Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Species:

Leishmania major

UniProt:

Q4QDB9_LEIMA

TriTrypDb:

LmjF.19.0970 , LMJLV39_190015000 , LMJSD75_190014800

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 4
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QDB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDB9

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	3
GO:0006457	protein folding	2	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018208	peptidyl-proline modification	6	3
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044238	primary metabolic process	2	3
GO:0061077	chaperone-mediated protein folding	3	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	13
GO:0003824	catalytic activity	1	13
GO:0016853	isomerase activity	2	13
GO:0016859	cis-trans isomerase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.338
CLV_NRD_NRD_1	70	72	PF00675	0.430
CLV_PCSK_KEX2_1	109	111	PF00082	0.338
CLV_PCSK_KEX2_1	70	72	PF00082	0.431
CLV_PCSK_SKI1_1	184	188	PF00082	0.329
CLV_PCSK_SKI1_1	50	54	PF00082	0.554
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.265
DOC_PP2B_LxvP_1	134	137	PF13499	0.302
DOC_USP7_MATH_1	55	59	PF00917	0.413
DOC_USP7_UBL2_3	144	148	PF12436	0.281
DOC_WW_Pin1_4	108	113	PF00397	0.352
LIG_14-3-3_CanoR_1	3	8	PF00244	0.556
LIG_14-3-3_CanoR_1	38	43	PF00244	0.400
LIG_BIR_II_1	1	5	PF00653	0.369
LIG_Clathr_ClatBox_1	65	69	PF01394	0.308
LIG_FHA_1	14	20	PF00498	0.499
LIG_FHA_2	172	178	PF00498	0.319
LIG_LIR_Apic_2	89	95	PF02991	0.217
LIG_LIR_Gen_1	130	140	PF02991	0.278
LIG_LIR_Gen_1	198	202	PF02991	0.452
LIG_LIR_Gen_1	41	48	PF02991	0.410
LIG_LIR_Nem_3	130	136	PF02991	0.274
LIG_LIR_Nem_3	198	202	PF02991	0.452
LIG_LIR_Nem_3	41	45	PF02991	0.416
LIG_OCRL_FandH_1	3	15	PF00620	0.362
LIG_PDZ_Class_1	197	202	PF00595	0.414
LIG_SH2_CRK	42	46	PF00017	0.314
LIG_SH2_CRK	92	96	PF00017	0.217
LIG_SH2_NCK_1	42	46	PF00017	0.314
LIG_SH2_SRC	133	136	PF00017	0.311
LIG_SH2_STAP1	88	92	PF00017	0.217
LIG_SH2_STAT5	133	136	PF00017	0.323
LIG_SH2_STAT5	181	184	PF00017	0.450
LIG_SH2_STAT5	199	202	PF00017	0.422
LIG_SH2_STAT5	47	50	PF00017	0.375
LIG_SH2_STAT5	88	91	PF00017	0.244
LIG_SUMO_SIM_anti_2	16	21	PF11976	0.401
LIG_SUMO_SIM_par_1	23	28	PF11976	0.364
LIG_TYR_ITIM	197	202	PF00017	0.446
MOD_CK1_1	171	177	PF00069	0.393
MOD_CK1_1	30	36	PF00069	0.432
MOD_CK1_1	6	12	PF00069	0.484
MOD_CK2_1	171	177	PF00069	0.374
MOD_GlcNHglycan	168	171	PF01048	0.538
MOD_GlcNHglycan	174	177	PF01048	0.337
MOD_GlcNHglycan	57	60	PF01048	0.317
MOD_GlcNHglycan	61	64	PF01048	0.341
MOD_GSK3_1	168	175	PF00069	0.383
MOD_GSK3_1	2	9	PF00069	0.462
MOD_GSK3_1	23	30	PF00069	0.449
MOD_GSK3_1	55	62	PF00069	0.449
MOD_N-GLC_1	55	60	PF02516	0.418
MOD_NEK2_1	86	91	PF00069	0.271
MOD_PIKK_1	110	116	PF00454	0.407
MOD_PKA_2	2	8	PF00069	0.578
MOD_Plk_1	27	33	PF00069	0.413
MOD_Plk_1	55	61	PF00069	0.424
MOD_Plk_4	13	19	PF00069	0.398
MOD_Plk_4	27	33	PF00069	0.341
MOD_Plk_4	6	12	PF00069	0.496
MOD_ProDKin_1	108	114	PF00069	0.352
MOD_SUMO_rev_2	145	153	PF00179	0.249
TRG_DiLeu_BaEn_1	121	126	PF01217	0.244
TRG_ENDOCYTIC_2	133	136	PF00928	0.233
TRG_ENDOCYTIC_2	199	202	PF00928	0.592
TRG_ENDOCYTIC_2	42	45	PF00928	0.383
TRG_ER_diArg_1	108	110	PF00400	0.312
TRG_NES_CRM1_1	114	128	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	30%	100%
A0A0N1II12	Leptomonas seymouri	65%	100%
A0A1X0P7N1	Trypanosomatidae	40%	95%
A0A3S5H764	Leishmania donovani	96%	100%
A0A3S5IR72	Trypanosoma rangeli	39%	100%
A4H677	Leishmania braziliensis	30%	100%
A4HA48	Leishmania braziliensis	77%	99%
A4HYB4	Leishmania infantum	96%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q09734	Trypanosoma cruzi	38%	100%
Q4QHC5	Leishmania major	28%	100%
Q9JYI8	Neisseria meningitidis serogroup B (strain MC58)	28%	74%