Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATG8/AUT7/APG8/PAZ2, putative

Species:

Leishmania major

UniProt:

Q4QDC8_LEIMA

TriTrypDb:

LmjF.19.0900 , LMJLV39_190014300 , LMJSD75_190014000

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 46
NetGPI	no	yes: 0, no: 46

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	46
GO:0110165	cellular anatomical entity	1	46

Expansion

Sequence features

Q4QDC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC8

Function

Biological processes
Term	Name	Level	Count
GO:0006914	autophagy	3	15
GO:0006950	response to stress	2	15
GO:0006995	cellular response to nitrogen starvation	5	15
GO:0007154	cell communication	2	15
GO:0008152	metabolic process	1	15
GO:0009056	catabolic process	2	15
GO:0009267	cellular response to starvation	4	15
GO:0009605	response to external stimulus	2	15
GO:0009987	cellular process	1	27
GO:0009991	response to extracellular stimulus	3	15
GO:0031667	response to nutrient levels	4	15
GO:0031668	cellular response to extracellular stimulus	3	15
GO:0031669	cellular response to nutrient levels	4	15
GO:0033554	cellular response to stress	3	15
GO:0042594	response to starvation	3	15
GO:0043562	cellular response to nitrogen levels	5	15
GO:0044237	cellular metabolic process	2	15
GO:0044248	cellular catabolic process	3	15
GO:0050896	response to stimulus	1	15
GO:0051716	cellular response to stimulus	2	15
GO:0061919	process utilizing autophagic mechanism	2	15
GO:0071496	cellular response to external stimulus	3	15

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.363
CLV_NRD_NRD_1	13	15	PF00675	0.402
CLV_PCSK_KEX2_1	13	15	PF00082	0.402
CLV_PCSK_KEX2_1	94	96	PF00082	0.403
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.377
CLV_PCSK_SKI1_1	49	53	PF00082	0.341
CLV_PCSK_SKI1_1	61	65	PF00082	0.361
CLV_PCSK_SKI1_1	69	73	PF00082	0.428
DOC_MAPK_gen_1	69	75	PF00069	0.377
DOC_MAPK_gen_1	94	102	PF00069	0.377
DOC_MAPK_HePTP_8	20	32	PF00069	0.273
DOC_MAPK_MEF2A_6	23	32	PF00069	0.405
DOC_MAPK_MEF2A_6	95	104	PF00069	0.377
DOC_PP1_RVXF_1	39	45	PF00149	0.339
DOC_PP2B_LxvP_1	45	48	PF13499	0.395
DOC_USP7_MATH_1	119	123	PF00917	0.567
DOC_USP7_MATH_1	3	7	PF00917	0.640
DOC_USP7_UBL2_3	37	41	PF12436	0.299
DOC_WW_Pin1_4	76	81	PF00397	0.376
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_FHA_1	70	76	PF00498	0.348
LIG_FHA_1	77	83	PF00498	0.368
LIG_FHA_2	50	56	PF00498	0.399
LIG_FHA_2	83	89	PF00498	0.464
LIG_LIR_Gen_1	96	104	PF02991	0.314
LIG_LIR_Nem_3	96	102	PF02991	0.313
LIG_SH2_PTP2	101	104	PF00017	0.326
LIG_SH2_STAT5	101	104	PF00017	0.331
LIG_SUMO_SIM_par_1	71	76	PF11976	0.375
MOD_CK1_1	103	109	PF00069	0.301
MOD_CK2_1	49	55	PF00069	0.386
MOD_GlcNHglycan	1	4	PF01048	0.603
MOD_GlcNHglycan	121	124	PF01048	0.451
MOD_GlcNHglycan	66	69	PF01048	0.388
MOD_GSK3_1	76	83	PF00069	0.419
MOD_NEK2_1	100	105	PF00069	0.346
MOD_NEK2_1	64	69	PF00069	0.313
MOD_PKA_1	69	75	PF00069	0.312
MOD_Plk_1	49	55	PF00069	0.378
MOD_ProDKin_1	76	82	PF00069	0.376
TRG_ENDOCYTIC_2	101	104	PF00928	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR42	Leptomonas seymouri	47%	100%
A0A0N1P9V5	Leptomonas seymouri	71%	100%
A0A0N1PD53	Leptomonas seymouri	29%	100%
A0A0S4JA79	Bodo saltans	30%	100%
A0A1X0P492	Trypanosomatidae	42%	89%
A0A1X0P5E7	Trypanosomatidae	42%	89%
A0A381MAT2	Leishmania infantum	51%	93%
A0A381MBG2	Leishmania infantum	51%	100%
A0A381MCF0	Leishmania infantum	51%	100%
A0A381MFR9	Leishmania infantum	95%	100%
A0A3Q8IB99	Leishmania donovani	91%	100%
A0A3Q8IK22	Leishmania donovani	58%	92%
A0A3S5H6B2	Leishmania donovani	51%	93%
A0A3S5H6B3	Leishmania donovani	51%	100%
A0A3S5H761	Leishmania donovani	95%	100%
A0A3S5H762	Leishmania donovani	90%	100%
A0A3S7WQH8	Leishmania donovani	51%	100%
A0A3S7WQJ1	Leishmania donovani	51%	100%
A0A3S7WVM4	Leishmania donovani	92%	100%
A0A3S7WVQ8	Leishmania donovani	30%	100%
A0A422NM46	Trypanosoma rangeli	26%	100%
A0A422NM79	Trypanosoma rangeli	28%	100%
A1CQS1	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	100%
A1D3N4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	28%	100%
A2QPN1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A2XXR7	Oryza sativa subsp. indica	30%	100%
A2YS06	Oryza sativa subsp. indica	32%	100%
A4H5J2	Leishmania braziliensis	51%	100%
A4H5J3	Leishmania braziliensis	50%	100%
A4HA39	Leishmania braziliensis	54%	92%
A4HA42	Leishmania braziliensis	80%	100%
A4HA43	Leishmania braziliensis	80%	100%
A4HAB2	Leishmania braziliensis	30%	100%
A4HTT6	Leishmania infantum	51%	100%
A4HYA4	Leishmania infantum	94%	100%
A4HYA5	Leishmania infantum	91%	78%
A4HYJ2	Leishmania infantum	30%	100%
A4LA70	Colletotrichum lindemuthianum	29%	100%
A5DWI6	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	29%	86%
A6RPU4	Botryotinia fuckeliana (strain B05.10)	30%	100%
A6ZKM4	Saccharomyces cerevisiae (strain YJM789)	29%	100%
A7E8H4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	30%	100%
A7KAL9	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	28%	100%
A7TDU7	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	27%	100%
C4B4E4	Glomerella lagenarium	29%	100%
E9AGS4	Leishmania infantum	57%	92%
E9AML6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AS34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AS37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AS38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AS40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	92%
E9AS41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9ASB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
I1S1W5	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	29%	100%
J4UTT5	Beauveria bassiana (strain ARSEF 2860)	29%	100%
M1C146	Solanum tuberosum	32%	100%
M2SQA5	Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O)	29%	100%
N4X184	Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)	29%	100%
O94272	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O95166	Homo sapiens	30%	100%
P0C075	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	93%
P0CO54	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	29%	99%
P0CO55	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	29%	99%
P38182	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P60517	Rattus norvegicus	30%	100%
P60518	Cavia porcellus	29%	100%
P60519	Bos taurus	30%	100%
P60520	Homo sapiens	30%	100%
P60521	Mus musculus	30%	100%
P60522	Rattus norvegicus	30%	100%
P87068	Laccaria bicolor	29%	68%
Q09490	Caenorhabditis elegans	30%	100%
Q0C804	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	28%	100%
Q0V3Y9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	29%	100%
Q0VGK0	Rattus norvegicus	29%	100%
Q1E4K5	Coccidioides immitis (strain RS)	29%	100%
Q2GVL1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	28%	100%
Q2UBH5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	100%
Q2XPP5	Oryza sativa subsp. indica	29%	100%
Q4P2U6	Ustilago maydis (strain 521 / FGSC 9021)	30%	100%
Q4QD46	Leishmania major	30%	100%
Q4QDC5	Leishmania major	96%	100%
Q4QDD0	Leishmania major	94%	100%
Q4QDD1	Leishmania major	55%	92%
Q4QDD3	Leishmania major	93%	100%
Q4QDD4	Leishmania major	56%	92%
Q4QDD6	Leishmania major	92%	100%
Q4QI08	Leishmania major	48%	100%
Q4QI09	Leishmania major	48%	93%
Q4QI11	Leishmania major	50%	93%
Q4QI13	Leishmania major	49%	100%
Q4QI15	Leishmania major	46%	100%
Q4QI18	Leishmania major	50%	93%
Q4QI19	Leishmania major	50%	100%
Q4WJ27	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q51MW4	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	28%	100%
Q5B2U9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	100%
Q5BIZ2	Xenopus tropicalis	29%	100%
Q5QFG1	Pichia angusta	25%	100%
Q5RF21	Pongo abelii	29%	100%
Q69RC4	Oryza sativa subsp. japonica	29%	100%
Q6C794	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%
Q6CMF8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6FXR8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	100%
Q6GQ27	Xenopus laevis	29%	100%
Q6Z1D5	Oryza sativa subsp. japonica	32%	100%
Q755X2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	29%	100%
Q7XPR1	Oryza sativa subsp. japonica	30%	100%
Q86CR8	Dictyostelium discoideum	26%	100%
Q8H715	Phytophthora infestans	30%	100%
Q8HYB6	Bos taurus	29%	100%
Q8J282	Podospora anserina	29%	100%
Q8LEM4	Arabidopsis thaliana	32%	100%
Q8MK68	Oryctolagus cuniculus	30%	100%
Q8NJJ4	Komagataella pastoris	28%	100%
Q8R3R8	Mus musculus	29%	100%
Q8S926	Arabidopsis thaliana	30%	100%
Q8S927	Arabidopsis thaliana	32%	100%
Q8VYK7	Arabidopsis thaliana	34%	100%
Q8WZY7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	28%	100%
Q9DCD6	Mus musculus	30%	100%
Q9GJW7	Bos taurus	30%	100%
Q9H0R8	Homo sapiens	29%	100%
Q9LZZ9	Arabidopsis thaliana	31%	100%
Q9SL04	Arabidopsis thaliana	33%	100%
Q9XEB5	Arabidopsis thaliana	33%	100%
W0THY6	Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)	31%	100%