Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDC3_LEIMA

TriTrypDb:

LmjF.19.0930 , LMJLV39_190014600 , LMJSD75_190014400

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.473
CLV_C14_Caspase3-7	312	316	PF00656	0.581
CLV_C14_Caspase3-7	553	557	PF00656	0.646
CLV_C14_Caspase3-7	79	83	PF00656	0.546
CLV_C14_Caspase3-7	822	826	PF00656	0.598
CLV_MEL_PAP_1	363	369	PF00089	0.620
CLV_NRD_NRD_1	128	130	PF00675	0.682
CLV_NRD_NRD_1	180	182	PF00675	0.491
CLV_NRD_NRD_1	27	29	PF00675	0.748
CLV_NRD_NRD_1	427	429	PF00675	0.654
CLV_NRD_NRD_1	459	461	PF00675	0.504
CLV_NRD_NRD_1	702	704	PF00675	0.536
CLV_NRD_NRD_1	706	708	PF00675	0.520
CLV_NRD_NRD_1	803	805	PF00675	0.675
CLV_NRD_NRD_1	839	841	PF00675	0.403
CLV_PCSK_FUR_1	126	130	PF00082	0.665
CLV_PCSK_FUR_1	25	29	PF00082	0.625
CLV_PCSK_FUR_1	425	429	PF00082	0.653
CLV_PCSK_FUR_1	703	707	PF00082	0.578
CLV_PCSK_KEX2_1	128	130	PF00082	0.684
CLV_PCSK_KEX2_1	27	29	PF00082	0.748
CLV_PCSK_KEX2_1	425	427	PF00082	0.667
CLV_PCSK_KEX2_1	434	436	PF00082	0.637
CLV_PCSK_KEX2_1	459	461	PF00082	0.504
CLV_PCSK_KEX2_1	702	704	PF00082	0.501
CLV_PCSK_KEX2_1	705	707	PF00082	0.507
CLV_PCSK_KEX2_1	803	805	PF00082	0.675
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.698
CLV_PCSK_PC7_1	702	708	PF00082	0.487
CLV_PCSK_SKI1_1	182	186	PF00082	0.463
CLV_PCSK_SKI1_1	462	466	PF00082	0.542
CLV_PCSK_SKI1_1	834	838	PF00082	0.462
CLV_PCSK_SKI1_1	841	845	PF00082	0.497
CLV_Separin_Metazoa	236	240	PF03568	0.541
DEG_APCC_DBOX_1	522	530	PF00400	0.566
DEG_APCC_DBOX_1	539	547	PF00400	0.627
DEG_Nend_UBRbox_2	1	3	PF02207	0.627
DEG_SCF_FBW7_1	746	752	PF00400	0.635
DEG_SCF_FBW7_1	895	900	PF00400	0.600
DEG_SPOP_SBC_1	356	360	PF00917	0.501
DEG_SPOP_SBC_1	583	587	PF00917	0.736
DEG_SPOP_SBC_1	588	592	PF00917	0.724
DEG_SPOP_SBC_1	749	753	PF00917	0.590
DOC_ANK_TNKS_1	127	134	PF00023	0.620
DOC_CDC14_PxL_1	847	855	PF14671	0.572
DOC_CKS1_1	473	478	PF01111	0.606
DOC_CKS1_1	746	751	PF01111	0.637
DOC_CYCLIN_RxL_1	834	846	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.628
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.557
DOC_MAPK_gen_1	181	187	PF00069	0.462
DOC_MAPK_gen_1	304	311	PF00069	0.479
DOC_MAPK_gen_1	520	528	PF00069	0.566
DOC_MAPK_MEF2A_6	304	311	PF00069	0.503
DOC_MAPK_MEF2A_6	776	785	PF00069	0.581
DOC_MAPK_RevD_3	826	841	PF00069	0.425
DOC_MIT_MIM_1	786	795	PF04212	0.497
DOC_PP2B_LxvP_1	206	209	PF13499	0.667
DOC_PP2B_LxvP_1	31	34	PF13499	0.649
DOC_PP2B_LxvP_1	329	332	PF13499	0.573
DOC_USP7_MATH_1	102	106	PF00917	0.784
DOC_USP7_MATH_1	107	111	PF00917	0.728
DOC_USP7_MATH_1	135	139	PF00917	0.583
DOC_USP7_MATH_1	16	20	PF00917	0.603
DOC_USP7_MATH_1	274	278	PF00917	0.537
DOC_USP7_MATH_1	320	324	PF00917	0.589
DOC_USP7_MATH_1	35	39	PF00917	0.678
DOC_USP7_MATH_1	356	360	PF00917	0.569
DOC_USP7_MATH_1	365	369	PF00917	0.559
DOC_USP7_MATH_1	389	393	PF00917	0.557
DOC_USP7_MATH_1	514	518	PF00917	0.606
DOC_USP7_MATH_1	521	525	PF00917	0.691
DOC_USP7_MATH_1	583	587	PF00917	0.656
DOC_USP7_MATH_1	59	63	PF00917	0.516
DOC_USP7_MATH_1	598	602	PF00917	0.720
DOC_USP7_MATH_1	630	634	PF00917	0.795
DOC_USP7_MATH_1	649	653	PF00917	0.650
DOC_USP7_MATH_1	677	681	PF00917	0.550
DOC_USP7_MATH_1	71	75	PF00917	0.538
DOC_USP7_MATH_1	726	730	PF00917	0.716
DOC_USP7_MATH_1	740	744	PF00917	0.536
DOC_USP7_MATH_1	897	901	PF00917	0.596
DOC_WW_Pin1_4	100	105	PF00397	0.735
DOC_WW_Pin1_4	159	164	PF00397	0.635
DOC_WW_Pin1_4	204	209	PF00397	0.592
DOC_WW_Pin1_4	281	286	PF00397	0.635
DOC_WW_Pin1_4	324	329	PF00397	0.645
DOC_WW_Pin1_4	357	362	PF00397	0.660
DOC_WW_Pin1_4	472	477	PF00397	0.592
DOC_WW_Pin1_4	589	594	PF00397	0.678
DOC_WW_Pin1_4	607	612	PF00397	0.668
DOC_WW_Pin1_4	745	750	PF00397	0.650
DOC_WW_Pin1_4	893	898	PF00397	0.629
DOC_WW_Pin1_4	93	98	PF00397	0.742
LIG_14-3-3_CanoR_1	114	122	PF00244	0.489
LIG_14-3-3_CanoR_1	249	255	PF00244	0.581
LIG_14-3-3_CanoR_1	266	272	PF00244	0.542
LIG_14-3-3_CanoR_1	27	32	PF00244	0.601
LIG_14-3-3_CanoR_1	351	356	PF00244	0.523
LIG_14-3-3_CanoR_1	366	374	PF00244	0.569
LIG_14-3-3_CanoR_1	402	408	PF00244	0.487
LIG_14-3-3_CanoR_1	441	449	PF00244	0.582
LIG_14-3-3_CanoR_1	462	470	PF00244	0.438
LIG_14-3-3_CanoR_1	504	509	PF00244	0.569
LIG_14-3-3_CanoR_1	520	529	PF00244	0.474
LIG_14-3-3_CanoR_1	67	71	PF00244	0.581
LIG_14-3-3_CanoR_1	719	725	PF00244	0.720
LIG_14-3-3_CanoR_1	791	796	PF00244	0.601
LIG_Actin_WH2_2	446	461	PF00022	0.608
LIG_BIR_III_4	492	496	PF00653	0.469
LIG_BRCT_BRCA1_1	42	46	PF00533	0.591
LIG_CaM_IQ_9	446	462	PF13499	0.561
LIG_CaM_NSCaTE_8	310	317	PF13499	0.571
LIG_CaM_NSCaTE_8	508	515	PF13499	0.618
LIG_Clathr_ClatBox_1	842	846	PF01394	0.497
LIG_CSL_BTD_1	253	256	PF09270	0.570
LIG_eIF4E_1	371	377	PF01652	0.671
LIG_eIF4E_1	848	854	PF01652	0.565
LIG_FHA_1	137	143	PF00498	0.583
LIG_FHA_1	160	166	PF00498	0.607
LIG_FHA_1	274	280	PF00498	0.585
LIG_FHA_1	347	353	PF00498	0.565
LIG_FHA_1	358	364	PF00498	0.534
LIG_FHA_1	371	377	PF00498	0.460
LIG_FHA_1	590	596	PF00498	0.615
LIG_FHA_1	795	801	PF00498	0.569
LIG_FHA_2	178	184	PF00498	0.476
LIG_FHA_2	728	734	PF00498	0.657
LIG_LIR_Apic_2	846	851	PF02991	0.494
LIG_LIR_Gen_1	291	302	PF02991	0.462
LIG_LIR_Gen_1	410	418	PF02991	0.503
LIG_LIR_Gen_1	505	514	PF02991	0.606
LIG_LIR_Nem_3	253	257	PF02991	0.536
LIG_LIR_Nem_3	291	297	PF02991	0.486
LIG_LIR_Nem_3	368	374	PF02991	0.562
LIG_LIR_Nem_3	410	414	PF02991	0.497
LIG_LIR_Nem_3	505	509	PF02991	0.518
LIG_NRBOX	189	195	PF00104	0.436
LIG_PDZ_Class_2	905	910	PF00595	0.620
LIG_PTAP_UEV_1	321	326	PF05743	0.666
LIG_SH2_CRK	608	612	PF00017	0.601
LIG_SH2_CRK	693	697	PF00017	0.566
LIG_SH2_GRB2like	355	358	PF00017	0.566
LIG_SH2_NCK_1	711	715	PF00017	0.653
LIG_SH2_PTP2	848	851	PF00017	0.487
LIG_SH2_SRC	223	226	PF00017	0.601
LIG_SH2_SRC	355	358	PF00017	0.493
LIG_SH2_STAP1	693	697	PF00017	0.490
LIG_SH2_STAP1	838	842	PF00017	0.469
LIG_SH2_STAT3	243	246	PF00017	0.514
LIG_SH2_STAT3	827	830	PF00017	0.591
LIG_SH2_STAT5	186	189	PF00017	0.460
LIG_SH2_STAT5	371	374	PF00017	0.675
LIG_SH2_STAT5	827	830	PF00017	0.591
LIG_SH2_STAT5	848	851	PF00017	0.492
LIG_SH3_3	101	107	PF00018	0.634
LIG_SH3_3	205	211	PF00018	0.764
LIG_SH3_3	282	288	PF00018	0.643
LIG_SH3_3	31	37	PF00018	0.640
LIG_SH3_3	319	325	PF00018	0.739
LIG_SH3_3	372	378	PF00018	0.552
LIG_SH3_3	470	476	PF00018	0.563
LIG_SH3_3	590	596	PF00018	0.709
LIG_SH3_3	601	607	PF00018	0.601
LIG_SH3_3	645	651	PF00018	0.621
LIG_SH3_3	94	100	PF00018	0.683
LIG_SH3_CIN85_PxpxPR_1	594	599	PF14604	0.716
LIG_SH3_CIN85_PxpxPR_1	607	612	PF14604	0.583
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.555
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.523
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.482
LIG_SUMO_SIM_par_1	212	217	PF11976	0.532
LIG_SUMO_SIM_par_1	373	379	PF11976	0.558
LIG_SxIP_EBH_1	101	114	PF03271	0.537
LIG_TRAF2_1	545	548	PF00917	0.623
LIG_ULM_U2AF65_1	459	464	PF00076	0.506
LIG_WRC_WIRS_1	503	508	PF05994	0.596
LIG_WW_2	593	596	PF00397	0.608
MOD_CDK_SPK_2	594	599	PF00069	0.640
MOD_CDK_SPK_2	607	612	PF00069	0.641
MOD_CDK_SPxK_1	893	899	PF00069	0.607
MOD_CDK_SPxxK_3	472	479	PF00069	0.602
MOD_CK1_1	103	109	PF00069	0.661
MOD_CK1_1	116	122	PF00069	0.516
MOD_CK1_1	17	23	PF00069	0.673
MOD_CK1_1	207	213	PF00069	0.647
MOD_CK1_1	250	256	PF00069	0.581
MOD_CK1_1	277	283	PF00069	0.654
MOD_CK1_1	289	295	PF00069	0.724
MOD_CK1_1	316	322	PF00069	0.618
MOD_CK1_1	327	333	PF00069	0.592
MOD_CK1_1	359	365	PF00069	0.625
MOD_CK1_1	40	46	PF00069	0.711
MOD_CK1_1	550	556	PF00069	0.620
MOD_CK1_1	587	593	PF00069	0.639
MOD_CK1_1	623	629	PF00069	0.682
MOD_CK1_1	739	745	PF00069	0.774
MOD_CK1_1	794	800	PF00069	0.576
MOD_CK1_1	882	888	PF00069	0.601
