CAP-Gly domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QDC2_LEIMA

TriTrypDb:

LmjF.19.0940 , LMJLV39_190014700 , LMJSD75_190014500

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0035371	microtubule plus-end	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990752	microtubule end	2	2

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Expansion

Sequence features

Q4QDC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC2

Function

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Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0051010	microtubule plus-end binding	6	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.478
CLV_C14_Caspase3-7	376	380	PF00656	0.409
CLV_C14_Caspase3-7	635	639	PF00656	0.515
CLV_NRD_NRD_1	117	119	PF00675	0.540
CLV_NRD_NRD_1	314	316	PF00675	0.465
CLV_NRD_NRD_1	33	35	PF00675	0.304
CLV_PCSK_KEX2_1	117	119	PF00082	0.540
CLV_PCSK_KEX2_1	209	211	PF00082	0.562
CLV_PCSK_KEX2_1	314	316	PF00082	0.508
CLV_PCSK_KEX2_1	32	34	PF00082	0.304

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	35%	91%
A0A3Q8IEJ2	Leishmania donovani	88%	98%
A4HA45	Leishmania braziliensis	67%	100%
A4HYB1	Leishmania infantum	89%	98%
E9AS44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%

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