LeishMANIAdb
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Putative ATG8/AUT7/APG8/PAZ2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ATG8/AUT7/APG8/PAZ2
Gene product:
ATG8/AUT7/APG8/PAZ2, putative
Species:
Leishmania major
UniProt:
Q4QDD0_LEIMA
TriTrypDb:
LmjF.19.0850 , LMJLV39_190014200 , LMJSD75_190014200
Length:
121

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 46
NetGPI no yes: 0, no: 46
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 46
GO:0110165 cellular anatomical entity 1 46
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Expansion

Sequence features

Q4QDD0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDD0

Function

Biological processes
TermNameLevelCount
GO:0006914 autophagy 3 14
GO:0006950 response to stress 2 15
GO:0006995 cellular response to nitrogen starvation 5 15
GO:0007154 cell communication 2 15
GO:0008152 metabolic process 1 14
GO:0009056 catabolic process 2 14
GO:0009267 cellular response to starvation 4 15
GO:0009605 response to external stimulus 2 15
GO:0009987 cellular process 1 27
GO:0009991 response to extracellular stimulus 3 15
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Could not find GO molecular_function term for this entry.

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 88 92 PF00656 0.380
CLV_NRD_NRD_1 13 15 PF00675 0.398
CLV_PCSK_KEX2_1 13 15 PF00082 0.396
CLV_PCSK_KEX2_1 94 96 PF00082 0.398
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.371
CLV_PCSK_SKI1_1 49 53 PF00082 0.335
CLV_PCSK_SKI1_1 61 65 PF00082 0.191
CLV_PCSK_SKI1_1 69 73 PF00082 0.425
DOC_MAPK_gen_1 94 102 PF00069 0.371
DOC_MAPK_MEF2A_6 95 104 PF00069 0.371
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HR42 Leptomonas seymouri 47% 100%
A0A0N1P9V5 Leptomonas seymouri 69% 100%
A0A0N1PD53 Leptomonas seymouri 29% 100%
A0A0S4JA79 Bodo saltans 31% 98%
A0A1X0P492 Trypanosomatidae 42% 86%
A0A1X0P5E7 Trypanosomatidae 42% 86%
A0A381MAT2 Leishmania infantum 49% 90%
A0A381MBG2 Leishmania infantum 49% 98%
A0A381MCF0 Leishmania infantum 49% 98%
A0A381MFR9 Leishmania infantum 90% 97%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS