Putative ATP-binding cassette protein subfamily F,member 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transport system ATP-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QDE1_LEIMA

TriTrypDb:

LmjF.19.0800 , LMJLV39_190013600 , LMJSD75_190013300

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE1

Function

Biological processes
Term	Name	Level	Count
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0090069	regulation of ribosome biogenesis	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.225
CLV_C14_Caspase3-7	190	194	PF00656	0.218
CLV_C14_Caspase3-7	25	29	PF00656	0.559
CLV_C14_Caspase3-7	508	512	PF00656	0.203
CLV_C14_Caspase3-7	542	546	PF00656	0.397
CLV_NRD_NRD_1	216	218	PF00675	0.324
CLV_PCSK_KEX2_1	187	189	PF00082	0.213
CLV_PCSK_KEX2_1	216	218	PF00082	0.324
CLV_PCSK_KEX2_1	525	527	PF00082	0.324
CLV_PCSK_KEX2_1	584	586	PF00082	0.425
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.213
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.313
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.425
CLV_PCSK_SKI1_1	203	207	PF00082	0.213
CLV_PCSK_SKI1_1	269	273	PF00082	0.248
CLV_PCSK_SKI1_1	329	333	PF00082	0.198
CLV_PCSK_SKI1_1	489	493	PF00082	0.328
CLV_PCSK_SKI1_1	5	9	PF00082	0.480
CLV_PCSK_SKI1_1	516	520	PF00082	0.246
DEG_MDM2_SWIB_1	222	230	PF02201	0.213
DEG_SCF_FBW7_1	503	508	PF00400	0.206
DOC_CKS1_1	502	507	PF01111	0.213
DOC_CYCLIN_RxL_1	266	275	PF00134	0.264
DOC_MAPK_FxFP_2	376	379	PF00069	0.296
DOC_MAPK_FxFP_2	396	399	PF00069	0.259
DOC_MAPK_gen_1	200	210	PF00069	0.210
DOC_MAPK_gen_1	525	532	PF00069	0.324
DOC_PP1_RVXF_1	201	207	PF00149	0.213
DOC_PP1_RVXF_1	371	377	PF00149	0.349
DOC_PP1_RVXF_1	390	397	PF00149	0.409
DOC_PP1_RVXF_1	514	520	PF00149	0.213
DOC_PP2B_LxvP_1	384	387	PF13499	0.330
DOC_PP4_FxxP_1	237	240	PF00568	0.213
DOC_PP4_FxxP_1	376	379	PF00568	0.296
DOC_PP4_FxxP_1	396	399	PF00568	0.259
DOC_PP4_FxxP_1	63	66	PF00568	0.364
DOC_SPAK_OSR1_1	494	498	PF12202	0.213
DOC_USP7_MATH_1	126	130	PF00917	0.425
DOC_USP7_MATH_1	15	19	PF00917	0.614
DOC_USP7_MATH_1	54	58	PF00917	0.401
DOC_USP7_MATH_1	59	63	PF00917	0.350
DOC_USP7_MATH_2	471	477	PF00917	0.208
DOC_USP7_UBL2_3	156	160	PF12436	0.208
DOC_USP7_UBL2_3	354	358	PF12436	0.478
DOC_USP7_UBL2_3	5	9	PF12436	0.469
DOC_WW_Pin1_4	33	38	PF00397	0.552
DOC_WW_Pin1_4	467	472	PF00397	0.213
DOC_WW_Pin1_4	501	506	PF00397	0.213
LIG_14-3-3_CanoR_1	227	233	PF00244	0.240
LIG_14-3-3_CanoR_1	361	369	PF00244	0.367
LIG_BRCT_BRCA1_1	276	280	PF00533	0.281
LIG_FHA_1	239	245	PF00498	0.217
LIG_FHA_1	247	253	PF00498	0.208
LIG_FHA_1	363	369	PF00498	0.346
LIG_FHA_1	38	44	PF00498	0.528
LIG_FHA_1	534	540	PF00498	0.362
LIG_FHA_1	92	98	PF00498	0.213
LIG_FHA_2	307	313	PF00498	0.402
LIG_FHA_2	404	410	PF00498	0.260
LIG_FHA_2	468	474	PF00498	0.331
LIG_FHA_2	506	512	PF00498	0.203
LIG_IRF3_LxIS_1	76	83	PF10401	0.296
LIG_LIR_Apic_2	393	399	PF02991	0.307
LIG_LIR_Apic_2	62	66	PF02991	0.418
LIG_LIR_Gen_1	403	412	PF02991	0.242
LIG_LIR_Nem_3	183	189	PF02991	0.213
LIG_LIR_Nem_3	300	306	PF02991	0.406
LIG_LIR_Nem_3	403	408	PF02991	0.317
LIG_LIR_Nem_3	476	482	PF02991	0.217
LIG_LYPXL_yS_3	479	482	PF13949	0.224
LIG_MAD2	118	126	PF02301	0.213
LIG_PCNA_yPIPBox_3	594	605	PF02747	0.330
LIG_Pex14_1	259	263	PF04695	0.256
LIG_Pex14_2	206	210	PF04695	0.213
LIG_Pex14_2	222	226	PF04695	0.213
LIG_Pex14_2	457	461	PF04695	0.213
LIG_PTB_Apo_2	62	69	PF02174	0.366
LIG_PTB_Phospho_1	62	68	PF10480	0.459
LIG_Rb_LxCxE_1	115	137	PF01857	0.267
LIG_Rb_LxCxE_1	429	442	PF01857	0.213
LIG_SH2_CRK	103	107	PF00017	0.308
LIG_SH2_CRK	524	528	PF00017	0.222
LIG_SH2_STAP1	608	612	PF00017	0.453
LIG_SH2_STAT3	135	138	PF00017	0.222
LIG_SH2_STAT5	135	138	PF00017	0.215
LIG_SH2_STAT5	263	266	PF00017	0.271
LIG_SH2_STAT5	306	309	PF00017	0.406
LIG_SH2_STAT5	334	337	PF00017	0.398
LIG_SH2_STAT5	445	448	PF00017	0.213
LIG_SH2_STAT5	6	9	PF00017	0.465
LIG_SH3_3	380	386	PF00018	0.333
LIG_SH3_3	396	402	PF00018	0.312
LIG_SH3_3	479	485	PF00018	0.224
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.213
LIG_SUMO_SIM_par_1	149	155	PF11976	0.213
LIG_SUMO_SIM_par_1	240	247	PF11976	0.214
LIG_SUMO_SIM_par_1	557	562	PF11976	0.239
LIG_TRAF2_1	309	312	PF00917	0.478
LIG_TRAF2_1	50	53	PF00917	0.501
LIG_UBA3_1	204	212	PF00899	0.324
LIG_WRC_WIRS_1	60	65	PF05994	0.419
MOD_CDK_SPxK_1	501	507	PF00069	0.324
MOD_CK1_1	143	149	PF00069	0.203
MOD_CK1_1	27	33	PF00069	0.594
MOD_CK1_1	36	42	PF00069	0.671
MOD_CK1_1	403	409	PF00069	0.208
MOD_CK2_1	160	166	PF00069	0.402
MOD_CK2_1	306	312	PF00069	0.398
MOD_CK2_1	467	473	PF00069	0.321
MOD_GlcNHglycan	144	148	PF01048	0.332
MOD_GlcNHglycan	222	225	PF01048	0.213
MOD_GlcNHglycan	341	344	PF01048	0.198
MOD_GlcNHglycan	489	492	PF01048	0.283
MOD_GlcNHglycan	497	500	PF01048	0.323
MOD_GlcNHglycan	56	59	PF01048	0.371
MOD_GlcNHglycan	98	101	PF01048	0.324
MOD_GSK3_1	216	223	PF00069	0.213
MOD_GSK3_1	33	40	PF00069	0.710
MOD_GSK3_1	348	355	PF00069	0.398
MOD_GSK3_1	501	508	PF00069	0.240
MOD_N-GLC_1	33	38	PF02516	0.729
MOD_N-GLC_1	91	96	PF02516	0.213
MOD_N-GLC_2	109	111	PF02516	0.213
MOD_N-GLC_2	283	285	PF02516	0.277
MOD_NEK2_1	228	233	PF00069	0.218
MOD_NEK2_1	267	272	PF00069	0.274
MOD_NEK2_1	495	500	PF00069	0.317
MOD_NEK2_1	80	85	PF00069	0.297
MOD_PIKK_1	134	140	PF00454	0.222
MOD_PIKK_1	274	280	PF00454	0.272
MOD_PIKK_1	473	479	PF00454	0.217
MOD_PIKK_1	480	486	PF00454	0.206
MOD_PKA_1	216	222	PF00069	0.324
MOD_PKA_2	216	222	PF00069	0.213
MOD_PKA_2	228	234	PF00069	0.213
MOD_PKA_2	400	406	PF00069	0.385
MOD_Plk_1	143	149	PF00069	0.203
MOD_Plk_1	352	358	PF00069	0.398
MOD_Plk_1	392	398	PF00069	0.314
MOD_Plk_1	80	86	PF00069	0.312
MOD_Plk_1	91	97	PF00069	0.213
MOD_Plk_2-3	540	546	PF00069	0.297
MOD_Plk_4	112	118	PF00069	0.213
MOD_Plk_4	238	244	PF00069	0.213
MOD_Plk_4	267	273	PF00069	0.331
MOD_Plk_4	400	406	PF00069	0.385
MOD_ProDKin_1	33	39	PF00069	0.551
MOD_ProDKin_1	467	473	PF00069	0.213
MOD_ProDKin_1	501	507	PF00069	0.213
MOD_SUMO_for_1	50	53	PF00179	0.484
MOD_SUMO_rev_2	579	586	PF00179	0.322
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.265
TRG_ENDOCYTIC_2	103	106	PF00928	0.308
TRG_ENDOCYTIC_2	186	189	PF00928	0.213
TRG_ENDOCYTIC_2	479	482	PF00928	0.213
TRG_ER_diArg_1	216	218	PF00400	0.240
TRG_ER_diArg_1	226	229	PF00400	0.192
TRG_NES_CRM1_1	144	157	PF08389	0.231
TRG_NES_CRM1_1	159	174	PF08389	0.187
TRG_NES_CRM1_1	549	564	PF08389	0.378
TRG_NLS_MonoExtN_4	5	12	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VBH0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	38%	96%
A0A0H2VFI8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
A0A0N0P4L2	Leptomonas seymouri	42%	85%
A0A0N1I593	Leptomonas seymouri	40%	91%
A0A0N1PAH6	Leptomonas seymouri	88%	100%
A0A0S4IYK6	Bodo saltans	33%	100%
A0A0S4JRN6	Bodo saltans	40%	90%
A0A0S4JUD9	Bodo saltans	40%	100%
A0A1X0P0L3	Trypanosomatidae	41%	91%
A0A1X0P688	Trypanosomatidae	79%	100%
A0A1X0P8V9	Trypanosomatidae	43%	85%
A0A3Q8IHB5	Leishmania donovani	41%	92%
A0A3R7LWT1	Trypanosoma rangeli	81%	100%
A0A3S5H525	Leishmania donovani	41%	85%
A0A3S7WVI6	Leishmania donovani	98%	100%
A0A422N7J4	Trypanosoma rangeli	42%	85%
A0A422NHP3	Trypanosoma rangeli	41%	91%
A4H3I8	Leishmania braziliensis	41%	85%
A4HA37	Leishmania braziliensis	93%	99%
A4HL68	Leishmania braziliensis	40%	92%
A4HRS7	Leishmania infantum	42%	85%
A4HYA0	Leishmania infantum	98%	100%
A4I8P8	Leishmania infantum	41%	92%
D0A0N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
D0A223	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	85%
D0A4N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	89%
E9ACG3	Leishmania major	42%	100%
E9AJQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	85%
E9AS32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B3L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	92%
O05519	Bacillus subtilis (strain 168)	29%	95%
O06476	Bacillus subtilis (strain 168)	29%	97%
O31716	Bacillus subtilis (strain 168)	30%	100%
O34362	Bacillus subtilis (strain 168)	23%	100%
O34512	Bacillus subtilis (strain 168)	28%	100%
O42943	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	99%
O59672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	83%
P0A9U3	Escherichia coli (strain K12)	31%	100%
P0A9U4	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	31%	100%
P0A9U5	Escherichia coli O157:H7	31%	100%
P0A9W3	Escherichia coli (strain K12)	27%	100%
P0A9W4	Escherichia coli O157:H7	27%	100%
P0A9W5	Shigella flexneri	27%	100%
P25256	Streptomyces fradiae	28%	100%
P39115	Bacillus subtilis (strain 168)	25%	100%
P40024	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P43535	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	81%
P43672	Escherichia coli (strain K12)	30%	96%
P44808	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	96%
P45127	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P63389	Escherichia coli (strain K12)	37%	96%
P63390	Escherichia coli O157:H7	37%	96%
P9WQK2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WQK3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
Q2KJA2	Bos taurus	51%	98%
Q45978	Caulobacter vibrioides (strain ATCC 19089 / CB15)	27%	100%
Q4Q4I8	Leishmania major	41%	100%
Q57242	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	95%
Q5R9Z5	Pongo abelii	40%	86%
Q66H39	Rattus norvegicus	40%	86%
Q6MG08	Rattus norvegicus	42%	73%
Q6P542	Mus musculus	41%	73%
Q73R11	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	21%	100%
Q767L0	Sus scrofa	43%	76%
Q7MFH3	Vibrio vulnificus (strain YJ016)	23%	100%
Q7YR37	Pan troglodytes	42%	76%
Q88ZZ2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	24%	100%
Q8D3Z9	Vibrio vulnificus (strain CMCP6)	22%	100%
Q8DQY5	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	22%	100%
Q8G838	Bifidobacterium longum (strain NCC 2705)	24%	78%
Q8H0V6	Arabidopsis thaliana	44%	86%
Q8K268	Mus musculus	40%	86%
Q8K9I3	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	100%
Q8NE71	Homo sapiens	43%	72%
Q8PSR0	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	24%	100%
Q8R9L8	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	23%	100%
Q8SRV5	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q8T6B7	Dictyostelium discoideum	45%	100%
Q8TQ05	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	100%
Q99LE6	Mus musculus	53%	97%
Q9FIB4	Arabidopsis thaliana	31%	90%
Q9FJH6	Arabidopsis thaliana	58%	100%
Q9LV93	Arabidopsis thaliana	32%	88%
Q9M1H3	Arabidopsis thaliana	44%	85%
Q9NUQ8	Homo sapiens	40%	86%
Q9UG63	Homo sapiens	53%	98%
Q9USH9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	74%
V5AVV7	Trypanosoma cruzi	41%	100%
V5BD93	Trypanosoma cruzi	43%	96%
V5DFD4	Trypanosoma cruzi	78%	100%