LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain, G-beta repeat, putative
Species:
Leishmania major
UniProt:
Q4QDB4_LEIMA
TriTrypDb:
LmjF.19.1010 , LMJLV39_190015700 , LMJSD75_190015600
Length:
814

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005840 ribosome 5 6
GO:0031931 TORC1 complex 4 8
GO:0031932 TORC2 complex 4 8
GO:0032991 protein-containing complex 1 8
GO:0038201 TOR complex 3 8
GO:0043226 organelle 2 6
GO:0043228 non-membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043232 intracellular non-membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6
GO:0140535 intracellular protein-containing complex 2 8
GO:1990904 ribonucleoprotein complex 2 6

Expansion

Sequence features

Q4QDB4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDB4

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 8
GO:0009987 cellular process 1 8
GO:0031929 TOR signaling 4 8
GO:0032956 regulation of actin cytoskeleton organization 5 2
GO:0032970 regulation of actin filament-based process 4 2
GO:0033043 regulation of organelle organization 5 2
GO:0035556 intracellular signal transduction 3 8
GO:0050789 regulation of biological process 2 8
GO:0050794 regulation of cellular process 3 8
GO:0051128 regulation of cellular component organization 4 2
GO:0051493 regulation of cytoskeleton organization 6 2
GO:0065007 biological regulation 1 8
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 662 666 PF00656 0.607
CLV_C14_Caspase3-7 681 685 PF00656 0.812
CLV_NRD_NRD_1 213 215 PF00675 0.549
CLV_NRD_NRD_1 809 811 PF00675 0.625
CLV_PCSK_KEX2_1 213 215 PF00082 0.618
CLV_PCSK_KEX2_1 808 810 PF00082 0.583
CLV_PCSK_PC1ET2_1 808 810 PF00082 0.637
CLV_PCSK_SKI1_1 132 136 PF00082 0.647
CLV_PCSK_SKI1_1 193 197 PF00082 0.489
CLV_PCSK_SKI1_1 214 218 PF00082 0.494
CLV_PCSK_SKI1_1 24 28 PF00082 0.524
CLV_PCSK_SKI1_1 275 279 PF00082 0.565
CLV_PCSK_SKI1_1 353 357 PF00082 0.594
CLV_PCSK_SKI1_1 441 445 PF00082 0.730
CLV_PCSK_SKI1_1 548 552 PF00082 0.451
CLV_PCSK_SKI1_1 746 750 PF00082 0.311
DEG_APCC_DBOX_1 294 302 PF00400 0.551
DEG_SCF_FBW7_2 160 167 PF00400 0.478
DOC_ANK_TNKS_1 724 731 PF00023 0.571
DOC_MAPK_MEF2A_6 548 555 PF00069 0.437
DOC_MAPK_MEF2A_6 797 804 PF00069 0.474
DOC_PP2B_LxvP_1 580 583 PF13499 0.513
DOC_PP4_FxxP_1 40 43 PF00568 0.544
DOC_PP4_FxxP_1 574 577 PF00568 0.435
DOC_SPAK_OSR1_1 573 577 PF12202 0.431
DOC_USP7_MATH_1 250 254 PF00917 0.659
DOC_USP7_MATH_1 309 313 PF00917 0.424
DOC_USP7_MATH_1 401 405 PF00917 0.767
DOC_USP7_MATH_1 428 432 PF00917 0.703
DOC_USP7_MATH_1 523 527 PF00917 0.773
DOC_USP7_MATH_1 626 630 PF00917 0.612
DOC_USP7_UBL2_3 394 398 PF12436 0.727
DOC_WW_Pin1_4 160 165 PF00397 0.474
DOC_WW_Pin1_4 207 212 PF00397 0.456
DOC_WW_Pin1_4 256 261 PF00397 0.726
DOC_WW_Pin1_4 388 393 PF00397 0.798
DOC_WW_Pin1_4 471 476 PF00397 0.730
DOC_WW_Pin1_4 553 558 PF00397 0.429
DOC_WW_Pin1_4 684 689 PF00397 0.825
DOC_WW_Pin1_4 732 737 PF00397 0.658
LIG_14-3-3_CanoR_1 24 30 PF00244 0.443
LIG_14-3-3_CanoR_1 353 358 PF00244 0.682
LIG_14-3-3_CanoR_1 476 485 PF00244 0.650
LIG_14-3-3_CanoR_1 786 791 PF00244 0.509
LIG_APCC_ABBAyCdc20_2 27 33 PF00400 0.580
LIG_BIR_II_1 1 5 PF00653 0.516
LIG_BRCT_BRCA1_1 102 106 PF00533 0.521
LIG_BRCT_BRCA1_1 27 31 PF00533 0.491
LIG_BRCT_BRCA1_1 788 792 PF00533 0.547
LIG_eIF4E_1 549 555 PF01652 0.485
LIG_FHA_1 137 143 PF00498 0.546
LIG_FHA_1 154 160 PF00498 0.596
LIG_FHA_1 354 360 PF00498 0.723
LIG_FHA_1 403 409 PF00498 0.804
LIG_FHA_1 414 420 PF00498 0.625
LIG_FHA_1 43 49 PF00498 0.496
LIG_FHA_1 647 653 PF00498 0.787
LIG_FHA_1 794 800 PF00498 0.461
LIG_FHA_2 173 179 PF00498 0.426
LIG_FHA_2 260 266 PF00498 0.575
LIG_FHA_2 363 369 PF00498 0.753
LIG_LIR_Apic_2 226 231 PF02991 0.431
LIG_LIR_Apic_2 38 43 PF02991 0.530
LIG_LIR_Apic_2 391 396 PF02991 0.712
LIG_LIR_Apic_2 431 435 PF02991 0.734
LIG_LIR_Gen_1 103 114 PF02991 0.507
LIG_LIR_Gen_1 167 174 PF02991 0.592
LIG_LIR_Gen_1 306 315 PF02991 0.460
LIG_LIR_Gen_1 44 55 PF02991 0.434
LIG_LIR_Gen_1 538 547 PF02991 0.523
LIG_LIR_Gen_1 718 727 PF02991 0.640
LIG_LIR_LC3C_4 442 446 PF02991 0.730
LIG_LIR_Nem_3 103 109 PF02991 0.482
LIG_LIR_Nem_3 167 173 PF02991 0.600
LIG_LIR_Nem_3 306 310 PF02991 0.526
LIG_LIR_Nem_3 44 50 PF02991 0.418
LIG_LIR_Nem_3 538 543 PF02991 0.528
LIG_LIR_Nem_3 718 722 PF02991 0.702
LIG_LIR_Nem_3 741 745 PF02991 0.430
LIG_Pex14_1 756 760 PF04695 0.517
LIG_SH2_CRK 307 311 PF00017 0.429
LIG_SH2_CRK 393 397 PF00017 0.790
LIG_SH2_CRK 432 436 PF00017 0.726
LIG_SH2_CRK 547 551 PF00017 0.490
LIG_SH2_STAP1 11 15 PF00017 0.434
LIG_SH2_STAT3 11 14 PF00017 0.439
LIG_SH2_STAT5 215 218 PF00017 0.490
LIG_SH2_STAT5 47 50 PF00017 0.391
LIG_SH2_STAT5 549 552 PF00017 0.445
LIG_SH3_3 368 374 PF00018 0.768
LIG_SH3_3 605 611 PF00018 0.725
LIG_SH3_3 741 747 PF00018 0.385
LIG_SUMO_SIM_anti_2 3 8 PF11976 0.548
LIG_SUMO_SIM_par_1 3 8 PF11976 0.548
LIG_TRAF2_1 284 287 PF00917 0.678
LIG_TRAF2_1 687 690 PF00917 0.718
LIG_TYR_ITSM 43 50 PF00017 0.502
LIG_WRC_WIRS_1 26 31 PF05994 0.496
LIG_WRC_WIRS_1 61 66 PF05994 0.617
LIG_WRC_WIRS_1 716 721 PF05994 0.677
LIG_WRC_WIRS_1 95 100 PF05994 0.537
LIG_WW_1 92 95 PF00397 0.565
MOD_CDC14_SPxK_1 210 213 PF00782 0.488
MOD_CDC14_SPxK_1 391 394 PF00782 0.718
MOD_CDC14_SPxK_1 395 398 PF00782 0.732
MOD_CDK_SPK_2 471 476 PF00069 0.574
MOD_CDK_SPxK_1 160 166 PF00069 0.479
MOD_CDK_SPxK_1 207 213 PF00069 0.464
MOD_CDK_SPxK_1 388 394 PF00069 0.723
MOD_CDK_SPxxK_3 207 214 PF00069 0.523
MOD_CDK_SPxxK_3 732 739 PF00069 0.594
MOD_CK1_1 125 131 PF00069 0.688
MOD_CK1_1 137 143 PF00069 0.631
MOD_CK1_1 188 194 PF00069 0.509
MOD_CK1_1 207 213 PF00069 0.464
MOD_CK1_1 22 28 PF00069 0.469
MOD_CK1_1 253 259 PF00069 0.752
MOD_CK1_1 345 351 PF00069 0.701
MOD_CK1_1 402 408 PF00069 0.817
MOD_CK1_1 418 424 PF00069 0.721
MOD_CK1_1 457 463 PF00069 0.711
MOD_CK1_1 499 505 PF00069 0.763
MOD_CK1_1 526 532 PF00069 0.625
MOD_CK1_1 585 591 PF00069 0.741
MOD_CK1_1 597 603 PF00069 0.555
MOD_CK1_1 732 738 PF00069 0.707
MOD_CK1_1 761 767 PF00069 0.548
MOD_CK1_1 772 778 PF00069 0.556
MOD_CK1_1 82 88 PF00069 0.785
MOD_CK1_1 97 103 PF00069 0.412
MOD_CK2_1 397 403 PF00069 0.813
MOD_CK2_1 418 424 PF00069 0.782
MOD_CK2_1 683 689 PF00069 0.812
MOD_CK2_1 93 99 PF00069 0.499
MOD_GlcNHglycan 127 130 PF01048 0.689
MOD_GlcNHglycan 136 139 PF01048 0.658
MOD_GlcNHglycan 187 190 PF01048 0.573
MOD_GlcNHglycan 206 209 PF01048 0.402
MOD_GlcNHglycan 21 24 PF01048 0.487
MOD_GlcNHglycan 306 310 PF01048 0.529
MOD_GlcNHglycan 353 356 PF01048 0.762
MOD_GlcNHglycan 384 387 PF01048 0.824
MOD_GlcNHglycan 399 402 PF01048 0.769
MOD_GlcNHglycan 405 408 PF01048 0.677
MOD_GlcNHglycan 441 444 PF01048 0.655
MOD_GlcNHglycan 458 462 PF01048 0.690
MOD_GlcNHglycan 511 514 PF01048 0.803
MOD_GlcNHglycan 525 528 PF01048 0.632
MOD_GlcNHglycan 565 568 PF01048 0.474
MOD_GlcNHglycan 584 587 PF01048 0.707
MOD_GlcNHglycan 599 602 PF01048 0.546
MOD_GlcNHglycan 616 619 PF01048 0.636
MOD_GlcNHglycan 66 69 PF01048 0.712
MOD_GlcNHglycan 661 664 PF01048 0.724
MOD_GlcNHglycan 7 10 PF01048 0.416
MOD_GlcNHglycan 711 714 PF01048 0.770
MOD_GlcNHglycan 74 77 PF01048 0.666
MOD_GSK3_1 121 128 PF00069 0.713
MOD_GSK3_1 132 139 PF00069 0.655
MOD_GSK3_1 18 25 PF00069 0.464
MOD_GSK3_1 229 236 PF00069 0.503
MOD_GSK3_1 246 253 PF00069 0.658
MOD_GSK3_1 305 312 PF00069 0.487
MOD_GSK3_1 31 38 PF00069 0.524
MOD_GSK3_1 338 345 PF00069 0.652
MOD_GSK3_1 349 356 PF00069 0.729
MOD_GSK3_1 380 387 PF00069 0.801
MOD_GSK3_1 388 395 PF00069 0.722
MOD_GSK3_1 397 404 PF00069 0.675
MOD_GSK3_1 411 418 PF00069 0.592
MOD_GSK3_1 435 442 PF00069 0.621
MOD_GSK3_1 477 484 PF00069 0.746
MOD_GSK3_1 563 570 PF00069 0.478
MOD_GSK3_1 581 588 PF00069 0.559
MOD_GSK3_1 590 597 PF00069 0.671
MOD_GSK3_1 60 67 PF00069 0.620
MOD_GSK3_1 610 617 PF00069 0.788
MOD_GSK3_1 653 660 PF00069 0.746
MOD_GSK3_1 676 683 PF00069 0.758
MOD_GSK3_1 684 691 PF00069 0.699
MOD_GSK3_1 72 79 PF00069 0.600
MOD_GSK3_1 768 775 PF00069 0.556
MOD_GSK3_1 81 88 PF00069 0.702
MOD_GSK3_1 93 100 PF00069 0.391
MOD_N-GLC_1 104 109 PF02516 0.445
MOD_N-GLC_1 428 433 PF02516 0.783
MOD_N-GLC_1 499 504 PF02516 0.760
MOD_N-GLC_1 701 706 PF02516 0.724
MOD_N-GLC_1 82 87 PF02516 0.763
MOD_NEK2_1 104 109 PF00069 0.415
MOD_NEK2_1 134 139 PF00069 0.716
MOD_NEK2_1 147 152 PF00069 0.558
MOD_NEK2_1 153 158 PF00069 0.388
MOD_NEK2_1 159 164 PF00069 0.548
MOD_NEK2_1 183 188 PF00069 0.570
MOD_NEK2_1 31 36 PF00069 0.507
MOD_NEK2_1 382 387 PF00069 0.766
MOD_NEK2_1 411 416 PF00069 0.792
MOD_NEK2_1 468 473 PF00069 0.706
MOD_NEK2_1 561 566 PF00069 0.411
MOD_NEK2_1 616 621 PF00069 0.623
MOD_NEK2_1 64 69 PF00069 0.676
MOD_NEK2_1 646 651 PF00069 0.584
MOD_NEK2_1 766 771 PF00069 0.517
MOD_NEK2_2 435 440 PF00069 0.657
MOD_PIKK_1 183 189 PF00454 0.483
MOD_PIKK_1 31 37 PF00454 0.452
MOD_PIKK_1 353 359 PF00454 0.761
MOD_PIKK_1 646 652 PF00454 0.820
MOD_PIKK_1 97 103 PF00454 0.521
MOD_PK_1 338 344 PF00069 0.677
MOD_PK_1 786 792 PF00069 0.543
MOD_PKA_2 342 348 PF00069 0.745
MOD_PKA_2 435 441 PF00069 0.798
MOD_PKA_2 454 460 PF00069 0.662
MOD_PKA_2 614 620 PF00069 0.760
MOD_Plk_1 104 110 PF00069 0.446
MOD_Plk_1 305 311 PF00069 0.532
MOD_Plk_1 338 344 PF00069 0.677
MOD_Plk_1 428 434 PF00069 0.725
MOD_Plk_1 567 573 PF00069 0.426
MOD_Plk_1 59 65 PF00069 0.355
MOD_Plk_1 772 778 PF00069 0.556
MOD_Plk_2-3 729 735 PF00069 0.726
MOD_Plk_4 138 144 PF00069 0.601
MOD_Plk_4 223 229 PF00069 0.453
MOD_Plk_4 25 31 PF00069 0.581
MOD_Plk_4 35 41 PF00069 0.247
MOD_Plk_4 435 441 PF00069 0.625
MOD_Plk_4 60 66 PF00069 0.496
MOD_Plk_4 788 794 PF00069 0.578
MOD_ProDKin_1 160 166 PF00069 0.479
MOD_ProDKin_1 207 213 PF00069 0.464
MOD_ProDKin_1 256 262 PF00069 0.728
MOD_ProDKin_1 388 394 PF00069 0.801
MOD_ProDKin_1 471 477 PF00069 0.730
MOD_ProDKin_1 553 559 PF00069 0.427
MOD_ProDKin_1 684 690 PF00069 0.826
MOD_ProDKin_1 732 738 PF00069 0.655
MOD_SUMO_rev_2 236 244 PF00179 0.588
MOD_SUMO_rev_2 265 271 PF00179 0.537
MOD_SUMO_rev_2 623 632 PF00179 0.597
MOD_SUMO_rev_2 684 694 PF00179 0.646
TRG_DiLeu_BaEn_1 167 172 PF01217 0.532
TRG_DiLeu_BaLyEn_6 355 360 PF01217 0.685
TRG_DiLeu_BaLyEn_6 711 716 PF01217 0.718
TRG_ENDOCYTIC_2 307 310 PF00928 0.451
TRG_ENDOCYTIC_2 47 50 PF00928 0.407
TRG_ENDOCYTIC_2 547 550 PF00928 0.499
TRG_ENDOCYTIC_2 95 98 PF00928 0.486
TRG_ER_diArg_1 213 215 PF00400 0.618
TRG_ER_diArg_1 809 811 PF00400 0.628
TRG_Pf-PMV_PEXEL_1 132 136 PF00026 0.703
TRG_Pf-PMV_PEXEL_1 193 197 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 725 729 PF00026 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7T2 Leptomonas seymouri 55% 100%
A0A1X0P678 Trypanosomatidae 34% 100%
A0A3S7WVI8 Leishmania donovani 91% 100%
A4HA53 Leishmania braziliensis 72% 100%
A4HYB8 Leishmania infantum 91% 100%
E9AS52 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 94%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS