LeishMANIAdb
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DAGKc domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DAGKc domain-containing protein
Gene product:
Diacylglycerol kinase catalytic domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4QDA8_LEIMA
TriTrypDb:
LmjF.19.1070 , LMJLV39_190016300 * , LMJSD75_190016300
Length:
966

Annotations

LeishMANIAdb annotations

Could be a sphingosine kinase. Membrane-associated without any TM segments.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 2
GO:0042721 TIM22 mitochondrial import inner membrane insertion complex 4 2
GO:0098796 membrane protein complex 2 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:0098800 inner mitochondrial membrane protein complex 3 2
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QDA8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDA8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006839 mitochondrial transport 4 2
GO:0006886 intracellular protein transport 4 2
GO:0006996 organelle organization 4 2
GO:0007005 mitochondrion organization 5 2
GO:0007006 mitochondrial membrane organization 5 2
GO:0007007 inner mitochondrial membrane organization 6 2
GO:0008104 protein localization 4 2
GO:0009987 cellular process 1 3
GO:0015031 protein transport 4 2
GO:0016043 cellular component organization 3 2
GO:0033036 macromolecule localization 2 2
GO:0033365 protein localization to organelle 5 2
GO:0045039 protein insertion into mitochondrial inner membrane 6 2
GO:0045184 establishment of protein localization 3 2
GO:0046907 intracellular transport 3 2
GO:0051179 localization 1 2
GO:0051204 protein insertion into mitochondrial membrane 5 2
GO:0051205 protein insertion into membrane 5 2
GO:0051234 establishment of localization 2 2
GO:0051641 cellular localization 2 2
GO:0051649 establishment of localization in cell 3 2
GO:0051668 localization within membrane 3 2
GO:0061024 membrane organization 4 2
GO:0070585 protein localization to mitochondrion 6 2
GO:0070727 cellular macromolecule localization 3 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0072594 establishment of protein localization to organelle 4 2
GO:0072655 establishment of protein localization to mitochondrion 5 2
GO:0072657 protein localization to membrane 4 2
GO:0090150 establishment of protein localization to membrane 4 2
GO:0090151 establishment of protein localization to mitochondrial membrane 4 2
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016301 kinase activity 4 6
GO:0016740 transferase activity 2 6
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 6
GO:0017050 D-erythro-sphingosine kinase activity 5 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 363 367 PF00656 0.619
CLV_C14_Caspase3-7 493 497 PF00656 0.544
CLV_C14_Caspase3-7 851 855 PF00656 0.530
CLV_NRD_NRD_1 568 570 PF00675 0.669
CLV_NRD_NRD_1 937 939 PF00675 0.477
CLV_NRD_NRD_1 951 953 PF00675 0.477
CLV_PCSK_FUR_1 566 570 PF00082 0.650
CLV_PCSK_KEX2_1 568 570 PF00082 0.737
CLV_PCSK_KEX2_1 937 939 PF00082 0.477
CLV_PCSK_KEX2_1 951 953 PF00082 0.497
CLV_PCSK_SKI1_1 348 352 PF00082 0.320
CLV_PCSK_SKI1_1 411 415 PF00082 0.300
CLV_PCSK_SKI1_1 684 688 PF00082 0.732
CLV_PCSK_SKI1_1 884 888 PF00082 0.364
DEG_APCC_DBOX_1 942 950 PF00400 0.656
DEG_SPOP_SBC_1 28 32 PF00917 0.631
DEG_SPOP_SBC_1 666 670 PF00917 0.567
DEG_SPOP_SBC_1 693 697 PF00917 0.560
DEG_SPOP_SBC_1 92 96 PF00917 0.728
DOC_ANK_TNKS_1 575 582 PF00023 0.579
DOC_CKS1_1 552 557 PF01111 0.328
DOC_CKS1_1 632 637 PF01111 0.450
DOC_CYCLIN_RxL_1 221 231 PF00134 0.650
DOC_CYCLIN_RxL_1 345 355 PF00134 0.528
DOC_CYCLIN_yCln2_LP_2 310 316 PF00134 0.534
DOC_CYCLIN_yCln2_LP_2 598 604 PF00134 0.522
DOC_MAPK_gen_1 222 230 PF00069 0.671
DOC_MAPK_MEF2A_6 222 230 PF00069 0.650
DOC_MAPK_MEF2A_6 35 42 PF00069 0.590
DOC_MAPK_MEF2A_6 468 475 PF00069 0.428
DOC_PP1_RVXF_1 400 406 PF00149 0.500
DOC_PP1_RVXF_1 882 888 PF00149 0.499
DOC_PP2B_LxvP_1 315 318 PF13499 0.465
DOC_PP2B_LxvP_1 598 601 PF13499 0.505
DOC_PP2B_LxvP_1 781 784 PF13499 0.334
DOC_PP2B_LxvP_1 932 935 PF13499 0.723
DOC_PP4_FxxP_1 887 890 PF00568 0.492
DOC_SPAK_OSR1_1 830 834 PF12202 0.475
DOC_USP7_MATH_1 111 115 PF00917 0.812
DOC_USP7_MATH_1 149 153 PF00917 0.722
DOC_USP7_MATH_1 210 214 PF00917 0.774
DOC_USP7_MATH_1 282 286 PF00917 0.439
DOC_USP7_MATH_1 293 297 PF00917 0.534
DOC_USP7_MATH_1 352 356 PF00917 0.752
DOC_USP7_MATH_1 380 384 PF00917 0.645
DOC_USP7_MATH_1 387 391 PF00917 0.569
DOC_USP7_MATH_1 4 8 PF00917 0.699
DOC_USP7_MATH_1 420 424 PF00917 0.547
DOC_USP7_MATH_1 449 453 PF00917 0.408
DOC_USP7_MATH_1 666 670 PF00917 0.510
DOC_USP7_MATH_1 693 697 PF00917 0.517
DOC_USP7_MATH_1 76 80 PF00917 0.580
DOC_USP7_MATH_1 92 96 PF00917 0.662
DOC_WW_Pin1_4 104 109 PF00397 0.712
DOC_WW_Pin1_4 203 208 PF00397 0.738
DOC_WW_Pin1_4 246 251 PF00397 0.562
DOC_WW_Pin1_4 331 336 PF00397 0.475
DOC_WW_Pin1_4 374 379 PF00397 0.722
DOC_WW_Pin1_4 527 532 PF00397 0.566
DOC_WW_Pin1_4 536 541 PF00397 0.468
DOC_WW_Pin1_4 551 556 PF00397 0.307
DOC_WW_Pin1_4 615 620 PF00397 0.592
DOC_WW_Pin1_4 631 636 PF00397 0.368
DOC_WW_Pin1_4 643 648 PF00397 0.461
LIG_14-3-3_CanoR_1 232 238 PF00244 0.746
LIG_14-3-3_CanoR_1 381 387 PF00244 0.723
LIG_14-3-3_CanoR_1 389 396 PF00244 0.544
LIG_14-3-3_CanoR_1 437 442 PF00244 0.545
LIG_14-3-3_CanoR_1 566 575 PF00244 0.544
LIG_14-3-3_CanoR_1 629 633 PF00244 0.566
LIG_14-3-3_CanoR_1 808 813 PF00244 0.444
LIG_14-3-3_CanoR_1 819 826 PF00244 0.450
LIG_14-3-3_CanoR_1 830 839 PF00244 0.477
LIG_Actin_WH2_2 553 570 PF00022 0.408
LIG_BIR_II_1 1 5 PF00653 0.740
LIG_BIR_III_2 744 748 PF00653 0.461
LIG_BIR_III_3 1 5 PF00653 0.702
LIG_BIR_III_4 578 582 PF00653 0.556
LIG_BRCT_BRCA1_1 669 673 PF00533 0.540
LIG_CaM_IQ_9 424 439 PF13499 0.556
LIG_Clathr_ClatBox_1 758 762 PF01394 0.294
LIG_DLG_GKlike_1 437 445 PF00625 0.534
LIG_EH1_1 636 644 PF00400 0.454
LIG_eIF4E_1 776 782 PF01652 0.334
LIG_FHA_1 162 168 PF00498 0.578
LIG_FHA_1 265 271 PF00498 0.542
LIG_FHA_1 28 34 PF00498 0.661
LIG_FHA_1 527 533 PF00498 0.544
LIG_FHA_1 787 793 PF00498 0.312
LIG_FHA_1 794 800 PF00498 0.275
LIG_FHA_1 844 850 PF00498 0.589
LIG_FHA_1 890 896 PF00498 0.668
LIG_FHA_1 926 932 PF00498 0.660
LIG_FHA_2 260 266 PF00498 0.475
LIG_FHA_2 319 325 PF00498 0.475
LIG_FHA_2 332 338 PF00498 0.534
LIG_FHA_2 491 497 PF00498 0.564
LIG_FHA_2 902 908 PF00498 0.650
LIG_Integrin_isoDGR_2 772 774 PF01839 0.475
LIG_IRF3_LxIS_1 639 646 PF10401 0.417
LIG_LIR_Gen_1 234 245 PF02991 0.645
LIG_LIR_Gen_1 323 330 PF02991 0.478
LIG_LIR_Gen_1 36 46 PF02991 0.601
LIG_LIR_Gen_1 451 461 PF02991 0.396
LIG_LIR_Gen_1 757 768 PF02991 0.349
LIG_LIR_Nem_3 234 240 PF02991 0.645
LIG_LIR_Nem_3 323 328 PF02991 0.478
LIG_LIR_Nem_3 36 42 PF02991 0.602
LIG_LIR_Nem_3 451 456 PF02991 0.396
LIG_LIR_Nem_3 757 763 PF02991 0.353
LIG_NRBOX 945 951 PF00104 0.649
LIG_Pex14_2 64 68 PF04695 0.598
LIG_SH2_CRK 237 241 PF00017 0.726
LIG_SH2_PTP2 39 42 PF00017 0.512
LIG_SH2_PTP2 734 737 PF00017 0.398
LIG_SH2_SRC 734 737 PF00017 0.493
LIG_SH2_STAP1 126 130 PF00017 0.646
LIG_SH2_STAP1 396 400 PF00017 0.561
LIG_SH2_STAP1 612 616 PF00017 0.498
LIG_SH2_STAT3 956 959 PF00017 0.609
LIG_SH2_STAT5 39 42 PF00017 0.512
LIG_SH2_STAT5 465 468 PF00017 0.326
LIG_SH2_STAT5 612 615 PF00017 0.474
LIG_SH2_STAT5 734 737 PF00017 0.493
LIG_SH2_STAT5 813 816 PF00017 0.335
LIG_SH3_1 468 474 PF00018 0.422
LIG_SH3_2 601 606 PF14604 0.516
LIG_SH3_3 102 108 PF00018 0.693
LIG_SH3_3 139 145 PF00018 0.695
LIG_SH3_3 195 201 PF00018 0.763
LIG_SH3_3 20 26 PF00018 0.734
