LeishMANIAdb
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PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PHB domain-containing protein
Gene product:
SPFH domain / Band 7 family, putative
Species:
Leishmania major
UniProt:
Q4QD86_LEIMA
TriTrypDb:
LmjF.19.1290 , LMJLV39_190018600 , LMJSD75_190018600
Length:
283

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0005886 plasma membrane 3 2
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

Q4QD86
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD86

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 168 170 PF00675 0.341
CLV_PCSK_KEX2_1 168 170 PF00082 0.341
CLV_PCSK_KEX2_1 194 196 PF00082 0.432
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.432
CLV_PCSK_SKI1_1 210 214 PF00082 0.566
CLV_PCSK_SKI1_1 254 258 PF00082 0.629
DOC_MAPK_gen_1 194 201 PF00069 0.424
DOC_MAPK_gen_1 227 236 PF00069 0.564
DOC_MAPK_gen_1 59 68 PF00069 0.384
DOC_MAPK_MEF2A_6 227 236 PF00069 0.445
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7U5 Leptomonas seymouri 32% 100%
A0A0N0P871 Leptomonas seymouri 82% 99%
A0A0S4INL5 Bodo saltans 47% 100%
A0A0S4IW13 Bodo saltans 41% 100%
A0A0S4JWM2 Bodo saltans 33% 91%
A0A1X0NF09 Trypanosomatidae 35% 100%
A0A1X0NZM1 Trypanosomatidae 59% 100%
A0A3Q8IK54 Leishmania donovani 98% 100%
A0A3R7M6V7 Trypanosoma rangeli 23% 74%
A0A3R7NUY2 Trypanosoma rangeli 60% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS