Vps53_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vps53-like domain protein

Species:

Leishmania major

UniProt:

Q4QDE0_LEIMA

TriTrypDb:

LmjF.19.0810 , LMJLV39_190013700 , LMJSD75_190013400

Length:

869

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000938	GARP complex	3	12
GO:0005829	cytosol	2	12
GO:0010008	endosome membrane	5	12
GO:0012506	vesicle membrane	4	12
GO:0016020	membrane	2	12
GO:0030659	cytoplasmic vesicle membrane	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QDE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDE0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0016192	vesicle-mediated transport	4	12
GO:0016197	endosomal transport	4	12
GO:0016482	cytosolic transport	4	12
GO:0042147	retrograde transport, endosome to Golgi	5	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.461
CLV_MEL_PAP_1	93	99	PF00089	0.185
CLV_NRD_NRD_1	155	157	PF00675	0.187
CLV_NRD_NRD_1	267	269	PF00675	0.176
CLV_NRD_NRD_1	449	451	PF00675	0.242
CLV_NRD_NRD_1	474	476	PF00675	0.254
CLV_NRD_NRD_1	58	60	PF00675	0.419
CLV_NRD_NRD_1	617	619	PF00675	0.308
CLV_NRD_NRD_1	662	664	PF00675	0.252
CLV_NRD_NRD_1	713	715	PF00675	0.302
CLV_PCSK_FUR_1	252	256	PF00082	0.197
CLV_PCSK_FUR_1	615	619	PF00082	0.296
CLV_PCSK_KEX2_1	154	156	PF00082	0.197
CLV_PCSK_KEX2_1	254	256	PF00082	0.182
CLV_PCSK_KEX2_1	267	269	PF00082	0.165
CLV_PCSK_KEX2_1	352	354	PF00082	0.185
CLV_PCSK_KEX2_1	430	432	PF00082	0.251
CLV_PCSK_KEX2_1	449	451	PF00082	0.228
CLV_PCSK_KEX2_1	473	475	PF00082	0.319
CLV_PCSK_KEX2_1	617	619	PF00082	0.308
CLV_PCSK_KEX2_1	713	715	PF00082	0.301
CLV_PCSK_KEX2_1	726	728	PF00082	0.332
CLV_PCSK_KEX2_1	734	736	PF00082	0.392
CLV_PCSK_KEX2_1	863	865	PF00082	0.571
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.303
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.185
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.185
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.251
CLV_PCSK_PC1ET2_1	726	728	PF00082	0.346
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.392
CLV_PCSK_PC1ET2_1	863	865	PF00082	0.571
CLV_PCSK_SKI1_1	161	165	PF00082	0.174
CLV_PCSK_SKI1_1	20	24	PF00082	0.477
CLV_PCSK_SKI1_1	268	272	PF00082	0.188
CLV_PCSK_SKI1_1	273	277	PF00082	0.167
CLV_PCSK_SKI1_1	284	288	PF00082	0.152
CLV_PCSK_SKI1_1	337	341	PF00082	0.176
CLV_PCSK_SKI1_1	384	388	PF00082	0.254
CLV_PCSK_SKI1_1	430	434	PF00082	0.417
CLV_PCSK_SKI1_1	572	576	PF00082	0.331
CLV_PCSK_SKI1_1	595	599	PF00082	0.221
CLV_PCSK_SKI1_1	636	640	PF00082	0.259
CLV_PCSK_SKI1_1	671	675	PF00082	0.249
CLV_PCSK_SKI1_1	84	88	PF00082	0.211
DEG_APCC_DBOX_1	448	456	PF00400	0.346
DEG_APCC_DBOX_1	594	602	PF00400	0.218
DEG_SPOP_SBC_1	147	151	PF00917	0.197
DOC_CDC14_PxL_1	534	542	PF14671	0.286
DOC_CYCLIN_RxL_1	267	280	PF00134	0.176
DOC_CYCLIN_RxL_1	592	599	PF00134	0.220
DOC_MAPK_gen_1	264	272	PF00069	0.176
DOC_MAPK_gen_1	449	455	PF00069	0.303
DOC_MAPK_gen_1	473	480	PF00069	0.234
DOC_MAPK_MEF2A_6	369	376	PF00069	0.268
DOC_MAPK_NFAT4_5	369	377	PF00069	0.176
DOC_MAPK_RevD_3	461	475	PF00069	0.354
DOC_PP1_RVXF_1	504	511	PF00149	0.340
DOC_PP2B_LxvP_1	639	642	PF13499	0.254
DOC_PP2B_LxvP_1	780	783	PF13499	0.478
DOC_PP4_FxxP_1	650	653	PF00568	0.255
DOC_USP7_MATH_1	104	108	PF00917	0.197
DOC_USP7_MATH_1	565	569	PF00917	0.385
DOC_USP7_MATH_1	581	585	PF00917	0.264
DOC_USP7_MATH_1	776	780	PF00917	0.576
DOC_USP7_MATH_1	786	790	PF00917	0.576
DOC_USP7_MATH_1	817	821	PF00917	0.617
DOC_USP7_UBL2_3	178	182	PF12436	0.196
DOC_USP7_UBL2_3	426	430	PF12436	0.257
DOC_WW_Pin1_4	466	471	PF00397	0.380
DOC_WW_Pin1_4	790	795	PF00397	0.564
LIG_14-3-3_CanoR_1	155	164	PF00244	0.164
LIG_14-3-3_CanoR_1	202	206	PF00244	0.215
LIG_14-3-3_CanoR_1	57	66	PF00244	0.173
LIG_14-3-3_CanoR_1	850	859	PF00244	0.426
LIG_Actin_WH2_1	268	286	PF00022	0.143
LIG_Actin_WH2_2	269	286	PF00022	0.143
LIG_Actin_WH2_2	414	432	PF00022	0.239
LIG_Actin_WH2_2	44	61	PF00022	0.209
LIG_APCC_ABBA_1	686	691	PF00400	0.263
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.197
LIG_BIR_III_4	558	562	PF00653	0.358
LIG_BRCT_BRCA1_1	148	152	PF00533	0.176
LIG_BRCT_BRCA1_1	170	174	PF00533	0.195
LIG_BRCT_BRCA1_1	249	253	PF00533	0.197
LIG_BRCT_BRCA1_1	513	517	PF00533	0.261
LIG_BRCT_BRCA1_1	854	858	PF00533	0.457
LIG_BRCT_BRCA1_2	148	154	PF00533	0.303
LIG_DLG_GKlike_1	739	747	PF00625	0.444
LIG_FHA_1	127	133	PF00498	0.176
LIG_FHA_1	298	304	PF00498	0.176
LIG_FHA_1	324	330	PF00498	0.176
LIG_FHA_1	480	486	PF00498	0.250
LIG_FHA_1	520	526	PF00498	0.413
LIG_FHA_1	573	579	PF00498	0.307
LIG_FHA_1	654	660	PF00498	0.332
LIG_FHA_1	801	807	PF00498	0.506
LIG_FHA_1	825	831	PF00498	0.610
LIG_FHA_2	303	309	PF00498	0.176
LIG_FHA_2	342	348	PF00498	0.185
LIG_FHA_2	487	493	PF00498	0.336
LIG_FHA_2	575	581	PF00498	0.366
LIG_FHA_2	731	737	PF00498	0.376
LIG_FHA_2	75	81	PF00498	0.241
LIG_GBD_Chelix_1	455	463	PF00786	0.226
LIG_LIR_Gen_1	171	181	PF02991	0.184
LIG_LIR_Gen_1	266	276	PF02991	0.176
LIG_LIR_Gen_1	277	287	PF02991	0.176
LIG_LIR_Gen_1	419	429	PF02991	0.229
LIG_LIR_Gen_1	507	517	PF02991	0.287
LIG_LIR_Gen_1	635	644	PF02991	0.246
LIG_LIR_Gen_1	656	666	PF02991	0.254
LIG_LIR_Gen_1	682	693	PF02991	0.280
LIG_LIR_Gen_1	843	853	PF02991	0.522
LIG_LIR_Nem_3	204	209	PF02991	0.207
LIG_LIR_Nem_3	266	272	PF02991	0.176
LIG_LIR_Nem_3	277	282	PF02991	0.176
LIG_LIR_Nem_3	411	417	PF02991	0.267
LIG_LIR_Nem_3	419	425	PF02991	0.213
LIG_LIR_Nem_3	507	513	PF02991	0.304
LIG_LIR_Nem_3	514	520	PF02991	0.230
LIG_LIR_Nem_3	635	641	PF02991	0.244
LIG_LIR_Nem_3	656	661	PF02991	0.262
LIG_LIR_Nem_3	665	669	PF02991	0.226
LIG_LIR_Nem_3	682	688	PF02991	0.261
LIG_NRBOX	271	277	PF00104	0.280
LIG_NRBOX	593	599	PF00104	0.215
LIG_PCNA_yPIPBox_3	697	710	PF02747	0.264
LIG_Pex14_1	345	349	PF04695	0.176
LIG_Pex14_2	287	291	PF04695	0.179
LIG_Pex14_2	768	772	PF04695	0.468
LIG_PTB_Apo_2	200	207	PF02174	0.303
LIG_PTB_Apo_2	32	39	PF02174	0.176
LIG_PTB_Apo_2	542	549	PF02174	0.273
LIG_PTB_Apo_2	608	615	PF02174	0.369
LIG_PTB_Phospho_1	608	614	PF10480	0.361
LIG_SH2_CRK	279	283	PF00017	0.303
LIG_SH2_GRB2like	33	36	PF00017	0.185
LIG_SH2_NCK_1	644	648	PF00017	0.312
LIG_SH2_PTP2	269	272	PF00017	0.166
LIG_SH2_PTP2	658	661	PF00017	0.237
LIG_SH2_PTP2	94	97	PF00017	0.185
LIG_SH2_SRC	33	36	PF00017	0.215
LIG_SH2_SRC	414	417	PF00017	0.246
LIG_SH2_STAP1	170	174	PF00017	0.185
LIG_SH2_STAP1	249	253	PF00017	0.185
LIG_SH2_STAP1	279	283	PF00017	0.185
LIG_SH2_STAP1	5	9	PF00017	0.490
LIG_SH2_STAP1	521	525	PF00017	0.226
LIG_SH2_STAP1	690	694	PF00017	0.282
LIG_SH2_STAT3	327	330	PF00017	0.176
LIG_SH2_STAT5	200	203	PF00017	0.177
LIG_SH2_STAT5	269	272	PF00017	0.185
LIG_SH2_STAT5	327	330	PF00017	0.203
LIG_SH2_STAT5	33	36	PF00017	0.185
LIG_SH2_STAT5	414	417	PF00017	0.246
LIG_SH2_STAT5	521	524	PF00017	0.238
LIG_SH2_STAT5	658	661	PF00017	0.345
LIG_SH2_STAT5	94	97	PF00017	0.185
LIG_SH3_3	13	19	PF00018	0.406
LIG_SH3_3	585	591	PF00018	0.250
LIG_SH3_3	689	695	PF00018	0.345
LIG_SH3_3	780	786	PF00018	0.617
LIG_Sin3_3	222	229	PF02671	0.185
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.178
LIG_SUMO_SIM_par_1	224	233	PF11976	0.431
LIG_SUMO_SIM_par_1	321	326	PF11976	0.181
LIG_SUMO_SIM_par_1	331	336	PF11976	0.170
LIG_TRAF2_1	163	166	PF00917	0.303
LIG_TRAF2_1	305	308	PF00917	0.303
LIG_TRAF2_1	835	838	PF00917	0.515
LIG_TYR_ITIM	688	693	PF00017	0.388
LIG_UBA3_1	173	182	PF00899	0.197
LIG_UBA3_1	421	430	PF00899	0.236
LIG_WW_3	17	21	PF00397	0.414
LIG_WW_3	503	507	PF00397	0.362
LIG_WW_3	781	785	PF00397	0.489
MOD_CDK_SPxxK_3	466	473	PF00069	0.362
MOD_CK1_1	131	137	PF00069	0.188
MOD_CK1_1	394	400	PF00069	0.360
MOD_CK1_1	524	530	PF00069	0.381
MOD_CK1_1	74	80	PF00069	0.274
MOD_CK1_1	759	765	PF00069	0.555
MOD_CK1_1	770	776	PF00069	0.442
MOD_CK1_1	790	796	PF00069	0.544
MOD_CK1_1	851	857	PF00069	0.452
MOD_CK2_1	102	108	PF00069	0.210
MOD_CK2_1	147	153	PF00069	0.185
MOD_CK2_1	302	308	PF00069	0.185
MOD_CK2_1	401	407	PF00069	0.435
MOD_CK2_1	466	472	PF00069	0.368
MOD_CK2_1	74	80	PF00069	0.274
MOD_GlcNHglycan	170	173	PF01048	0.235
MOD_GlcNHglycan	365	368	PF01048	0.245
MOD_GlcNHglycan	393	396	PF01048	0.422
MOD_GlcNHglycan	410	413	PF01048	0.354
MOD_GlcNHglycan	459	462	PF01048	0.533
MOD_GlcNHglycan	517	520	PF01048	0.225
MOD_GlcNHglycan	750	753	PF01048	0.472
MOD_GlcNHglycan	761	764	PF01048	0.413
MOD_GlcNHglycan	77	80	PF01048	0.224
MOD_GSK3_1	123	130	PF00069	0.245
MOD_GSK3_1	337	344	PF00069	0.185
MOD_GSK3_1	406	413	PF00069	0.394
MOD_GSK3_1	511	518	PF00069	0.253
MOD_GSK3_1	71	78	PF00069	0.201
MOD_GSK3_1	739	746	PF00069	0.438
MOD_GSK3_1	770	777	PF00069	0.451
MOD_GSK3_1	786	793	PF00069	0.497
MOD_GSK3_1	800	807	PF00069	0.531
MOD_GSK3_1	840	847	PF00069	0.476
MOD_GSK3_1	848	855	PF00069	0.410
MOD_GSK3_1	95	102	PF00069	0.369
MOD_N-GLC_1	126	131	PF02516	0.176
MOD_N-GLC_1	696	701	PF02516	0.295
MOD_N-GLC_1	74	79	PF02516	0.303
MOD_N-GLC_1	786	791	PF02516	0.501
MOD_NEK2_1	128	133	PF00069	0.179
MOD_NEK2_1	168	173	PF00069	0.208
MOD_NEK2_1	214	219	PF00069	0.189
MOD_NEK2_1	297	302	PF00069	0.190
MOD_NEK2_1	363	368	PF00069	0.185
MOD_NEK2_1	485	490	PF00069	0.325
MOD_NEK2_1	601	606	PF00069	0.272
MOD_NEK2_1	634	639	PF00069	0.267
MOD_NEK2_1	743	748	PF00069	0.446
MOD_NEK2_1	800	805	PF00069	0.595
MOD_NEK2_1	848	853	PF00069	0.382
MOD_NEK2_2	609	614	PF00069	0.359
MOD_PIKK_1	155	161	PF00454	0.164
MOD_PIKK_1	188	194	PF00454	0.303
MOD_PIKK_1	337	343	PF00454	0.277
MOD_PIKK_1	487	493	PF00454	0.306
MOD_PIKK_1	99	105	PF00454	0.185
MOD_PK_1	278	284	PF00069	0.171
MOD_PK_1	840	846	PF00069	0.412
MOD_PKA_1	155	161	PF00069	0.164
MOD_PKA_1	254	260	PF00069	0.185
MOD_PKA_1	551	557	PF00069	0.482
MOD_PKA_2	155	161	PF00069	0.164
MOD_PKA_2	201	207	PF00069	0.197
MOD_PKA_2	254	260	PF00069	0.175
MOD_PKA_2	3	9	PF00069	0.350
MOD_PKA_2	58	64	PF00069	0.185
MOD_PKA_2	849	855	PF00069	0.413
MOD_PKA_2	95	101	PF00069	0.185
MOD_Plk_1	214	220	PF00069	0.184
MOD_Plk_1	337	343	PF00069	0.176
MOD_Plk_1	40	46	PF00069	0.186
MOD_Plk_1	634	640	PF00069	0.255
MOD_Plk_1	696	702	PF00069	0.312
MOD_Plk_1	739	745	PF00069	0.438
MOD_Plk_4	201	207	PF00069	0.197
MOD_Plk_4	214	220	PF00069	0.197
MOD_Plk_4	278	284	PF00069	0.207
MOD_Plk_4	323	329	PF00069	0.176
MOD_Plk_4	410	416	PF00069	0.330
MOD_Plk_4	524	530	PF00069	0.212
MOD_Plk_4	601	607	PF00069	0.254
MOD_Plk_4	609	615	PF00069	0.245
MOD_Plk_4	634	640	PF00069	0.297
MOD_Plk_4	767	773	PF00069	0.372
MOD_Plk_4	840	846	PF00069	0.426
MOD_ProDKin_1	466	472	PF00069	0.381
MOD_ProDKin_1	790	796	PF00069	0.563
MOD_SUMO_for_1	260	263	PF00179	0.197
MOD_SUMO_rev_2	171	180	PF00179	0.143
MOD_SUMO_rev_2	258	262	PF00179	0.187
MOD_SUMO_rev_2	566	571	PF00179	0.442
MOD_SUMO_rev_2	78	86	PF00179	0.262
MOD_SUMO_rev_2	98	102	PF00179	0.148
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.417
TRG_ENDOCYTIC_2	170	173	PF00928	0.185
TRG_ENDOCYTIC_2	269	272	PF00928	0.176
TRG_ENDOCYTIC_2	279	282	PF00928	0.176
TRG_ENDOCYTIC_2	360	363	PF00928	0.176
TRG_ENDOCYTIC_2	414	417	PF00928	0.246
TRG_ENDOCYTIC_2	658	661	PF00928	0.242
TRG_ENDOCYTIC_2	689	692	PF00928	0.269
TRG_ENDOCYTIC_2	94	97	PF00928	0.185
TRG_ER_diArg_1	155	157	PF00400	0.303
TRG_ER_diArg_1	267	269	PF00400	0.176
TRG_ER_diArg_1	448	450	PF00400	0.357
TRG_ER_diArg_1	473	475	PF00400	0.258
TRG_ER_diArg_1	614	617	PF00400	0.292
TRG_ER_diArg_1	712	714	PF00400	0.304
TRG_NES_CRM1_1	667	679	PF08389	0.269
TRG_NLS_MonoExtC_3	233	238	PF00514	0.303
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.176
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.221
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	735	740	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSX2	Leptomonas seymouri	78%	98%
A0A0S4J071	Bodo saltans	53%	100%
A0A1X0P670	Trypanosomatidae	59%	95%
A0A3R7KBJ1	Trypanosoma rangeli	58%	98%
A0A3S7WVF6	Leishmania donovani	96%	100%
A4HA38	Leishmania braziliensis	88%	99%
A4HYA1	Leishmania infantum	96%	100%
D0A0N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AS33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
P34561	Caenorhabditis elegans	23%	100%
P87129	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	100%
Q0WQF4	Arabidopsis thaliana	26%	100%
Q5R5J4	Pongo abelii	22%	100%
Q5VIR6	Homo sapiens	23%	100%
Q5ZLD7	Gallus gallus	23%	100%
Q8CCB4	Mus musculus	23%	100%
V5AZ39	Trypanosoma cruzi	59%	100%