LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QD99_LEIMA
TriTrypDb:
LmjF.19.1160 , LMJLV39_190017200 , LMJSD75_190017200
Length:
369

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD99
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD99

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 165 169 PF00656 0.508
CLV_C14_Caspase3-7 191 195 PF00656 0.463
CLV_NRD_NRD_1 107 109 PF00675 0.696
CLV_NRD_NRD_1 247 249 PF00675 0.619
CLV_NRD_NRD_1 305 307 PF00675 0.534
CLV_NRD_NRD_1 79 81 PF00675 0.734
CLV_NRD_NRD_1 85 87 PF00675 0.606
CLV_NRD_NRD_1 92 94 PF00675 0.493
CLV_PCSK_FUR_1 56 60 PF00082 0.689
CLV_PCSK_KEX2_1 107 109 PF00082 0.706
CLV_PCSK_KEX2_1 299 301 PF00082 0.603
CLV_PCSK_KEX2_1 58 60 PF00082 0.589
CLV_PCSK_KEX2_1 78 80 PF00082 0.740
CLV_PCSK_KEX2_1 84 86 PF00082 0.611
CLV_PCSK_PC1ET2_1 299 301 PF00082 0.644
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.597
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.659
CLV_PCSK_PC7_1 74 80 PF00082 0.627
CLV_PCSK_SKI1_1 179 183 PF00082 0.602
DEG_APCC_DBOX_1 247 255 PF00400 0.522
DEG_SCF_FBW7_1 324 330 PF00400 0.535
DEG_SPOP_SBC_1 362 366 PF00917 0.619
DOC_CKS1_1 274 279 PF01111 0.635
DOC_CKS1_1 324 329 PF01111 0.528
DOC_MAPK_gen_1 53 63 PF00069 0.568
DOC_USP7_MATH_1 308 312 PF00917 0.533
DOC_USP7_MATH_1 313 317 PF00917 0.492
DOC_USP7_MATH_1 362 366 PF00917 0.769
DOC_WW_Pin1_4 273 278 PF00397 0.607
DOC_WW_Pin1_4 323 328 PF00397 0.609
DOC_WW_Pin1_4 358 363 PF00397 0.827
LIG_14-3-3_CanoR_1 118 124 PF00244 0.545
LIG_14-3-3_CanoR_1 265 274 PF00244 0.664
LIG_14-3-3_CanoR_1 312 320 PF00244 0.398
LIG_BRCT_BRCA1_1 195 199 PF00533 0.622
LIG_FHA_1 176 182 PF00498 0.597
LIG_FHA_1 23 29 PF00498 0.626
LIG_FHA_1 261 267 PF00498 0.672
LIG_FHA_2 161 167 PF00498 0.625
LIG_FHA_2 226 232 PF00498 0.643
LIG_LIR_Apic_2 272 277 PF02991 0.685
LIG_SH2_CRK 274 278 PF00017 0.688
LIG_SH2_GRB2like 135 138 PF00017 0.624
LIG_SH2_SRC 192 195 PF00017 0.470
LIG_SH2_STAP1 262 266 PF00017 0.541
LIG_SH2_STAT5 189 192 PF00017 0.456
LIG_SH2_STAT5 262 265 PF00017 0.701
LIG_SH3_3 221 227 PF00018 0.552
LIG_SH3_3 350 356 PF00018 0.625
LIG_TRAF2_1 120 123 PF00917 0.701
LIG_TRAF2_1 143 146 PF00917 0.738
LIG_TRAF2_1 163 166 PF00917 0.616
LIG_TRAF2_1 228 231 PF00917 0.596
LIG_TRAF2_1 233 236 PF00917 0.517
LIG_TRAF2_1 331 334 PF00917 0.750
LIG_TRAF2_1 65 68 PF00917 0.667
MOD_CK1_1 354 360 PF00069 0.780
MOD_CK1_1 361 367 PF00069 0.751
MOD_CK2_1 117 123 PF00069 0.717
MOD_CK2_1 140 146 PF00069 0.778
MOD_CK2_1 160 166 PF00069 0.683
MOD_CK2_1 207 213 PF00069 0.554
MOD_CK2_1 225 231 PF00069 0.568
MOD_CK2_1 332 338 PF00069 0.768
MOD_GlcNHglycan 119 122 PF01048 0.750
MOD_GlcNHglycan 128 131 PF01048 0.767
MOD_GlcNHglycan 150 156 PF01048 0.730
MOD_GlcNHglycan 168 171 PF01048 0.681
MOD_GlcNHglycan 184 187 PF01048 0.636
MOD_GlcNHglycan 19 22 PF01048 0.639
MOD_GlcNHglycan 267 270 PF01048 0.550
MOD_GlcNHglycan 287 291 PF01048 0.508
MOD_GlcNHglycan 315 318 PF01048 0.513
MOD_GlcNHglycan 366 369 PF01048 0.799
MOD_GSK3_1 136 143 PF00069 0.772
MOD_GSK3_1 193 200 PF00069 0.521
MOD_GSK3_1 203 210 PF00069 0.458
MOD_GSK3_1 323 330 PF00069 0.614
MOD_GSK3_1 354 361 PF00069 0.790
MOD_N-GLC_1 136 141 PF02516 0.625
MOD_N-GLC_1 207 212 PF02516 0.590
MOD_NEK2_1 181 186 PF00069 0.590
MOD_NEK2_1 193 198 PF00069 0.380
MOD_NEK2_1 219 224 PF00069 0.669
MOD_NEK2_1 301 306 PF00069 0.620
MOD_PIKK_1 123 129 PF00454 0.589
MOD_PIKK_1 160 166 PF00454 0.726
MOD_PIKK_1 351 357 PF00454 0.626
MOD_PKA_2 117 123 PF00069 0.736
MOD_PKA_2 243 249 PF00069 0.506
MOD_Plk_1 230 236 PF00069 0.589
MOD_Plk_1 286 292 PF00069 0.591
MOD_Plk_2-3 140 146 PF00069 0.778
MOD_Plk_2-3 230 236 PF00069 0.659
MOD_Plk_4 153 159 PF00069 0.719
MOD_Plk_4 188 194 PF00069 0.462
MOD_ProDKin_1 273 279 PF00069 0.603
MOD_ProDKin_1 323 329 PF00069 0.620
MOD_ProDKin_1 358 364 PF00069 0.825
MOD_SUMO_for_1 202 205 PF00179 0.621
MOD_SUMO_rev_2 296 301 PF00179 0.637
TRG_ENDOCYTIC_2 10 13 PF00928 0.729
TRG_ENDOCYTIC_2 15 18 PF00928 0.654
TRG_ENDOCYTIC_2 38 41 PF00928 0.751
TRG_ER_diArg_1 78 80 PF00400 0.740
TRG_NES_CRM1_1 52 67 PF08389 0.666
TRG_Pf-PMV_PEXEL_1 108 113 PF00026 0.703
TRG_Pf-PMV_PEXEL_1 255 259 PF00026 0.601

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P630 Trypanosomatidae 31% 100%
A0A3Q8IBB1 Leishmania donovani 86% 99%
A4HYD4 Leishmania infantum 86% 99%
D0A0R5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AS67 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 100%
V5AZ24 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS