TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD93_LEIMA

TriTrypDb:

LmjF.19.1220 , LMJLV39_190017800 , LMJSD75_190017800

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.545
CLV_NRD_NRD_1	11	13	PF00675	0.603
CLV_NRD_NRD_1	118	120	PF00675	0.559
CLV_NRD_NRD_1	199	201	PF00675	0.531
CLV_NRD_NRD_1	95	97	PF00675	0.540
CLV_PCSK_FUR_1	199	203	PF00082	0.537
CLV_PCSK_KEX2_1	10	12	PF00082	0.584
CLV_PCSK_KEX2_1	118	120	PF00082	0.520
CLV_PCSK_KEX2_1	199	201	PF00082	0.531
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.535
CLV_PCSK_PC7_1	195	201	PF00082	0.615
CLV_PCSK_SKI1_1	119	123	PF00082	0.543
DEG_Nend_UBRbox_3	1	3	PF02207	0.453
DEG_SCF_FBW7_1	107	112	PF00400	0.519
DOC_USP7_MATH_1	109	113	PF00917	0.458
DOC_USP7_MATH_1	175	179	PF00917	0.732
DOC_USP7_UBL2_3	209	213	PF12436	0.562
DOC_WW_Pin1_4	105	110	PF00397	0.533
DOC_WW_Pin1_4	216	221	PF00397	0.646
LIG_14-3-3_CanoR_1	171	175	PF00244	0.617
LIG_14-3-3_CanoR_1	223	231	PF00244	0.763
LIG_BRCT_BRCA1_1	111	115	PF00533	0.441
LIG_FHA_1	27	33	PF00498	0.470
LIG_FHA_2	171	177	PF00498	0.682
LIG_Integrin_RGD_1	45	47	PF01839	0.390
LIG_LIR_Apic_2	226	231	PF02991	0.717
LIG_LIR_Nem_3	129	134	PF02991	0.467
LIG_NRBOX	31	37	PF00104	0.352
LIG_SH2_CRK	131	135	PF00017	0.374
LIG_SH2_SRC	187	190	PF00017	0.514
LIG_SH2_SRC	31	34	PF00017	0.489
LIG_SH2_STAP1	90	94	PF00017	0.406
LIG_SH2_STAT3	212	215	PF00017	0.554
LIG_SH2_STAT3	57	60	PF00017	0.560
LIG_SH2_STAT5	187	190	PF00017	0.633
LIG_SH2_STAT5	31	34	PF00017	0.456
LIG_SH2_STAT5	57	60	PF00017	0.414
LIG_SH2_STAT5	73	76	PF00017	0.304
MOD_CDK_SPxxK_3	216	223	PF00069	0.563
MOD_CK1_1	101	107	PF00069	0.538
MOD_CK1_1	219	225	PF00069	0.616
MOD_CK1_1	67	73	PF00069	0.453
MOD_GlcNHglycan	103	106	PF01048	0.518
MOD_GlcNHglycan	115	118	PF01048	0.406
MOD_GlcNHglycan	149	152	PF01048	0.686
MOD_GlcNHglycan	154	157	PF01048	0.661
MOD_GlcNHglycan	160	163	PF01048	0.620
MOD_GlcNHglycan	49	52	PF01048	0.464
MOD_GSK3_1	101	108	PF00069	0.482
MOD_GSK3_1	109	116	PF00069	0.428
MOD_GSK3_1	215	222	PF00069	0.662
MOD_NEK2_1	147	152	PF00069	0.580
MOD_NEK2_1	38	43	PF00069	0.354
MOD_NEK2_1	74	79	PF00069	0.329
MOD_PIKK_1	223	229	PF00454	0.504
MOD_PKA_1	25	31	PF00069	0.538
MOD_PKA_2	147	153	PF00069	0.686
MOD_PKA_2	158	164	PF00069	0.750
MOD_PKA_2	167	173	PF00069	0.688
MOD_Plk_1	26	32	PF00069	0.577
MOD_Plk_1	98	104	PF00069	0.502
MOD_Plk_4	109	115	PF00069	0.488
MOD_Plk_4	31	37	PF00069	0.395
MOD_Plk_4	67	73	PF00069	0.363
MOD_ProDKin_1	105	111	PF00069	0.532
MOD_ProDKin_1	216	222	PF00069	0.649
MOD_SUMO_rev_2	18	28	PF00179	0.436
TRG_ENDOCYTIC_2	131	134	PF00928	0.363
TRG_ER_diArg_1	10	12	PF00400	0.545
TRG_ER_diArg_1	199	202	PF00400	0.540
TRG_NLS_MonoExtC_3	121	127	PF00514	0.428
TRG_NLS_MonoExtN_4	119	126	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU4	Leptomonas seymouri	65%	85%
A0A0S4JKU3	Bodo saltans	34%	100%
A0A1X0P732	Trypanosomatidae	49%	79%
A0A3R7K6K4	Trypanosoma rangeli	50%	86%
A0A3S7WVI0	Leishmania donovani	94%	100%
A4HA59	Leishmania braziliensis	81%	79%
A4HYE0	Leishmania infantum	94%	100%
D0A0S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	85%
E9AS73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	79%
V5BNH1	Trypanosoma cruzi	49%	80%