FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FYVE zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QDB8_LEIMA

TriTrypDb:

LmjF.19.0980 , LMJLV39_190015100 , LMJSD75_190014900

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDB8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.599
CLV_NRD_NRD_1	123	125	PF00675	0.658
CLV_NRD_NRD_1	219	221	PF00675	0.643
CLV_NRD_NRD_1	287	289	PF00675	0.621
CLV_NRD_NRD_1	427	429	PF00675	0.482
CLV_NRD_NRD_1	431	433	PF00675	0.436
CLV_NRD_NRD_1	439	441	PF00675	0.352
CLV_NRD_NRD_1	467	469	PF00675	0.297
CLV_NRD_NRD_1	474	476	PF00675	0.297
CLV_NRD_NRD_1	482	484	PF00675	0.183
CLV_NRD_NRD_1	487	489	PF00675	0.297
CLV_NRD_NRD_1	557	559	PF00675	0.297
CLV_NRD_NRD_1	630	632	PF00675	0.480
CLV_NRD_NRD_1	92	94	PF00675	0.452
CLV_PCSK_FUR_1	472	476	PF00082	0.297
CLV_PCSK_FUR_1	628	632	PF00082	0.467
CLV_PCSK_KEX2_1	123	125	PF00082	0.658
CLV_PCSK_KEX2_1	219	221	PF00082	0.740
CLV_PCSK_KEX2_1	287	289	PF00082	0.601
CLV_PCSK_KEX2_1	427	429	PF00082	0.600
CLV_PCSK_KEX2_1	431	433	PF00082	0.508
CLV_PCSK_KEX2_1	439	441	PF00082	0.342
CLV_PCSK_KEX2_1	467	469	PF00082	0.297
CLV_PCSK_KEX2_1	474	476	PF00082	0.297
CLV_PCSK_KEX2_1	482	484	PF00082	0.183
CLV_PCSK_KEX2_1	487	489	PF00082	0.297
CLV_PCSK_KEX2_1	557	559	PF00082	0.297
CLV_PCSK_KEX2_1	630	632	PF00082	0.480
CLV_PCSK_KEX2_1	91	93	PF00082	0.468
CLV_PCSK_PC7_1	427	433	PF00082	0.437
CLV_PCSK_PC7_1	483	489	PF00082	0.297
CLV_PCSK_PC7_1	88	94	PF00082	0.480
CLV_PCSK_SKI1_1	405	409	PF00082	0.623
CLV_PCSK_SKI1_1	440	444	PF00082	0.413
CLV_PCSK_SKI1_1	474	478	PF00082	0.297
CLV_PCSK_SKI1_1	745	749	PF00082	0.574
DEG_SPOP_SBC_1	329	333	PF00917	0.596
DOC_CKS1_1	1	6	PF01111	0.583
DOC_CKS1_1	248	253	PF01111	0.624
DOC_CKS1_1	304	309	PF01111	0.629
DOC_CKS1_1	709	714	PF01111	0.524
DOC_CYCLIN_RxL_1	468	481	PF00134	0.297
DOC_MAPK_gen_1	609	618	PF00069	0.297
DOC_MAPK_gen_1	91	99	PF00069	0.460
DOC_MAPK_RevD_3	616	631	PF00069	0.297
DOC_MAPK_RevD_3	79	93	PF00069	0.500
DOC_PP2B_LxvP_1	257	260	PF13499	0.593
DOC_PP2B_LxvP_1	326	329	PF13499	0.621
DOC_USP7_MATH_1	133	137	PF00917	0.658
DOC_USP7_MATH_1	14	18	PF00917	0.616
DOC_USP7_MATH_1	164	168	PF00917	0.633
DOC_USP7_MATH_1	286	290	PF00917	0.683
DOC_USP7_MATH_1	311	315	PF00917	0.619
DOC_USP7_MATH_1	330	334	PF00917	0.762
DOC_USP7_MATH_1	359	363	PF00917	0.628
DOC_USP7_MATH_1	495	499	PF00917	0.297
DOC_USP7_MATH_1	725	729	PF00917	0.517
DOC_USP7_MATH_1	758	762	PF00917	0.619
DOC_WW_Pin1_4	115	120	PF00397	0.608
DOC_WW_Pin1_4	123	128	PF00397	0.629
DOC_WW_Pin1_4	129	134	PF00397	0.613
DOC_WW_Pin1_4	187	192	PF00397	0.610
DOC_WW_Pin1_4	203	208	PF00397	0.683
DOC_WW_Pin1_4	247	252	PF00397	0.620
DOC_WW_Pin1_4	303	308	PF00397	0.613
DOC_WW_Pin1_4	312	317	PF00397	0.605
DOC_WW_Pin1_4	362	367	PF00397	0.622
DOC_WW_Pin1_4	374	379	PF00397	0.593
DOC_WW_Pin1_4	388	393	PF00397	0.667
DOC_WW_Pin1_4	563	568	PF00397	0.305
DOC_WW_Pin1_4	708	713	PF00397	0.525
LIG_14-3-3_CanoR_1	214	221	PF00244	0.684
LIG_14-3-3_CanoR_1	243	251	PF00244	0.674
LIG_14-3-3_CanoR_1	275	279	PF00244	0.688
LIG_14-3-3_CanoR_1	287	296	PF00244	0.558
LIG_14-3-3_CanoR_1	337	341	PF00244	0.667
LIG_14-3-3_CanoR_1	405	415	PF00244	0.584
LIG_14-3-3_CanoR_1	474	480	PF00244	0.353
LIG_14-3-3_CanoR_1	663	671	PF00244	0.594
LIG_14-3-3_CanoR_1	730	737	PF00244	0.526
LIG_14-3-3_CanoR_1	82	90	PF00244	0.495
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_BIR_III_1	1	5	PF00653	0.534
LIG_BIR_III_3	1	5	PF00653	0.534
LIG_BIR_III_4	179	183	PF00653	0.632
LIG_BRCT_BRCA1_1	260	264	PF00533	0.668
LIG_Clathr_ClatBox_1	23	27	PF01394	0.592
LIG_Clathr_ClatBox_1	57	61	PF01394	0.614
LIG_Clathr_ClatBox_1	786	790	PF01394	0.635
LIG_deltaCOP1_diTrp_1	230	239	PF00928	0.601
LIG_eIF4E_1	437	443	PF01652	0.441
LIG_eIF4E_1	471	477	PF01652	0.297
LIG_FHA_1	173	179	PF00498	0.630
LIG_FHA_1	248	254	PF00498	0.626
LIG_FHA_1	330	336	PF00498	0.616
LIG_FHA_1	362	368	PF00498	0.625
LIG_FHA_1	505	511	PF00498	0.297
LIG_FHA_1	532	538	PF00498	0.353
LIG_FHA_1	540	546	PF00498	0.268
LIG_FHA_1	578	584	PF00498	0.305
LIG_FHA_1	597	603	PF00498	0.333
LIG_FHA_1	656	662	PF00498	0.527
LIG_FHA_1	68	74	PF00498	0.510
LIG_FHA_1	709	715	PF00498	0.526
LIG_FHA_1	82	88	PF00498	0.479
LIG_FHA_2	14	20	PF00498	0.544
LIG_FHA_2	167	173	PF00498	0.639
LIG_FHA_2	356	362	PF00498	0.526
LIG_FHA_2	392	398	PF00498	0.739
LIG_FHA_2	4	10	PF00498	0.613
LIG_FHA_2	417	423	PF00498	0.492
LIG_FHA_2	536	542	PF00498	0.277
LIG_FHA_2	655	661	PF00498	0.456
LIG_FHA_2	730	736	PF00498	0.524
LIG_FHA_2	817	823	PF00498	0.654
LIG_HCF-1_HBM_1	552	555	PF13415	0.297
LIG_KLC1_Yacidic_2	56	61	PF13176	0.611
LIG_LIR_Gen_1	56	64	PF02991	0.563
LIG_LIR_Nem_3	56	62	PF02991	0.567
LIG_LIR_Nem_3	647	653	PF02991	0.467
LIG_MYND_1	251	255	PF01753	0.614
LIG_MYND_1	374	378	PF01753	0.588
LIG_SH2_GRB2like	623	626	PF00017	0.297
LIG_SH2_PTP2	59	62	PF00017	0.566
LIG_SH2_STAP1	290	294	PF00017	0.679
LIG_SH2_STAP1	533	537	PF00017	0.297
LIG_SH2_STAT3	221	224	PF00017	0.687
LIG_SH2_STAT5	221	224	PF00017	0.797
LIG_SH2_STAT5	290	293	PF00017	0.599
LIG_SH2_STAT5	479	482	PF00017	0.353
LIG_SH2_STAT5	500	503	PF00017	0.297
LIG_SH2_STAT5	509	512	PF00017	0.297
LIG_SH2_STAT5	533	536	PF00017	0.339
LIG_SH2_STAT5	555	558	PF00017	0.220
LIG_SH2_STAT5	59	62	PF00017	0.566
LIG_SH2_STAT5	692	695	PF00017	0.591
LIG_SH2_STAT5	736	739	PF00017	0.545
LIG_SH2_STAT5	740	743	PF00017	0.567
LIG_SH3_2	119	124	PF14604	0.648
LIG_SH3_3	113	119	PF00018	0.654
LIG_SH3_3	122	128	PF00018	0.596
LIG_SH3_3	252	258	PF00018	0.670
LIG_SH3_3	375	381	PF00018	0.617
LIG_SH3_3	507	513	PF00018	0.353
LIG_SH3_3	615	621	PF00018	0.458
LIG_SUMO_SIM_anti_2	391	399	PF11976	0.530
LIG_SUMO_SIM_anti_2	579	586	PF11976	0.293
LIG_SUMO_SIM_anti_2	782	788	PF11976	0.601
LIG_SUMO_SIM_par_1	391	399	PF11976	0.571
LIG_SUMO_SIM_par_1	414	422	PF11976	0.460
LIG_SUMO_SIM_par_1	579	586	PF11976	0.293
LIG_SUMO_SIM_par_1	831	838	PF11976	0.670
LIG_TRAF2_1	419	422	PF00917	0.460
LIG_TRAF2_1	657	660	PF00917	0.525
LIG_TYR_ITIM	57	62	PF00017	0.569
MOD_CDK_SPK_2	187	192	PF00069	0.638
MOD_CDK_SPK_2	203	208	PF00069	0.595
MOD_CDK_SPxxK_3	312	319	PF00069	0.619
MOD_CK1_1	126	132	PF00069	0.654
MOD_CK1_1	147	153	PF00069	0.704
MOD_CK1_1	241	247	PF00069	0.616
MOD_CK1_1	249	255	PF00069	0.612
MOD_CK1_1	277	283	PF00069	0.604
MOD_CK1_1	302	308	PF00069	0.648
MOD_CK1_1	362	368	PF00069	0.589
MOD_CK1_1	383	389	PF00069	0.781
MOD_CK1_1	478	484	PF00069	0.297
MOD_CK1_1	531	537	PF00069	0.297
MOD_CK1_1	700	706	PF00069	0.522
MOD_CK1_1	782	788	PF00069	0.601
MOD_CK2_1	166	172	PF00069	0.596
MOD_CK2_1	3	9	PF00069	0.613
MOD_CK2_1	362	368	PF00069	0.590
MOD_CK2_1	416	422	PF00069	0.448
MOD_CK2_1	568	574	PF00069	0.296
MOD_CK2_1	654	660	PF00069	0.446
MOD_Cter_Amidation	501	504	PF01082	0.297
MOD_GlcNHglycan	106	109	PF01048	0.546
MOD_GlcNHglycan	149	152	PF01048	0.613
MOD_GlcNHglycan	183	186	PF01048	0.705
MOD_GlcNHglycan	216	219	PF01048	0.804
MOD_GlcNHglycan	297	300	PF01048	0.666
MOD_GlcNHglycan	301	304	PF01048	0.595
MOD_GlcNHglycan	332	335	PF01048	0.577
MOD_GlcNHglycan	348	351	PF01048	0.580
MOD_GlcNHglycan	353	356	PF01048	0.573
MOD_GlcNHglycan	361	364	PF01048	0.579
MOD_GlcNHglycan	368	372	PF01048	0.518
MOD_GlcNHglycan	408	411	PF01048	0.595
MOD_GlcNHglycan	639	642	PF01048	0.533
MOD_GlcNHglycan	687	691	PF01048	0.555
MOD_GlcNHglycan	699	702	PF01048	0.490
MOD_GlcNHglycan	727	730	PF01048	0.536
MOD_GlcNHglycan	762	765	PF01048	0.712
MOD_GSK3_1	123	130	PF00069	0.671
MOD_GSK3_1	149	156	PF00069	0.699
MOD_GSK3_1	187	194	PF00069	0.709
MOD_GSK3_1	210	217	PF00069	0.654
MOD_GSK3_1	235	242	PF00069	0.613
MOD_GSK3_1	243	250	PF00069	0.621
MOD_GSK3_1	295	302	PF00069	0.621
MOD_GSK3_1	324	331	PF00069	0.754
MOD_GSK3_1	351	358	PF00069	0.619
MOD_GSK3_1	513	520	PF00069	0.501
MOD_GSK3_1	531	538	PF00069	0.189
MOD_GSK3_1	592	599	PF00069	0.353
MOD_GSK3_1	63	70	PF00069	0.694
MOD_GSK3_1	725	732	PF00069	0.518
MOD_N-GLC_1	147	152	PF02516	0.655
MOD_N-GLC_1	153	158	PF02516	0.628
MOD_N-GLC_1	228	233	PF02516	0.651
MOD_N-GLC_1	312	317	PF02516	0.582
MOD_N-GLC_2	642	644	PF02516	0.442
MOD_NEK2_1	239	244	PF00069	0.619
MOD_NEK2_1	279	284	PF00069	0.767
MOD_NEK2_1	346	351	PF00069	0.574
MOD_NEK2_1	367	372	PF00069	0.634
MOD_NEK2_1	385	390	PF00069	0.544
MOD_NEK2_1	741	746	PF00069	0.570
MOD_PIKK_1	219	225	PF00454	0.649
MOD_PIKK_1	380	386	PF00454	0.554
MOD_PIKK_1	396	402	PF00454	0.568
MOD_PKA_1	219	225	PF00069	0.609
MOD_PKA_1	427	433	PF00069	0.477
MOD_PKA_2	104	110	PF00069	0.531
MOD_PKA_2	141	147	PF00069	0.644
MOD_PKA_2	191	197	PF00069	0.682
MOD_PKA_2	219	225	PF00069	0.682
MOD_PKA_2	239	245	PF00069	0.559
MOD_PKA_2	274	280	PF00069	0.610
MOD_PKA_2	286	292	PF00069	0.601
MOD_PKA_2	336	342	PF00069	0.665
MOD_PKA_2	427	433	PF00069	0.489
MOD_PKA_2	517	523	PF00069	0.313
MOD_PKA_2	662	668	PF00069	0.588
MOD_PKA_2	729	735	PF00069	0.517
MOD_PKA_2	81	87	PF00069	0.503
MOD_PKB_1	293	301	PF00069	0.625
MOD_Plk_1	495	501	PF00069	0.297
MOD_Plk_1	505	511	PF00069	0.297
MOD_Plk_1	551	557	PF00069	0.346
MOD_Plk_1	782	788	PF00069	0.586
MOD_Plk_2-3	816	822	PF00069	0.672
MOD_Plk_4	134	140	PF00069	0.637
MOD_Plk_4	274	280	PF00069	0.738
MOD_Plk_4	391	397	PF00069	0.612
MOD_Plk_4	505	511	PF00069	0.303
MOD_Plk_4	551	557	PF00069	0.237
MOD_Plk_4	577	583	PF00069	0.293
MOD_Plk_4	782	788	PF00069	0.641
MOD_ProDKin_1	115	121	PF00069	0.612
MOD_ProDKin_1	123	129	PF00069	0.630
MOD_ProDKin_1	187	193	PF00069	0.611
MOD_ProDKin_1	203	209	PF00069	0.683
MOD_ProDKin_1	247	253	PF00069	0.623
MOD_ProDKin_1	303	309	PF00069	0.615
MOD_ProDKin_1	312	318	PF00069	0.603
MOD_ProDKin_1	362	368	PF00069	0.626
MOD_ProDKin_1	374	380	PF00069	0.593
MOD_ProDKin_1	388	394	PF00069	0.662
MOD_ProDKin_1	563	569	PF00069	0.305
MOD_ProDKin_1	708	714	PF00069	0.526
MOD_SUMO_for_1	529	532	PF00179	0.297
MOD_SUMO_rev_2	420	426	PF00179	0.479
TRG_DiLeu_BaEn_4	421	427	PF01217	0.413
TRG_DiLeu_BaEn_4	659	665	PF01217	0.551
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.667
TRG_DiLeu_BaLyEn_6	446	451	PF01217	0.493
TRG_ENDOCYTIC_2	59	62	PF00928	0.566
TRG_ENDOCYTIC_2	652	655	PF00928	0.445
TRG_ER_diArg_1	103	106	PF00400	0.523
TRG_ER_diArg_1	122	124	PF00400	0.669
TRG_ER_diArg_1	139	142	PF00400	0.587
TRG_ER_diArg_1	219	221	PF00400	0.643
TRG_ER_diArg_1	426	428	PF00400	0.490
TRG_ER_diArg_1	431	433	PF00400	0.431
TRG_ER_diArg_1	471	474	PF00400	0.297
TRG_ER_diArg_1	556	558	PF00400	0.297
TRG_ER_diArg_1	627	630	PF00400	0.434
TRG_ER_diArg_1	90	93	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R7	Leptomonas seymouri	50%	100%
A0A3S7WVE0	Leishmania donovani	94%	100%
A4HA51	Leishmania braziliensis	79%	87%
A4HYB5	Leishmania infantum	94%	100%
E9AS48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	94%