Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDC1_LEIMA

TriTrypDb:

LmjF.19.0950 , LMJLV39_190014800 , LMJSD75_190014600

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	523	527	PF00656	0.504
CLV_C14_Caspase3-7	607	611	PF00656	0.754
CLV_C14_Caspase3-7	715	719	PF00656	0.749
CLV_NRD_NRD_1	121	123	PF00675	0.623
CLV_NRD_NRD_1	134	136	PF00675	0.666
CLV_NRD_NRD_1	145	147	PF00675	0.646
CLV_NRD_NRD_1	168	170	PF00675	0.750
CLV_NRD_NRD_1	326	328	PF00675	0.635
CLV_NRD_NRD_1	583	585	PF00675	0.771
CLV_NRD_NRD_1	588	590	PF00675	0.716
CLV_NRD_NRD_1	613	615	PF00675	0.657
CLV_NRD_NRD_1	649	651	PF00675	0.714
CLV_PCSK_FUR_1	586	590	PF00082	0.739
CLV_PCSK_KEX2_1	121	123	PF00082	0.623
CLV_PCSK_KEX2_1	168	170	PF00082	0.750
CLV_PCSK_KEX2_1	328	330	PF00082	0.831
CLV_PCSK_KEX2_1	339	341	PF00082	0.649
CLV_PCSK_KEX2_1	456	458	PF00082	0.528
CLV_PCSK_KEX2_1	585	587	PF00082	0.842
CLV_PCSK_KEX2_1	588	590	PF00082	0.814
CLV_PCSK_KEX2_1	613	615	PF00082	0.657
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.831
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.649
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.630
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.809
CLV_PCSK_PC7_1	584	590	PF00082	0.776
CLV_PCSK_SKI1_1	342	346	PF00082	0.785
CLV_PCSK_SKI1_1	532	536	PF00082	0.671
CLV_PCSK_SKI1_1	537	541	PF00082	0.585
CLV_PCSK_SKI1_1	594	598	PF00082	0.774
CLV_PCSK_SKI1_1	87	91	PF00082	0.603
CLV_Separin_Metazoa	541	545	PF03568	0.431
DEG_APCC_DBOX_1	721	729	PF00400	0.771
DEG_SCF_FBW7_1	354	361	PF00400	0.571
DEG_SPOP_SBC_1	566	570	PF00917	0.775
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.571
DOC_MAPK_DCC_7	770	778	PF00069	0.669
DOC_MAPK_gen_1	168	176	PF00069	0.732
DOC_MAPK_gen_1	339	346	PF00069	0.632
DOC_MAPK_gen_1	367	377	PF00069	0.693
DOC_MAPK_gen_1	650	661	PF00069	0.787
DOC_MAPK_MEF2A_6	169	178	PF00069	0.836
DOC_MAPK_MEF2A_6	770	778	PF00069	0.669
DOC_PP1_RVXF_1	397	403	PF00149	0.576
DOC_PP2B_LxvP_1	303	306	PF13499	0.674
DOC_PP2B_LxvP_1	310	313	PF13499	0.645
DOC_PP2B_LxvP_1	685	688	PF13499	0.742
DOC_PP2B_LxvP_1	69	72	PF13499	0.684
DOC_PP4_MxPP_1	411	414	PF00568	0.603
DOC_USP7_MATH_1	205	209	PF00917	0.830
DOC_USP7_MATH_1	229	233	PF00917	0.686
DOC_USP7_MATH_1	299	303	PF00917	0.602
DOC_USP7_MATH_1	332	336	PF00917	0.760
DOC_USP7_MATH_1	416	420	PF00917	0.751
DOC_USP7_MATH_1	439	443	PF00917	0.490
DOC_USP7_MATH_1	475	479	PF00917	0.677
DOC_USP7_MATH_1	554	558	PF00917	0.787
DOC_USP7_MATH_1	565	569	PF00917	0.691
DOC_USP7_MATH_1	596	600	PF00917	0.698
DOC_USP7_MATH_1	624	628	PF00917	0.699
DOC_USP7_MATH_1	630	634	PF00917	0.599
DOC_USP7_MATH_1	655	659	PF00917	0.792
DOC_USP7_MATH_1	736	740	PF00917	0.733
