PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SPFH domain / Band 7 family, putative

Species:

Leishmania major

UniProt:

Q4QD86_LEIMA

TriTrypDb:

LmjF.19.1290 , LMJLV39_190018600 , LMJSD75_190018600

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.341
CLV_PCSK_KEX2_1	168	170	PF00082	0.341
CLV_PCSK_KEX2_1	194	196	PF00082	0.432
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.432
CLV_PCSK_SKI1_1	210	214	PF00082	0.566
CLV_PCSK_SKI1_1	254	258	PF00082	0.629
DOC_MAPK_gen_1	194	201	PF00069	0.424
DOC_MAPK_gen_1	227	236	PF00069	0.564
DOC_MAPK_gen_1	59	68	PF00069	0.384
DOC_MAPK_MEF2A_6	227	236	PF00069	0.445
DOC_MAPK_MEF2A_6	42	51	PF00069	0.338
DOC_MAPK_NFAT4_5	229	237	PF00069	0.477
DOC_PP4_FxxP_1	88	91	PF00568	0.388
DOC_USP7_MATH_1	151	155	PF00917	0.425
DOC_USP7_MATH_1	222	226	PF00917	0.618
LIG_14-3-3_CanoR_1	42	48	PF00244	0.343
LIG_Actin_WH2_2	34	50	PF00022	0.421
LIG_eIF4E_1	110	116	PF01652	0.401
LIG_FHA_1	129	135	PF00498	0.452
LIG_FHA_1	51	57	PF00498	0.365
LIG_FHA_1	9	15	PF00498	0.322
LIG_FHA_2	109	115	PF00498	0.327
LIG_FHA_2	145	151	PF00498	0.307
LIG_FHA_2	168	174	PF00498	0.346
LIG_LIR_Nem_3	2	6	PF02991	0.395
LIG_LIR_Nem_3	82	88	PF02991	0.353
LIG_PTB_Apo_2	235	242	PF02174	0.424
LIG_SH2_CRK	74	78	PF00017	0.307
LIG_SH2_STAT5	110	113	PF00017	0.333
LIG_SH2_STAT5	240	243	PF00017	0.464
LIG_TYR_ITIM	72	77	PF00017	0.307
LIG_UBA3_1	115	123	PF00899	0.360
LIG_UBA3_1	208	213	PF00899	0.574
LIG_WRC_WIRS_1	216	221	PF05994	0.475
LIG_WRC_WIRS_1	95	100	PF05994	0.322
MOD_CK1_1	140	146	PF00069	0.495
MOD_CK1_1	154	160	PF00069	0.452
MOD_CK1_1	215	221	PF00069	0.455
MOD_CK1_1	249	255	PF00069	0.596
MOD_CK1_1	89	95	PF00069	0.414
MOD_CK2_1	108	114	PF00069	0.335
MOD_CK2_1	144	150	PF00069	0.341
MOD_CK2_1	167	173	PF00069	0.341
MOD_CK2_1	211	217	PF00069	0.488
MOD_CK2_1	7	13	PF00069	0.407
MOD_GlcNHglycan	126	129	PF01048	0.360
MOD_GlcNHglycan	150	154	PF01048	0.466
MOD_GlcNHglycan	196	199	PF01048	0.487
MOD_GlcNHglycan	248	251	PF01048	0.664
MOD_GSK3_1	124	131	PF00069	0.447
MOD_GSK3_1	137	144	PF00069	0.464
MOD_GSK3_1	211	218	PF00069	0.490
MOD_GSK3_1	94	101	PF00069	0.452
MOD_N-GLC_2	260	262	PF02516	0.587
MOD_NEK2_1	141	146	PF00069	0.341
MOD_NEK2_1	98	103	PF00069	0.441
MOD_NEK2_2	151	156	PF00069	0.406
MOD_NEK2_2	37	42	PF00069	0.329
MOD_NEK2_2	43	48	PF00069	0.266
MOD_NEK2_2	50	55	PF00069	0.307
MOD_PIKK_1	157	163	PF00454	0.360
MOD_PKA_1	194	200	PF00069	0.484
MOD_PKA_2	167	173	PF00069	0.367
MOD_PKA_2	194	200	PF00069	0.510
MOD_PKA_2	86	92	PF00069	0.391
MOD_Plk_1	141	147	PF00069	0.341
MOD_Plk_4	141	147	PF00069	0.322
MOD_Plk_4	215	221	PF00069	0.468
MOD_Plk_4	98	104	PF00069	0.452
MOD_SUMO_rev_2	119	125	PF00179	0.452
MOD_SUMO_rev_2	188	196	PF00179	0.440
MOD_SUMO_rev_2	52	60	PF00179	0.344
TRG_ENDOCYTIC_2	74	77	PF00928	0.310
TRG_ER_diArg_1	167	169	PF00400	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7U5	Leptomonas seymouri	32%	100%
A0A0N0P871	Leptomonas seymouri	82%	99%
A0A0S4INL5	Bodo saltans	47%	100%
A0A0S4IW13	Bodo saltans	41%	100%
A0A0S4JWM2	Bodo saltans	33%	91%
A0A1X0NF09	Trypanosomatidae	35%	100%
A0A1X0NZM1	Trypanosomatidae	59%	100%
A0A3Q8IK54	Leishmania donovani	98%	100%
A0A3R7M6V7	Trypanosoma rangeli	23%	74%
A0A3R7NUY2	Trypanosoma rangeli	60%	100%
A0A3S7WVJ3	Leishmania donovani	32%	100%
A4HA74	Leishmania braziliensis	31%	100%
A4HYE6	Leishmania infantum	32%	100%
A4HYE7	Leishmania infantum	99%	100%
E9AS79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AS80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O26788	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	89%
P0AA53	Escherichia coli (strain K12)	22%	93%
P0AA54	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	93%
P0AA55	Escherichia coli O157:H7	22%	93%
P0AA56	Shigella flexneri	22%	93%
P0DKS0	Wigglesworthia glossinidia brevipalpis	25%	90%
P63694	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	26%	74%
P72655	Synechocystis sp. (strain PCC 6803 / Kazusa)	21%	88%
P9WPR8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	74%
P9WPR9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	74%
Q32LL2	Bos taurus	23%	79%
Q4FZT0	Rattus norvegicus	23%	80%
Q4QD87	Leishmania major	32%	100%
Q5GI04	Capsicum annuum	40%	99%
Q5UP73	Acanthamoeba polyphaga mimivirus	22%	93%
Q6K550	Oryza sativa subsp. japonica	39%	99%
Q6L4S3	Oryza sativa subsp. japonica	41%	98%
Q6ZIV7	Oryza sativa subsp. japonica	41%	100%
Q99JB2	Mus musculus	23%	80%
Q9CAR7	Arabidopsis thaliana	40%	99%
Q9FHM7	Arabidopsis thaliana	39%	97%
Q9FM19	Arabidopsis thaliana	41%	99%
Q9SRH6	Arabidopsis thaliana	38%	99%
Q9UJZ1	Homo sapiens	23%	79%
V5BBU5	Trypanosoma cruzi	23%	70%
V5BQ22	Trypanosoma cruzi	61%	100%
V5D2B9	Trypanosoma cruzi	36%	100%