LIG_SH3_3 242 248 PF00018 0.775
LIG_SH3_3 40 46 PF00018 0.469
LIG_SH3_3 468 474 PF00018 0.457
LIG_SH3_3 549 555 PF00018 0.359
LIG_SH3_3 574 580 PF00018 0.507
LIG_SH3_3 598 604 PF00018 0.605
LIG_SH3_3 616 622 PF00018 0.452
LIG_SH3_3 758 764 PF00018 0.386
LIG_SH3_3 928 934 PF00018 0.656
LIG_SUMO_SIM_anti_2 451 458 PF11976 0.396
LIG_SUMO_SIM_anti_2 752 760 PF11976 0.323
LIG_SUMO_SIM_par_1 163 169 PF11976 0.519
LIG_SUMO_SIM_par_1 641 646 PF11976 0.423
LIG_TRAF2_1 497 500 PF00917 0.540
LIG_UBA3_1 56 62 PF00899 0.340
LIG_UBA3_1 642 649 PF00899 0.480
LIG_UBA3_1 949 958 PF00899 0.553
LIG_WW_3 469 473 PF00397 0.507
MOD_CDC14_SPxK_1 646 649 PF00782 0.504
MOD_CDK_SPK_2 203 208 PF00069 0.582
MOD_CDK_SPxK_1 643 649 PF00069 0.581
MOD_CDK_SPxxK_3 374 381 PF00069 0.660
MOD_CDK_SPxxK_3 551 558 PF00069 0.394
MOD_CK1_1 122 128 PF00069 0.607
MOD_CK1_1 152 158 PF00069 0.528
MOD_CK1_1 24 30 PF00069 0.637
MOD_CK1_1 264 270 PF00069 0.396
MOD_CK1_1 285 291 PF00069 0.439
MOD_CK1_1 385 391 PF00069 0.535
MOD_CK1_1 452 458 PF00069 0.419
MOD_CK1_1 476 482 PF00069 0.696
MOD_CK1_1 503 509 PF00069 0.730
MOD_CK1_1 526 532 PF00069 0.650
MOD_CK1_1 546 552 PF00069 0.533
MOD_CK1_1 584 590 PF00069 0.661
MOD_CK1_1 688 694 PF00069 0.705
MOD_CK1_1 811 817 PF00069 0.307
MOD_CK1_1 848 854 PF00069 0.363
MOD_CK1_1 891 897 PF00069 0.495
MOD_CK1_1 925 931 PF00069 0.708
MOD_CK2_1 259 265 PF00069 0.251
MOD_CK2_1 45 51 PF00069 0.476
MOD_CK2_1 693 699 PF00069 0.732
MOD_CK2_1 837 843 PF00069 0.398
MOD_CK2_1 901 907 PF00069 0.546
MOD_CK2_1 91 97 PF00069 0.797
MOD_Cter_Amidation 935 938 PF01082 0.581
MOD_GlcNHglycan 100 103 PF01048 0.649
MOD_GlcNHglycan 111 114 PF01048 0.712
MOD_GlcNHglycan 121 124 PF01048 0.631
MOD_GlcNHglycan 127 130 PF01048 0.560
MOD_GlcNHglycan 208 211 PF01048 0.726
MOD_GlcNHglycan 212 215 PF01048 0.700
MOD_GlcNHglycan 233 236 PF01048 0.710
MOD_GlcNHglycan 284 287 PF01048 0.292
MOD_GlcNHglycan 384 387 PF01048 0.654
MOD_GlcNHglycan 390 393 PF01048 0.440
MOD_GlcNHglycan 417 421 PF01048 0.394
MOD_GlcNHglycan 47 50 PF01048 0.517
MOD_GlcNHglycan 475 478 PF01048 0.638
MOD_GlcNHglycan 569 572 PF01048 0.678
MOD_GlcNHglycan 589 593 PF01048 0.764
MOD_GlcNHglycan 696 699 PF01048 0.793
MOD_GlcNHglycan 729 732 PF01048 0.614
MOD_GlcNHglycan 834 837 PF01048 0.355
MOD_GlcNHglycan 839 842 PF01048 0.424
MOD_GlcNHglycan 898 901 PF01048 0.488
MOD_GlcNHglycan 924 927 PF01048 0.680
MOD_GSK3_1 124 131 PF00069 0.591
MOD_GSK3_1 148 155 PF00069 0.674
MOD_GSK3_1 176 183 PF00069 0.401
MOD_GSK3_1 202 209 PF00069 0.661
MOD_GSK3_1 24 31 PF00069 0.607
MOD_GSK3_1 281 288 PF00069 0.470
MOD_GSK3_1 416 423 PF00069 0.348
MOD_GSK3_1 448 455 PF00069 0.433
MOD_GSK3_1 523 530 PF00069 0.679
MOD_GSK3_1 584 591 PF00069 0.649
MOD_GSK3_1 667 674 PF00069 0.713
MOD_GSK3_1 684 691 PF00069 0.598
MOD_GSK3_1 72 79 PF00069 0.451
MOD_GSK3_1 793 800 PF00069 0.377
MOD_LATS_1 174 180 PF00433 0.389
MOD_LATS_1 435 441 PF00433 0.396
MOD_LATS_1 817 823 PF00433 0.381
MOD_N-GLC_1 134 139 PF02516 0.531
MOD_N-GLC_2 170 172 PF02516 0.575
MOD_N-GLC_2 416 418 PF02516 0.443
MOD_NEK2_1 202 207 PF00069 0.635
MOD_NEK2_1 281 286 PF00069 0.356
MOD_NEK2_1 3 8 PF00069 0.683
MOD_NEK2_1 405 410 PF00069 0.411
MOD_NEK2_1 448 453 PF00069 0.429
MOD_NEK2_1 567 572 PF00069 0.734
MOD_NEK2_1 64 69 PF00069 0.488
MOD_NEK2_1 793 798 PF00069 0.313
MOD_NEK2_1 831 836 PF00069 0.396
MOD_NEK2_1 845 850 PF00069 0.301
MOD_NEK2_2 610 615 PF00069 0.608
MOD_NEK2_2 69 74 PF00069 0.504
MOD_OFUCOSY 418 424 PF10250 0.436
MOD_PIKK_1 180 186 PF00454 0.449
MOD_PIKK_1 4 10 PF00454 0.527
MOD_PIKK_1 495 501 PF00454 0.687
MOD_PK_1 821 827 PF00069 0.396
MOD_PKA_2 231 237 PF00069 0.727
MOD_PKA_2 380 386 PF00069 0.663
MOD_PKA_2 388 394 PF00069 0.443
MOD_PKA_2 567 573 PF00069 0.661
MOD_PKA_2 628 634 PF00069 0.722
MOD_PKA_2 659 665 PF00069 0.693
MOD_PKA_2 69 75 PF00069 0.451
MOD_PKA_2 820 826 PF00069 0.365
MOD_PKB_1 725 733 PF00069 0.519
MOD_PKB_1 819 827 PF00069 0.363
MOD_Plk_4 449 455 PF00069 0.350
MOD_Plk_4 763 769 PF00069 0.343
MOD_Plk_4 821 827 PF00069 0.403
MOD_Plk_4 945 951 PF00069 0.500
MOD_ProDKin_1 104 110 PF00069 0.645
MOD_ProDKin_1 203 209 PF00069 0.679
MOD_ProDKin_1 246 252 PF00069 0.450
MOD_ProDKin_1 331 337 PF00069 0.313
MOD_ProDKin_1 374 380 PF00069 0.658
MOD_ProDKin_1 527 533 PF00069 0.720
MOD_ProDKin_1 536 542 PF00069 0.577
MOD_ProDKin_1 551 557 PF00069 0.365
MOD_ProDKin_1 615 621 PF00069 0.756
MOD_ProDKin_1 631 637 PF00069 0.444
MOD_ProDKin_1 643 649 PF00069 0.573
MOD_SUMO_for_1 326 329 PF00179 0.263
MOD_SUMO_rev_2 519 527 PF00179 0.541
TRG_ENDOCYTIC_2 237 240 PF00928 0.565
TRG_ENDOCYTIC_2 39 42 PF00928 0.364
TRG_ER_diArg_1 566 569 PF00400 0.602
TRG_ER_diArg_1 594 597 PF00400 0.586
TRG_ER_diArg_1 937 939 PF00400 0.719
TRG_ER_diArg_1 950 952 PF00400 0.636
TRG_ER_FFAT_2 669 678 PF00635 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM78 Leptomonas seymouri 38% 100%
A0A3S7WVF1 Leishmania donovani 88% 100%
A4HYC4 Leishmania infantum 88% 100%
E9AS58 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS