Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDA6_LEIMA

TriTrypDb:

LmjF.19.1090 , LMJLV39_190016500 , LMJSD75_190016500

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QDA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.412
CLV_PCSK_FUR_1	2	6	PF00082	0.419
CLV_PCSK_KEX2_1	4	6	PF00082	0.425
CLV_PCSK_SKI1_1	166	170	PF00082	0.422
DEG_MDM2_SWIB_1	186	193	PF02201	0.597
DEG_Nend_UBRbox_1	1	4	PF02207	0.629
DOC_MAPK_DCC_7	98	107	PF00069	0.562
DOC_MAPK_gen_1	32	40	PF00069	0.571
DOC_MAPK_gen_1	98	107	PF00069	0.562
DOC_MAPK_MEF2A_6	34	42	PF00069	0.564
DOC_MAPK_MEF2A_6	98	107	PF00069	0.567
DOC_PP1_RVXF_1	82	89	PF00149	0.619
DOC_PP2B_LxvP_1	71	74	PF13499	0.679
DOC_USP7_MATH_1	124	128	PF00917	0.780
DOC_WW_Pin1_4	48	53	PF00397	0.556
LIG_14-3-3_CanoR_1	140	150	PF00244	0.608
LIG_14-3-3_CanoR_1	2	12	PF00244	0.636
LIG_deltaCOP1_diTrp_1	87	95	PF00928	0.609
LIG_EVH1_2	89	93	PF00568	0.605
LIG_FHA_1	210	216	PF00498	0.487
LIG_FHA_1	5	11	PF00498	0.647
LIG_GBD_Chelix_1	201	209	PF00786	0.316
LIG_LIR_Gen_1	134	142	PF02991	0.617
LIG_LIR_Gen_1	175	186	PF02991	0.603
LIG_LIR_Gen_1	188	198	PF02991	0.450
LIG_LIR_Nem_3	134	139	PF02991	0.623
LIG_LIR_Nem_3	175	181	PF02991	0.632
LIG_LIR_Nem_3	188	193	PF02991	0.429
LIG_MYND_2	101	105	PF01753	0.555
LIG_NRBOX	146	152	PF00104	0.617
LIG_Pex14_2	186	190	PF04695	0.603
LIG_Pex14_2	206	210	PF04695	0.316
LIG_PTB_Apo_2	180	187	PF02174	0.581
LIG_SH2_STAP1	36	40	PF00017	0.568
LIG_SH2_STAT3	112	115	PF00017	0.607
LIG_SH2_STAT5	178	181	PF00017	0.633
LIG_SH2_STAT5	207	210	PF00017	0.526
MOD_GlcNHglycan	126	129	PF01048	0.527
MOD_GlcNHglycan	170	173	PF01048	0.441
MOD_GSK3_1	168	175	PF00069	0.600
MOD_NEK2_1	151	156	PF00069	0.630
MOD_NEK2_1	3	8	PF00069	0.639
MOD_NEK2_1	94	99	PF00069	0.749
MOD_PIKK_1	4	10	PF00454	0.601
MOD_PKA_1	4	10	PF00069	0.601
MOD_PKA_2	3	9	PF00069	0.629
MOD_PKB_1	2	10	PF00069	0.607
MOD_Plk_4	146	152	PF00069	0.617
MOD_Plk_4	60	66	PF00069	0.563
MOD_ProDKin_1	48	54	PF00069	0.558
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.577
TRG_ENDOCYTIC_2	136	139	PF00928	0.622
TRG_ENDOCYTIC_2	178	181	PF00928	0.599
TRG_ER_diArg_1	1	4	PF00400	0.629
TRG_ER_diArg_1	118	121	PF00400	0.633
TRG_ER_diArg_1	32	35	PF00400	0.574
TRG_ER_diArg_1	98	101	PF00400	0.580
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HYC6	Leishmania infantum	78%	90%
E9AS60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%