Protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDA1_LEIMA

TriTrypDb:

LmjF.19.1140 , LMJLV39_190017000 , LMJSD75_190017000

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 0
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.685
CLV_C14_Caspase3-7	592	596	PF00656	0.644
CLV_NRD_NRD_1	159	161	PF00675	0.705
CLV_NRD_NRD_1	187	189	PF00675	0.660
CLV_NRD_NRD_1	227	229	PF00675	0.692
CLV_NRD_NRD_1	336	338	PF00675	0.710
CLV_NRD_NRD_1	395	397	PF00675	0.635
CLV_NRD_NRD_1	442	444	PF00675	0.649
CLV_NRD_NRD_1	655	657	PF00675	0.588
CLV_NRD_NRD_1	751	753	PF00675	0.769
CLV_NRD_NRD_1	809	811	PF00675	0.582
CLV_PCSK_KEX2_1	158	160	PF00082	0.710
CLV_PCSK_KEX2_1	187	189	PF00082	0.660
CLV_PCSK_KEX2_1	227	229	PF00082	0.692
CLV_PCSK_KEX2_1	395	397	PF00082	0.635
CLV_PCSK_KEX2_1	484	486	PF00082	0.560
CLV_PCSK_KEX2_1	655	657	PF00082	0.588
CLV_PCSK_KEX2_1	751	753	PF00082	0.650
CLV_PCSK_KEX2_1	809	811	PF00082	0.582
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.560
CLV_PCSK_SKI1_1	382	386	PF00082	0.617
CLV_PCSK_SKI1_1	518	522	PF00082	0.657
CLV_PCSK_SKI1_1	698	702	PF00082	0.547
DEG_Nend_UBRbox_2	1	3	PF02207	0.675
DEG_SPOP_SBC_1	117	121	PF00917	0.625
DEG_SPOP_SBC_1	143	147	PF00917	0.568
DEG_SPOP_SBC_1	272	276	PF00917	0.658
DEG_SPOP_SBC_1	81	85	PF00917	0.596
DOC_CKS1_1	233	238	PF01111	0.623
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.673
DOC_MAPK_DCC_7	443	451	PF00069	0.606
DOC_MAPK_gen_1	443	451	PF00069	0.606
DOC_MAPK_gen_1	684	692	PF00069	0.617
DOC_MAPK_MEF2A_6	443	451	PF00069	0.606
DOC_PP1_SILK_1	518	523	PF00149	0.582
DOC_PP2B_LxvP_1	521	524	PF13499	0.578
DOC_PP2B_LxvP_1	699	702	PF13499	0.587
DOC_PP4_FxxP_1	407	410	PF00568	0.541
DOC_PP4_FxxP_1	423	426	PF00568	0.513
DOC_PP4_FxxP_1	609	612	PF00568	0.695
DOC_PP4_FxxP_1	704	707	PF00568	0.620
DOC_PP4_FxxP_1	9	12	PF00568	0.664
DOC_USP7_MATH_1	109	113	PF00917	0.824
DOC_USP7_MATH_1	117	121	PF00917	0.786
DOC_USP7_MATH_1	135	139	PF00917	0.648
DOC_USP7_MATH_1	143	147	PF00917	0.590
DOC_USP7_MATH_1	272	276	PF00917	0.770
DOC_USP7_MATH_1	303	307	PF00917	0.748
DOC_USP7_MATH_1	471	475	PF00917	0.508
DOC_USP7_MATH_1	509	513	PF00917	0.742
DOC_USP7_MATH_1	567	571	PF00917	0.648
DOC_USP7_MATH_1	603	607	PF00917	0.779
DOC_USP7_MATH_1	738	742	PF00917	0.570
DOC_USP7_MATH_1	754	758	PF00917	0.734
DOC_USP7_MATH_1	80	84	PF00917	0.814
DOC_USP7_MATH_2	33	39	PF00917	0.537
DOC_WW_Pin1_4	113	118	PF00397	0.717
DOC_WW_Pin1_4	232	237	PF00397	0.610
DOC_WW_Pin1_4	255	260	PF00397	0.776
DOC_WW_Pin1_4	342	347	PF00397	0.813
DOC_WW_Pin1_4	406	411	PF00397	0.598
DOC_WW_Pin1_4	476	481	PF00397	0.644
DOC_WW_Pin1_4	76	81	PF00397	0.695
DOC_WW_Pin1_4	82	87	PF00397	0.680
LIG_14-3-3_CanoR_1	159	165	PF00244	0.838
LIG_14-3-3_CanoR_1	228	234	PF00244	0.735
LIG_14-3-3_CanoR_1	386	394	PF00244	0.573
LIG_14-3-3_CanoR_1	723	731	PF00244	0.678
LIG_BRCT_BRCA1_1	605	609	PF00533	0.700
LIG_BRCT_BRCA1_1	704	708	PF00533	0.616
LIG_deltaCOP1_diTrp_1	694	704	PF00928	0.552
LIG_EH1_1	283	291	PF00400	0.566
LIG_FHA_1	171	177	PF00498	0.615
LIG_FHA_1	240	246	PF00498	0.721
LIG_FHA_1	252	258	PF00498	0.655
LIG_FHA_1	302	308	PF00498	0.546
LIG_FHA_1	561	567	PF00498	0.609
LIG_FHA_1	662	668	PF00498	0.554
LIG_FHA_2	246	252	PF00498	0.683
LIG_FHA_2	256	262	PF00498	0.510
LIG_FHA_2	544	550	PF00498	0.672
LIG_FHA_2	608	614	PF00498	0.804
LIG_FHA_2	69	75	PF00498	0.620
LIG_FHA_2	723	729	PF00498	0.523
LIG_GBD_Chelix_1	453	461	PF00786	0.542
LIG_Integrin_RGD_1	774	776	PF01839	0.575
LIG_LIR_Apic_2	606	612	PF02991	0.697
LIG_LIR_Apic_2	703	707	PF02991	0.616
LIG_LIR_Gen_1	20	31	PF02991	0.571
LIG_LIR_Gen_1	685	695	PF02991	0.595
LIG_LIR_Gen_1	728	739	PF02991	0.522
LIG_LIR_Nem_3	20	26	PF02991	0.575
LIG_LIR_Nem_3	379	384	PF02991	0.615
LIG_LIR_Nem_3	401	407	PF02991	0.572
LIG_LIR_Nem_3	548	554	PF02991	0.600
LIG_LIR_Nem_3	685	690	PF02991	0.758
LIG_LIR_Nem_3	694	700	PF02991	0.478
LIG_LIR_Nem_3	728	734	PF02991	0.541
LIG_LIR_Nem_3	767	773	PF02991	0.630
LIG_NRBOX	306	312	PF00104	0.630
LIG_NRBOX	456	462	PF00104	0.543
LIG_PCNA_yPIPBox_3	793	804	PF02747	0.545
LIG_Pex14_2	704	708	PF04695	0.616
LIG_RPA_C_Fungi	454	466	PF08784	0.550
LIG_SH2_STAP1	17	21	PF00017	0.595
LIG_SH2_STAT3	139	142	PF00017	0.661
LIG_SH2_STAT5	139	142	PF00017	0.668
LIG_SH2_STAT5	486	489	PF00017	0.812
LIG_SH3_1	8	14	PF00018	0.666
LIG_SH3_2	480	485	PF14604	0.545
LIG_SH3_3	230	236	PF00018	0.744
LIG_SH3_3	256	262	PF00018	0.765
LIG_SH3_3	400	406	PF00018	0.657
LIG_SH3_3	474	480	PF00018	0.764
LIG_SH3_3	530	536	PF00018	0.702
LIG_SH3_3	8	14	PF00018	0.736
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.603
LIG_SUMO_SIM_par_1	251	258	PF11976	0.654
LIG_SUMO_SIM_par_1	306	314	PF11976	0.518
LIG_TRAF2_1	123	126	PF00917	0.676
LIG_TRAF2_1	358	361	PF00917	0.619
LIG_TRAF2_1	372	375	PF00917	0.527
LIG_TRAF2_1	570	573	PF00917	0.757
LIG_TRAF2_1	612	615	PF00917	0.695
LIG_WRC_WIRS_1	701	706	PF05994	0.594
LIG_WW_3	10	14	PF00397	0.633
LIG_WW_3	121	125	PF00397	0.616
LIG_WW_3	523	527	PF00397	0.603
MOD_CDK_SPK_2	232	237	PF00069	0.629
MOD_CDK_SPxK_1	118	124	PF00069	0.624
MOD_CK1_1	112	118	PF00069	0.712
MOD_CK1_1	162	168	PF00069	0.807
MOD_CK1_1	180	186	PF00069	0.586
MOD_CK1_1	198	204	PF00069	0.510
MOD_CK1_1	244	250	PF00069	0.632
MOD_CK1_1	271	277	PF00069	0.683
MOD_CK1_1	345	351	PF00069	0.649
MOD_CK1_1	388	394	PF00069	0.661
MOD_CK1_1	516	522	PF00069	0.833
MOD_CK1_1	555	561	PF00069	0.646
MOD_CK1_1	598	604	PF00069	0.696
MOD_CK1_1	661	667	PF00069	0.689
MOD_CK1_1	710	716	PF00069	0.710
MOD_CK1_1	757	763	PF00069	0.775
MOD_CK2_1	180	186	PF00069	0.735
MOD_CK2_1	245	251	PF00069	0.688
MOD_CK2_1	255	261	PF00069	0.513
MOD_CK2_1	373	379	PF00069	0.545
MOD_CK2_1	567	573	PF00069	0.733
MOD_CK2_1	688	694	PF00069	0.582
MOD_CK2_1	70	76	PF00069	0.679
MOD_CK2_1	811	817	PF00069	0.629
MOD_Cter_Amidation	225	228	PF01082	0.588
MOD_GlcNHglycan	112	115	PF01048	0.678
MOD_GlcNHglycan	182	185	PF01048	0.738
MOD_GlcNHglycan	270	273	PF01048	0.661
MOD_GlcNHglycan	291	294	PF01048	0.779
MOD_GlcNHglycan	347	350	PF01048	0.672
MOD_GlcNHglycan	390	393	PF01048	0.601
MOD_GlcNHglycan	413	416	PF01048	0.760
MOD_GlcNHglycan	423	426	PF01048	0.645
MOD_GlcNHglycan	511	514	PF01048	0.772
MOD_GlcNHglycan	515	518	PF01048	0.797
MOD_GlcNHglycan	554	557	PF01048	0.698
MOD_GlcNHglycan	56	59	PF01048	0.779
MOD_GlcNHglycan	600	604	PF01048	0.683
MOD_GlcNHglycan	639	645	PF01048	0.712
MOD_GlcNHglycan	704	707	PF01048	0.606
MOD_GlcNHglycan	731	734	PF01048	0.741
MOD_GlcNHglycan	747	750	PF01048	0.547
MOD_GlcNHglycan	760	763	PF01048	0.646
MOD_GSK3_1	109	116	PF00069	0.757
MOD_GSK3_1	144	151	PF00069	0.621
MOD_GSK3_1	162	169	PF00069	0.638
MOD_GSK3_1	194	201	PF00069	0.712
MOD_GSK3_1	228	235	PF00069	0.713
MOD_GSK3_1	240	247	PF00069	0.641
MOD_GSK3_1	251	258	PF00069	0.528
MOD_GSK3_1	268	275	PF00069	0.607
MOD_GSK3_1	289	296	PF00069	0.683
MOD_GSK3_1	301	308	PF00069	0.561
MOD_GSK3_1	411	418	PF00069	0.674
MOD_GSK3_1	48	55	PF00069	0.695
MOD_GSK3_1	485	492	PF00069	0.627
MOD_GSK3_1	509	516	PF00069	0.638
MOD_GSK3_1	554	561	PF00069	0.646
MOD_GSK3_1	595	602	PF00069	0.686
MOD_GSK3_1	603	610	PF00069	0.525
MOD_GSK3_1	658	665	PF00069	0.784
MOD_GSK3_1	686	693	PF00069	0.572
MOD_GSK3_1	709	716	PF00069	0.664
MOD_GSK3_1	754	761	PF00069	0.709
