CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QDC2_LEIMA

TriTrypDb:

LmjF.19.0940 , LMJLV39_190014700 , LMJSD75_190014500

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0035371	microtubule plus-end	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990752	microtubule end	2	2

Expansion

Sequence features

Q4QDC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC2

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0051010	microtubule plus-end binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.478
CLV_C14_Caspase3-7	376	380	PF00656	0.409
CLV_C14_Caspase3-7	635	639	PF00656	0.515
CLV_NRD_NRD_1	117	119	PF00675	0.540
CLV_NRD_NRD_1	314	316	PF00675	0.465
CLV_NRD_NRD_1	33	35	PF00675	0.304
CLV_PCSK_KEX2_1	117	119	PF00082	0.540
CLV_PCSK_KEX2_1	209	211	PF00082	0.562
CLV_PCSK_KEX2_1	314	316	PF00082	0.508
CLV_PCSK_KEX2_1	32	34	PF00082	0.304
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.562
CLV_PCSK_SKI1_1	181	185	PF00082	0.497
CLV_PCSK_SKI1_1	191	195	PF00082	0.511
CLV_PCSK_SKI1_1	275	279	PF00082	0.441
CLV_PCSK_SKI1_1	34	38	PF00082	0.369
CLV_PCSK_SKI1_1	347	351	PF00082	0.511
CLV_PCSK_SKI1_1	645	649	PF00082	0.604
CLV_PCSK_SKI1_1	67	71	PF00082	0.325
DEG_SCF_FBW7_1	647	654	PF00400	0.588
DEG_SCF_FBW7_2	95	100	PF00400	0.461
DEG_SIAH_1	560	568	PF03145	0.506
DEG_SPOP_SBC_1	442	446	PF00917	0.590
DOC_CKS1_1	648	653	PF01111	0.632
DOC_CYCLIN_RxL_1	469	480	PF00134	0.577
DOC_CYCLIN_RxL_1	625	638	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.449
DOC_MAPK_gen_1	279	288	PF00069	0.432
DOC_MAPK_gen_1	32	39	PF00069	0.304
DOC_MAPK_gen_1	583	592	PF00069	0.490
DOC_MAPK_gen_1	612	621	PF00069	0.639
DOC_MAPK_MEF2A_6	452	459	PF00069	0.535
DOC_MAPK_MEF2A_6	615	623	PF00069	0.592
DOC_MAPK_RevD_3	21	34	PF00069	0.482
DOC_PP1_RVXF_1	174	180	PF00149	0.466
DOC_PP1_RVXF_1	628	635	PF00149	0.519
DOC_PP1_SILK_1	34	39	PF00149	0.369
DOC_PP2B_LxvP_1	86	89	PF13499	0.419
DOC_PP4_FxxP_1	648	651	PF00568	0.664
DOC_PP4_FxxP_1	81	84	PF00568	0.304
DOC_USP7_MATH_1	16	20	PF00917	0.396
DOC_USP7_MATH_1	193	197	PF00917	0.517
DOC_USP7_MATH_1	257	261	PF00917	0.556
DOC_USP7_MATH_1	265	269	PF00917	0.366
DOC_USP7_MATH_1	293	297	PF00917	0.478
DOC_USP7_MATH_1	328	332	PF00917	0.570
DOC_USP7_MATH_1	402	406	PF00917	0.518
DOC_USP7_MATH_1	442	446	PF00917	0.590
DOC_USP7_MATH_1	504	508	PF00917	0.574
DOC_USP7_MATH_1	567	571	PF00917	0.497
DOC_USP7_MATH_1	6	10	PF00917	0.631
DOC_USP7_UBL2_3	154	158	PF12436	0.574
DOC_WW_Pin1_4	647	652	PF00397	0.665
DOC_WW_Pin1_4	91	96	PF00397	0.472
LIG_14-3-3_CanoR_1	181	190	PF00244	0.414
LIG_14-3-3_CanoR_1	512	516	PF00244	0.568
LIG_14-3-3_CanoR_1	583	588	PF00244	0.563
LIG_14-3-3_CanoR_1	598	607	PF00244	0.467
LIG_14-3-3_CanoR_1	8	16	PF00244	0.561
LIG_Actin_WH2_2	130	147	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_DLG_GKlike_1	583	590	PF00625	0.513
LIG_FHA_1	380	386	PF00498	0.543
LIG_FHA_1	560	566	PF00498	0.508
LIG_FHA_1	94	100	PF00498	0.463
LIG_FHA_2	137	143	PF00498	0.405
LIG_FHA_2	151	157	PF00498	0.590
LIG_FHA_2	228	234	PF00498	0.439
LIG_FHA_2	318	324	PF00498	0.539
LIG_FHA_2	343	349	PF00498	0.513
LIG_FHA_2	374	380	PF00498	0.408
LIG_LIR_Apic_2	601	607	PF02991	0.562
LIG_LIR_Gen_1	18	28	PF02991	0.415
LIG_LIR_Nem_3	18	23	PF02991	0.389
LIG_LIR_Nem_3	47	53	PF02991	0.318
LIG_NRBOX	362	368	PF00104	0.467
LIG_NRBOX	586	592	PF00104	0.509
LIG_RPA_C_Fungi	213	225	PF08784	0.539
LIG_SH2_NCK_1	90	94	PF00017	0.450
LIG_SH2_SRC	90	93	PF00017	0.504
LIG_SH2_STAP1	580	584	PF00017	0.462
LIG_SH2_STAT5	71	74	PF00017	0.348
LIG_SH3_3	10	16	PF00018	0.553
LIG_SH3_3	22	28	PF00018	0.362
LIG_SH3_3	417	423	PF00018	0.469
LIG_SH3_3	86	92	PF00018	0.449
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.394
LIG_TRAF2_1	108	111	PF00917	0.508
LIG_TRAF2_1	398	401	PF00917	0.513
LIG_TRAF2_1	406	409	PF00917	0.484
LIG_WRC_WIRS_1	17	22	PF05994	0.401
MOD_CK1_1	133	139	PF00069	0.541
MOD_CK1_1	342	348	PF00069	0.467
MOD_CK1_1	443	449	PF00069	0.655
MOD_CK2_1	136	142	PF00069	0.426
MOD_CK2_1	16	22	PF00069	0.407
MOD_CK2_1	193	199	PF00069	0.565
MOD_CK2_1	342	348	PF00069	0.508
MOD_CK2_1	474	480	PF00069	0.440
MOD_GlcNHglycan	102	105	PF01048	0.582
MOD_GlcNHglycan	195	198	PF01048	0.562
MOD_GlcNHglycan	215	218	PF01048	0.366
MOD_GlcNHglycan	255	258	PF01048	0.499
MOD_GlcNHglycan	266	270	PF01048	0.425
MOD_GlcNHglycan	404	407	PF01048	0.558
MOD_GlcNHglycan	557	560	PF01048	0.575
MOD_GlcNHglycan	600	603	PF01048	0.581
MOD_GlcNHglycan	642	645	PF01048	0.519
MOD_GlcNHglycan	9	12	PF01048	0.686
MOD_GSK3_1	126	133	PF00069	0.558
MOD_GSK3_1	253	260	PF00069	0.530
MOD_GSK3_1	375	382	PF00069	0.555
MOD_GSK3_1	436	443	PF00069	0.676
MOD_GSK3_1	555	562	PF00069	0.632
MOD_GSK3_1	568	575	PF00069	0.457
MOD_GSK3_1	594	601	PF00069	0.466
MOD_GSK3_1	606	613	PF00069	0.622
MOD_GSK3_1	647	654	PF00069	0.588
MOD_N-GLC_1	258	263	PF02516	0.524
MOD_N-GLC_1	572	577	PF02516	0.427
MOD_NEK2_1	126	131	PF00069	0.532
MOD_NEK2_1	317	322	PF00069	0.544
MOD_NEK2_1	474	479	PF00069	0.493
MOD_NEK2_1	568	573	PF00069	0.454
MOD_NEK2_1	632	637	PF00069	0.503
MOD_NEK2_1	70	75	PF00069	0.246
MOD_PIKK_1	248	254	PF00454	0.507
MOD_PIKK_1	373	379	PF00454	0.399
MOD_PIKK_1	606	612	PF00454	0.532
MOD_PKA_2	440	446	PF00069	0.620
MOD_PKA_2	511	517	PF00069	0.568
MOD_PKA_2	597	603	PF00069	0.575
MOD_PKA_2	614	620	PF00069	0.474
MOD_PKA_2	7	13	PF00069	0.606
MOD_Plk_1	237	243	PF00069	0.495
MOD_Plk_2-3	156	162	PF00069	0.579
MOD_Plk_2-3	451	457	PF00069	0.564
MOD_Plk_4	16	22	PF00069	0.407
MOD_ProDKin_1	647	653	PF00069	0.666
MOD_ProDKin_1	91	97	PF00069	0.474
MOD_SUMO_for_1	104	107	PF00179	0.508
MOD_SUMO_for_1	157	160	PF00179	0.583
MOD_SUMO_for_1	343	346	PF00179	0.509
MOD_SUMO_rev_2	187	193	PF00179	0.543
MOD_SUMO_rev_2	368	376	PF00179	0.469
TRG_DiLeu_BaEn_1	362	367	PF01217	0.465
TRG_DiLeu_BaEn_1	409	414	PF01217	0.515
TRG_DiLeu_BaEn_4	358	364	PF01217	0.523
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.593
TRG_ER_diArg_1	32	34	PF00400	0.304
TRG_ER_diArg_1	470	473	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	35%	91%
A0A3Q8IEJ2	Leishmania donovani	88%	98%
A4HA45	Leishmania braziliensis	67%	100%
A4HYB1	Leishmania infantum	89%	98%
E9AS44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%