MOD_CK1_1	893	899	PF00069	0.598
MOD_CK1_1	93	99	PF00069	0.712
MOD_CK2_1	281	287	PF00069	0.678
MOD_CK2_1	51	57	PF00069	0.636
MOD_CK2_1	542	548	PF00069	0.671
MOD_CK2_1	692	698	PF00069	0.510
MOD_CK2_1	71	77	PF00069	0.584
MOD_CK2_1	718	724	PF00069	0.709
MOD_CK2_1	727	733	PF00069	0.643
MOD_Cter_Amidation	126	129	PF01082	0.670
MOD_Cter_Amidation	423	426	PF01082	0.538
MOD_DYRK1A_RPxSP_1	204	208	PF00069	0.605
MOD_DYRK1A_RPxSP_1	281	285	PF00069	0.612
MOD_GlcNHglycan	115	118	PF01048	0.747
MOD_GlcNHglycan	16	19	PF01048	0.639
MOD_GlcNHglycan	240	243	PF01048	0.677
MOD_GlcNHglycan	276	279	PF01048	0.635
MOD_GlcNHglycan	281	284	PF01048	0.619
MOD_GlcNHglycan	287	291	PF01048	0.549
MOD_GlcNHglycan	315	318	PF01048	0.614
MOD_GlcNHglycan	322	325	PF01048	0.610
MOD_GlcNHglycan	367	370	PF01048	0.573
MOD_GlcNHglycan	37	40	PF01048	0.677
MOD_GlcNHglycan	391	394	PF01048	0.591
MOD_GlcNHglycan	403	406	PF01048	0.684
MOD_GlcNHglycan	414	417	PF01048	0.530
MOD_GlcNHglycan	435	438	PF01048	0.579
MOD_GlcNHglycan	552	555	PF01048	0.708
MOD_GlcNHglycan	600	603	PF01048	0.650
MOD_GlcNHglycan	616	619	PF01048	0.697
MOD_GlcNHglycan	623	626	PF01048	0.686
MOD_GlcNHglycan	679	682	PF01048	0.605
MOD_GlcNHglycan	738	741	PF01048	0.644
MOD_GlcNHglycan	92	95	PF01048	0.713
MOD_GSK3_1	103	110	PF00069	0.753
MOD_GSK3_1	116	123	PF00069	0.475
MOD_GSK3_1	16	23	PF00069	0.606
MOD_GSK3_1	173	180	PF00069	0.506
MOD_GSK3_1	238	245	PF00069	0.755
MOD_GSK3_1	273	280	PF00069	0.648
MOD_GSK3_1	316	323	PF00069	0.560
MOD_GSK3_1	35	42	PF00069	0.660
MOD_GSK3_1	351	358	PF00069	0.606
MOD_GSK3_1	397	404	PF00069	0.683
MOD_GSK3_1	458	465	PF00069	0.654
MOD_GSK3_1	47	54	PF00069	0.620
MOD_GSK3_1	498	505	PF00069	0.499
MOD_GSK3_1	583	590	PF00069	0.658
MOD_GSK3_1	594	601	PF00069	0.683
MOD_GSK3_1	616	623	PF00069	0.689
MOD_GSK3_1	626	633	PF00069	0.654
MOD_GSK3_1	736	743	PF00069	0.805
MOD_GSK3_1	744	751	PF00069	0.624
MOD_GSK3_1	756	763	PF00069	0.479
MOD_GSK3_1	875	882	PF00069	0.612
MOD_GSK3_1	893	900	PF00069	0.485
MOD_N-GLC_1	136	141	PF02516	0.525
MOD_N-GLC_1	356	361	PF02516	0.599
MOD_N-GLC_1	499	504	PF02516	0.575
MOD_N-GLC_1	570	575	PF02516	0.583
MOD_N-GLC_1	621	626	PF02516	0.710
MOD_N-GLC_1	740	745	PF02516	0.597
MOD_NEK2_1	173	178	PF00069	0.558
MOD_NEK2_1	185	190	PF00069	0.466
MOD_NEK2_1	194	199	PF00069	0.454
MOD_NEK2_1	417	422	PF00069	0.544
MOD_NEK2_1	458	463	PF00069	0.606
MOD_NEK2_1	477	482	PF00069	0.633
MOD_NEK2_1	498	503	PF00069	0.521
MOD_NEK2_1	51	56	PF00069	0.623
MOD_NEK2_1	641	646	PF00069	0.559
MOD_NEK2_1	686	691	PF00069	0.539
MOD_NEK2_1	692	697	PF00069	0.534
MOD_NEK2_2	397	402	PF00069	0.574
MOD_PIKK_1	242	248	PF00454	0.692
MOD_PIKK_1	532	538	PF00454	0.620
MOD_PKA_1	27	33	PF00069	0.634
MOD_PKA_2	113	119	PF00069	0.491
MOD_PKA_2	147	153	PF00069	0.434
MOD_PKA_2	238	244	PF00069	0.535
MOD_PKA_2	267	273	PF00069	0.603
MOD_PKA_2	27	33	PF00069	0.630
MOD_PKA_2	365	371	PF00069	0.543
MOD_PKA_2	401	407	PF00069	0.507
MOD_PKA_2	442	448	PF00069	0.706
MOD_PKA_2	458	464	PF00069	0.417
MOD_PKA_2	480	486	PF00069	0.788
MOD_PKA_2	519	525	PF00069	0.562
MOD_PKA_2	548	554	PF00069	0.557
MOD_PKA_2	598	604	PF00069	0.658
MOD_PKA_2	66	72	PF00069	0.583
MOD_PKA_2	718	724	PF00069	0.733
MOD_PKA_2	873	879	PF00069	0.605
MOD_PKB_1	25	33	PF00069	0.631
MOD_PKB_1	460	468	PF00069	0.502
MOD_Plk_1	136	142	PF00069	0.523
MOD_Plk_1	216	222	PF00069	0.553
MOD_Plk_1	292	298	PF00069	0.576
MOD_Plk_1	499	505	PF00069	0.571
MOD_Plk_1	740	746	PF00069	0.606
MOD_Plk_4	167	173	PF00069	0.510
MOD_Plk_4	194	200	PF00069	0.588
MOD_Plk_4	216	222	PF00069	0.548
MOD_Plk_4	47	53	PF00069	0.565
MOD_Plk_4	623	629	PF00069	0.562
MOD_Plk_4	641	647	PF00069	0.509
MOD_Plk_4	692	698	PF00069	0.693
MOD_Plk_4	849	855	PF00069	0.684
MOD_ProDKin_1	100	106	PF00069	0.735
MOD_ProDKin_1	159	165	PF00069	0.634
MOD_ProDKin_1	204	210	PF00069	0.594
MOD_ProDKin_1	281	287	PF00069	0.635
MOD_ProDKin_1	324	330	PF00069	0.642
MOD_ProDKin_1	357	363	PF00069	0.661
MOD_ProDKin_1	472	478	PF00069	0.597
MOD_ProDKin_1	589	595	PF00069	0.678
MOD_ProDKin_1	607	613	PF00069	0.667
MOD_ProDKin_1	745	751	PF00069	0.651
MOD_ProDKin_1	893	899	PF00069	0.631
MOD_ProDKin_1	93	99	PF00069	0.743
MOD_SUMO_for_1	579	582	PF00179	0.632
MOD_SUMO_rev_2	429	436	PF00179	0.626
TRG_DiLeu_BaEn_4	699	705	PF01217	0.563
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.438
TRG_ENDOCYTIC_2	371	374	PF00928	0.554
TRG_ENDOCYTIC_2	693	696	PF00928	0.572
TRG_ER_diArg_1	125	128	PF00400	0.642
TRG_ER_diArg_1	25	28	PF00400	0.627
TRG_ER_diArg_1	265	268	PF00400	0.616
TRG_ER_diArg_1	303	306	PF00400	0.530
TRG_ER_diArg_1	350	353	PF00400	0.578
TRG_ER_diArg_1	425	428	PF00400	0.653
TRG_ER_diArg_1	458	460	PF00400	0.520
TRG_ER_diArg_1	478	481	PF00400	0.507
TRG_ER_diArg_1	701	703	PF00400	0.501
TRG_ER_diArg_1	704	707	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.721

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P316	Leptomonas seymouri	34%	100%
A0A3S7WVF4	Leishmania donovani	88%	100%
A4HA44	Leishmania braziliensis	67%	100%
A4HYB0	Leishmania infantum	89%	100%
E9AS43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	91%