Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QD88_LEIMA

TriTrypDb:

LmjF.19.1270 , LMJLV39_190018400 , LMJSD75_190018400

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	7
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005686	U2 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	7
GO:0071004	U2-type prespliceosome	5	2
GO:0071010	prespliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	7
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4QD88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD88

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	7
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	7
GO:0000398	mRNA splicing, via spliceosome	8	7
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006397	mRNA processing	7	7
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008380	RNA splicing	7	7
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016071	mRNA metabolic process	6	7
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0045292	mRNA cis splicing, via spliceosome	9	7
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.591
CLV_NRD_NRD_1	223	225	PF00675	0.462
CLV_PCSK_KEX2_1	225	227	PF00082	0.497
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.554
DOC_USP7_MATH_1	149	153	PF00917	0.608
LIG_14-3-3_CanoR_1	156	164	PF00244	0.672
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_FHA_1	9	15	PF00498	0.605
LIG_FHA_2	163	169	PF00498	0.568
LIG_FHA_2	22	28	PF00498	0.479
LIG_IBAR_NPY_1	57	59	PF08397	0.504
LIG_LIR_Gen_1	209	216	PF02991	0.582
LIG_LIR_Nem_3	113	119	PF02991	0.570
LIG_LIR_Nem_3	209	215	PF02991	0.584
LIG_PCNA_yPIPBox_3	25	33	PF02747	0.294
LIG_PTB_Apo_2	54	61	PF02174	0.504
LIG_SH2_CRK	73	77	PF00017	0.457
LIG_SH2_NCK_1	4	8	PF00017	0.601
LIG_SH2_SRC	146	149	PF00017	0.626
LIG_SH2_SRC	181	184	PF00017	0.642
LIG_SH2_STAP1	167	171	PF00017	0.522
LIG_SH2_STAP1	212	216	PF00017	0.565
LIG_SH2_STAT3	123	126	PF00017	0.580
LIG_SH2_STAT5	146	149	PF00017	0.616
LIG_SH2_STAT5	32	35	PF00017	0.514
LIG_SH2_STAT5	36	39	PF00017	0.476
LIG_SH2_STAT5	59	62	PF00017	0.457
LIG_SH2_STAT5	75	78	PF00017	0.480
MOD_CK1_1	166	172	PF00069	0.571
MOD_CK2_1	125	131	PF00069	0.738
MOD_CK2_1	162	168	PF00069	0.571
MOD_GlcNHglycan	127	130	PF01048	0.672
MOD_GlcNHglycan	151	154	PF01048	0.606
MOD_GlcNHglycan	159	162	PF01048	0.624
MOD_GlcNHglycan	182	186	PF01048	0.755
MOD_GSK3_1	162	169	PF00069	0.651
MOD_LATS_1	154	160	PF00433	0.510
MOD_N-GLC_1	156	161	PF02516	0.601
MOD_NEK2_1	76	81	PF00069	0.457
MOD_PIKK_1	99	105	PF00454	0.598
MOD_PKA_2	84	90	PF00069	0.549
MOD_Plk_2-3	142	148	PF00069	0.591
MOD_Plk_2-3	163	169	PF00069	0.502
MOD_Plk_4	142	148	PF00069	0.657
TRG_ENDOCYTIC_2	212	215	PF00928	0.594
TRG_ENDOCYTIC_2	59	62	PF00928	0.457
TRG_ENDOCYTIC_2	73	76	PF00928	0.371
TRG_ER_diArg_1	224	227	PF00400	0.550
TRG_ER_diArg_1	50	53	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET4	Leptomonas seymouri	51%	100%
A0A3S7WVH7	Leishmania donovani	94%	100%
A4HA73	Leishmania braziliensis	80%	91%
A4HYE5	Leishmania infantum	95%	100%
D0A0T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
E9AS78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%