Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QDC4_LEIMA

TriTrypDb:

LmjF.19.0920 , LMJLV39_190014500 , LMJSD75_190014300

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QDC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.513
CLV_NRD_NRD_1	194	196	PF00675	0.234
CLV_NRD_NRD_1	40	42	PF00675	0.385
CLV_PCSK_KEX2_1	135	137	PF00082	0.294
CLV_PCSK_KEX2_1	193	195	PF00082	0.256
CLV_PCSK_KEX2_1	40	42	PF00082	0.427
CLV_PCSK_KEX2_1	523	525	PF00082	0.519
CLV_PCSK_KEX2_1	651	653	PF00082	0.287
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.294
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.519
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.304
CLV_PCSK_PC7_1	190	196	PF00082	0.212
CLV_PCSK_SKI1_1	118	122	PF00082	0.352
CLV_PCSK_SKI1_1	371	375	PF00082	0.260
CLV_PCSK_SKI1_1	652	656	PF00082	0.431
DEG_APCC_DBOX_1	95	103	PF00400	0.426
DEG_ODPH_VHL_1	622	634	PF01847	0.354
DEG_SPOP_SBC_1	299	303	PF00917	0.395
DOC_CDC14_PxL_1	609	617	PF14671	0.329
DOC_CKS1_1	602	607	PF01111	0.195
DOC_CYCLIN_yCln2_LP_2	626	632	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	633	639	PF00134	0.340
DOC_MAPK_gen_1	259	269	PF00069	0.550
DOC_MAPK_gen_1	287	294	PF00069	0.595
DOC_MAPK_gen_1	40	48	PF00069	0.472
DOC_MAPK_gen_1	523	531	PF00069	0.320
DOC_MAPK_HePTP_8	494	506	PF00069	0.395
DOC_MAPK_MEF2A_6	497	506	PF00069	0.475
DOC_MAPK_MEF2A_6	523	531	PF00069	0.355
DOC_PP2B_LxvP_1	444	447	PF13499	0.370
DOC_PP2B_LxvP_1	626	629	PF13499	0.360
DOC_PP2B_LxvP_1	632	635	PF13499	0.326
DOC_USP7_MATH_1	158	162	PF00917	0.273
DOC_USP7_MATH_1	2	6	PF00917	0.758
DOC_USP7_MATH_1	201	205	PF00917	0.325
DOC_USP7_MATH_1	449	453	PF00917	0.338
DOC_USP7_MATH_1	565	569	PF00917	0.482
DOC_USP7_MATH_1	58	62	PF00917	0.562
DOC_USP7_UBL2_3	651	655	PF12436	0.456
DOC_WW_Pin1_4	295	300	PF00397	0.575
DOC_WW_Pin1_4	601	606	PF00397	0.346
LIG_14-3-3_CanoR_1	106	113	PF00244	0.479
LIG_14-3-3_CanoR_1	501	505	PF00244	0.492
LIG_APCC_ABBA_1	250	255	PF00400	0.401
LIG_APCC_ABBA_1	52	57	PF00400	0.636
LIG_BIR_II_1	1	5	PF00653	0.758
LIG_BRCT_BRCA1_1	467	471	PF00533	0.314
LIG_CSL_BTD_1	552	555	PF09270	0.393
LIG_eIF4E_1	87	93	PF01652	0.395
LIG_EVH1_2	605	609	PF00568	0.358
LIG_FHA_1	119	125	PF00498	0.574
LIG_FHA_1	18	24	PF00498	0.617
LIG_FHA_1	255	261	PF00498	0.469
LIG_FHA_1	386	392	PF00498	0.390
LIG_FHA_1	401	407	PF00498	0.265
LIG_FHA_1	501	507	PF00498	0.492
LIG_FHA_2	300	306	PF00498	0.484
LIG_GBD_Chelix_1	505	513	PF00786	0.472
LIG_HP1_1	555	559	PF01393	0.395
LIG_LIR_Apic_2	32	37	PF02991	0.595
LIG_LIR_Apic_2	421	426	PF02991	0.412
LIG_LIR_Gen_1	126	133	PF02991	0.519
LIG_LIR_Gen_1	185	196	PF02991	0.529
LIG_LIR_Gen_1	470	479	PF02991	0.327
LIG_LIR_Gen_1	489	495	PF02991	0.390
LIG_LIR_Gen_1	515	522	PF02991	0.330
LIG_LIR_Gen_1	570	580	PF02991	0.514
LIG_LIR_Gen_1	608	617	PF02991	0.271
LIG_LIR_LC3C_4	503	506	PF02991	0.202
LIG_LIR_Nem_3	126	131	PF02991	0.493
LIG_LIR_Nem_3	134	140	PF02991	0.493
LIG_LIR_Nem_3	185	191	PF02991	0.538
LIG_LIR_Nem_3	204	210	PF02991	0.290
LIG_LIR_Nem_3	361	367	PF02991	0.536
LIG_LIR_Nem_3	421	425	PF02991	0.385
LIG_LIR_Nem_3	468	472	PF02991	0.298
LIG_LIR_Nem_3	489	494	PF02991	0.337
LIG_LIR_Nem_3	515	520	PF02991	0.340
LIG_LIR_Nem_3	552	556	PF02991	0.326
LIG_LIR_Nem_3	596	602	PF02991	0.289
LIG_LIR_Nem_3	608	612	PF02991	0.266
LIG_Pex14_1	205	209	PF04695	0.370
LIG_Pex14_2	171	175	PF04695	0.361
LIG_Pex14_2	374	378	PF04695	0.487
LIG_Pex14_2	467	471	PF04695	0.308
LIG_Pex14_2	491	495	PF04695	0.367
LIG_PTB_Apo_2	489	496	PF02174	0.436
LIG_SH2_CRK	104	108	PF00017	0.510
LIG_SH2_CRK	188	192	PF00017	0.512
LIG_SH2_CRK	383	387	PF00017	0.343
LIG_SH2_CRK	43	47	PF00017	0.687
LIG_SH2_CRK	472	476	PF00017	0.300
LIG_SH2_NCK_1	472	476	PF00017	0.298
LIG_SH2_PTP2	34	37	PF00017	0.591
LIG_SH2_SRC	34	37	PF00017	0.597
LIG_SH2_STAP1	133	137	PF00017	0.498
LIG_SH2_STAP1	188	192	PF00017	0.487
LIG_SH2_STAP1	383	387	PF00017	0.392
LIG_SH2_STAP1	573	577	PF00017	0.334
LIG_SH2_STAT3	87	90	PF00017	0.415
LIG_SH2_STAT5	133	136	PF00017	0.499
LIG_SH2_STAT5	15	18	PF00017	0.565
LIG_SH2_STAT5	30	33	PF00017	0.659
LIG_SH2_STAT5	34	37	PF00017	0.586
LIG_SH2_STAT5	437	440	PF00017	0.350
LIG_SH2_STAT5	443	446	PF00017	0.343
LIG_SH2_STAT5	454	457	PF00017	0.284
LIG_SH2_STAT5	469	472	PF00017	0.260
LIG_SH2_STAT5	493	496	PF00017	0.451
LIG_SH2_STAT5	537	540	PF00017	0.291
LIG_SH2_STAT5	550	553	PF00017	0.374
LIG_SH2_STAT5	657	660	PF00017	0.579
LIG_SH2_STAT5	74	77	PF00017	0.525
LIG_SH3_3	353	359	PF00018	0.597
LIG_SH3_3	459	465	PF00018	0.286
LIG_SH3_3	599	605	PF00018	0.310
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.409
LIG_SUMO_SIM_par_1	502	508	PF11976	0.331
LIG_SUMO_SIM_par_1	555	561	PF11976	0.324
LIG_TRAF2_1	456	459	PF00917	0.195
LIG_TYR_ITIM	102	107	PF00017	0.295
LIG_TYR_ITIM	441	446	PF00017	0.329
LIG_TYR_ITSM	468	475	PF00017	0.400
LIG_UBA3_1	151	159	PF00899	0.349
LIG_Vh1_VBS_1	392	410	PF01044	0.445
LIG_WRC_WIRS_1	450	455	PF05994	0.331
MOD_CK1_1	108	114	PF00069	0.357
MOD_CK1_1	162	168	PF00069	0.289
MOD_CK1_1	176	182	PF00069	0.510
MOD_CK1_1	225	231	PF00069	0.284
MOD_CK1_1	298	304	PF00069	0.306
MOD_CK1_1	496	502	PF00069	0.354
MOD_CK1_1	589	595	PF00069	0.314
MOD_CK1_1	663	669	PF00069	0.606
MOD_CK2_1	2	8	PF00069	0.641
MOD_CK2_1	299	305	PF00069	0.418
MOD_CMANNOS	205	208	PF00535	0.248
MOD_GlcNHglycan	160	164	PF01048	0.359
MOD_GlcNHglycan	325	329	PF01048	0.391
MOD_GlcNHglycan	475	478	PF01048	0.426
MOD_GlcNHglycan	666	669	PF01048	0.692
MOD_GlcNHglycan	99	102	PF01048	0.278
MOD_GSK3_1	105	112	PF00069	0.403
MOD_GSK3_1	158	165	PF00069	0.309
MOD_GSK3_1	295	302	PF00069	0.357
MOD_GSK3_1	381	388	PF00069	0.361
MOD_GSK3_1	467	474	PF00069	0.375
MOD_GSK3_1	496	503	PF00069	0.366
MOD_GSK3_1	53	60	PF00069	0.377
MOD_GSK3_1	582	589	PF00069	0.371
MOD_GSK3_1	656	663	PF00069	0.609
MOD_NEK2_1	113	118	PF00069	0.374
MOD_NEK2_1	131	136	PF00069	0.336
MOD_NEK2_1	139	144	PF00069	0.346
MOD_NEK2_1	17	22	PF00069	0.418
MOD_NEK2_1	224	229	PF00069	0.362
MOD_NEK2_1	324	329	PF00069	0.375
MOD_NEK2_1	381	386	PF00069	0.370
MOD_NEK2_1	400	405	PF00069	0.302
MOD_NEK2_1	467	472	PF00069	0.358
MOD_NEK2_1	504	509	PF00069	0.363
MOD_NEK2_1	582	587	PF00069	0.351
MOD_NEK2_2	449	454	PF00069	0.332
MOD_PK_1	106	112	PF00069	0.449
MOD_PKA_2	105	111	PF00069	0.327
MOD_PKA_2	500	506	PF00069	0.349
MOD_PKA_2	565	571	PF00069	0.330
MOD_Plk_1	225	231	PF00069	0.272
MOD_Plk_2-3	344	350	PF00069	0.298
MOD_Plk_4	201	207	PF00069	0.342
MOD_Plk_4	225	231	PF00069	0.333
MOD_Plk_4	381	387	PF00069	0.357
MOD_Plk_4	411	417	PF00069	0.416
MOD_Plk_4	418	424	PF00069	0.393
MOD_Plk_4	449	455	PF00069	0.335
MOD_Plk_4	467	473	PF00069	0.461
MOD_Plk_4	500	506	PF00069	0.341
MOD_Plk_4	512	518	PF00069	0.322
MOD_Plk_4	549	555	PF00069	0.312
MOD_Plk_4	567	573	PF00069	0.394
MOD_Plk_4	589	595	PF00069	0.335
MOD_Plk_4	628	634	PF00069	0.378
MOD_Plk_4	80	86	PF00069	0.314
MOD_ProDKin_1	295	301	PF00069	0.454
MOD_ProDKin_1	601	607	PF00069	0.414
MOD_SUMO_for_1	650	653	PF00179	0.373
TRG_ENDOCYTIC_2	104	107	PF00928	0.318
TRG_ENDOCYTIC_2	188	191	PF00928	0.340
TRG_ENDOCYTIC_2	383	386	PF00928	0.343
TRG_ENDOCYTIC_2	43	46	PF00928	0.497
TRG_ENDOCYTIC_2	437	440	PF00928	0.354
TRG_ENDOCYTIC_2	443	446	PF00928	0.356
TRG_ENDOCYTIC_2	472	475	PF00928	0.352
TRG_ENDOCYTIC_2	573	576	PF00928	0.339
TRG_ER_diArg_1	192	195	PF00400	0.271
TRG_ER_diArg_1	353	356	PF00400	0.421
TRG_ER_diArg_1	40	42	PF00400	0.588
TRG_NES_CRM1_1	358	372	PF08389	0.225
TRG_NES_CRM1_1	445	459	PF08389	0.297
TRG_NES_CRM1_1	584	596	PF08389	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	50%	95%
A0A0N1HY49	Leptomonas seymouri	53%	100%
A0A0N1HZ06	Leptomonas seymouri	43%	100%
A0A0N1IHL1	Leptomonas seymouri	45%	94%
A0A0N1PAY4	Leptomonas seymouri	50%	76%
A0A0N1PB77	Leptomonas seymouri	42%	100%
A0A0N1PBZ2	Leptomonas seymouri	53%	100%
A0A0N1PCC1	Leptomonas seymouri	49%	100%
A0A381MBI0	Leishmania infantum	47%	100%
A0A3Q8I8X7	Leishmania donovani	47%	100%
A0A3Q8IAZ0	Leishmania donovani	52%	96%
A0A3Q8IH50	Leishmania donovani	60%	93%
A0A3Q8IVN0	Leishmania donovani	42%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	49%	99%
A0A3S5H5V2	Leishmania donovani	46%	100%
A0A3S5H6F6	Leishmania donovani	51%	96%
A0A3S5H763	Leishmania donovani	95%	100%
A0A3S7WR10	Leishmania donovani	48%	90%
A0A3S7WR14	Leishmania donovani	55%	98%
A0A3S7WR15	Leishmania donovani	52%	79%
A0A3S7WR24	Leishmania donovani	51%	95%
A4H4T8	Leishmania braziliensis	47%	100%
A4H5Y4	Leishmania braziliensis	48%	100%
A4H617	Leishmania braziliensis	52%	96%
A4H618	Leishmania braziliensis	51%	98%
A4H619	Leishmania braziliensis	51%	96%
A4H620	Leishmania braziliensis	60%	95%
A4H6C3	Leishmania braziliensis	48%	100%
A4HNH7	Leishmania braziliensis	40%	100%
A4HSS2	Leishmania infantum	50%	99%
A4HUE4	Leishmania infantum	48%	90%
A4HUE5	Leishmania infantum	51%	97%
A4HUE6	Leishmania infantum	55%	98%
A4HUE7	Leishmania infantum	52%	96%
A4HUE8	Leishmania infantum	51%	95%
A4HUF4	Leishmania infantum	51%	96%
A4HUF5	Leishmania infantum	60%	100%
A4HYA9	Leishmania infantum	96%	100%
A4IC33	Leishmania infantum	42%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	96%
E9AG72	Leishmania infantum	46%	100%
E9AI40	Leishmania braziliensis	53%	99%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	90%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	94%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	61%	94%
Q4QHH8	Leishmania major	51%	92%
Q4QHH9	Leishmania major	51%	95%
Q4QHI0	Leishmania major	51%	97%
Q4QHI1	Leishmania major	55%	100%
Q4QHI2	Leishmania major	52%	100%
Q4QIU9	Leishmania major	46%	100%
Q4QJ48	Leishmania major	52%	99%
Q7KIP2	Leishmania major	40%	99%