Phenylalanine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phenylalanyl-tRNA synthetase, putative

Species:

Leishmania major

UniProt:

Q4QDB1_LEIMA

TriTrypDb:

LmjF.19.1040 , LMJLV39_190016000 , LMJSD75_190015900

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0009328	phenylalanine-tRNA ligase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QDB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDB1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006432	phenylalanyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043038	amino acid activation	4	12
GO:0043039	tRNA aminoacylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0000287	magnesium ion binding	5	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004826	phenylalanine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.592
CLV_NRD_NRD_1	162	164	PF00675	0.288
CLV_PCSK_KEX2_1	161	163	PF00082	0.299
CLV_PCSK_SKI1_1	121	125	PF00082	0.530
CLV_PCSK_SKI1_1	262	266	PF00082	0.271
CLV_PCSK_SKI1_1	323	327	PF00082	0.422
CLV_PCSK_SKI1_1	42	46	PF00082	0.328
CLV_PCSK_SKI1_1	51	55	PF00082	0.328
DEG_APCC_DBOX_1	161	169	PF00400	0.499
DEG_SCF_FBW7_1	307	312	PF00400	0.536
DEG_SCF_FBW7_2	315	321	PF00400	0.571
DOC_ANK_TNKS_1	372	379	PF00023	0.573
DOC_CKS1_1	315	320	PF01111	0.498
DOC_CKS1_1	74	79	PF01111	0.485
DOC_MAPK_DCC_7	504	512	PF00069	0.573
DOC_MAPK_gen_1	186	193	PF00069	0.499
DOC_MAPK_MEF2A_6	331	340	PF00069	0.499
DOC_MAPK_MEF2A_6	504	512	PF00069	0.573
DOC_PP1_RVXF_1	134	141	PF00149	0.457
DOC_PP1_SILK_1	473	478	PF00149	0.499
DOC_PP2B_LxvP_1	244	247	PF13499	0.487
DOC_PP2B_LxvP_1	553	556	PF13499	0.548
DOC_PP2B_LxvP_1	629	632	PF13499	0.554
DOC_USP7_MATH_1	441	445	PF00917	0.559
DOC_WW_Pin1_4	109	114	PF00397	0.402
DOC_WW_Pin1_4	305	310	PF00397	0.478
DOC_WW_Pin1_4	314	319	PF00397	0.427
DOC_WW_Pin1_4	406	411	PF00397	0.440
DOC_WW_Pin1_4	614	619	PF00397	0.509
DOC_WW_Pin1_4	73	78	PF00397	0.485
LIG_14-3-3_CanoR_1	116	120	PF00244	0.472
LIG_14-3-3_CanoR_1	143	149	PF00244	0.500
LIG_14-3-3_CanoR_1	161	166	PF00244	0.410
LIG_Actin_WH2_2	123	138	PF00022	0.266
LIG_Actin_WH2_2	538	554	PF00022	0.573
LIG_AP_GAE_1	21	27	PF02883	0.426
LIG_AP2alpha_2	293	295	PF02296	0.509
LIG_APCC_ABBA_1	287	292	PF00400	0.291
LIG_BRCT_BRCA1_1	535	539	PF00533	0.499
LIG_eIF4E_1	274	280	PF01652	0.409
LIG_FHA_1	1	7	PF00498	0.487
LIG_FHA_1	168	174	PF00498	0.487
LIG_FHA_1	177	183	PF00498	0.487
LIG_FHA_1	197	203	PF00498	0.592
LIG_FHA_1	229	235	PF00498	0.537
LIG_FHA_1	259	265	PF00498	0.487
LIG_FHA_1	310	316	PF00498	0.497
LIG_FHA_1	324	330	PF00498	0.271
LIG_FHA_1	364	370	PF00498	0.508
LIG_FHA_1	372	378	PF00498	0.497
LIG_FHA_1	426	432	PF00498	0.499
LIG_FHA_1	97	103	PF00498	0.595
LIG_FHA_2	18	24	PF00498	0.533
LIG_FHA_2	267	273	PF00498	0.487
LIG_FHA_2	354	360	PF00498	0.549
LIG_FHA_2	394	400	PF00498	0.487
LIG_GBD_Chelix_1	414	422	PF00786	0.378
LIG_LIR_Gen_1	142	151	PF02991	0.499
LIG_LIR_Gen_1	21	31	PF02991	0.486
LIG_LIR_Gen_1	252	259	PF02991	0.499
LIG_LIR_Gen_1	440	448	PF02991	0.501
LIG_LIR_Gen_1	536	545	PF02991	0.497
LIG_LIR_Gen_1	620	629	PF02991	0.487
LIG_LIR_Nem_3	142	148	PF02991	0.489
LIG_LIR_Nem_3	190	196	PF02991	0.499
LIG_LIR_Nem_3	21	27	PF02991	0.486
LIG_LIR_Nem_3	227	232	PF02991	0.505
LIG_LIR_Nem_3	252	257	PF02991	0.499
LIG_LIR_Nem_3	440	445	PF02991	0.490
LIG_LIR_Nem_3	503	509	PF02991	0.512
LIG_LIR_Nem_3	536	542	PF02991	0.497
LIG_LIR_Nem_3	566	572	PF02991	0.573
LIG_LIR_Nem_3	620	624	PF02991	0.511
LIG_LYPXL_yS_3	232	235	PF13949	0.487
LIG_MYND_1	469	473	PF01753	0.487
LIG_PCNA_yPIPBox_3	275	284	PF02747	0.446
LIG_PDZ_Class_2	628	633	PF00595	0.551
LIG_PTB_Apo_2	134	141	PF02174	0.528
LIG_PTB_Apo_2	248	255	PF02174	0.499
LIG_PTB_Apo_2	391	398	PF02174	0.583
LIG_PTB_Phospho_1	248	254	PF10480	0.528
LIG_PTB_Phospho_1	391	397	PF10480	0.580
LIG_SH2_CRK	105	109	PF00017	0.504
LIG_SH2_CRK	254	258	PF00017	0.528
LIG_SH2_CRK	392	396	PF00017	0.438
LIG_SH2_CRK	613	617	PF00017	0.512
LIG_SH2_GRB2like	392	395	PF00017	0.434
LIG_SH2_NCK_1	254	258	PF00017	0.528
LIG_SH2_NCK_1	304	308	PF00017	0.464
LIG_SH2_NCK_1	392	396	PF00017	0.558
LIG_SH2_NCK_1	613	617	PF00017	0.512
LIG_SH2_PTP2	222	225	PF00017	0.528
LIG_SH2_SRC	304	307	PF00017	0.471
LIG_SH2_SRC	392	395	PF00017	0.434
LIG_SH2_SRC	613	616	PF00017	0.512
LIG_SH2_STAP1	427	431	PF00017	0.528
LIG_SH2_STAT3	274	277	PF00017	0.509
LIG_SH2_STAT5	10	13	PF00017	0.499
LIG_SH2_STAT5	129	132	PF00017	0.491
LIG_SH2_STAT5	19	22	PF00017	0.487
LIG_SH2_STAT5	222	225	PF00017	0.526
LIG_SH2_STAT5	290	293	PF00017	0.394
LIG_SH2_STAT5	355	358	PF00017	0.592
LIG_SH2_STAT5	397	400	PF00017	0.506
LIG_SH2_STAT5	427	430	PF00017	0.512
LIG_SH2_STAT5	570	573	PF00017	0.502
LIG_SH3_3	227	233	PF00018	0.573
LIG_SH3_3	364	370	PF00018	0.487
LIG_SH3_3	463	469	PF00018	0.521
LIG_SH3_3	601	607	PF00018	0.487
LIG_SH3_4	485	492	PF00018	0.537
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.499
LIG_SUMO_SIM_anti_2	546	552	PF11976	0.573
LIG_SUMO_SIM_par_1	428	434	PF11976	0.573
LIG_SUMO_SIM_par_1	496	501	PF11976	0.494
LIG_SUMO_SIM_par_1	508	515	PF11976	0.474
LIG_TRAF2_1	20	23	PF00917	0.592
LIG_UBA3_1	335	341	PF00899	0.508
LIG_UBA3_1	349	358	PF00899	0.475
LIG_UBA3_1	471	477	PF00899	0.487
LIG_UBA3_1	550	558	PF00899	0.530
LIG_WRC_WIRS_1	145	150	PF05994	0.487
MOD_CDK_SPxxK_3	109	116	PF00069	0.411
MOD_CDK_SPxxK_3	406	413	PF00069	0.425
MOD_CDK_SPxxK_3	73	80	PF00069	0.487
MOD_CK1_1	144	150	PF00069	0.489
MOD_CK1_1	167	173	PF00069	0.487
MOD_CK1_1	228	234	PF00069	0.505
MOD_CK1_1	252	258	PF00069	0.493
MOD_CK1_1	314	320	PF00069	0.534
MOD_CK1_1	363	369	PF00069	0.565
MOD_CK1_1	434	440	PF00069	0.480
MOD_CK1_1	617	623	PF00069	0.509
MOD_CK2_1	17	23	PF00069	0.523
MOD_CK2_1	339	345	PF00069	0.507
MOD_CK2_1	353	359	PF00069	0.570
MOD_CK2_1	37	43	PF00069	0.356
MOD_CK2_1	393	399	PF00069	0.552
MOD_CK2_1	534	540	PF00069	0.487
MOD_CK2_1	617	623	PF00069	0.487
MOD_GlcNHglycan	254	257	PF01048	0.347
MOD_GlcNHglycan	341	344	PF01048	0.327
MOD_GlcNHglycan	51	54	PF01048	0.373
MOD_GlcNHglycan	536	539	PF01048	0.295
MOD_GSK3_1	115	122	PF00069	0.425
MOD_GSK3_1	224	231	PF00069	0.570
MOD_GSK3_1	305	312	PF00069	0.498
MOD_GSK3_1	319	326	PF00069	0.445
MOD_GSK3_1	353	360	PF00069	0.537
MOD_GSK3_1	425	432	PF00069	0.512
MOD_GSK3_1	511	518	PF00069	0.559
MOD_GSK3_1	534	541	PF00069	0.526
MOD_N-GLC_1	176	181	PF02516	0.309
MOD_N-GLC_1	393	398	PF02516	0.549
MOD_N-GLC_1	481	486	PF02516	0.299
MOD_N-GLC_1	532	537	PF02516	0.342
MOD_NEK2_1	225	230	PF00069	0.548
MOD_NEK2_1	353	358	PF00069	0.594
MOD_NEK2_1	431	436	PF00069	0.478
MOD_NEK2_1	96	101	PF00069	0.577
MOD_NEK2_2	187	192	PF00069	0.548
MOD_NEK2_2	285	290	PF00069	0.279
MOD_NEK2_2	538	543	PF00069	0.573
MOD_PIKK_1	404	410	PF00454	0.363
MOD_PK_1	331	337	PF00069	0.585
MOD_PKA_1	161	167	PF00069	0.499
MOD_PKA_2	115	121	PF00069	0.494
MOD_PKA_2	161	167	PF00069	0.512
MOD_PKA_2	187	193	PF00069	0.555
MOD_PKA_2	196	202	PF00069	0.559
MOD_PKA_2	467	473	PF00069	0.487
MOD_Plk_1	119	125	PF00069	0.416
MOD_Plk_1	141	147	PF00069	0.502
MOD_Plk_1	323	329	PF00069	0.425
MOD_Plk_1	363	369	PF00069	0.517
MOD_Plk_1	393	399	PF00069	0.482
MOD_Plk_2-3	293	299	PF00069	0.404
MOD_Plk_2-3	37	43	PF00069	0.487
MOD_Plk_2-3	393	399	PF00069	0.569
MOD_Plk_2-3	568	574	PF00069	0.499
MOD_Plk_4	144	150	PF00069	0.548
MOD_Plk_4	331	337	PF00069	0.509
MOD_Plk_4	467	473	PF00069	0.487
MOD_Plk_4	617	623	PF00069	0.499
MOD_ProDKin_1	109	115	PF00069	0.393
MOD_ProDKin_1	305	311	PF00069	0.482
MOD_ProDKin_1	314	320	PF00069	0.425
MOD_ProDKin_1	406	412	PF00069	0.440
MOD_ProDKin_1	614	620	PF00069	0.509
MOD_ProDKin_1	73	79	PF00069	0.485
MOD_SUMO_rev_2	393	402	PF00179	0.609
MOD_SUMO_rev_2	67	71	PF00179	0.597
TRG_DiLeu_BaEn_1	345	350	PF01217	0.548
TRG_DiLeu_BaEn_2	188	194	PF01217	0.499
TRG_DiLeu_BaEn_2	40	46	PF01217	0.592
TRG_DiLeu_BaEn_4	22	28	PF01217	0.592
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.573
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.487
TRG_ENDOCYTIC_2	105	108	PF00928	0.480
TRG_ENDOCYTIC_2	145	148	PF00928	0.487
TRG_ENDOCYTIC_2	222	225	PF00928	0.528
TRG_ENDOCYTIC_2	232	235	PF00928	0.478
TRG_ENDOCYTIC_2	254	257	PF00928	0.528
TRG_ENDOCYTIC_2	392	395	PF00928	0.434
TRG_ENDOCYTIC_2	427	430	PF00928	0.499
TRG_ENDOCYTIC_2	569	572	PF00928	0.570
TRG_ENDOCYTIC_2	621	624	PF00928	0.499
TRG_ER_diArg_1	161	163	PF00400	0.499
TRG_NES_CRM1_1	277	293	PF08389	0.281

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I086	Leptomonas seymouri	81%	100%
A0A0S4KEG0	Bodo saltans	59%	98%
A0A1X0P5R6	Trypanosomatidae	62%	100%
A0A3R7MC08	Trypanosoma rangeli	65%	100%
A0A3S7WVI5	Leishmania donovani	97%	100%
A0B993	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A1QZU9	Borrelia turicatae (strain 91E135)	23%	100%
A1RYS1	Thermofilum pendens (strain DSM 2475 / Hrk 5)	22%	100%
A2ST82	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A3CT77	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A4FWS3	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	27%	100%
A4HA56	Leishmania braziliensis	89%	100%
A4HYC1	Leishmania infantum	97%	100%
A4YIL0	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A5K464	Plasmodium vivax (strain Salvador I)	32%	100%
A6UPQ4	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6UWT1	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	26%	100%
A6VGJ4	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	27%	100%
A7I615	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	29%	100%
A9AA58	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	27%	100%
A9CS50	Enterocytozoon bieneusi (strain H348)	27%	100%
B0R807	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	25%	100%
B1L7C0	Korarchaeum cryptofilum (strain OPF8)	30%	100%
B2S0L6	Borrelia hermsii (strain HS1 / DAH)	22%	100%
B2S1W3	Treponema pallidum subsp. pallidum (strain SS14)	25%	100%
B5RM71	Borrelia duttonii (strain Ly)	22%	100%
B5RPL7	Borrelia recurrentis (strain A1)	22%	100%
B6YTJ3	Thermococcus onnurineus (strain NA1)	28%	100%
B7J278	Borreliella burgdorferi (strain ZS7)	24%	100%
B8GEX4	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	27%	100%
B9LU47	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	25%	100%
C3MJ88	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	26%	100%
C3MYY0	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	26%	100%
C3N028	Sulfolobus islandicus (strain M.16.27)	26%	100%
C3N8B1	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	26%	100%
C3NMS5	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	26%	100%
C4KJ68	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	26%	100%
C4VA52	Nosema ceranae (strain BRL01)	32%	100%
C5A5Z0	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	28%	100%
C6A237	Thermococcus sibiricus (strain DSM 12597 / MM 739)	28%	100%
D0A643	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AS55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13432	Candida albicans	38%	100%
O26864	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	27%	100%
O28848	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O42849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O73984	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	100%
O83059	Treponema pallidum (strain Nichols)	25%	100%
P15624	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	100%
P57694	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	24%	100%
P94283	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	23%	100%
P95960	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	26%	100%
Q0SMZ4	Borreliella afzelii (strain PKo)	23%	100%
Q0W0X4	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	25%	100%
Q12YP2	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	27%	100%
Q19713	Caenorhabditis elegans	39%	100%
Q2FLL1	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	28%	100%
Q2NGX9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	27%	100%
Q3ITU5	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	24%	100%
Q468N7	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q4J8Q0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	26%	100%
Q550D2	Dictyostelium discoideum	37%	100%
Q58508	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q5R7F7	Pongo abelii	41%	100%
Q5UYF3	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	25%	100%
Q661A7	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	22%	100%
Q6LXU2	Methanococcus maripaludis (strain S2 / LL)	28%	100%
Q76KA7	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	28%	100%
Q8PTA5	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	26%	100%
Q8SS40	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q8TPF7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	27%	100%
Q8TX56	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	24%	100%
Q8U260	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	100%
Q8ZWQ7	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	23%	100%
Q971D8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	27%	100%
Q97B53	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	24%	100%
Q9HMK3	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	25%	100%
Q9NSD9	Homo sapiens	41%	100%
Q9SGE9	Arabidopsis thaliana	38%	100%
Q9UYX2	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9VCA5	Drosophila melanogaster	42%	100%
Q9WUA2	Mus musculus	41%	100%
Q9Y9I3	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	24%	100%
V5DHA5	Trypanosoma cruzi	64%	100%