DOC_WW_Pin1_4	1	6	PF00397	0.678
DOC_WW_Pin1_4	162	167	PF00397	0.706
DOC_WW_Pin1_4	207	212	PF00397	0.826
DOC_WW_Pin1_4	214	219	PF00397	0.695
DOC_WW_Pin1_4	274	279	PF00397	0.653
DOC_WW_Pin1_4	354	359	PF00397	0.737
DOC_WW_Pin1_4	379	384	PF00397	0.824
DOC_WW_Pin1_4	405	410	PF00397	0.715
DOC_WW_Pin1_4	437	442	PF00397	0.738
DOC_WW_Pin1_4	567	572	PF00397	0.751
DOC_WW_Pin1_4	576	581	PF00397	0.627
LIG_14-3-3_CanoR_1	105	111	PF00244	0.742
LIG_14-3-3_CanoR_1	146	152	PF00244	0.591
LIG_14-3-3_CanoR_1	209	218	PF00244	0.653
LIG_14-3-3_CanoR_1	285	294	PF00244	0.811
LIG_14-3-3_CanoR_1	340	345	PF00244	0.825
LIG_14-3-3_CanoR_1	576	580	PF00244	0.680
LIG_14-3-3_CanoR_1	598	608	PF00244	0.637
LIG_14-3-3_CanoR_1	676	685	PF00244	0.717
LIG_14-3-3_CanoR_1	726	736	PF00244	0.794
LIG_14-3-3_CanoR_1	758	764	PF00244	0.708
LIG_Actin_WH2_2	756	772	PF00022	0.708
LIG_BRCT_BRCA1_1	657	661	PF00533	0.798
LIG_eIF4E_1	468	474	PF01652	0.602
LIG_FHA_1	152	158	PF00498	0.735
LIG_FHA_1	18	24	PF00498	0.710
LIG_FHA_1	28	34	PF00498	0.626
LIG_FHA_1	355	361	PF00498	0.724
LIG_FHA_1	469	475	PF00498	0.536
LIG_FHA_1	528	534	PF00498	0.475
LIG_FHA_1	538	544	PF00498	0.420
LIG_FHA_1	682	688	PF00498	0.645
LIG_FHA_1	93	99	PF00498	0.745
LIG_FHA_2	113	119	PF00498	0.757
LIG_FHA_2	499	505	PF00498	0.596
LIG_FHA_2	553	559	PF00498	0.749
LIG_FHA_2	600	606	PF00498	0.840
LIG_FHA_2	74	80	PF00498	0.684
LIG_HCF-1_HBM_1	452	455	PF13415	0.457
LIG_Integrin_isoDGR_2	130	132	PF01839	0.631
LIG_LIR_Apic_2	710	714	PF02991	0.780
LIG_LIR_Gen_1	22	32	PF02991	0.735
LIG_LIR_Gen_1	249	258	PF02991	0.853
LIG_LIR_Nem_3	20	24	PF02991	0.767
LIG_LIR_Nem_3	249	253	PF02991	0.848
LIG_LIR_Nem_3	789	795	PF02991	0.745
LIG_LYPXL_SIV_4	46	54	PF13949	0.661
LIG_MYND_3	696	700	PF01753	0.805
LIG_NRBOX	468	474	PF00104	0.602
LIG_PTAP_UEV_1	4	9	PF05743	0.737
LIG_SH2_CRK	104	108	PF00017	0.756
LIG_SH2_CRK	24	28	PF00017	0.735
LIG_SH2_NCK_1	88	92	PF00017	0.521
LIG_SH2_SRC	47	50	PF00017	0.661
LIG_SH2_SRC	794	797	PF00017	0.734
LIG_SH2_STAP1	47	51	PF00017	0.523
LIG_SH2_STAP1	529	533	PF00017	0.523
LIG_SH2_STAT5	271	274	PF00017	0.824
LIG_SH2_STAT5	286	289	PF00017	0.571
LIG_SH2_STAT5	468	471	PF00017	0.521
LIG_SH2_STAT5	529	532	PF00017	0.440
LIG_SH2_STAT5	711	714	PF00017	0.634
LIG_SH2_STAT5	794	797	PF00017	0.734
LIG_SH3_1	403	409	PF00018	0.686
LIG_SH3_2	384	389	PF14604	0.846
LIG_SH3_2	5	10	PF14604	0.734
LIG_SH3_3	2	8	PF00018	0.737
LIG_SH3_3	303	309	PF00018	0.661
LIG_SH3_3	381	387	PF00018	0.832
LIG_SH3_3	403	409	PF00018	0.686
LIG_SH3_3	769	775	PF00018	0.788
LIG_SUMO_SIM_anti_2	530	538	PF11976	0.631
LIG_SUMO_SIM_anti_2	605	610	PF11976	0.719
LIG_SUMO_SIM_anti_2	633	641	PF11976	0.706
LIG_SUMO_SIM_par_1	25	30	PF11976	0.729
LIG_SUMO_SIM_par_1	774	780	PF11976	0.654
LIG_TRAF2_1	680	683	PF00917	0.830
LIG_TRAF2_1	76	79	PF00917	0.687
LIG_UBA3_1	106	111	PF00899	0.740
MOD_CDC14_SPxK_1	386	389	PF00782	0.843
MOD_CDK_SPxK_1	162	168	PF00069	0.743
MOD_CDK_SPxK_1	214	220	PF00069	0.664
MOD_CDK_SPxK_1	383	389	PF00069	0.844
MOD_CDK_SPxxK_3	162	169	PF00069	0.854
MOD_CK1_1	148	154	PF00069	0.827
MOD_CK1_1	210	216	PF00069	0.844
MOD_CK1_1	230	236	PF00069	0.785
MOD_CK1_1	249	255	PF00069	0.592
MOD_CK1_1	263	269	PF00069	0.671
MOD_CK1_1	290	296	PF00069	0.599
MOD_CK1_1	3	9	PF00069	0.696
MOD_CK1_1	322	328	PF00069	0.761
MOD_CK1_1	382	388	PF00069	0.827
MOD_CK1_1	407	413	PF00069	0.701
MOD_CK1_1	520	526	PF00069	0.555
MOD_CK1_1	527	533	PF00069	0.470
MOD_CK1_1	57	63	PF00069	0.703
MOD_CK1_1	587	593	PF00069	0.750
MOD_CK1_1	599	605	PF00069	0.595
MOD_CK1_1	640	646	PF00069	0.703
MOD_CK1_1	663	669	PF00069	0.677
MOD_CK1_1	677	683	PF00069	0.634
MOD_CK1_1	730	736	PF00069	0.687
MOD_CK2_1	112	118	PF00069	0.756
MOD_CK2_1	196	202	PF00069	0.760
MOD_CK2_1	498	504	PF00069	0.602
MOD_CK2_1	552	558	PF00069	0.744
MOD_CK2_1	630	636	PF00069	0.629
MOD_CK2_1	664	670	PF00069	0.740
MOD_CK2_1	677	683	PF00069	0.593
MOD_CK2_1	73	79	PF00069	0.533
MOD_CMANNOS	402	405	PF00535	0.721
MOD_Cter_Amidation	582	585	PF01082	0.619
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.820
MOD_GlcNHglycan	224	227	PF01048	0.679
MOD_GlcNHglycan	232	235	PF01048	0.652
MOD_GlcNHglycan	294	297	PF01048	0.703
MOD_GlcNHglycan	303	306	PF01048	0.653
MOD_GlcNHglycan	33	36	PF01048	0.571
MOD_GlcNHglycan	481	484	PF01048	0.610
MOD_GlcNHglycan	5	8	PF01048	0.849
MOD_GlcNHglycan	526	529	PF01048	0.660
MOD_GlcNHglycan	545	549	PF01048	0.662
MOD_GlcNHglycan	56	59	PF01048	0.626
MOD_GlcNHglycan	580	583	PF01048	0.675
MOD_GlcNHglycan	591	594	PF01048	0.731
MOD_GlcNHglycan	626	629	PF01048	0.787
MOD_GlcNHglycan	632	635	PF01048	0.542
MOD_GlcNHglycan	667	670	PF01048	0.687
MOD_GlcNHglycan	729	732	PF01048	0.597
MOD_GlcNHglycan	745	748	PF01048	0.758
MOD_GSK3_1	147	154	PF00069	0.707
MOD_GSK3_1	19	26	PF00069	0.726
MOD_GSK3_1	207	214	PF00069	0.846
MOD_GSK3_1	218	225	PF00069	0.644
MOD_GSK3_1	27	34	PF00069	0.589
MOD_GSK3_1	286	293	PF00069	0.645
MOD_GSK3_1	315	322	PF00069	0.781
MOD_GSK3_1	340	347	PF00069	0.799
MOD_GSK3_1	354	361	PF00069	0.600
MOD_GSK3_1	379	386	PF00069	0.764
MOD_GSK3_1	475	482	PF00069	0.573
MOD_GSK3_1	498	505	PF00069	0.715
MOD_GSK3_1	520	527	PF00069	0.543
MOD_GSK3_1	566	573	PF00069	0.737
MOD_GSK3_1	57	64	PF00069	0.551
MOD_GSK3_1	584	591	PF00069	0.824
MOD_GSK3_1	594	601	PF00069	0.681
MOD_GSK3_1	620	627	PF00069	0.680
MOD_GSK3_1	640	647	PF00069	0.613
MOD_GSK3_1	660	667	PF00069	0.803
MOD_GSK3_1	674	681	PF00069	0.615
MOD_GSK3_1	764	771	PF00069	0.723
MOD_LATS_1	796	802	PF00433	0.769
MOD_NEK2_1	106	111	PF00069	0.740
MOD_NEK2_1	479	484	PF00069	0.660
MOD_NEK2_1	637	642	PF00069	0.785
MOD_NEK2_2	19	24	PF00069	0.544
MOD_PIKK_1	332	338	PF00454	0.828
MOD_PIKK_1	344	350	PF00454	0.628
MOD_PIKK_1	358	364	PF00454	0.615
MOD_PIKK_1	570	576	PF00454	0.785
MOD_PIKK_1	674	680	PF00454	0.846
MOD_PIKK_1	764	770	PF00454	0.785
MOD_PK_1	340	346	PF00069	0.825
MOD_PKA_1	456	462	PF00069	0.465
MOD_PKA_1	584	590	PF00069	0.776
MOD_PKA_2	145	151	PF00069	0.708
MOD_PKA_2	456	462	PF00069	0.479
MOD_PKA_2	575	581	PF00069	0.677
MOD_PKA_2	587	593	PF00069	0.723
MOD_PKA_2	597	603	PF00069	0.686
MOD_PKA_2	655	661	PF00069	0.794
MOD_PKB_1	340	348	PF00069	0.787
MOD_PKB_1	586	594	PF00069	0.741
MOD_Plk_1	148	154	PF00069	0.710
MOD_Plk_1	544	550	PF00069	0.593
MOD_Plk_1	669	675	PF00069	0.765
MOD_Plk_1	681	687	PF00069	0.672
MOD_Plk_1	736	742	PF00069	0.616
MOD_Plk_4	23	29	PF00069	0.739
MOD_Plk_4	246	252	PF00069	0.697
MOD_Plk_4	407	413	PF00069	0.701
MOD_Plk_4	439	445	PF00069	0.482
MOD_Plk_4	468	474	PF00069	0.544
MOD_Plk_4	644	650	PF00069	0.780
MOD_Plk_4	777	783	PF00069	0.752
MOD_Plk_4	798	804	PF00069	0.681
MOD_ProDKin_1	1	7	PF00069	0.677
MOD_ProDKin_1	162	168	PF00069	0.706
MOD_ProDKin_1	207	213	PF00069	0.825
MOD_ProDKin_1	214	220	PF00069	0.696
MOD_ProDKin_1	274	280	PF00069	0.653
MOD_ProDKin_1	354	360	PF00069	0.733
MOD_ProDKin_1	379	385	PF00069	0.827
MOD_ProDKin_1	405	411	PF00069	0.721
MOD_ProDKin_1	437	443	PF00069	0.735
MOD_ProDKin_1	567	573	PF00069	0.753
MOD_ProDKin_1	576	582	PF00069	0.627
MOD_SUMO_for_1	178	181	PF00179	0.815
MOD_SUMO_for_1	219	222	PF00179	0.778
MOD_SUMO_for_1	253	256	PF00179	0.856
MOD_SUMO_rev_2	557	565	PF00179	0.801
TRG_DiLeu_BaEn_1	531	536	PF01217	0.638
TRG_DiLeu_BaEn_1	94	99	PF01217	0.638
TRG_DiLeu_BaEn_2	372	378	PF01217	0.725
TRG_DiLeu_BaEn_4	682	688	PF01217	0.824
TRG_DiLeu_BaLyEn_6	102	107	PF01217	0.752
TRG_ENDOCYTIC_2	104	107	PF00928	0.754
TRG_ENDOCYTIC_2	24	27	PF00928	0.738
TRG_ER_diArg_1	327	330	PF00400	0.597
TRG_ER_diArg_1	586	589	PF00400	0.742
TRG_NLS_Bipartite_1	121	139	PF00514	0.775
TRG_NLS_Bipartite_1	327	343	PF00514	0.822
TRG_NLS_MonoExtC_3	583	588	PF00514	0.737
TRG_NLS_MonoExtN_4	132	139	PF00514	0.652
TRG_NLS_MonoExtN_4	338	343	PF00514	0.730
TRG_NLS_MonoExtN_4	584	589	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	512	516	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAA0	Leishmania donovani	90%	100%
A4HA46	Leishmania braziliensis	70%	100%
A4HYB2	Leishmania infantum	90%	100%
E9AS45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%