MOD_GSK3_1	76	83	PF00069	0.716
MOD_LATS_1	550	556	PF00433	0.684
MOD_N-GLC_1	133	138	PF02516	0.663
MOD_N-GLC_1	249	254	PF02516	0.676
MOD_N-GLC_1	415	420	PF02516	0.656
MOD_N-GLC_1	81	86	PF02516	0.589
MOD_N-GLC_2	202	204	PF02516	0.566
MOD_N-GLC_2	430	432	PF02516	0.636
MOD_NEK2_1	241	246	PF00069	0.811
MOD_NEK2_1	289	294	PF00069	0.688
MOD_NEK2_1	385	390	PF00069	0.665
MOD_NEK2_1	421	426	PF00069	0.595
MOD_NEK2_1	48	53	PF00069	0.837
MOD_NEK2_1	554	559	PF00069	0.671
MOD_NEK2_1	599	604	PF00069	0.685
MOD_NEK2_1	668	673	PF00069	0.665
MOD_NEK2_1	708	713	PF00069	0.652
MOD_NEK2_2	471	476	PF00069	0.513
MOD_PIKK_1	2	8	PF00454	0.677
MOD_PIKK_1	415	421	PF00454	0.646
MOD_PIKK_1	94	100	PF00454	0.679
MOD_PK_1	160	166	PF00069	0.701
MOD_PK_1	485	491	PF00069	0.558
MOD_PK_1	686	692	PF00069	0.607
MOD_PKA_1	159	165	PF00069	0.698
MOD_PKA_2	127	133	PF00069	0.697
MOD_PKA_2	148	154	PF00069	0.604
MOD_PKA_2	159	165	PF00069	0.698
MOD_PKA_2	166	172	PF00069	0.653
MOD_PKA_2	385	391	PF00069	0.614
MOD_PKA_2	531	537	PF00069	0.708
MOD_PKA_2	680	686	PF00069	0.535
MOD_PKA_2	722	728	PF00069	0.677
MOD_PKB_1	158	166	PF00069	0.699
MOD_Plk_1	212	218	PF00069	0.615
MOD_Plk_1	250	256	PF00069	0.678
MOD_Plk_1	48	54	PF00069	0.695
MOD_Plk_1	659	665	PF00069	0.564
MOD_Plk_2-3	595	601	PF00069	0.575
MOD_Plk_2-3	811	817	PF00069	0.601
MOD_Plk_4	135	141	PF00069	0.658
MOD_Plk_4	17	23	PF00069	0.590
MOD_Plk_4	212	218	PF00069	0.555
MOD_Plk_4	273	279	PF00069	0.652
MOD_Plk_4	305	311	PF00069	0.519
MOD_Plk_4	738	744	PF00069	0.597
MOD_ProDKin_1	113	119	PF00069	0.720
MOD_ProDKin_1	232	238	PF00069	0.607
MOD_ProDKin_1	255	261	PF00069	0.777
MOD_ProDKin_1	342	348	PF00069	0.813
MOD_ProDKin_1	406	412	PF00069	0.600
MOD_ProDKin_1	476	482	PF00069	0.645
MOD_ProDKin_1	76	82	PF00069	0.699
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.569
TRG_ENDOCYTIC_2	404	407	PF00928	0.654
TRG_ENDOCYTIC_2	486	489	PF00928	0.602
TRG_ENDOCYTIC_2	770	773	PF00928	0.620
TRG_ER_diArg_1	12	15	PF00400	0.766
TRG_ER_diArg_1	158	160	PF00400	0.703
TRG_ER_diArg_1	394	396	PF00400	0.634
TRG_ER_diArg_1	654	656	PF00400	0.594
TRG_ER_diArg_1	750	752	PF00400	0.654
TRG_ER_diArg_1	808	810	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	655	660	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVJ5	Leishmania donovani	85%	100%
A4HYD2	Leishmania infantum	85%	100%
E9AS65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%