Cir_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDB2_LEIMA

TriTrypDb:

LmjF.19.1030 , LMJLV39_190015900 , LMJSD75_190015800

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.565
CLV_NRD_NRD_1	168	170	PF00675	0.671
CLV_NRD_NRD_1	219	221	PF00675	0.504
CLV_NRD_NRD_1	24	26	PF00675	0.514
CLV_NRD_NRD_1	54	56	PF00675	0.483
CLV_PCSK_KEX2_1	170	172	PF00082	0.643
CLV_PCSK_KEX2_1	196	198	PF00082	0.728
CLV_PCSK_KEX2_1	24	26	PF00082	0.528
CLV_PCSK_KEX2_1	263	265	PF00082	0.684
CLV_PCSK_KEX2_1	54	56	PF00082	0.483
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.643
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.728
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.684
CLV_PCSK_SKI1_1	276	280	PF00082	0.550
CLV_PCSK_SKI1_1	79	83	PF00082	0.513
CLV_PCSK_SKI1_1	91	95	PF00082	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_MAPK_gen_1	228	237	PF00069	0.615
DOC_MAPK_gen_1	274	281	PF00069	0.551
DOC_MAPK_gen_1	54	61	PF00069	0.447
DOC_USP7_MATH_1	104	108	PF00917	0.697
DOC_USP7_MATH_1	117	121	PF00917	0.702
DOC_USP7_MATH_1	122	126	PF00917	0.694
DOC_USP7_MATH_1	153	157	PF00917	0.756
DOC_USP7_MATH_1	158	162	PF00917	0.715
DOC_USP7_UBL2_3	282	286	PF12436	0.420
DOC_WW_Pin1_4	100	105	PF00397	0.642
DOC_WW_Pin1_4	163	168	PF00397	0.601
DOC_WW_Pin1_4	177	182	PF00397	0.599
LIG_FHA_1	206	212	PF00498	0.541
LIG_FHA_1	256	262	PF00498	0.523
LIG_FHA_1	76	82	PF00498	0.599
LIG_FHA_2	210	216	PF00498	0.544
LIG_LIR_Gen_1	53	62	PF02991	0.561
LIG_LIR_Nem_3	19	23	PF02991	0.419
LIG_LIR_Nem_3	53	59	PF02991	0.562
LIG_PCNA_yPIPBox_3	270	279	PF02747	0.570
LIG_Pex14_2	126	130	PF04695	0.617
LIG_SH2_CRK	20	24	PF00017	0.442
LIG_SH2_GRB2like	240	243	PF00017	0.546
LIG_SH2_SRC	240	243	PF00017	0.546
LIG_SH2_STAP1	56	60	PF00017	0.446
LIG_SH2_STAP1	86	90	PF00017	0.588
LIG_SH3_3	103	109	PF00018	0.681
LIG_SH3_4	108	115	PF00018	0.581
LIG_TYR_ITIM	18	23	PF00017	0.439
LIG_UBA3_1	278	286	PF00899	0.463
LIG_WRC_WIRS_1	123	128	PF05994	0.503
MOD_CDK_SPxK_1	163	169	PF00069	0.585
MOD_CDK_SPxxK_3	163	170	PF00069	0.585
MOD_CK1_1	125	131	PF00069	0.609
MOD_CK1_1	135	141	PF00069	0.630
MOD_CK1_1	180	186	PF00069	0.630
MOD_CK1_1	64	70	PF00069	0.486
MOD_CK1_1	97	103	PF00069	0.625
MOD_CK2_1	104	110	PF00069	0.746
MOD_CK2_1	209	215	PF00069	0.589
MOD_GlcNHglycan	115	118	PF01048	0.593
MOD_GlcNHglycan	156	159	PF01048	0.790
MOD_GlcNHglycan	160	163	PF01048	0.580
MOD_GlcNHglycan	187	190	PF01048	0.709
MOD_GlcNHglycan	203	206	PF01048	0.560
MOD_GlcNHglycan	212	215	PF01048	0.454
MOD_GlcNHglycan	63	66	PF01048	0.489
MOD_GlcNHglycan	68	71	PF01048	0.510
MOD_GSK3_1	100	107	PF00069	0.658
MOD_GSK3_1	113	120	PF00069	0.617
MOD_GSK3_1	132	139	PF00069	0.672
MOD_GSK3_1	154	161	PF00069	0.789
MOD_GSK3_1	175	182	PF00069	0.722
MOD_GSK3_1	201	208	PF00069	0.568
MOD_N-GLC_1	185	190	PF02516	0.720
MOD_N-GLC_2	242	244	PF02516	0.536
MOD_NEK2_1	113	118	PF00069	0.600
MOD_PK_1	94	100	PF00069	0.483
MOD_PKA_2	75	81	PF00069	0.563
MOD_Plk_1	132	138	PF00069	0.567
MOD_Plk_1	94	100	PF00069	0.483
MOD_Plk_4	122	128	PF00069	0.603
MOD_ProDKin_1	100	106	PF00069	0.642
MOD_ProDKin_1	163	169	PF00069	0.605
MOD_ProDKin_1	177	183	PF00069	0.599
MOD_SUMO_for_1	130	133	PF00179	0.579
MOD_SUMO_for_1	143	146	PF00179	0.631
MOD_SUMO_for_1	262	265	PF00179	0.511
MOD_SUMO_for_1	29	32	PF00179	0.564
MOD_SUMO_rev_2	85	93	PF00179	0.530
TRG_ENDOCYTIC_2	20	23	PF00928	0.442
TRG_ENDOCYTIC_2	56	59	PF00928	0.445
TRG_ER_diArg_1	168	171	PF00400	0.727
TRG_ER_diArg_1	23	25	PF00400	0.521
TRG_ER_diArg_1	54	56	PF00400	0.453
TRG_ER_diLys_1	282	286	PF00400	0.533
TRG_NLS_MonoCore_2	281	286	PF00514	0.536
TRG_NLS_MonoExtC_3	168	173	PF00514	0.668
TRG_NLS_MonoExtC_3	281	286	PF00514	0.536
TRG_NLS_MonoExtN_4	167	173	PF00514	0.674
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD46	Leptomonas seymouri	54%	100%
A0A3S7WVP3	Leishmania donovani	92%	97%
A0A422NC58	Trypanosoma rangeli	41%	100%
A4HA55	Leishmania braziliensis	77%	100%
A4HYC0	Leishmania infantum	91%	97%
D0A642	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AS54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BKZ5	Trypanosoma cruzi	41%	100%