Putative proteasome regulatory non-ATP-ase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 9, putative

Species:

Leishmania major

UniProt:

Q4QDA3_LEIMA

TriTrypDb:

LmjF.19.1120 , LMJLV39_190016800 , LMJSD75_190016800

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0005838	proteasome regulatory particle	2	2
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0000502	proteasome complex	3	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10

Expansion

Sequence features

Q4QDA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDA3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0005198	structural molecule activity	1	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.519
CLV_NRD_NRD_1	193	195	PF00675	0.534
CLV_NRD_NRD_1	305	307	PF00675	0.371
CLV_PCSK_KEX2_1	193	195	PF00082	0.534
CLV_PCSK_KEX2_1	364	366	PF00082	0.345
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.268
CLV_PCSK_SKI1_1	128	132	PF00082	0.431
CLV_PCSK_SKI1_1	156	160	PF00082	0.473
CLV_PCSK_SKI1_1	201	205	PF00082	0.441
CLV_PCSK_SKI1_1	263	267	PF00082	0.556
CLV_PCSK_SKI1_1	325	329	PF00082	0.275
CLV_PCSK_SKI1_1	404	408	PF00082	0.629
CLV_Separin_Metazoa	267	271	PF03568	0.577
DEG_APCC_DBOX_1	262	270	PF00400	0.415
DEG_SCF_FBW7_2	317	324	PF00400	0.493
DEG_SPOP_SBC_1	94	98	PF00917	0.537
DOC_CKS1_1	1	6	PF01111	0.630
DOC_CKS1_1	318	323	PF01111	0.483
DOC_CYCLIN_RxL_1	125	136	PF00134	0.440
DOC_CYCLIN_RxL_1	153	163	PF00134	0.573
DOC_CYCLIN_RxL_1	238	249	PF00134	0.491
DOC_MAPK_DCC_7	170	179	PF00069	0.554
DOC_MAPK_gen_1	306	316	PF00069	0.508
DOC_MAPK_MEF2A_6	201	210	PF00069	0.446
DOC_MAPK_MEF2A_6	309	318	PF00069	0.509
DOC_PP1_RVXF_1	242	249	PF00149	0.480
DOC_PP1_RVXF_1	366	372	PF00149	0.446
DOC_PP1_RVXF_1	86	93	PF00149	0.518
DOC_PP4_FxxP_1	318	321	PF00568	0.483
DOC_USP7_MATH_1	108	112	PF00917	0.455
DOC_USP7_MATH_1	138	142	PF00917	0.602
DOC_USP7_MATH_1	29	33	PF00917	0.479
DOC_USP7_UBL2_3	404	408	PF12436	0.523
DOC_WW_Pin1_4	134	139	PF00397	0.533
DOC_WW_Pin1_4	147	152	PF00397	0.595
DOC_WW_Pin1_4	317	322	PF00397	0.483
DOC_WW_Pin1_4	76	81	PF00397	0.444
LIG_14-3-3_CanoR_1	194	200	PF00244	0.496
LIG_14-3-3_CanoR_1	325	330	PF00244	0.468
LIG_14-3-3_CanoR_1	368	372	PF00244	0.475
LIG_14-3-3_CanoR_1	375	380	PF00244	0.389
LIG_APCC_ABBA_1	206	211	PF00400	0.520
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	88	92	PF00533	0.532
LIG_Clathr_ClatBox_1	130	134	PF01394	0.414
LIG_Clathr_ClatBox_1	245	249	PF01394	0.534
LIG_FHA_1	398	404	PF00498	0.506
LIG_FHA_1	405	411	PF00498	0.582
LIG_FHA_2	134	140	PF00498	0.604
LIG_FHA_2	368	374	PF00498	0.430
LIG_FHA_2	98	104	PF00498	0.358
LIG_LIR_Gen_1	326	333	PF02991	0.483
LIG_LIR_Gen_1	65	74	PF02991	0.520
LIG_LIR_Nem_3	326	332	PF02991	0.483
LIG_LIR_Nem_3	61	67	PF02991	0.507
LIG_LYPXL_SIV_4	226	234	PF13949	0.370
LIG_NRBOX	309	315	PF00104	0.483
LIG_Pex14_2	280	284	PF04695	0.537
LIG_Pex14_2	38	42	PF04695	0.490
LIG_REV1ctd_RIR_1	281	289	PF16727	0.537
LIG_SH2_CRK	122	126	PF00017	0.505
LIG_SH2_CRK	227	231	PF00017	0.456
LIG_SH2_CRK	319	323	PF00017	0.585
LIG_SH2_PTP2	83	86	PF00017	0.392
LIG_SH2_SRC	165	168	PF00017	0.497
LIG_SH2_SRC	67	70	PF00017	0.428
LIG_SH2_STAP1	64	68	PF00017	0.552
LIG_SH2_STAT3	37	40	PF00017	0.479
LIG_SH2_STAT5	11	14	PF00017	0.419
LIG_SH2_STAT5	165	168	PF00017	0.564
LIG_SH2_STAT5	319	322	PF00017	0.483
LIG_SH2_STAT5	37	40	PF00017	0.546
LIG_SH2_STAT5	83	86	PF00017	0.372
LIG_SH3_3	145	151	PF00018	0.636
LIG_SUMO_SIM_anti_2	100	106	PF11976	0.343
LIG_SUMO_SIM_par_1	129	137	PF11976	0.429
LIG_SUMO_SIM_par_1	344	349	PF11976	0.585
LIG_SUMO_SIM_par_1	373	381	PF11976	0.462
LIG_TRAF2_1	137	140	PF00917	0.564
LIG_TRAF2_1	378	381	PF00917	0.447
LIG_TYR_ITIM	225	230	PF00017	0.457
LIG_TYR_ITIM	317	322	PF00017	0.585
LIG_TYR_ITIM	81	86	PF00017	0.468
LIG_UBA3_1	206	212	PF00899	0.554
MOD_CK1_1	323	329	PF00069	0.593
MOD_CK2_1	112	118	PF00069	0.502
MOD_CK2_1	133	139	PF00069	0.567
MOD_CK2_1	14	20	PF00069	0.452
MOD_CK2_1	338	344	PF00069	0.556
MOD_CK2_1	367	373	PF00069	0.412
MOD_CK2_1	375	381	PF00069	0.398
MOD_CK2_1	399	405	PF00069	0.544
MOD_CK2_1	97	103	PF00069	0.516
MOD_GlcNHglycan	139	143	PF01048	0.616
MOD_GlcNHglycan	25	28	PF01048	0.487
MOD_GlcNHglycan	298	301	PF01048	0.365
MOD_GlcNHglycan	340	343	PF01048	0.371
MOD_GSK3_1	108	115	PF00069	0.521
MOD_GSK3_1	134	141	PF00069	0.546
MOD_GSK3_1	147	154	PF00069	0.607
MOD_GSK3_1	23	30	PF00069	0.618
MOD_GSK3_1	296	303	PF00069	0.563
MOD_GSK3_1	367	374	PF00069	0.551
MOD_GSK3_1	93	100	PF00069	0.452
MOD_N-GLC_1	23	28	PF02516	0.498
MOD_NEK2_1	112	117	PF00069	0.597
MOD_NEK2_1	132	137	PF00069	0.282
MOD_NEK2_1	399	404	PF00069	0.516
MOD_NEK2_2	300	305	PF00069	0.585
MOD_PIKK_1	289	295	PF00454	0.537
MOD_PIKK_1	387	393	PF00454	0.610
MOD_PIKK_1	95	101	PF00454	0.521
MOD_PKA_2	367	373	PF00069	0.405
MOD_Plk_1	220	226	PF00069	0.504
MOD_Plk_1	323	329	PF00069	0.493
MOD_Plk_4	108	114	PF00069	0.512
MOD_Plk_4	195	201	PF00069	0.482
MOD_Plk_4	226	232	PF00069	0.453
MOD_ProDKin_1	134	140	PF00069	0.540
MOD_ProDKin_1	147	153	PF00069	0.592
MOD_ProDKin_1	317	323	PF00069	0.483
MOD_ProDKin_1	76	82	PF00069	0.438
MOD_SUMO_for_1	363	366	PF00179	0.520
MOD_SUMO_rev_2	378	385	PF00179	0.448
TRG_DiLeu_BaEn_1	49	54	PF01217	0.455
TRG_DiLeu_BaEn_4	139	145	PF01217	0.576
TRG_DiLeu_BaEn_4	380	386	PF01217	0.574
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.493
TRG_ENDOCYTIC_2	122	125	PF00928	0.508
TRG_ENDOCYTIC_2	227	230	PF00928	0.457
TRG_ENDOCYTIC_2	319	322	PF00928	0.493
TRG_ENDOCYTIC_2	67	70	PF00928	0.480
TRG_ENDOCYTIC_2	83	86	PF00928	0.315
TRG_ER_diArg_1	15	18	PF00400	0.615
TRG_ER_diArg_1	192	194	PF00400	0.520
TRG_ER_diLys_1	408	412	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	375	380	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8H3	Leptomonas seymouri	83%	100%
A0A0S4JGV7	Bodo saltans	39%	100%
A0A1X0P6E2	Trypanosomatidae	49%	100%
A0A3Q8IBF9	Leishmania donovani	99%	100%
A0A422N714	Trypanosoma rangeli	50%	100%
A4HA68	Leishmania braziliensis	93%	100%
A4HYC9	Leishmania infantum	99%	100%
B0BN93	Rattus norvegicus	26%	100%
D0A0Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AS63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P84169	Gallus gallus	26%	100%
Q04062	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
Q54NQ0	Dictyostelium discoideum	24%	100%
Q5E964	Bos taurus	26%	100%
Q8GYA6	Arabidopsis thaliana	23%	100%
Q9UNM6	Homo sapiens	25%	100%
Q9US13	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9WVJ2	Mus musculus	26%	100%
V5AZ27	Trypanosoma cruzi	49%	100%