Signal recognition particle subunit SRP72

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

signal recognition particle protein, putative

Species:

Leishmania major

UniProt:

Q4QDE2_LEIMA

TriTrypDb:

LmjF.19.0790 , LMJLV39_190013500 , LMJSD75_190013200

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	12
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0048500	signal recognition particle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

Q4QDE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE2

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0008312	7S RNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.441
CLV_C14_Caspase3-7	413	417	PF00656	0.643
CLV_NRD_NRD_1	11	13	PF00675	0.537
CLV_NRD_NRD_1	287	289	PF00675	0.525
CLV_NRD_NRD_1	324	326	PF00675	0.409
CLV_NRD_NRD_1	445	447	PF00675	0.552
CLV_NRD_NRD_1	483	485	PF00675	0.445
CLV_NRD_NRD_1	559	561	PF00675	0.333
CLV_NRD_NRD_1	631	633	PF00675	0.631
CLV_NRD_NRD_1	658	660	PF00675	0.255
CLV_NRD_NRD_1	662	664	PF00675	0.248
CLV_NRD_NRD_1	692	694	PF00675	0.497
CLV_NRD_NRD_1	698	700	PF00675	0.536
CLV_NRD_NRD_1	709	711	PF00675	0.518
CLV_PCSK_FUR_1	656	660	PF00082	0.282
CLV_PCSK_FUR_1	692	696	PF00082	0.425
CLV_PCSK_KEX2_1	287	289	PF00082	0.525
CLV_PCSK_KEX2_1	447	449	PF00082	0.578
CLV_PCSK_KEX2_1	483	485	PF00082	0.475
CLV_PCSK_KEX2_1	582	584	PF00082	0.570
CLV_PCSK_KEX2_1	631	633	PF00082	0.618
CLV_PCSK_KEX2_1	656	658	PF00082	0.262
CLV_PCSK_KEX2_1	662	664	PF00082	0.251
CLV_PCSK_KEX2_1	692	694	PF00082	0.484
CLV_PCSK_KEX2_1	698	700	PF00082	0.519
CLV_PCSK_KEX2_1	708	710	PF00082	0.498
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.578
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.570
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.436
CLV_PCSK_PC1ET2_1	708	710	PF00082	0.559
CLV_PCSK_PC7_1	658	664	PF00082	0.296
CLV_PCSK_SKI1_1	114	118	PF00082	0.296
CLV_PCSK_SKI1_1	13	17	PF00082	0.587
CLV_PCSK_SKI1_1	221	225	PF00082	0.496
CLV_PCSK_SKI1_1	260	264	PF00082	0.354
CLV_PCSK_SKI1_1	325	329	PF00082	0.421
CLV_PCSK_SKI1_1	385	389	PF00082	0.414
CLV_PCSK_SKI1_1	391	395	PF00082	0.450
CLV_PCSK_SKI1_1	412	416	PF00082	0.624
CLV_PCSK_SKI1_1	525	529	PF00082	0.371
CLV_PCSK_SKI1_1	563	567	PF00082	0.428
CLV_PCSK_SKI1_1	631	635	PF00082	0.673
CLV_PCSK_SKI1_1	663	667	PF00082	0.316
DEG_APCC_DBOX_1	113	121	PF00400	0.502
DEG_SCF_SKP2-CKS1_1	67	74	PF00560	0.477
DOC_CYCLIN_RxL_1	446	456	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.586
DOC_MAPK_gen_1	287	294	PF00069	0.443
DOC_MAPK_gen_1	325	335	PF00069	0.533
DOC_MAPK_gen_1	446	454	PF00069	0.584
DOC_MAPK_gen_1	560	570	PF00069	0.452
DOC_MAPK_MEF2A_6	287	294	PF00069	0.409
DOC_MAPK_NFAT4_5	287	295	PF00069	0.422
DOC_MAPK_RevD_3	384	397	PF00069	0.549
DOC_PP2B_LxvP_1	238	241	PF13499	0.562
DOC_PP2B_LxvP_1	242	245	PF13499	0.668
DOC_USP7_MATH_1	228	232	PF00917	0.562
DOC_USP7_MATH_1	298	302	PF00917	0.420
DOC_USP7_MATH_1	414	418	PF00917	0.620
DOC_USP7_MATH_1	438	442	PF00917	0.700
DOC_USP7_MATH_1	555	559	PF00917	0.475
DOC_USP7_MATH_1	623	627	PF00917	0.590
DOC_USP7_MATH_1	735	739	PF00917	0.730
DOC_USP7_UBL2_3	9	13	PF12436	0.544
DOC_WW_Pin1_4	177	182	PF00397	0.537
DOC_WW_Pin1_4	254	259	PF00397	0.461
DOC_WW_Pin1_4	400	405	PF00397	0.720
DOC_WW_Pin1_4	68	73	PF00397	0.560
DOC_WW_Pin1_4	731	736	PF00397	0.683
LIG_14-3-3_CanoR_1	106	116	PF00244	0.517
LIG_14-3-3_CanoR_1	12	20	PF00244	0.541
LIG_14-3-3_CanoR_1	31	36	PF00244	0.539
LIG_14-3-3_CanoR_1	338	345	PF00244	0.442
LIG_14-3-3_CanoR_1	363	369	PF00244	0.539
LIG_14-3-3_CanoR_1	412	421	PF00244	0.648
LIG_14-3-3_CanoR_1	483	489	PF00244	0.490
LIG_14-3-3_CanoR_1	511	521	PF00244	0.528
LIG_Actin_WH2_2	534	552	PF00022	0.461
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	316	320	PF00533	0.552
LIG_BRCT_BRCA1_1	52	56	PF00533	0.477
LIG_BRCT_BRCA1_1	75	79	PF00533	0.541
LIG_CtBP_PxDLS_1	679	683	PF00389	0.505
LIG_eIF4E_1	85	91	PF01652	0.516
LIG_FHA_1	155	161	PF00498	0.420
LIG_FHA_1	178	184	PF00498	0.459
LIG_FHA_1	187	193	PF00498	0.336
LIG_FHA_1	301	307	PF00498	0.401
LIG_FHA_1	349	355	PF00498	0.388
LIG_FHA_1	379	385	PF00498	0.381
LIG_FHA_1	454	460	PF00498	0.552
LIG_FHA_1	564	570	PF00498	0.515
LIG_FHA_1	76	82	PF00498	0.540
LIG_FHA_2	14	20	PF00498	0.564
LIG_FHA_2	254	260	PF00498	0.587
LIG_FHA_2	411	417	PF00498	0.604
LIG_FHA_2	632	638	PF00498	0.637
LIG_GBD_Chelix_1	306	314	PF00786	0.480
LIG_LIR_Nem_3	627	633	PF02991	0.624
LIG_PDZ_Class_1	735	740	PF00595	0.672
LIG_SH2_CRK	134	138	PF00017	0.500
LIG_SH2_CRK	542	546	PF00017	0.497
LIG_SH2_CRK	630	634	PF00017	0.571
LIG_SH2_NCK_1	127	131	PF00017	0.516
LIG_SH2_NCK_1	197	201	PF00017	0.529
LIG_SH2_NCK_1	542	546	PF00017	0.471
LIG_SH2_SRC	127	130	PF00017	0.541
LIG_SH2_STAP1	127	131	PF00017	0.461
LIG_SH2_STAP1	134	138	PF00017	0.427
LIG_SH2_STAP1	156	160	PF00017	0.472
LIG_SH2_STAP1	428	432	PF00017	0.559
LIG_SH2_STAP1	519	523	PF00017	0.514
LIG_SH2_STAT3	41	44	PF00017	0.537
LIG_SH2_STAT5	156	159	PF00017	0.434
LIG_SH2_STAT5	275	278	PF00017	0.360
LIG_SH2_STAT5	685	688	PF00017	0.466
LIG_SH2_STAT5	85	88	PF00017	0.445
LIG_SH2_STAT5	93	96	PF00017	0.445
LIG_Sin3_3	567	574	PF02671	0.490
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.529
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.456
LIG_SUMO_SIM_par_1	386	392	PF11976	0.532
LIG_TYR_ITIM	628	633	PF00017	0.595
LIG_UBA3_1	289	297	PF00899	0.284
LIG_WW_3	653	657	PF00397	0.542
MOD_CDC14_SPxK_1	257	260	PF00782	0.412
MOD_CDK_SPxK_1	254	260	PF00069	0.462
MOD_CDK_SPxK_1	68	74	PF00069	0.416
MOD_CK1_1	253	259	PF00069	0.565
MOD_CK1_1	300	306	PF00069	0.388
MOD_CK1_1	337	343	PF00069	0.507
MOD_CK1_1	378	384	PF00069	0.400
MOD_CK1_1	403	409	PF00069	0.707
MOD_CK1_1	599	605	PF00069	0.531
MOD_CK1_1	681	687	PF00069	0.342
MOD_CK1_1	734	740	PF00069	0.658
MOD_CK2_1	24	30	PF00069	0.466
MOD_CK2_1	253	259	PF00069	0.615
MOD_CK2_1	438	444	PF00069	0.603
MOD_CK2_1	58	64	PF00069	0.428
MOD_GlcNHglycan	160	163	PF01048	0.431
MOD_GlcNHglycan	303	306	PF01048	0.405
MOD_GlcNHglycan	316	319	PF01048	0.468
MOD_GlcNHglycan	356	359	PF01048	0.546
MOD_GlcNHglycan	405	408	PF01048	0.716
MOD_GlcNHglycan	416	419	PF01048	0.618
MOD_GlcNHglycan	52	55	PF01048	0.429
MOD_GlcNHglycan	596	599	PF01048	0.636
MOD_GlcNHglycan	648	651	PF01048	0.774
MOD_GlcNHglycan	737	740	PF01048	0.743
MOD_GlcNHglycan	75	78	PF01048	0.455
MOD_GSK3_1	154	161	PF00069	0.395
MOD_GSK3_1	20	27	PF00069	0.502
MOD_GSK3_1	215	222	PF00069	0.380
MOD_GSK3_1	244	251	PF00069	0.686
MOD_GSK3_1	292	299	PF00069	0.462
MOD_GSK3_1	334	341	PF00069	0.514
MOD_GSK3_1	395	402	PF00069	0.577
MOD_GSK3_1	410	417	PF00069	0.605
MOD_GSK3_1	483	490	PF00069	0.557
MOD_GSK3_1	513	520	PF00069	0.499
MOD_GSK3_1	594	601	PF00069	0.555
MOD_GSK3_1	731	738	PF00069	0.691
MOD_LATS_1	332	338	PF00433	0.556
MOD_N-GLC_1	154	159	PF02516	0.421
MOD_NEK2_1	20	25	PF00069	0.340
MOD_NEK2_1	292	297	PF00069	0.468
MOD_NEK2_1	320	325	PF00069	0.430
MOD_NEK2_1	354	359	PF00069	0.407
MOD_NEK2_1	380	385	PF00069	0.424
MOD_NEK2_1	50	55	PF00069	0.408
MOD_NEK2_1	512	517	PF00069	0.503
MOD_NEK2_1	596	601	PF00069	0.533
MOD_NEK2_1	7	12	PF00069	0.566
MOD_NEK2_1	73	78	PF00069	0.422
MOD_NEK2_2	216	221	PF00069	0.462
MOD_NEK2_2	555	560	PF00069	0.323
MOD_PKA_1	395	401	PF00069	0.525
MOD_PKA_1	483	489	PF00069	0.435
MOD_PKA_1	631	637	PF00069	0.670
MOD_PKA_2	337	343	PF00069	0.422
MOD_PKA_2	483	489	PF00069	0.552
MOD_PKA_2	510	516	PF00069	0.521
MOD_PKA_2	631	637	PF00069	0.595
MOD_Plk_1	555	561	PF00069	0.534
MOD_Plk_1	563	569	PF00069	0.518
MOD_Plk_1	7	13	PF00069	0.548
MOD_Plk_4	200	206	PF00069	0.450
MOD_Plk_4	484	490	PF00069	0.420
MOD_Plk_4	58	64	PF00069	0.365
MOD_ProDKin_1	177	183	PF00069	0.529
MOD_ProDKin_1	254	260	PF00069	0.452
MOD_ProDKin_1	400	406	PF00069	0.721
MOD_ProDKin_1	68	74	PF00069	0.455
MOD_ProDKin_1	731	737	PF00069	0.689
MOD_SUMO_for_1	5	8	PF00179	0.486
MOD_SUMO_rev_2	174	181	PF00179	0.463
MOD_SUMO_rev_2	575	584	PF00179	0.533
TRG_DiLeu_BaEn_1	148	153	PF01217	0.442
TRG_DiLeu_BaEn_1	564	569	PF01217	0.403
TRG_ENDOCYTIC_2	134	137	PF00928	0.296
TRG_ENDOCYTIC_2	275	278	PF00928	0.477
TRG_ENDOCYTIC_2	542	545	PF00928	0.476
TRG_ENDOCYTIC_2	630	633	PF00928	0.562
TRG_ENDOCYTIC_2	88	91	PF00928	0.324
TRG_ER_diArg_1	279	282	PF00400	0.517
TRG_ER_diArg_1	287	289	PF00400	0.423
TRG_ER_diArg_1	342	345	PF00400	0.325
TRG_ER_diArg_1	448	451	PF00400	0.548
TRG_ER_diArg_1	483	485	PF00400	0.477
TRG_ER_diArg_1	630	632	PF00400	0.664
TRG_ER_diArg_1	655	658	PF00400	0.304
TRG_ER_diArg_1	661	663	PF00400	0.298
TRG_ER_diArg_1	692	695	PF00400	0.491
TRG_ER_diArg_1	697	699	PF00400	0.541
TRG_NES_CRM1_1	379	392	PF08389	0.426
TRG_NES_CRM1_1	497	510	PF08389	0.538
TRG_NLS_Bipartite_1	692	712	PF00514	0.576
TRG_NLS_MonoCore_2	393	398	PF00514	0.487
TRG_NLS_MonoExtC_3	445	450	PF00514	0.490
TRG_NLS_MonoExtN_4	391	398	PF00514	0.486
TRG_NLS_MonoExtN_4	446	451	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I027	Leptomonas seymouri	63%	100%
A0A0S4J0A8	Bodo saltans	34%	100%
A0A1X0P6G4	Trypanosomatidae	42%	100%
A0A3Q8IDA7	Leishmania donovani	93%	100%
A0A422NHC6	Trypanosoma rangeli	43%	100%
A4HA36	Leishmania braziliensis	83%	99%
A4HY99	Leishmania infantum	93%	100%
D0A0N5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AS31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O76094	Homo sapiens	23%	100%
P33731	Canis lupus familiaris	23%	100%
Q54EP7	Dictyostelium discoideum	21%	100%
V5BJ44	Trypanosoma cruzi	44%	100%