Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD92_LEIMA

TriTrypDb:

LmjF.19.1230 , LMJLV39_190017900 , LMJSD75_190017900

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD92

PDB structure(s): 7aih_Aq , 7ane_Aq

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.664
CLV_NRD_NRD_1	165	167	PF00675	0.516
CLV_NRD_NRD_1	319	321	PF00675	0.541
CLV_PCSK_KEX2_1	165	167	PF00082	0.516
CLV_PCSK_KEX2_1	319	321	PF00082	0.541
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.445
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.506
DOC_MAPK_gen_1	127	135	PF00069	0.397
DOC_MAPK_MEF2A_6	118	126	PF00069	0.398
DOC_MAPK_MEF2A_6	35	42	PF00069	0.458
DOC_MAPK_NFAT4_5	35	43	PF00069	0.456
DOC_PP2B_LxvP_1	26	29	PF13499	0.562
DOC_USP7_MATH_1	255	259	PF00917	0.670
DOC_USP7_MATH_1	293	297	PF00917	0.521
LIG_14-3-3_CanoR_1	127	135	PF00244	0.414
LIG_14-3-3_CanoR_1	165	172	PF00244	0.454
LIG_14-3-3_CanoR_1	271	280	PF00244	0.527
LIG_14-3-3_CanoR_1	320	326	PF00244	0.567
LIG_14-3-3_CanoR_1	98	106	PF00244	0.694
LIG_FHA_1	109	115	PF00498	0.519
LIG_FHA_1	128	134	PF00498	0.265
LIG_FHA_1	200	206	PF00498	0.653
LIG_FHA_1	219	225	PF00498	0.322
LIG_LIR_Apic_2	178	184	PF02991	0.459
LIG_LIR_Gen_1	167	175	PF02991	0.512
LIG_LIR_Nem_3	167	172	PF02991	0.506
LIG_LIR_Nem_3	274	280	PF02991	0.595
LIG_SH2_CRK	169	173	PF00017	0.550
LIG_SH2_CRK	181	185	PF00017	0.620
LIG_SH2_CRK	51	55	PF00017	0.620
LIG_SH2_NCK_1	181	185	PF00017	0.695
LIG_SH2_NCK_1	51	55	PF00017	0.599
LIG_SH2_STAT3	10	13	PF00017	0.511
LIG_SH2_STAT5	10	13	PF00017	0.511
LIG_SH3_3	217	223	PF00018	0.371
LIG_SH3_3	245	251	PF00018	0.654
LIG_SH3_3	296	302	PF00018	0.463
LIG_SH3_3	9	15	PF00018	0.536
LIG_SUMO_SIM_anti_2	215	221	PF11976	0.473
LIG_TRAF2_1	195	198	PF00917	0.541
MOD_CK1_1	164	170	PF00069	0.456
MOD_CK1_1	215	221	PF00069	0.454
MOD_CK1_1	231	237	PF00069	0.524
MOD_CK1_1	263	269	PF00069	0.596
MOD_CK1_1	291	297	PF00069	0.541
MOD_GlcNHglycan	230	233	PF01048	0.756
MOD_GlcNHglycan	258	261	PF01048	0.669
MOD_GlcNHglycan	262	265	PF01048	0.649
MOD_GlcNHglycan	267	270	PF01048	0.529
MOD_GlcNHglycan	290	293	PF01048	0.497
MOD_GlcNHglycan	296	299	PF01048	0.453
MOD_GSK3_1	226	233	PF00069	0.624
MOD_GSK3_1	256	263	PF00069	0.639
MOD_N-GLC_1	100	105	PF02516	0.706
MOD_N-GLC_1	288	293	PF02516	0.492
MOD_NEK2_2	279	284	PF00069	0.448
MOD_PIKK_1	164	170	PF00454	0.501
MOD_PIKK_1	271	277	PF00454	0.559
MOD_PKA_1	319	325	PF00069	0.541
MOD_PKA_2	164	170	PF00069	0.511
MOD_PKA_2	294	300	PF00069	0.447
MOD_PKA_2	319	325	PF00069	0.541
MOD_Plk_1	100	106	PF00069	0.698
MOD_Plk_1	215	221	PF00069	0.521
MOD_Plk_1	64	70	PF00069	0.636
MOD_Plk_2-3	65	71	PF00069	0.637
MOD_Plk_4	215	221	PF00069	0.448
MOD_Plk_4	27	33	PF00069	0.475
MOD_SUMO_rev_2	309	316	PF00179	0.513
TRG_ENDOCYTIC_2	169	172	PF00928	0.497
TRG_ENDOCYTIC_2	51	54	PF00928	0.621
TRG_ER_diArg_1	126	129	PF00400	0.402
TRG_ER_diArg_1	133	136	PF00400	0.403
TRG_NLS_MonoExtC_3	318	323	PF00514	0.540
TRG_NLS_MonoExtN_4	319	324	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM80	Leptomonas seymouri	64%	96%
A0A3Q8IDC8	Leishmania donovani	94%	99%
A0A3R7NH36	Trypanosoma rangeli	43%	100%
A4HA69	Leishmania braziliensis	82%	90%
A4HYE1	Leishmania infantum	94%	99%
D0A0S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AS74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5AZ17	Trypanosoma cruzi	43%	100%