082	0.460
CLV_PCSK_SKI1_1	138	142	PF00082	0.394
CLV_PCSK_SKI1_1	64	68	PF00082	0.594
CLV_PCSK_SKI1_1	69	73	PF00082	0.521
CLV_PCSK_SKI1_1	98	102	PF00082	0.653
DEG_APCC_DBOX_1	68	76	PF00400	0.367
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SIAH_1	8	16	PF03145	0.672
DOC_MAPK_gen_1	133	141	PF00069	0.542
DOC_MAPK_gen_1	214	223	PF00069	0.628
DOC_USP7_MATH_1	131	135	PF00917	0.606
DOC_WW_Pin1_4	209	214	PF00397	0.516
LIG_14-3-3_CanoR_1	22	28	PF00244	0.585
LIG_14-3-3_CanoR_1	56	63	PF00244	0.453
LIG_APCC_ABBA_1	13	18	PF00400	0.657
LIG_BRCT_BRCA1_1	38	42	PF00533	0.357
LIG_CSL_BTD_1	154	157	PF09270	0.691
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.548
LIG_deltaCOP1_diTrp_1	245	252	PF00928	0.685
LIG_FHA_1	173	179	PF00498	0.533
LIG_FHA_1	39	45	PF00498	0.297
LIG_FHA_1	75	81	PF00498	0.359
LIG_LIR_Apic_2	208	213	PF02991	0.506
LIG_LIR_Gen_1	168	178	PF02991	0.537
LIG_LIR_Gen_1	196	202	PF02991	0.541
LIG_LIR_Nem_3	14	19	PF02991	0.646
LIG_LIR_Nem_3	158	163	PF02991	0.599
LIG_LIR_Nem_3	166	172	PF02991	0.576
LIG_LIR_Nem_3	177	182	PF02991	0.664
LIG_LIR_Nem_3	196	201	PF02991	0.542
LIG_LIR_Nem_3	217	221	PF02991	0.544
LIG_NRBOX	177	183	PF00104	0.575
LIG_Pex14_2	201	205	PF04695	0.575
LIG_PTB_Apo_2	201	208	PF02174	0.582
LIG_PTB_Phospho_1	201	207	PF10480	0.588
LIG_SH2_SRC	129	132	PF00017	0.565
LIG_SH2_STAP1	198	202	PF00017	0.538
LIG_SH2_STAT5	129	132	PF00017	0.616
LIG_SH3_3	151	157	PF00018	0.644
LIG_SH3_3	6	12	PF00018	0.647
LIG_SH3_5	15	19	PF00018	0.576
LIG_SUMO_SIM_par_1	71	77	PF11976	0.363
MOD_CDK_SPK_2	209	214	PF00069	0.510
MOD_CDK_SPxxK_3	209	216	PF00069	0.507
MOD_CK1_1	107	113	PF00069	0.241
MOD_CK1_1	91	97	PF00069	0.398
MOD_CMANNOS	215	218	PF00535	0.308
MOD_GlcNHglycan	106	109	PF01048	0.500
MOD_GlcNHglycan	38	41	PF01048	0.309
MOD_GSK3_1	116	123	PF00069	0.208
MOD_GSK3_1	205	212	PF00069	0.526
MOD_GSK3_1	38	45	PF00069	0.375
MOD_GSK3_1	74	81	PF00069	0.343
MOD_GSK3_1	98	105	PF00069	0.450
MOD_N-GLC_1	110	115	PF02516	0.393
MOD_NEK2_1	121	126	PF00069	0.329
MOD_NEK2_1	3	8	PF00069	0.710
MOD_NEK2_1	36	41	PF00069	0.366
MOD_NEK2_1	42	47	PF00069	0.304
MOD_NEK2_1	88	93	PF00069	0.379
MOD_NEK2_2	174	179	PF00069	0.547
MOD_PIKK_1	3	9	PF00454	0.663
MOD_PIKK_1	98	104	PF00454	0.453
MOD_PKA_1	23	29	PF00069	0.529
MOD_PKA_2	55	61	PF00069	0.477
MOD_Plk_1	110	116	PF00069	0.393
MOD_Plk_4	110	116	PF00069	0.380
MOD_Plk_4	155	161	PF00069	0.645
MOD_Plk_4	174	180	PF00069	0.452
MOD_Plk_4	184	190	PF00069	0.539
MOD_Plk_4	237	243	PF00069	0.624
MOD_Plk_4	42	48	PF00069	0.297
MOD_Plk_4	88	94	PF00069	0.367
MOD_ProDKin_1	209	215	PF00069	0.514
TRG_ENDOCYTIC_2	170	173	PF00928	0.558
TRG_ENDOCYTIC_2	179	182	PF00928	0.582
TRG_ENDOCYTIC_2	198	201	PF00928	0.539
TRG_ER_diArg_1	127	129	PF00400	0.619
TRG_ER_diArg_1	146	149	PF00400	0.576
TRG_ER_diArg_1	21	23	PF00400	0.633
TRG_ER_diArg_1	223	225	PF00400	0.641
TRG_ER_diArg_1	247	250	PF00400	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN8	Leptomonas seymouri	77%	100%
A0A0S4IWK7	Bodo saltans	39%	82%
A0A1X0P7P1	Trypanosomatidae	58%	100%
A0A3Q8IA89	Leishmania donovani	95%	100%
A4HA35	Leishmania braziliensis	89%	100%
A4HY98	Leishmania infantum	95%	100%
D0A0N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AS30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%